miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-374b-5p ABI3BP 0.0804104684417872 0.365593963035077 0.353033521886912 0.0878367110802271 mirMAP -0.373312083891091 0.00401370652003153 NA NA NA hsa-miR-590-5p ABI3BP 0.709763558412506 1.11883921359361e-11 0.353033521886912 0.0878367110802271 miRanda -0.279883881582977 0.00846577189320452 NA NA NA hsa-miR-10b-3p ADAM12 -0.8205021989966 7.84331443044781e-21 1.67281581945959 5.93424290307862e-10 mirMAP -1.24760303333396 3.90180647191674e-15 NA NA NA hsa-miR-139-5p ADAM12 -0.704802495091118 2.36904108453776e-06 1.67281581945959 5.93424290307862e-10 miRanda -0.668801300823939 9.82635524536885e-12 NA NA NA hsa-miR-188-5p ADAM12 -1.74586655806628 1.50431624674552e-28 1.67281581945959 5.93424290307862e-10 mirMAP -0.491126090556542 5.43641140782e-08 NA NA NA hsa-miR-204-5p ADAM12 -1.67490789640238 9.14741888352476e-10 1.67281581945959 5.93424290307862e-10 mirMAP -0.467219802108867 1.0888060571113e-19 NA NA NA hsa-miR-20b-5p ADAM12 -1.30218163823367 6.87172815978149e-17 1.67281581945959 5.93424290307862e-10 mirMAP -0.36032762557986 0.000108759468617159 NA NA NA hsa-miR-29c-3p ADAM12 -0.238671318446745 0.0141475322347596 1.67281581945959 5.93424290307862e-10 miRNATAP -0.768695605212131 8.61244670096495e-07 NA NA NA hsa-miR-429 ADAM12 -2.16569233119434 2.66862243626443e-37 1.67281581945959 5.93424290307862e-10 miRanda;miRNATAP -0.582551296545264 4.96935444215704e-14 NA NA NA hsa-miR-501-3p ADAM12 -1.30538668412879 3.52127864608017e-18 1.67281581945959 5.93424290307862e-10 TargetScan -0.332616101909562 0.000570383311221428 NA NA NA hsa-miR-125a-5p ANPEP -0.561874059994802 7.3931856356891e-13 0.762941034488922 0.00458061064915934 PITA;miRanda;miRNATAP -0.723618099926472 8.85202744351959e-05 NA NA NA hsa-miR-96-5p ANPEP -1.00223771166604 3.91564621567028e-06 0.762941034488922 0.00458061064915934 mirMAP -0.266909366311504 0.000120548875738271 NA NA NA hsa-miR-3170 APLP1 0.664452094631118 2.78926402033808e-05 -1.10856110609407 7.97037333825449e-07 miRNATAP -0.290675603891026 0.000245606250163641 NA NA NA hsa-miR-217 AREG -1.32414431829977 4.20138196453017e-06 1.08083448160875 1.79410213062414e-06 miRanda -0.149583840613324 0.000552223055467858 NA NA NA hsa-miR-335-5p AREG -2.09515619961552 1.03765771499548e-25 1.08083448160875 1.79410213062414e-06 miRNAWalker2_validate -0.275659776397617 2.46001341247139e-06 NA NA NA hsa-miR-429 AREG -2.16569233119434 2.66862243626443e-37 1.08083448160875 1.79410213062414e-06 miRanda -0.265862560949342 5.65995820091643e-05 NA NA NA hsa-miR-139-5p BASP1 -0.704802495091118 2.36904108453776e-06 0.432589298225466 0.0097617573671509 miRanda -0.455448122506073 9.32563491150409e-15 NA NA NA hsa-miR-200b-3p BASP1 -1.70383252137161 2.38979336321755e-30 0.432589298225466 0.0097617573671509 TargetScan -0.204493620641243 0.000289239041732012 NA NA NA hsa-miR-429 BASP1 -2.16569233119434 2.66862243626443e-37 0.432589298225466 0.0097617573671509 PITA;miRanda;miRNATAP -0.191670359177535 7.07822575246041e-05 NA NA NA hsa-miR-532-3p BASP1 -1.759223962964 7.9077916669414e-40 0.432589298225466 0.0097617573671509 PITA -0.213635186665509 0.000484690808789075 NA NA NA hsa-miR-182-5p BDNF -0.608710746044567 0.0025264935278104 1.32053589639348 4.6461489093674e-09 MirTarget;miRNATAP -0.320911985212199 2.19358929074297e-07 NA NA NA hsa-miR-22-3p BDNF 0.198460552200729 0.00761005672059428 1.32053589639348 4.6461489093674e-09 miRNAWalker2_validate;miRTarBase -0.934418001650865 4.10404904290013e-08 NA NA NA hsa-miR-3065-3p BDNF -1.64500070417457 9.57561660036697e-16 1.32053589639348 4.6461489093674e-09 MirTarget;miRNATAP -0.173566329974244 0.00341422805602149 NA NA NA hsa-miR-30b-5p BDNF -1.18330589477119 6.8341618466966e-27 1.32053589639348 4.6461489093674e-09 miRNATAP -0.418679389730946 7.95864809848167e-05 NA NA NA hsa-miR-361-5p BDNF 0.0514169367202078 0.382929376393199 1.32053589639348 4.6461489093674e-09 PITA;miRanda;miRNATAP -0.579854997171823 0.00910447765702249 NA NA NA hsa-miR-3913-5p BDNF 0.136365354811444 0.24239516424369 1.32053589639348 4.6461489093674e-09 mirMAP -0.437476166734317 0.000137119405950826 NA NA NA hsa-miR-508-3p BDNF -3.41433288024917 3.47699261121175e-37 1.32053589639348 4.6461489093674e-09 PITA;miRNATAP -0.227379255506386 4.7723104940365e-08 NA NA NA hsa-miR-30b-3p BGN -1.64703050862226 1.89878531036464e-31 0.716257974223206 4.24635182492442e-06 mirMAP -0.340306079652352 6.44516666912765e-10 NA NA NA hsa-miR-125a-5p BMP1 -0.561874059994802 7.3931856356891e-13 1.8752531378355 1.83205069364508e-44 mirMAP -0.663703620578581 1.3113534550383e-10 NA NA NA hsa-miR-125b-5p BMP1 -0.825456421494266 2.13029877878434e-15 1.8752531378355 1.83205069364508e-44 mirMAP -0.361266934986005 3.37659386195539e-06 NA NA NA hsa-miR-139-3p BMP1 -0.591163696237154 0.000163218913171693 1.8752531378355 1.83205069364508e-44 miRNATAP -0.240094631604004 6.69863115817992e-06 NA NA NA hsa-miR-139-5p BMP1 -0.704802495091118 2.36904108453776e-06 1.8752531378355 1.83205069364508e-44 miRanda -0.329580756756624 2.06964968802334e-09 NA NA NA hsa-miR-27b-3p BMP1 -0.699527231242518 1.07356023759234e-15 1.8752531378355 1.83205069364508e-44 mirMAP -0.560800800058569 1.02846798207009e-09 NA NA NA hsa-miR-29a-3p BMP1 -0.431613225927952 4.10166815070288e-08 1.8752531378355 1.83205069364508e-44 miRNATAP -0.379373852571113 0.000384748817858132 NA NA NA hsa-miR-29c-3p BMP1 -0.238671318446745 0.0141475322347596 1.8752531378355 1.83205069364508e-44 miRNATAP -0.389272047228885 7.77916648130845e-06 NA NA NA hsa-miR-30b-3p BMP1 -1.64703050862226 1.89878531036464e-31 1.8752531378355 1.83205069364508e-44 miRNATAP -0.532486067270803 1.77883125949588e-25 NA NA NA hsa-miR-335-5p BMP1 -2.09515619961552 1.03765771499548e-25 1.8752531378355 1.83205069364508e-44 miRNAWalker2_validate -0.160152917606892 4.87618820735127e-05 NA NA NA hsa-miR-362-5p BMP1 -2.72767654824605 1.34821749679113e-49 1.8752531378355 1.83205069364508e-44 mirMAP -0.447133814207259 7.81399745041052e-37 NA NA NA hsa-miR-429 BMP1 -2.16569233119434 2.66862243626443e-37 1.8752531378355 1.83205069364508e-44 miRNATAP -0.396012908814919 3.64880608178775e-21 NA NA NA hsa-miR-101-3p CADM1 0.683973909682285 2.88573524246948e-15 -1.47255734718029 3.03997170543541e-24 MirTarget;miRNATAP -0.792540971277828 3.58112515845155e-18 NA NA NA hsa-miR-126-5p CADM1 0.785607261431085 5.77058629454465e-13 -1.47255734718029 3.03997170543541e-24 MirTarget -0.368721925738215 1.06949510811499e-06 26464628 MicroRNA 126 regulates migration and invasion of gastric cancer by targeting CADM1; Bioinformatics and luciferase reporter assay revealed that miR-126 specifically targeted the 3'UTR of cell adhesion molecule 1 CADM1 and regulated its expression; Furthermore in tumor tissues obtained from gastric cancer patients the expression of miR-126 was negatively correlated with CADM1 and the high expression of miR-126 combined with low expression of CADM1 might serve as a risk factor for stage1 gastric cancer patients; Our study showed that miR-126 by down-regulation CADM1 enhances migration and invasion in GC cells staging gastric cancer hsa-miR-142-5p CADM1 1.88417391525707 1.2096808039882e-27 -1.47255734718029 3.03997170543541e-24 PITA -0.237275902233378 1.36848086254196e-07 NA NA NA hsa-miR-144-3p CADM1 1.4617706700291 9.18139413836375e-11 -1.47255734718029 3.03997170543541e-24 miRNATAP -0.112514638547428 0.00239873314420532 NA NA NA hsa-miR-15a-5p CADM1 1.42663930007845 1.36006952074963e-57 -1.47255734718029 3.03997170543541e-24 miRNAWalker2_validate;miRTarBase;miRNATAP -0.641683824942125 1.21868260314628e-16 NA NA NA hsa-miR-15b-5p CADM1 0.773001494057531 1.71784656078957e-16 -1.47255734718029 3.03997170543541e-24 miRNATAP -0.301692764091112 0.000592980850313409 NA NA NA hsa-miR-16-5p CADM1 0.934012514027655 4.85417898318515e-24 -1.47255734718029 3.03997170543541e-24 miRNAWalker2_validate;miRTarBase;miRNATAP -0.485739771016954 1.41523292805776e-08 NA NA NA hsa-miR-192-3p CADM1 0.156650099616707 0.483496040900362 -1.47255734718029 3.03997170543541e-24 MirTarget -0.111437551630079 0.00405320007568144 NA NA NA hsa-miR-192-5p CADM1 0.442478872410106 0.0669238175123954 -1.47255734718029 3.03997170543541e-24 miRNAWalker2_validate -0.117391733176997 0.000950732605102179 NA NA NA hsa-miR-193a-3p CADM1 0.849206638484406 3.68101781083335e-14 -1.47255734718029 3.03997170543541e-24 MirTarget;PITA;miRanda;miRNATAP -0.217633743285963 0.00332967769222764 NA NA NA hsa-miR-194-5p CADM1 0.62222617402691 0.00659826803316099 -1.47255734718029 3.03997170543541e-24 miRNATAP -0.167663500170405 6.11143103106412e-06 NA NA NA hsa-miR-195-5p CADM1 0.346502644882604 0.0092562828415903 -1.47255734718029 3.03997170543541e-24 miRNATAP -0.2030035773333 0.001665416594787 NA NA NA hsa-miR-224-3p CADM1 0.918780460857403 2.47005991706282e-07 -1.47255734718029 3.03997170543541e-24 MirTarget -0.141448684246576 0.00403268438077539 NA NA NA hsa-miR-23a-3p CADM1 0.761438723382355 4.09310879199257e-27 -1.47255734718029 3.03997170543541e-24 miRNATAP -0.659195322935071 3.30973683706678e-09 NA NA NA hsa-miR-27a-3p CADM1 0.558934437526245 1.44256383086177e-12 -1.47255734718029 3.03997170543541e-24 MirTarget;miRNATAP -0.567155654835538 6.2954038542416e-08 NA NA NA hsa-miR-32-5p CADM1 0.407826130035097 7.26884631998646e-06 -1.47255734718029 3.03997170543541e-24 miRNATAP -0.576535704305875 3.85205084178553e-10 NA NA NA hsa-miR-338-3p CADM1 0.906250377628867 2.76970900371139e-15 -1.47255734718029 3.03997170543541e-24 PITA;miRanda -0.452691948624535 1.17964002717245e-10 NA NA NA hsa-miR-342-3p CADM1 1.4124432570595 1.07208971556131e-28 -1.47255734718029 3.03997170543541e-24 PITA;miRanda -0.293731520624925 1.74229806142602e-06 NA NA NA hsa-miR-455-5p CADM1 0.773674551205946 2.12957541541474e-09 -1.47255734718029 3.03997170543541e-24 miRanda -0.360801545600712 1.73831718071112e-08 NA NA NA hsa-miR-484 CADM1 0.571987778099603 9.67278224458421e-10 -1.47255734718029 3.03997170543541e-24 miRNAWalker2_validate -0.255789790735014 0.00466508046515876 NA NA NA hsa-miR-590-3p CADM1 1.13702599385212 3.53435739887793e-22 -1.47255734718029 3.03997170543541e-24 miRanda;mirMAP -0.361014688330823 1.03205487704553e-07 NA NA NA hsa-miR-590-5p CADM1 0.709763558412506 1.11883921359361e-11 -1.47255734718029 3.03997170543541e-24 PITA;miRanda;miRNATAP -0.321008993351983 5.62852843520941e-05 NA NA NA hsa-miR-27b-3p CALD1 -0.699527231242518 1.07356023759234e-15 0.629184294305535 2.78916562004268e-11 miRNATAP -0.218156924263234 0.000219809945266532 NA NA NA hsa-miR-429 CALD1 -2.16569233119434 2.66862243626443e-37 0.629184294305535 2.78916562004268e-11 miRanda -0.194326121069654 9.76105824149157e-13 NA NA NA hsa-miR-107 CALU 0.140046250553248 0.0943611632552367 0.683301202200484 5.9880797818303e-14 MirTarget;PITA;miRanda -0.22554475727652 0.00032631121164794 NA NA NA hsa-miR-10a-3p CALU -1.40380922426511 3.42207767326254e-23 0.683301202200484 5.9880797818303e-14 mirMAP -0.154978531051043 8.81318718784748e-06 NA NA NA hsa-miR-200b-3p CALU -1.70383252137161 2.38979336321755e-30 0.683301202200484 5.9880797818303e-14 MirTarget;TargetScan -0.246066878266987 8.29963284069853e-16 NA NA NA hsa-miR-23b-3p CALU -0.533749586990474 2.46924776953771e-10 0.683301202200484 5.9880797818303e-14 mirMAP -0.340727867623813 1.09537533998584e-08 NA NA NA hsa-miR-29c-3p CALU -0.238671318446745 0.0141475322347596 0.683301202200484 5.9880797818303e-14 MirTarget -0.329918813814414 3.58902441409969e-10 NA NA NA hsa-miR-30a-3p CALU -0.955360819934585 1.97009535429185e-20 0.683301202200484 5.9880797818303e-14 MirTarget -0.49799900617227 3.57601623123554e-30 NA NA NA hsa-miR-30a-5p CALU -0.778411951775343 2.73322451127932e-16 0.683301202200484 5.9880797818303e-14 MirTarget -0.56758013186094 1.03589238862192e-32 NA NA NA hsa-miR-30b-5p CALU -1.18330589477119 6.8341618466966e-27 0.683301202200484 5.9880797818303e-14 MirTarget -0.360818046595247 3.82958335554968e-18 NA NA NA hsa-miR-30c-5p CALU -1.08783070774238 2.02505402525786e-24 0.683301202200484 5.9880797818303e-14 MirTarget -0.363537336146711 6.23847150093752e-17 NA NA NA hsa-miR-30d-3p CALU -0.249777194282131 0.00235356711813496 0.683301202200484 5.9880797818303e-14 MirTarget -0.392617063675596 3.17318076701325e-10 NA NA NA hsa-miR-30d-5p CALU -0.202727675788184 0.00659067084745794 0.683301202200484 5.9880797818303e-14 MirTarget -0.440289985880171 1.70574045605643e-10 NA NA NA hsa-miR-30e-3p CALU -0.205602546270795 0.00132666419729688 0.683301202200484 5.9880797818303e-14 MirTarget;mirMAP -0.340053577016007 3.46824624969949e-05 NA NA NA hsa-miR-429 CALU -2.16569233119434 2.66862243626443e-37 0.683301202200484 5.9880797818303e-14 MirTarget;PITA;miRanda -0.237063648150525 4.1334210268272e-20 NA NA NA hsa-miR-125a-3p CAP2 -0.372794471295036 0.000941729459601642 0.269601766855227 0.00462289942065173 miRanda -0.150284627683969 0.00126099119954612 NA NA NA hsa-miR-335-3p CAP2 -1.36498175550207 6.84287752180534e-13 0.269601766855227 0.00462289942065173 mirMAP -0.104448046545817 8.448666980034e-05 NA NA NA hsa-miR-139-5p CAPG -0.704802495091118 2.36904108453776e-06 -0.0970635302456184 0.444727155337545 miRanda -0.336617201692238 3.6618184346764e-14 NA NA NA hsa-miR-10a-3p CD44 -1.40380922426511 3.42207767326254e-23 1.09698062096124 3.50437570720206e-14 mirMAP -0.301073372722584 4.83833068610726e-08 NA NA NA hsa-miR-27b-3p CD44 -0.699527231242518 1.07356023759234e-15 1.09698062096124 3.50437570720206e-14 miRNATAP -0.75317647612432 6.52868475466025e-18 NA NA NA hsa-miR-30a-3p CD44 -0.955360819934585 1.97009535429185e-20 1.09698062096124 3.50437570720206e-14 mirMAP -0.810529815686226 1.14342621795484e-31 NA NA NA hsa-miR-30a-5p CD44 -0.778411951775343 2.73322451127932e-16 1.09698062096124 3.50437570720206e-14 miRNAWalker2_validate -0.807611403828607 3.40705120029219e-25 NA NA NA hsa-miR-30c-2-3p CD44 -1.28402709024345 6.77577627955178e-25 1.09698062096124 3.50437570720206e-14 MirTarget -0.711630984441871 3.86514736550624e-38 NA NA NA hsa-miR-30e-3p CD44 -0.205602546270795 0.00132666419729688 1.09698062096124 3.50437570720206e-14 mirMAP -0.954797602397218 5.81592488140718e-14 NA NA NA hsa-miR-328-3p CD44 0.011417538344733 0.906769951090636 1.09698062096124 3.50437570720206e-14 miRNAWalker2_validate;miRTarBase -0.236236531134327 0.00610313827640028 NA NA NA hsa-miR-532-3p CD44 -1.759223962964 7.9077916669414e-40 1.09698062096124 3.50437570720206e-14 miRNATAP -0.478006207258165 4.51590113281816e-20 NA NA NA hsa-miR-577 CD44 -1.48881999472397 7.03080165111147e-10 1.09698062096124 3.50437570720206e-14 MirTarget;PITA;miRNATAP -0.161866832735411 1.14682180615453e-06 NA NA NA hsa-miR-744-5p CD44 -0.348985243196771 0.000187889982228835 1.09698062096124 3.50437570720206e-14 miRNAWalker2_validate -0.399822175959285 5.6864600889567e-06 NA NA NA hsa-let-7i-5p CD59 0.911372377723717 7.11483853341932e-31 -0.325225413927614 1.41231907625361e-07 MirTarget -0.130360256354979 0.00115445991445971 NA NA NA hsa-miR-590-3p CD59 1.13702599385212 3.53435739887793e-22 -0.325225413927614 1.41231907625361e-07 mirMAP -0.112008657284011 4.51186215025764e-05 NA NA NA hsa-miR-92a-3p CD59 0.178194888895831 0.0088835082650834 -0.325225413927614 1.41231907625361e-07 miRNAWalker2_validate -0.18383755377383 0.00034091291480915 NA NA NA hsa-miR-98-5p CD59 0.0569715596189075 0.450575962846765 -0.325225413927614 1.41231907625361e-07 MirTarget -0.136529860242181 0.00330695512935885 NA NA NA hsa-miR-200b-3p CDH11 -1.70383252137161 2.38979336321755e-30 0.545476448994591 0.000623542479752732 TargetScan -0.425548412977265 2.00412646825037e-16 NA NA NA hsa-miR-362-3p CDH11 -0.753214251798232 3.0025661608035e-07 0.545476448994591 0.000623542479752732 miRanda -0.252285324514908 3.21535191416479e-05 NA NA NA hsa-miR-429 CDH11 -2.16569233119434 2.66862243626443e-37 0.545476448994591 0.000623542479752732 PITA;miRanda -0.356756940269431 1.00483627628763e-15 NA NA NA hsa-miR-500a-5p CDH11 -1.28374735824553 1.95870374809798e-20 0.545476448994591 0.000623542479752732 mirMAP -0.247014711541318 3.64248756992145e-05 NA NA NA hsa-miR-218-5p CDH2 -0.81077534785501 3.0631582201951e-08 1.07932332381437 2.34739459198359e-07 miRNATAP -0.21711373100462 0.00571422889459504 24705471 ADAM9 up regulates N cadherin via miR 218 suppression in lung adenocarcinoma cells; Luciferase assays and western blot analysis showed that CDH2 is a target gene of miR-218 lung cancer hsa-miR-429 CDH2 -2.16569233119434 2.66862243626443e-37 1.07932332381437 2.34739459198359e-07 miRanda -0.306085915349991 4.5011434952368e-07 NA NA NA hsa-miR-532-3p CDH2 -1.759223962964 7.9077916669414e-40 1.07932332381437 2.34739459198359e-07 PITA -0.29852464118514 0.000114942404503503 NA NA NA hsa-miR-199a-5p CDH6 -1.64658415208633 1.01615659358973e-23 2.08655287496588 1.4586102239391e-21 miRanda -0.403113765336622 1.97094772154848e-08 NA NA NA hsa-miR-199b-5p CDH6 -2.39483476763681 1.04659509514884e-17 2.08655287496588 1.4586102239391e-21 miRanda -0.237124404973713 7.12128794404627e-08 NA NA NA hsa-miR-200b-3p CDH6 -1.70383252137161 2.38979336321755e-30 2.08655287496588 1.4586102239391e-21 TargetScan -0.361529689909956 3.63218920048098e-06 NA NA NA hsa-miR-24-1-5p CDH6 -1.09236439756236 3.27091225010919e-23 2.08655287496588 1.4586102239391e-21 MirTarget -0.436398649182399 6.09464092165022e-05 NA NA NA hsa-miR-29a-5p CDH6 -0.519003718107105 1.03351148282116e-06 2.08655287496588 1.4586102239391e-21 mirMAP -0.383925199521689 0.00135926245594297 NA NA NA hsa-miR-3913-5p CDH6 0.136365354811444 0.24239516424369 2.08655287496588 1.4586102239391e-21 mirMAP -0.3708789551029 0.00146108101459238 NA NA NA hsa-miR-429 CDH6 -2.16569233119434 2.66862243626443e-37 2.08655287496588 1.4586102239391e-21 miRanda;miRNATAP -0.317169961681522 2.07012367661561e-06 NA NA NA hsa-miR-501-3p CDH6 -1.30538668412879 3.52127864608017e-18 2.08655287496588 1.4586102239391e-21 MirTarget -0.306489925972786 0.000158362322899339 NA NA NA hsa-miR-502-3p CDH6 -1.10416310320528 1.55354569985732e-22 2.08655287496588 1.4586102239391e-21 MirTarget -0.886146101194398 2.48622595991164e-18 NA NA NA hsa-miR-582-5p CDH6 -0.323404837478908 0.0786820871592677 2.08655287496588 1.4586102239391e-21 mirMAP -0.23504128405261 0.000808112802027142 NA NA NA hsa-miR-654-3p CDH6 -1.07948413911035 1.47901771988248e-07 2.08655287496588 1.4586102239391e-21 mirMAP -0.163156920774476 0.00966113284344018 NA NA NA hsa-miR-139-5p COL11A1 -0.704802495091118 2.36904108453776e-06 1.24180885334442 0.00231683014269483 miRanda -0.515580796760347 0.000532692620685817 NA NA NA hsa-miR-141-3p COL11A1 -5.87110686537457 1.20877726722907e-85 1.24180885334442 0.00231683014269483 miRNATAP -0.161228023966267 0.00557883799910266 NA NA NA hsa-miR-200a-3p COL11A1 -1.43409013664263 2.00188483717828e-20 1.24180885334442 0.00231683014269483 miRNATAP -0.827802021574252 6.90494028390363e-10 NA NA NA hsa-miR-29c-3p COL11A1 -0.238671318446745 0.0141475322347596 1.24180885334442 0.00231683014269483 MirTarget;miRNATAP -0.919198274019896 7.49530330517097e-05 NA NA NA hsa-miR-3065-3p COL11A1 -1.64500070417457 9.57561660036697e-16 1.24180885334442 0.00231683014269483 MirTarget;miRNATAP -0.492594899767911 2.23977595969596e-06 NA NA NA hsa-miR-362-3p COL11A1 -0.753214251798232 3.0025661608035e-07 1.24180885334442 0.00231683014269483 miRanda -0.948913221270259 4.84150914054287e-10 NA NA NA hsa-miR-429 COL11A1 -2.16569233119434 2.66862243626443e-37 1.24180885334442 0.00231683014269483 miRanda -0.590271103789773 4.43529758567353e-07 NA NA NA hsa-miR-455-3p COL11A1 0.171798655137046 0.261841668213493 1.24180885334442 0.00231683014269483 MirTarget;PITA -0.449481039863768 0.00236031657484223 NA NA NA hsa-miR-107 COL12A1 0.140046250553248 0.0943611632552367 -0.652418462456845 2.07128302483944e-05 miRanda -0.575351920221467 1.37307467846573e-08 NA NA NA hsa-miR-1180-3p COL12A1 0.376303898573175 0.00170218787143085 -0.652418462456845 2.07128302483944e-05 MirTarget -0.297118054399837 2.59483754244349e-05 NA NA NA hsa-miR-15a-5p COL12A1 1.42663930007845 1.36006952074963e-57 -0.652418462456845 2.07128302483944e-05 MirTarget;miRNATAP -0.348539221074726 1.26433106670219e-05 NA NA NA hsa-miR-17-3p COL12A1 0.723795600017259 5.90151677164931e-18 -0.652418462456845 2.07128302483944e-05 MirTarget;miRNATAP -0.325822661771894 0.000817640480194197 NA NA NA hsa-miR-30a-5p COL12A1 -0.778411951775343 2.73322451127932e-16 -0.652418462456845 2.07128302483944e-05 mirMAP -0.249768359734124 0.00377464378028318 NA NA NA hsa-miR-30d-3p COL12A1 -0.249777194282131 0.00235356711813496 -0.652418462456845 2.07128302483944e-05 miRNATAP -0.331426407076849 0.0015358040955953 NA NA NA hsa-miR-30d-5p COL12A1 -0.202727675788184 0.00659067084745794 -0.652418462456845 2.07128302483944e-05 mirMAP -0.553669714070962 1.32707321986789e-06 NA NA NA hsa-miR-32-5p COL12A1 0.407826130035097 7.26884631998646e-06 -0.652418462456845 2.07128302483944e-05 miRNATAP -0.391870540543937 2.46226673109266e-05 NA NA NA hsa-miR-532-5p COL12A1 -1.09700348358668 8.34836230254408e-26 -0.652418462456845 2.07128302483944e-05 PITA -0.239524063859651 0.00158453162392938 NA NA NA hsa-miR-590-3p COL12A1 1.13702599385212 3.53435739887793e-22 -0.652418462456845 2.07128302483944e-05 miRanda -0.296334669857013 1.24042677578112e-05 NA NA NA hsa-let-7e-5p COL1A1 -0.727009689927955 1.30690859412163e-11 2.51766806092129 1.02912948146724e-23 miRNATAP -0.53535989142091 6.47275213324096e-05 NA NA NA hsa-let-7g-5p COL1A1 -0.739744008507763 1.07979566264383e-14 2.51766806092129 1.02912948146724e-23 miRNATAP -0.642234744411444 1.59926896633574e-05 NA NA NA hsa-miR-106a-5p COL1A1 -0.830908656792615 2.67547872901508e-10 2.51766806092129 1.02912948146724e-23 mirMAP -0.32756432227868 0.0029615476614717 NA NA NA hsa-miR-20b-5p COL1A1 -1.30218163823367 6.87172815978149e-17 2.51766806092129 1.02912948146724e-23 mirMAP -0.486396274967718 5.53040127711441e-08 NA NA NA hsa-miR-29c-3p COL1A1 -0.238671318446745 0.0141475322347596 2.51766806092129 1.02912948146724e-23 miRNAWalker2_validate;miRTarBase;miRNATAP -0.738288595178453 1.18033711323556e-06 NA NA NA hsa-miR-30a-3p COL1A1 -0.955360819934585 1.97009535429185e-20 2.51766806092129 1.02912948146724e-23 mirMAP -1.44063702622346 3.79732507754676e-31 NA NA NA hsa-miR-30b-3p COL1A1 -1.64703050862226 1.89878531036464e-31 2.51766806092129 1.02912948146724e-23 miRNATAP -0.790083787800381 6.551105530343e-18 NA NA NA hsa-miR-30d-3p COL1A1 -0.249777194282131 0.00235356711813496 2.51766806092129 1.02912948146724e-23 mirMAP -1.09866037015696 7.26440447084517e-10 NA NA NA hsa-miR-30e-3p COL1A1 -0.205602546270795 0.00132666419729688 2.51766806092129 1.02912948146724e-23 mirMAP -1.58167089874789 4.96187492537979e-12 NA NA NA hsa-miR-532-3p COL1A1 -1.759223962964 7.9077916669414e-40 2.51766806092129 1.02912948146724e-23 PITA;miRNATAP -0.947046892181277 5.49121285938181e-25 NA NA NA hsa-miR-577 COL1A1 -1.48881999472397 7.03080165111147e-10 2.51766806092129 1.02912948146724e-23 MirTarget;PITA;miRNATAP -0.400640006383739 7.58867069768276e-12 NA NA NA hsa-let-7g-5p COL1A2 -0.739744008507763 1.07979566264383e-14 1.44422646571225 4.13059504084961e-14 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.36703668279415 0.000890423021559005 NA NA NA hsa-miR-125a-5p COL1A2 -0.561874059994802 7.3931856356891e-13 1.44422646571225 4.13059504084961e-14 miRanda -0.381709309749795 0.00526772589851098 NA NA NA hsa-miR-29c-3p COL1A2 -0.238671318446745 0.0141475322347596 1.44422646571225 4.13059504084961e-14 miRNAWalker2_validate;miRTarBase;miRNATAP -0.589864349491137 1.2961351972275e-07 NA NA NA hsa-miR-30a-3p COL1A2 -0.955360819934585 1.97009535429185e-20 1.44422646571225 4.13059504084961e-14 MirTarget -0.986599645035033 2.9088696279621e-26 NA NA NA hsa-miR-30d-3p COL1A2 -0.249777194282131 0.00235356711813496 1.44422646571225 4.13059504084961e-14 MirTarget -0.843349197467083 1.30918007076291e-10 NA NA NA hsa-miR-30e-3p COL1A2 -0.205602546270795 0.00132666419729688 1.44422646571225 4.13059504084961e-14 MirTarget -1.09284815967613 1.20848944930221e-10 NA NA NA hsa-miR-363-3p COL1A2 -1.93551166555337 4.45368477487614e-32 1.44422646571225 4.13059504084961e-14 MirTarget -0.266081744954766 9.49238769907248e-06 NA NA NA hsa-miR-500a-5p COL1A2 -1.28374735824553 1.95870374809798e-20 1.44422646571225 4.13059504084961e-14 miRNATAP -0.521895584422556 5.17038442715073e-13 NA NA NA hsa-let-7g-5p COL3A1 -0.739744008507763 1.07979566264383e-14 1.16551162456759 8.76576026470242e-10 MirTarget;miRNATAP -0.32032706318252 0.00314620342481099 NA NA NA hsa-miR-107 COL3A1 0.140046250553248 0.0943611632552367 1.16551162456759 8.76576026470242e-10 miRanda -0.407029741883538 0.00172044122844494 NA NA NA hsa-miR-29c-3p COL3A1 -0.238671318446745 0.0141475322347596 1.16551162456759 8.76576026470242e-10 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.645148617085589 3.1717583968027e-09 NA NA NA hsa-miR-429 COL3A1 -2.16569233119434 2.66862243626443e-37 1.16551162456759 8.76576026470242e-10 miRanda -0.457920289383383 1.57496221534542e-17 NA NA NA hsa-let-7g-5p COL4A1 -0.739744008507763 1.07979566264383e-14 1.94183996411033 2.41643075670989e-41 miRNATAP -0.4636926813178 2.60842499328651e-07 NA NA NA hsa-miR-125a-5p COL4A1 -0.561874059994802 7.3931856356891e-13 1.94183996411033 2.41643075670989e-41 miRNAWalker2_validate;miRanda -0.309627336969526 0.00608677526515925 NA NA NA hsa-miR-193b-3p COL4A1 -0.273325765316079 0.104328826585392 1.94183996411033 2.41643075670989e-41 miRNAWalker2_validate -0.162154654064249 0.00258542407763727 NA NA NA hsa-miR-29a-3p COL4A1 -0.431613225927952 4.10166815070288e-08 1.94183996411033 2.41643075670989e-41 miRNAWalker2_validate;miRTarBase;miRNATAP -0.714590899084669 1.38694561418969e-10 NA NA NA hsa-miR-29b-3p COL4A1 -0.228125979913806 0.0271621721891603 1.94183996411033 2.41643075670989e-41 miRNAWalker2_validate;miRTarBase;miRNATAP -0.466990420904892 7.25931186395536e-08 NA NA NA hsa-miR-29c-3p COL4A1 -0.238671318446745 0.0141475322347596 1.94183996411033 2.41643075670989e-41 miRNAWalker2_validate;miRTarBase;miRNATAP -0.477745072574213 2.22805368463949e-07 NA NA NA hsa-miR-362-3p COL4A1 -0.753214251798232 3.0025661608035e-07 1.94183996411033 2.41643075670989e-41 miRanda -0.410332593708248 1.47656230956698e-11 NA NA NA hsa-miR-429 COL4A1 -2.16569233119434 2.66862243626443e-37 1.94183996411033 2.41643075670989e-41 miRanda;miRNATAP -0.472001078335547 4.38287232821249e-27 NA NA NA hsa-miR-99a-5p COL4A1 -0.609395142445514 1.66643233447031e-07 1.94183996411033 2.41643075670989e-41 miRNAWalker2_validate -0.316765997519408 3.16106692571417e-05 NA NA NA hsa-let-7g-5p COL4A2 -0.739744008507763 1.07979566264383e-14 1.57393045236065 5.49853780312115e-35 miRNATAP -0.420904326300412 6.44055693457281e-08 NA NA NA hsa-miR-10a-5p COL4A2 -1.17164272592931 4.86621098042279e-24 1.57393045236065 5.49853780312115e-35 miRNAWalker2_validate -0.400725593079404 7.2445275580152e-11 NA NA NA hsa-miR-29a-3p COL4A2 -0.431613225927952 4.10166815070288e-08 1.57393045236065 5.49853780312115e-35 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.521798741269153 8.45354922139295e-08 NA NA NA hsa-miR-29b-3p COL4A2 -0.228125979913806 0.0271621721891603 1.57393045236065 5.49853780312115e-35 miRTarBase;MirTarget;miRNATAP -0.38356161191029 3.53590299862073e-07 NA NA NA hsa-miR-29c-3p COL4A2 -0.238671318446745 0.0141475322347596 1.57393045236065 5.49853780312115e-35 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.355587770579371 9.66726137131373e-06 NA NA NA hsa-miR-30c-2-3p COL4A2 -1.28402709024345 6.77577627955178e-25 1.57393045236065 5.49853780312115e-35 MirTarget -0.443927201799034 2.55003587016513e-15 NA NA NA hsa-miR-9-5p COL4A2 -2.23538606210968 1.28143998950751e-12 1.57393045236065 5.49853780312115e-35 MirTarget;miRNATAP -0.100803286678184 2.29866127265654e-05 NA NA NA hsa-miR-107 COL5A1 0.140046250553248 0.0943611632552367 1.65063983345142 1.53934391217252e-15 miRanda -0.511392087207544 0.000378413097308227 NA NA NA hsa-miR-135a-5p COL5A1 -2.13422485001223 6.29449029671498e-14 1.65063983345142 1.53934391217252e-15 miRNATAP -0.169094280069384 3.8423933683928e-05 NA NA NA hsa-miR-192-5p COL5A1 0.442478872410106 0.0669238175123954 1.65063983345142 1.53934391217252e-15 miRNATAP -0.129808878402673 0.00865985968005001 NA NA NA hsa-miR-29c-3p COL5A1 -0.238671318446745 0.0141475322347596 1.65063983345142 1.53934391217252e-15 MirTarget;miRNATAP -0.695622351516665 9.35463981604801e-09 NA NA NA hsa-miR-3065-3p COL5A1 -1.64500070417457 9.57561660036697e-16 1.65063983345142 1.53934391217252e-15 miRNATAP -0.36203620374857 2.28244927240165e-11 NA NA NA hsa-miR-744-5p COL5A1 -0.348985243196771 0.000187889982228835 1.65063983345142 1.53934391217252e-15 miRNAWalker2_validate -0.557270535367746 1.10305281383827e-05 NA NA NA hsa-let-7e-5p COL5A2 -0.727009689927955 1.30690859412163e-11 1.88958043462814 3.78137887696891e-30 MirTarget;miRNATAP -0.267546984457983 0.00323858532048149 NA NA NA hsa-let-7g-5p COL5A2 -0.739744008507763 1.07979566264383e-14 1.88958043462814 3.78137887696891e-30 MirTarget;miRNATAP -0.432872724071034 1.61424500039633e-05 NA NA NA hsa-miR-29a-3p COL5A2 -0.431613225927952 4.10166815070288e-08 1.88958043462814 3.78137887696891e-30 MirTarget;miRNATAP -0.587501911987191 2.69673993551136e-06 NA NA NA hsa-miR-29b-3p COL5A2 -0.228125979913806 0.0271621721891603 1.88958043462814 3.78137887696891e-30 MirTarget;miRNATAP -0.352473018424125 0.000290461187424855 NA NA NA hsa-miR-29c-3p COL5A2 -0.238671318446745 0.0141475322347596 1.88958043462814 3.78137887696891e-30 MirTarget;miRNATAP -0.691398496879944 6.42742495717768e-12 NA NA NA hsa-miR-30a-3p COL5A2 -0.955360819934585 1.97009535429185e-20 1.88958043462814 3.78137887696891e-30 mirMAP -0.908083683745466 1.12608796204844e-26 NA NA NA hsa-miR-30e-3p COL5A2 -0.205602546270795 0.00132666419729688 1.88958043462814 3.78137887696891e-30 mirMAP -0.982393981251453 2.53637073135759e-10 NA NA NA hsa-miR-335-5p COL5A2 -2.09515619961552 1.03765771499548e-25 1.88958043462814 3.78137887696891e-30 miRNATAP -0.150931574471735 0.00124505481145564 NA NA NA hsa-miR-508-3p COL5A2 -3.41433288024917 3.47699261121175e-37 1.88958043462814 3.78137887696891e-30 MirTarget;PITA -0.218349686161785 1.71215609238732e-11 NA NA NA hsa-miR-133a-3p COL5A3 -1.27121745308165 9.16266399887975e-11 4.06675170167147 2.2342740287362e-71 MirTarget -0.250738044498428 0.00132101399580317 NA NA NA hsa-miR-199a-5p COL5A3 -1.64658415208633 1.01615659358973e-23 4.06675170167147 2.2342740287362e-71 miRNATAP -0.388874349738836 1.04571569233663e-05 NA NA NA hsa-miR-204-5p COL5A3 -1.67490789640238 9.14741888352476e-10 4.06675170167147 2.2342740287362e-71 miRNAWalker2_validate;MirTarget -0.360082346479417 3.29977594639116e-11 NA NA NA hsa-miR-29a-3p COL5A3 -0.431613225927952 4.10166815070288e-08 4.06675170167147 2.2342740287362e-71 MirTarget;miRNATAP -1.02391370344662 1.49882921035743e-07 NA NA NA hsa-miR-29b-3p COL5A3 -0.228125979913806 0.0271621721891603 4.06675170167147 2.2342740287362e-71 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.566512926627107 0.000193845584020653 NA NA NA hsa-miR-29c-3p COL5A3 -0.238671318446745 0.0141475322347596 4.06675170167147 2.2342740287362e-71 MirTarget;miRNATAP -0.636260239914077 7.91131405467665e-05 NA NA NA hsa-miR-3065-3p COL5A3 -1.64500070417457 9.57561660036697e-16 4.06675170167147 2.2342740287362e-71 MirTarget;miRNATAP -0.519129713444236 1.92594193779625e-13 NA NA NA hsa-miR-362-3p COL5A3 -0.753214251798232 3.0025661608035e-07 4.06675170167147 2.2342740287362e-71 miRanda -0.524365191345065 9.68922788038952e-07 NA NA NA hsa-miR-429 COL5A3 -2.16569233119434 2.66862243626443e-37 4.06675170167147 2.2342740287362e-71 miRanda -0.930704410229266 9.7227921427242e-37 NA NA NA hsa-miR-10a-5p COL6A2 -1.17164272592931 4.86621098042279e-24 1.87594917872349 2.0995684314935e-26 miRNAWalker2_validate -0.63842896690357 5.13683973159565e-15 NA NA NA hsa-miR-10b-5p COL6A2 -0.89971464210447 1.18190532299934e-20 1.87594917872349 2.0995684314935e-26 miRNAWalker2_validate -0.571350460086774 1.84958291171703e-08 NA NA NA hsa-miR-29c-3p COL6A3 -0.238671318446745 0.0141475322347596 1.06724769903491 7.39257628260306e-08 MirTarget;miRNATAP -0.689227726823409 9.62463431932681e-10 NA NA NA hsa-miR-362-3p COL6A3 -0.753214251798232 3.0025661608035e-07 1.06724769903491 7.39257628260306e-08 miRanda -0.356686396451349 2.88049096903058e-06 NA NA NA hsa-miR-429 COL6A3 -2.16569233119434 2.66862243626443e-37 1.06724769903491 7.39257628260306e-08 miRNATAP -0.514353779137527 1.00696736631569e-20 NA NA NA hsa-miR-194-3p COL8A2 -0.0573594560647068 0.802137112420482 0.562311927806137 0.00181530153755664 MirTarget -0.196202618744461 7.72569765026268e-06 NA NA NA hsa-miR-132-3p CTGF 0.291409674711894 0.000912684337101876 -1.46941302681258 6.60266339692734e-19 MirTarget -0.346787901898476 0.00164022930627692 NA NA NA hsa-miR-19a-3p CTGF 0.722913586880779 2.76301458932381e-10 -1.46941302681258 6.60266339692734e-19 MirTarget;miRNATAP -0.276886343373103 0.000748854130778202 NA NA NA hsa-miR-361-3p CTGF 1.08992546227594 1.13197240706704e-36 -1.46941302681258 6.60266339692734e-19 MirTarget;miRNATAP -0.472505972141155 2.09550653361974e-06 NA NA NA hsa-miR-590-3p CTGF 1.13702599385212 3.53435739887793e-22 -1.46941302681258 6.60266339692734e-19 PITA;miRanda -0.441939578627256 5.41825255697319e-09 NA NA NA hsa-miR-7-1-3p CTGF 0.544601828025304 5.33830451326047e-07 -1.46941302681258 6.60266339692734e-19 MirTarget -0.296407368695659 0.000720347913179578 NA NA NA hsa-miR-30a-5p CTHRC1 -0.778411951775343 2.73322451127932e-16 2.86640087138213 1.75505457550827e-28 MirTarget -1.5937195430046 3.49982313770565e-28 NA NA NA hsa-miR-30b-5p CTHRC1 -1.18330589477119 6.8341618466966e-27 2.86640087138213 1.75505457550827e-28 MirTarget -1.05906362192669 1.98766878758822e-17 26388700 MiR-30b was down-regulated and Cthrc1 up-regulated in NSCLC tissues; Bioinformatics analysis identified Cthrc1 as a target of miR-30b and western blotting and luciferase reporter assays confirmed that miR-30b regulates Cthrc1 by directly binding to its 3'UTR; Transfection of Cthrc1 without the 3'UTR restored the miR-30b inhibiting cell invasion; Up-regulation of miR-30b or down-regulation of Cthrc1 had potential significance in the invasion and metastasis of NSCLC; MiR-30b was down-regulated and Cthrc1 up-regulated in NSCLC tissues; MiR-30b affected NSCLC cells invasion and migration by regulating Cthrc1 metastasis lung squamous cell cancer hsa-miR-30c-5p CTHRC1 -1.08783070774238 2.02505402525786e-24 2.86640087138213 1.75505457550827e-28 MirTarget -1.18505357198658 3.39180828425666e-20 NA NA NA hsa-miR-30d-5p CTHRC1 -0.202727675788184 0.00659067084745794 2.86640087138213 1.75505457550827e-28 MirTarget -1.3560281563295 4.60809699632274e-11 NA NA NA hsa-miR-30e-5p CTHRC1 -0.0905907245198101 0.21196704484334 2.86640087138213 1.75505457550827e-28 MirTarget -1.09919185203075 3.51526979845954e-07 NA NA NA hsa-miR-335-5p CTHRC1 -2.09515619961552 1.03765771499548e-25 2.86640087138213 1.75505457550827e-28 miRNAWalker2_validate -0.231298623847477 0.00147348755371935 NA NA NA hsa-miR-1271-5p CXCL12 0.900599702972936 3.07963385418853e-10 -1.51615203884134 5.66263873107683e-18 mirMAP -0.192625992002174 0.00562422195107331 NA NA NA hsa-miR-16-2-3p CXCL12 1.3046118743965 4.17207934608428e-19 -1.51615203884134 5.66263873107683e-18 mirMAP -0.195467709132853 0.00309247095185617 NA NA NA hsa-miR-221-3p CXCL12 0.337895669520713 0.0136448974691037 -1.51615203884134 5.66263873107683e-18 MirTarget -0.310485500640548 2.71454531625578e-05 NA NA NA hsa-miR-222-3p CXCL12 0.214811008033524 0.0965295551752457 -1.51615203884134 5.66263873107683e-18 MirTarget -0.24091683679465 0.00234527291196582 NA NA NA hsa-miR-23a-3p CXCL12 0.761438723382355 4.09310879199257e-27 -1.51615203884134 5.66263873107683e-18 miRNAWalker2_validate;miRTarBase;miRNATAP -0.54179559686751 5.30376556509868e-05 25322765 MiR-23a suppressed the transcription of RUNX2 and CXCL12 by binding to the 3' UTRs of these mRNAs; The cellular function of miR-23a is RUNX2/CXCL12-dependent and the overexpression of RUNX2 or CXCL12 rescued the impaired cell growth migration and invasion induced by miR-23a sarcoma hsa-miR-590-3p CXCL12 1.13702599385212 3.53435739887793e-22 -1.51615203884134 5.66263873107683e-18 PITA;miRanda;mirMAP -0.448250437037787 2.36164407662232e-08 NA NA NA hsa-miR-629-3p CXCL12 1.09330044556689 2.9533160808356e-14 -1.51615203884134 5.66263873107683e-18 MirTarget -0.249142492701079 0.000317739039282958 NA NA NA hsa-miR-362-3p CXCL6 -0.753214251798232 3.0025661608035e-07 -0.775819134200297 0.0565453402319061 miRanda -0.493046979612949 0.00145274625928042 NA NA NA hsa-miR-331-5p CYR61 0.661186030542026 1.83628790002785e-08 -0.553009900389791 0.0012163710737828 miRNATAP -0.271423131320555 0.00100095196082542 NA NA NA hsa-miR-149-5p DAB2 -1.95790336710741 8.46371715052367e-27 0.578804949270131 2.65654646464269e-07 miRNATAP -0.185456869089052 2.66532658339447e-09 NA NA NA hsa-miR-203a-3p DAB2 -2.25533513338731 1.77332845294014e-21 0.578804949270131 2.65654646464269e-07 MirTarget -0.150432286174686 6.32357030861123e-10 NA NA NA hsa-miR-335-5p DAB2 -2.09515619961552 1.03765771499548e-25 0.578804949270131 2.65654646464269e-07 miRNAWalker2_validate;miRNATAP -0.134909697927936 3.64484551682944e-06 NA NA NA hsa-miR-96-5p DAB2 -1.00223771166604 3.91564621567028e-06 0.578804949270131 2.65654646464269e-07 MirTarget;TargetScan -0.116309738173365 7.44979426406906e-05 NA NA NA hsa-let-7b-5p DCN 0.770868211539597 6.63408323707647e-21 -4.21079318247314 8.73709212936585e-31 MirTarget -0.932839468804948 0.000250888204184009 NA NA NA hsa-let-7i-5p DCN 0.911372377723717 7.11483853341932e-31 -4.21079318247314 8.73709212936585e-31 MirTarget -1.0639991324687 3.28410825725597e-05 NA NA NA hsa-miR-142-5p DCN 1.88417391525707 1.2096808039882e-27 -4.21079318247314 8.73709212936585e-31 mirMAP -0.493548256532562 2.39579374972133e-05 NA NA NA hsa-miR-181a-5p DCN 1.11111114875339 3.97880443756442e-29 -4.21079318247314 8.73709212936585e-31 MirTarget -1.42503959811686 7.44961342019317e-13 NA NA NA hsa-miR-181b-5p DCN 1.49054296272357 3.69051660739368e-41 -4.21079318247314 8.73709212936585e-31 MirTarget -1.30300503086206 1.55787670911521e-14 NA NA NA hsa-miR-186-5p DCN 0.507217561043443 9.04455748270995e-10 -4.21079318247314 8.73709212936585e-31 mirMAP -0.802267316925896 0.00232959094369486 NA NA NA hsa-miR-342-3p DCN 1.4124432570595 1.07208971556131e-28 -4.21079318247314 8.73709212936585e-31 miRanda -0.677442974365675 1.98028428377207e-05 NA NA NA hsa-miR-374b-3p DCN 0.611842481331529 3.85718194756943e-07 -4.21079318247314 8.73709212936585e-31 MirTarget -0.632823764763083 0.000734613022118445 NA NA NA hsa-miR-421 DCN 0.313155739887734 0.020433534776003 -4.21079318247314 8.73709212936585e-31 miRanda -0.449402645024161 0.00812595143035026 NA NA NA hsa-miR-590-3p DCN 1.13702599385212 3.53435739887793e-22 -4.21079318247314 8.73709212936585e-31 MirTarget;PITA;miRanda;mirMAP -1.00660158423754 7.28712454417694e-09 NA NA NA hsa-miR-7-1-3p DCN 0.544601828025304 5.33830451326047e-07 -4.21079318247314 8.73709212936585e-31 mirMAP -0.805001815134851 5.96696850501468e-05 NA NA NA hsa-miR-98-5p DCN 0.0569715596189075 0.450575962846765 -4.21079318247314 8.73709212936585e-31 MirTarget -0.926862743515677 0.00187887467924717 NA NA NA hsa-miR-217 DKK1 -1.32414431829977 4.20138196453017e-06 0.0492764483297469 0.828604787964088 miRanda;miRNATAP -0.123729232964846 0.0039417125206431 NA NA NA hsa-miR-141-3p DPYSL3 -5.87110686537457 1.20877726722907e-85 1.02209016389391 1.22072008844301e-09 TargetScan -0.160625609493842 1.47584203988996e-11 NA NA NA hsa-miR-26a-1-3p DPYSL3 -1.56107117111696 6.75439319582901e-15 1.02209016389391 1.22072008844301e-09 mirMAP -0.144577144164962 0.00190974523573274 NA NA NA hsa-miR-29c-3p DPYSL3 -0.238671318446745 0.0141475322347596 1.02209016389391 1.22072008844301e-09 MirTarget -0.279593592072753 0.00445257783313575 NA NA NA hsa-miR-362-3p DPYSL3 -0.753214251798232 3.0025661608035e-07 1.02209016389391 1.22072008844301e-09 PITA;miRanda;miRNATAP -0.351113405005545 5.58292382989293e-08 NA NA NA hsa-miR-532-3p DPYSL3 -1.759223962964 7.9077916669414e-40 1.02209016389391 1.22072008844301e-09 miRNATAP -0.488114634956388 6.90620907333665e-16 NA NA NA hsa-let-7i-5p DST 0.911372377723717 7.11483853341932e-31 -0.456336477501955 1.09051460159827e-06 miRNATAP -0.211715510267706 0.000488479681209091 NA NA NA hsa-miR-101-3p DST 0.683973909682285 2.88573524246948e-15 -0.456336477501955 1.09051460159827e-06 mirMAP -0.186493991599473 0.00136171801196856 NA NA NA hsa-miR-106b-5p DST 1.07509411417907 2.11739194181878e-36 -0.456336477501955 1.09051460159827e-06 mirMAP -0.333740141510975 6.06084897285315e-10 NA NA NA hsa-miR-130b-5p DST 0.92990617673277 3.75880436852717e-12 -0.456336477501955 1.09051460159827e-06 mirMAP -0.106404102459229 0.0049674567931715 NA NA NA hsa-miR-16-1-3p DST 1.51429140700091 3.17219833254498e-37 -0.456336477501955 1.09051460159827e-06 mirMAP -0.109100387262577 0.00632317299414459 NA NA NA hsa-miR-17-3p DST 0.723795600017259 5.90151677164931e-18 -0.456336477501955 1.09051460159827e-06 mirMAP;miRNATAP -0.270151503096061 5.01965558401411e-06 NA NA NA hsa-miR-18a-5p DST 0.936704393213466 1.05064580570579e-10 -0.456336477501955 1.09051460159827e-06 mirMAP -0.106930568452531 0.00229964132983235 NA NA NA hsa-miR-19b-1-5p DST 0.66692013055553 1.55789130176287e-09 -0.456336477501955 1.09051460159827e-06 mirMAP -0.126619617756776 0.006517304761721 NA NA NA hsa-miR-20a-5p DST 0.702602695798242 4.06372887613329e-13 -0.456336477501955 1.09051460159827e-06 mirMAP -0.156024682729115 0.00289805544138375 NA NA NA hsa-miR-21-5p DST 2.51462371613332 3.30620591950316e-66 -0.456336477501955 1.09051460159827e-06 mirMAP -0.118428495607807 4.24856583533794e-05 22403704 While the EDCs and estrogen similarly altered the expression of multiple microRNAs in MCF-7 cells including miR-21 differential patterns of microRNA expression were induced by DDT and BPA compared to estrogen breast cancer hsa-miR-25-3p DST 1.12016166564779 3.79069348635778e-48 -0.456336477501955 1.09051460159827e-06 mirMAP -0.184865040634382 0.00175086542181125 NA NA NA hsa-miR-26b-5p DST -0.251437253429904 0.00270935785098697 -0.456336477501955 1.09051460159827e-06 mirMAP;miRNATAP -0.164842217469526 0.00876918536581074 NA NA NA hsa-miR-27a-3p DST 0.558934437526245 1.44256383086177e-12 -0.456336477501955 1.09051460159827e-06 mirMAP -0.277729476763636 1.53576610079282e-05 NA NA NA hsa-miR-3127-5p DST 0.952801473575318 5.81162987769266e-14 -0.456336477501955 1.09051460159827e-06 mirMAP -0.147317534142609 0.000352249684198329 NA NA NA hsa-miR-32-5p DST 0.407826130035097 7.26884631998646e-06 -0.456336477501955 1.09051460159827e-06 miRNAWalker2_validate;mirMAP -0.181766225946567 0.00149555970065246 NA NA NA hsa-miR-320a DST 0.412740558379182 2.02929519701706e-05 -0.456336477501955 1.09051460159827e-06 mirMAP -0.235432685100587 1.02080686263636e-05 NA NA NA hsa-miR-320b DST 0.300497419754843 0.0245219177384172 -0.456336477501955 1.09051460159827e-06 mirMAP -0.166517835516377 1.86530988246844e-05 NA NA NA hsa-miR-330-5p DST 1.44960468659754 2.12131210588035e-45 -0.456336477501955 1.09051460159827e-06 miRanda;mirMAP -0.218362647020348 6.59610440300501e-07 NA NA NA hsa-miR-450b-5p DST 0.404819502355575 0.00357671373841274 -0.456336477501955 1.09051460159827e-06 mirMAP -0.102844964103538 0.00624274789509931 NA NA NA hsa-miR-452-5p DST 2.05325688842141 2.82238393643084e-40 -0.456336477501955 1.09051460159827e-06 mirMAP -0.118332067163372 6.71162385379132e-05 NA NA NA hsa-miR-455-5p DST 0.773674551205946 2.12957541541474e-09 -0.456336477501955 1.09051460159827e-06 miRanda -0.232510541837661 2.04258486283964e-09 NA NA NA hsa-miR-590-3p DST 1.13702599385212 3.53435739887793e-22 -0.456336477501955 1.09051460159827e-06 PITA;miRanda;mirMAP -0.156667767906897 0.00017135251925307 NA NA NA hsa-miR-590-5p DST 0.709763558412506 1.11883921359361e-11 -0.456336477501955 1.09051460159827e-06 mirMAP -0.151877198802889 0.00181116025822622 NA NA NA hsa-miR-629-3p DST 1.09330044556689 2.9533160808356e-14 -0.456336477501955 1.09051460159827e-06 mirMAP -0.105862449301636 0.00292691598905069 NA NA NA hsa-miR-629-5p DST 1.73389921851483 5.39614356468007e-48 -0.456336477501955 1.09051460159827e-06 mirMAP -0.226018218613021 1.06478309218109e-09 NA NA NA hsa-miR-93-5p DST 1.37365940377595 2.37567548683245e-46 -0.456336477501955 1.09051460159827e-06 mirMAP -0.19146507443063 4.69173726822485e-05 NA NA NA hsa-miR-429 ECM1 -2.16569233119434 2.66862243626443e-37 0.20958092492991 0.154781443766115 miRNATAP -0.13537936106771 0.00143232975593982 NA NA NA hsa-miR-107 EDIL3 0.140046250553248 0.0943611632552367 0.475542617424882 0.0256617068813932 miRanda -0.574613681585345 4.75980032920465e-05 NA NA NA hsa-miR-361-5p EDIL3 0.0514169367202078 0.382929376393199 0.475542617424882 0.0256617068813932 MirTarget;miRanda -0.658036784247883 0.00133054087856263 NA NA NA hsa-miR-374b-5p EDIL3 0.0804104684417872 0.365593963035077 0.475542617424882 0.0256617068813932 mirMAP -0.445308659276574 0.000861074315703999 NA NA NA hsa-miR-375 EDIL3 -1.46468479447701 9.20596529469647e-07 0.475542617424882 0.0256617068813932 miRanda -0.13019039642306 0.000754787097131399 NA NA NA hsa-miR-501-5p EDIL3 -1.1103073934745 1.81589804886553e-16 0.475542617424882 0.0256617068813932 mirMAP -0.369711108232593 7.52910105190729e-06 NA NA NA hsa-miR-29b-3p ELN -0.228125979913806 0.0271621721891603 0.210500890113594 0.302025406039869 MirTarget;miRNATAP -0.539635114025983 5.65056068657509e-07 NA NA NA hsa-miR-29c-3p ELN -0.238671318446745 0.0141475322347596 0.210500890113594 0.302025406039869 MirTarget;miRNATAP -0.34207202969663 0.00318385112287888 NA NA NA hsa-miR-421 ELN 0.313155739887734 0.020433534776003 0.210500890113594 0.302025406039869 miRanda -0.236625822052671 0.00590422536499576 NA NA NA hsa-miR-30a-5p FAP -0.778411951775343 2.73322451127932e-16 2.19295734612557 9.20868537825015e-18 miRNATAP -1.55097317517741 1.22977495492475e-29 NA NA NA hsa-miR-30c-5p FAP -1.08783070774238 2.02505402525786e-24 2.19295734612557 9.20868537825015e-18 miRNATAP -1.17553756483568 4.88241530339677e-22 NA NA NA hsa-miR-30d-5p FAP -0.202727675788184 0.00659067084745794 2.19295734612557 9.20868537825015e-18 miRNATAP -1.67408460854281 2.11180910883721e-18 NA NA NA hsa-miR-429 FAP -2.16569233119434 2.66862243626443e-37 2.19295734612557 9.20868537825015e-18 miRNATAP -0.693082481916715 3.16033414251492e-21 NA NA NA hsa-miR-106a-5p FAS -0.830908656792615 2.67547872901508e-10 1.2781702198996 1.39159398357076e-35 miRNAWalker2_validate;miRTarBase -0.17563422723919 0.000166805410564044 22431000;27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway tumorigenesis; gastric cancer;gastric cancer hsa-miR-23b-3p FAS -0.533749586990474 2.46924776953771e-10 1.2781702198996 1.39159398357076e-35 miRNATAP -0.365469144431479 5.00602609064883e-07 24356489 Moreover over-expression of Fas rescued the pro-proliferation effect of miR-23 indicating Fas is a direct mediator of miR-23 functions; Furthermore contrast to miR-23a/b which was up regulated the Fas expression level was down-regulated and inversely correlated with miR-23 in split radiation induced lymphoma tissue samples; Finally our data also indicates that miR-23a could repress Fas much more potent than miR-23b and the additional region besides conserved seed pairing enables miR-23a's higher regulation lymphoma hsa-miR-107 FBLN1 0.140046250553248 0.0943611632552367 -2.08012835683422 3.4642413706551e-22 miRanda -0.523759103602827 0.000604782398597424 NA NA NA hsa-miR-330-5p FBLN1 1.44960468659754 2.12131210588035e-45 -2.08012835683422 3.4642413706551e-22 miRanda -0.426057708041178 6.9190020065918e-05 NA NA NA hsa-miR-486-5p FBLN1 1.16748143760361 1.68410465883829e-08 -2.08012835683422 3.4642413706551e-22 miRanda -0.239413273975678 5.76590782644913e-05 NA NA NA hsa-miR-330-3p FBLN5 0.912906550436308 3.35037014057665e-13 -2.28724049493917 2.89048418923608e-30 miRNATAP -0.367881807317343 0.000106989434143469 NA NA NA hsa-miR-616-5p FBLN5 0.913426384742148 3.78418389333709e-09 -2.28724049493917 2.89048418923608e-30 miRNATAP -0.332937294211789 1.58310136937994e-05 NA NA NA hsa-miR-188-5p FBN1 -1.74586655806628 1.50431624674552e-28 0.544370320343445 7.18325187732981e-05 PITA -0.300004443634758 1.55864112364721e-11 NA NA NA hsa-miR-192-5p FBN1 0.442478872410106 0.0669238175123954 0.544370320343445 7.18325187732981e-05 miRNAWalker2_validate -0.103012856584377 0.00106685615238739 NA NA NA hsa-miR-29b-3p FBN1 -0.228125979913806 0.0271621721891603 0.544370320343445 7.18325187732981e-05 miRNATAP -0.21795832636999 0.00331673246046097 NA NA NA hsa-miR-29c-3p FBN1 -0.238671318446745 0.0141475322347596 0.544370320343445 7.18325187732981e-05 miRNAWalker2_validate;miRTarBase -0.501134006220264 6.76196836440781e-11 NA NA NA hsa-miR-30a-5p FBN1 -0.778411951775343 2.73322451127932e-16 0.544370320343445 7.18325187732981e-05 miRNAWalker2_validate -0.634767905413074 4.26667557920188e-18 NA NA NA hsa-miR-362-3p FBN1 -0.753214251798232 3.0025661608035e-07 0.544370320343445 7.18325187732981e-05 miRanda;miRNATAP -0.316132595848221 8.47782153997499e-10 NA NA NA hsa-miR-363-3p FBN1 -1.93551166555337 4.45368477487614e-32 0.544370320343445 7.18325187732981e-05 mirMAP -0.114868302418615 0.00642932051992051 NA NA NA hsa-miR-429 FBN1 -2.16569233119434 2.66862243626443e-37 0.544370320343445 7.18325187732981e-05 miRNATAP -0.277835207265165 7.05000341066628e-13 NA NA NA hsa-miR-577 FBN1 -1.48881999472397 7.03080165111147e-10 0.544370320343445 7.18325187732981e-05 mirMAP -0.104556172720396 0.000693884070547324 NA NA NA hsa-miR-101-3p FBN2 0.683973909682285 2.88573524246948e-15 -1.15624070458857 3.67460371409605e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.830272117288819 1.00934940452631e-10 NA NA NA hsa-miR-126-5p FBN2 0.785607261431085 5.77058629454465e-13 -1.15624070458857 3.67460371409605e-08 mirMAP -0.319772847340286 0.00231039187079538 NA NA NA hsa-miR-140-3p FBN2 0.989350547007025 6.14964028267239e-25 -1.15624070458857 3.67460371409605e-08 PITA -0.425792344586037 0.000197331590990617 NA NA NA hsa-miR-30d-5p FBN2 -0.202727675788184 0.00659067084745794 -1.15624070458857 3.67460371409605e-08 miRNAWalker2_validate -0.718221997455626 6.08307405470801e-06 NA NA NA hsa-miR-338-5p FBN2 0.628429807914222 1.27575140717947e-06 -1.15624070458857 3.67460371409605e-08 mirMAP -0.361020768768193 7.46056385120519e-05 NA NA NA hsa-miR-103a-3p FERMT2 0.779373475434461 7.37867196796994e-20 -0.70166491356051 2.17011792823802e-17 MirTarget -0.218068488624324 3.81937611067682e-05 NA NA NA hsa-miR-146b-5p FERMT2 1.40714170253819 2.9559871816487e-12 -0.70166491356051 2.17011792823802e-17 miRanda -0.143929155373599 1.25055133176801e-10 NA NA NA hsa-miR-15a-5p FERMT2 1.42663930007845 1.36006952074963e-57 -0.70166491356051 2.17011792823802e-17 MirTarget;miRNATAP -0.274941525637947 4.49399873115144e-10 NA NA NA hsa-miR-15b-5p FERMT2 0.773001494057531 1.71784656078957e-16 -0.70166491356051 2.17011792823802e-17 MirTarget;miRNATAP -0.291885592432296 1.14114201674458e-09 NA NA NA hsa-miR-16-5p FERMT2 0.934012514027655 4.85417898318515e-24 -0.70166491356051 2.17011792823802e-17 MirTarget;miRNATAP -0.226006845414292 2.52344926274937e-06 NA NA NA hsa-miR-21-5p FERMT2 2.51462371613332 3.30620591950316e-66 -0.70166491356051 2.17011792823802e-17 miRNAWalker2_validate -0.238968211639443 1.41785260437369e-21 NA NA NA hsa-miR-221-3p FERMT2 0.337895669520713 0.0136448974691037 -0.70166491356051 2.17011792823802e-17 MirTarget;miRNATAP -0.103623544473649 0.00303168608603215 NA NA NA hsa-miR-29b-3p FERMT2 -0.228125979913806 0.0271621721891603 -0.70166491356051 2.17011792823802e-17 MirTarget;miRNATAP -0.197628816856483 1.94096177074027e-05 NA NA NA hsa-miR-454-3p FERMT2 0.68285296887698 1.17407812677787e-08 -0.70166491356051 2.17011792823802e-17 miRNATAP -0.126399574331336 0.00126651465636617 NA NA NA hsa-miR-590-3p FERMT2 1.13702599385212 3.53435739887793e-22 -0.70166491356051 2.17011792823802e-17 MirTarget;miRanda;mirMAP;miRNATAP -0.222709147641248 3.03375232731126e-09 NA NA NA hsa-miR-590-5p FERMT2 0.709763558412506 1.11883921359361e-11 -0.70166491356051 2.17011792823802e-17 miRanda -0.195724772717263 9.65500682616369e-06 NA NA NA hsa-miR-7-1-3p FERMT2 0.544601828025304 5.33830451326047e-07 -0.70166491356051 2.17011792823802e-17 mirMAP -0.134410696017774 0.00202935698562723 NA NA NA hsa-let-7a-3p FGF2 0.0677487960013088 0.460458477653989 -0.589674911482514 4.9097503791125e-05 mirMAP -0.413855026311993 2.64122269531956e-06 NA NA NA hsa-miR-107 FGF2 0.140046250553248 0.0943611632552367 -0.589674911482514 4.9097503791125e-05 MirTarget;PITA;miRanda;miRNATAP -0.252364961790113 0.00988319837104476 NA NA NA hsa-miR-146a-5p FGF2 1.04938133739924 7.51013231709992e-12 -0.589674911482514 4.9097503791125e-05 mirMAP -0.210539194206361 3.35191542749017e-05 NA NA NA hsa-miR-15a-5p FGF2 1.42663930007845 1.36006952074963e-57 -0.589674911482514 4.9097503791125e-05 MirTarget;miRNATAP -0.255449530855187 0.000776459741728151 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-3p FGF2 1.49422666971434 5.44139893275088e-29 -0.589674911482514 4.9097503791125e-05 mirMAP -0.216697138822269 8.55843255884349e-05 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-1-3p FGF2 1.51429140700091 3.17219833254498e-37 -0.589674911482514 4.9097503791125e-05 mirMAP -0.163232052977134 0.00821869739056501 NA NA NA hsa-miR-16-2-3p FGF2 1.3046118743965 4.17207934608428e-19 -0.589674911482514 4.9097503791125e-05 mirMAP -0.186446224772941 0.000351536882101309 NA NA NA hsa-miR-16-5p FGF2 0.934012514027655 4.85417898318515e-24 -0.589674911482514 4.9097503791125e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.242955350739253 0.00300895920388753 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-192-5p FGF2 0.442478872410106 0.0669238175123954 -0.589674911482514 4.9097503791125e-05 miRNAWalker2_validate -0.102614170997363 0.00212550043678563 NA NA NA hsa-miR-19b-1-5p FGF2 0.66692013055553 1.55789130176287e-09 -0.589674911482514 4.9097503791125e-05 mirMAP -0.213543395777736 0.00295255172655819 NA NA NA hsa-miR-21-5p FGF2 2.51462371613332 3.30620591950316e-66 -0.589674911482514 4.9097503791125e-05 mirMAP -0.126618960975775 0.00490413708016251 NA NA NA hsa-miR-215-5p FGF2 1.57223951497888 6.18833867819653e-10 -0.589674911482514 4.9097503791125e-05 miRNAWalker2_validate -0.15555129616708 3.63011104027706e-07 NA NA NA hsa-miR-32-5p FGF2 0.407826130035097 7.26884631998646e-06 -0.589674911482514 4.9097503791125e-05 miRNAWalker2_validate -0.39260283335843 7.71884095801517e-06 NA NA NA hsa-miR-338-5p FGF2 0.628429807914222 1.27575140717947e-06 -0.589674911482514 4.9097503791125e-05 mirMAP -0.215263032074881 0.000575910517976575 NA NA NA hsa-miR-361-5p FGF2 0.0514169367202078 0.382929376393199 -0.589674911482514 4.9097503791125e-05 mirMAP -0.372320972807354 0.00839299302616162 NA NA NA hsa-miR-374a-3p FGF2 1.13863935833993 2.79089304015401e-44 -0.589674911482514 4.9097503791125e-05 mirMAP -0.301198297479784 0.0005177785699223 NA NA NA hsa-miR-374b-5p FGF2 0.0804104684417872 0.365593963035077 -0.589674911482514 4.9097503791125e-05 mirMAP -0.414924088923791 5.30808312664893e-06 NA NA NA hsa-miR-590-3p FGF2 1.13702599385212 3.53435739887793e-22 -0.589674911482514 4.9097503791125e-05 miRanda;mirMAP -0.223542377598034 0.000531270043941063 NA NA NA hsa-miR-590-5p FGF2 0.709763558412506 1.11883921359361e-11 -0.589674911482514 4.9097503791125e-05 miRanda;mirMAP -0.262470036573759 0.000472851744537926 NA NA NA hsa-miR-378a-3p FLNA 0.287244802401236 0.0501155019984562 0.493050812934669 2.00509364955269e-05 miRNAWalker2_validate -0.149269549378477 0.000666251297060202 NA NA NA hsa-miR-28-5p FMOD 0.461962042257226 3.32424690573327e-11 -1.04482824721712 1.08140134927367e-05 miRanda -0.521786989865945 0.00543109975506255 NA NA NA hsa-miR-340-5p FMOD 1.14479851941741 2.91936881701444e-15 -1.04482824721712 1.08140134927367e-05 MirTarget -0.25998073132113 0.00297664831259584 NA NA NA hsa-let-7g-5p FN1 -0.739744008507763 1.07979566264383e-14 1.7020002762399 2.74776700571101e-22 miRTarBase -0.347640287912278 0.000840211036349235 NA NA NA hsa-miR-139-5p FN1 -0.704802495091118 2.36904108453776e-06 1.7020002762399 2.74776700571101e-22 miRanda -0.236785162994945 0.00051355462200661 NA NA NA hsa-miR-200b-3p FN1 -1.70383252137161 2.38979336321755e-30 1.7020002762399 2.74776700571101e-22 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.576806526520913 2.49007139556473e-22 24391862 In contrast mesenchymal markers fibronectin and vimentin were significantly downregulated by miR-200 b prostate cancer hsa-miR-200c-3p FN1 -5.40303134829523 2.74173143360645e-94 1.7020002762399 2.74776700571101e-22 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.254959275555693 7.0639277027511e-20 NA NA NA hsa-miR-27b-3p FN1 -0.699527231242518 1.07356023759234e-15 1.7020002762399 2.74776700571101e-22 MirTarget -0.927919258785755 1.54644351248372e-17 NA NA NA hsa-miR-429 FN1 -2.16569233119434 2.66862243626443e-37 1.7020002762399 2.74776700571101e-22 MirTarget;PITA;miRanda;miRNATAP -0.525964902364629 1.34120335286919e-25 NA NA NA hsa-miR-101-5p FSTL1 -0.710089604234471 1.19159750684491e-09 1.33893871176786 1.00356110197831e-23 mirMAP -0.331953655468381 3.80222872262398e-07 NA NA NA hsa-miR-149-5p FSTL1 -1.95790336710741 8.46371715052367e-27 1.33893871176786 1.00356110197831e-23 miRNAWalker2_validate -0.129091689387656 0.00118757088711043 NA NA NA hsa-miR-200b-3p FSTL1 -1.70383252137161 2.38979336321755e-30 1.33893871176786 1.00356110197831e-23 MirTarget;TargetScan -0.452584645298457 1.16165549449109e-23 NA NA NA hsa-miR-200c-3p FSTL1 -5.40303134829523 2.74173143360645e-94 1.33893871176786 1.00356110197831e-23 MirTarget -0.215547794342701 1.01544867327689e-24 NA NA NA hsa-miR-203a-3p FSTL1 -2.25533513338731 1.77332845294014e-21 1.33893871176786 1.00356110197831e-23 MirTarget -0.166274237791101 6.17362807476877e-08 NA NA NA hsa-miR-24-1-5p FSTL1 -1.09236439756236 3.27091225010919e-23 1.33893871176786 1.00356110197831e-23 MirTarget -0.235445769131381 0.000438753367030807 NA NA NA hsa-miR-27b-5p FSTL1 -0.660506646244576 2.52529588436758e-11 1.33893871176786 1.00356110197831e-23 mirMAP -0.220884860472771 0.00458346419472494 NA NA NA hsa-miR-29a-5p FSTL1 -0.519003718107105 1.03351148282116e-06 1.33893871176786 1.00356110197831e-23 mirMAP -0.236703914013215 0.00128528687700484 NA NA NA hsa-miR-362-5p FSTL1 -2.72767654824605 1.34821749679113e-49 1.33893871176786 1.00356110197831e-23 mirMAP -0.352258440818492 4.99750139159123e-25 NA NA NA hsa-miR-429 FSTL1 -2.16569233119434 2.66862243626443e-37 1.33893871176786 1.00356110197831e-23 MirTarget;PITA;miRanda -0.38535887650148 2.40900934023901e-23 NA NA NA hsa-miR-199a-5p FSTL3 -1.64658415208633 1.01615659358973e-23 1.56265849748997 4.21968459046306e-18 mirMAP -0.236357136092056 6.42592728495409e-05 NA NA NA hsa-miR-199b-5p FSTL3 -2.39483476763681 1.04659509514884e-17 1.56265849748997 4.21968459046306e-18 mirMAP -0.145354628030063 5.87100513231427e-05 NA NA NA hsa-miR-362-3p FSTL3 -0.753214251798232 3.0025661608035e-07 1.56265849748997 4.21968459046306e-18 MirTarget;miRanda -0.292705633062126 4.77370590644094e-05 NA NA NA hsa-miR-375 FSTL3 -1.46468479447701 9.20596529469647e-07 1.56265849748997 4.21968459046306e-18 miRNAWalker2_validate -0.122390549217377 0.000374597841572124 NA NA NA hsa-miR-766-3p FSTL3 -0.230617949950715 0.0566289375252083 1.56265849748997 4.21968459046306e-18 mirMAP -0.29376932081861 0.000709005237037929 NA NA NA hsa-miR-330-5p FUCA1 1.44960468659754 2.12131210588035e-45 -0.593302266724219 1.24913078063001e-11 miRanda;miRNATAP -0.164021019671838 9.65030812617656e-05 NA NA NA hsa-miR-130b-3p GADD45A 1.12788913578446 2.939369462276e-16 -0.71804270155153 2.2880912615879e-10 MirTarget;miRNATAP -0.192802325941396 1.24534330083127e-05 NA NA NA hsa-miR-146b-5p GADD45A 1.40714170253819 2.9559871816487e-12 -0.71804270155153 2.2880912615879e-10 miRanda -0.121731151301817 6.74215575167157e-05 NA NA NA hsa-miR-301a-3p GADD45A 0.259400847075798 0.0216890736701418 -0.71804270155153 2.2880912615879e-10 MirTarget;miRNATAP -0.161714923757434 0.00452184693981742 NA NA NA hsa-miR-361-3p GADD45A 1.08992546227594 1.13197240706704e-36 -0.71804270155153 2.2880912615879e-10 MirTarget -0.218642571070405 0.00105969438528677 NA NA NA hsa-miR-454-3p GADD45A 0.68285296887698 1.17407812677787e-08 -0.71804270155153 2.2880912615879e-10 MirTarget;miRNATAP -0.236333328240283 5.72279489466588e-06 NA NA NA hsa-miR-590-3p GADD45A 1.13702599385212 3.53435739887793e-22 -0.71804270155153 2.2880912615879e-10 miRanda;mirMAP -0.217410143684049 1.97603197692947e-05 NA NA NA hsa-miR-140-5p GADD45B 0.504309496243674 3.09884038729031e-11 -0.441816165211003 0.00276475211524877 miRanda -0.283153773830058 0.00746764408150905 NA NA NA hsa-miR-1976 GADD45B 0.343475600930938 0.000360243844871748 -0.441816165211003 0.00276475211524877 miRNATAP -0.307872195722378 0.000272522224222968 NA NA NA hsa-miR-324-3p GADD45B -0.197662887871899 0.0298845059559819 -0.441816165211003 0.00276475211524877 MirTarget;miRNATAP -0.247089916093826 0.00645517764784922 NA NA NA hsa-miR-130b-3p GAS1 1.12788913578446 2.939369462276e-16 -2.5884856107851 1.59641982849998e-48 miRNAWalker2_validate -0.295193869283182 0.000168206483597717 NA NA NA hsa-miR-148a-3p GAS1 0.343233211643815 0.00402279073598165 -2.5884856107851 1.59641982849998e-48 miRNAWalker2_validate -0.288851753319471 0.00239943319947027 NA NA NA hsa-miR-186-5p GAS1 0.507217561043443 9.04455748270995e-10 -2.5884856107851 1.59641982849998e-48 mirMAP -0.461226735518419 0.000622906941853162 NA NA NA hsa-miR-193a-3p GAS1 0.849206638484406 3.68101781083335e-14 -2.5884856107851 1.59641982849998e-48 miRanda -0.421114928318387 1.44095475574979e-05 NA NA NA hsa-miR-34a-5p GAS1 1.07544567720768 1.81510842038009e-20 -2.5884856107851 1.59641982849998e-48 miRNAWalker2_validate;miRNATAP -0.55094728045836 1.1079833449067e-09 24220341 MiR 34a targets GAS1 to promote cell proliferation and inhibit apoptosis in papillary thyroid carcinoma via PI3K/Akt/Bad pathway; Both miR-34a and GAS1 are frequently down-regulated in various tumors; However it has been reported that while GAS1 is down-regulated in papillary thyroid carcinoma PTC miR-34a is up-regulated in this specific type of cancer although their potential roles in PTC tumorigenesis have not been examined to date; A computational search revealed that miR-34a putatively binds to the 3'-UTR of GAS1 gene; In the present study we confirmed previous findings that miR-34a is up-regulated and GAS1 down-regulated in PTC tissues; Further studies indicated that GAS1 is directly targeted by miR-34a; Silencing of GAS1 had similar growth-promoting effects as overexpression of miR-34a; Taken together our results demonstrate that miR-34a regulates GAS1 expression to promote proliferation and suppress apoptosis in PTC cells via PI3K/Akt/Bad pathway tumorigenesis thyroid cancer hsa-miR-486-5p GAS1 1.16748143760361 1.68410465883829e-08 -2.5884856107851 1.59641982849998e-48 miRanda -0.268208833803328 4.13876681697578e-07 NA NA NA hsa-miR-200a-3p GEM -1.43409013664263 2.00188483717828e-20 0.0504331398217577 0.718220306542042 MirTarget -0.179184421703348 0.000114851523312665 NA NA NA hsa-miR-429 GEM -2.16569233119434 2.66862243626443e-37 0.0504331398217577 0.718220306542042 MirTarget;PITA;miRanda;miRNATAP -0.115177304918007 0.00425553792109878 NA NA NA hsa-miR-125b-5p GJA1 -0.825456421494266 2.13029877878434e-15 1.72138484210441 2.15095331615079e-28 miRNATAP -0.421496059604659 8.50456448222425e-07 26335100 The carboxy terminal domain of connexin 43 CT Cx43 modulates the expression of p53 by altering miR 125b expression in low grade human breast cancers breast cancer hsa-miR-135a-5p GJA1 -2.13422485001223 6.29449029671498e-14 1.72138484210441 2.15095331615079e-28 miRNATAP -0.108076505397266 0.000848377237105417 NA NA NA hsa-miR-30a-3p GJA1 -0.955360819934585 1.97009535429185e-20 1.72138484210441 2.15095331615079e-28 MirTarget -0.506652250866525 1.73972160073949e-09 NA NA NA hsa-miR-30a-5p GJA1 -0.778411951775343 2.73322451127932e-16 1.72138484210441 2.15095331615079e-28 MirTarget;miRNATAP -0.56809903642348 8.44220431064152e-10 NA NA NA hsa-miR-30b-5p GJA1 -1.18330589477119 6.8341618466966e-27 1.72138484210441 2.15095331615079e-28 MirTarget;mirMAP -0.610413482698245 5.20334580642462e-16 NA NA NA hsa-miR-30c-5p GJA1 -1.08783070774238 2.02505402525786e-24 1.72138484210441 2.15095331615079e-28 MirTarget;mirMAP;miRNATAP -0.557853728997191 2.1919527233349e-12 NA NA NA hsa-miR-30d-3p GJA1 -0.249777194282131 0.00235356711813496 1.72138484210441 2.15095331615079e-28 MirTarget -0.454332264569587 7.09575152510787e-05 NA NA NA hsa-miR-30d-5p GJA1 -0.202727675788184 0.00659067084745794 1.72138484210441 2.15095331615079e-28 MirTarget;mirMAP;miRNATAP -0.494281197887523 9.31109480258944e-05 NA NA NA hsa-miR-30e-3p GJA1 -0.205602546270795 0.00132666419729688 1.72138484210441 2.15095331615079e-28 MirTarget -0.701891618079756 1.83856350020936e-06 NA NA NA hsa-miR-30e-5p GJA1 -0.0905907245198101 0.21196704484334 1.72138484210441 2.15095331615079e-28 MirTarget -0.627124735984482 1.39987221391433e-06 NA NA NA hsa-miR-429 GJA1 -2.16569233119434 2.66862243626443e-37 1.72138484210441 2.15095331615079e-28 miRanda;miRNATAP -0.386361777883217 2.09570647197512e-16 NA NA NA hsa-miR-149-5p GLIPR1 -1.95790336710741 8.46371715052367e-27 1.52000794786354 1.44054262875314e-25 MirTarget -0.201080080564275 3.48618168046578e-06 NA NA NA hsa-miR-23b-3p GLIPR1 -0.533749586990474 2.46924776953771e-10 1.52000794786354 1.44054262875314e-25 mirMAP -0.588506829599841 2.7800906269923e-09 NA NA NA hsa-miR-26a-1-3p GLIPR1 -1.56107117111696 6.75439319582901e-15 1.52000794786354 1.44054262875314e-25 mirMAP -0.249380933656778 2.11405621031325e-09 NA NA NA hsa-miR-30a-3p GLIPR1 -0.955360819934585 1.97009535429185e-20 1.52000794786354 1.44054262875314e-25 mirMAP -0.757811619757396 1.21564833147723e-24 NA NA NA hsa-miR-30a-5p GLIPR1 -0.778411951775343 2.73322451127932e-16 1.52000794786354 1.44054262875314e-25 miRNAWalker2_validate -0.753712627006606 8.58226986284213e-20 NA NA NA hsa-miR-30d-3p GLIPR1 -0.249777194282131 0.00235356711813496 1.52000794786354 1.44054262875314e-25 mirMAP -0.71714550851453 3.6524467542047e-12 NA NA NA hsa-miR-30e-3p GLIPR1 -0.205602546270795 0.00132666419729688 1.52000794786354 1.44054262875314e-25 mirMAP -0.605427411838832 9.06411999302289e-06 NA NA NA hsa-miR-194-3p GPC1 -0.0573594560647068 0.802137112420482 0.0725509522574566 0.56462280450929 mirMAP -0.129702652661697 2.04632066301273e-05 NA NA NA hsa-miR-29a-3p GPX7 -0.431613225927952 4.10166815070288e-08 0.458189429069818 1.39058537066e-06 MirTarget;miRNATAP -0.248346273102943 0.000193075289073723 NA NA NA hsa-miR-29c-3p GPX7 -0.238671318446745 0.0141475322347596 0.458189429069818 1.39058537066e-06 MirTarget;miRNATAP -0.235790833179184 1.45196281557201e-05 NA NA NA hsa-miR-429 GPX7 -2.16569233119434 2.66862243626443e-37 0.458189429069818 1.39058537066e-06 miRNATAP -0.104098808560739 0.000170603272935719 NA NA NA hsa-miR-107 GREM1 0.140046250553248 0.0943611632552367 -2.50594625686921 1.54864408339594e-09 miRanda -1.61252446815655 6.77477630152459e-09 NA NA NA hsa-miR-128-3p GREM1 0.475045893035043 2.6255647468e-06 -2.50594625686921 1.54864408339594e-09 MirTarget -1.1328340286561 6.32605576929778e-07 NA NA NA hsa-miR-151a-3p GREM1 0.657909055193034 1.46651056355997e-25 -2.50594625686921 1.54864408339594e-09 MirTarget -2.1171568266171 6.98129870610345e-10 NA NA NA hsa-miR-181a-5p GREM1 1.11111114875339 3.97880443756442e-29 -2.50594625686921 1.54864408339594e-09 MirTarget -1.11380780756174 2.03655866181623e-07 NA NA NA hsa-miR-181b-5p GREM1 1.49054296272357 3.69051660739368e-41 -2.50594625686921 1.54864408339594e-09 MirTarget -0.888244935900081 1.48315048027927e-06 NA NA NA hsa-miR-30d-3p GREM1 -0.249777194282131 0.00235356711813496 -2.50594625686921 1.54864408339594e-09 MirTarget -1.37162110348851 1.43632557506382e-06 NA NA NA hsa-miR-340-5p GREM1 1.14479851941741 2.91936881701444e-15 -2.50594625686921 1.54864408339594e-09 mirMAP -0.517665623826518 0.000820062839790712 NA NA NA hsa-miR-374a-3p GREM1 1.13863935833993 2.79089304015401e-44 -2.50594625686921 1.54864408339594e-09 mirMAP -0.751722200919528 0.00291119207785964 NA NA NA hsa-miR-616-5p GREM1 0.913426384742148 3.78418389333709e-09 -2.50594625686921 1.54864408339594e-09 mirMAP -0.502019605855402 0.000828353914971459 NA NA NA hsa-miR-200c-3p ID2 -5.40303134829523 2.74173143360645e-94 0.445337795024294 1.58113421282299e-06 miRNATAP -0.100566283563312 2.45882912723149e-12 NA NA NA hsa-miR-27b-3p ID2 -0.699527231242518 1.07356023759234e-15 0.445337795024294 1.58113421282299e-06 MirTarget;miRNATAP -0.16167700894291 0.00475411741852718 NA NA NA hsa-miR-126-3p IGFBP2 0.5342810966167 1.97593747290509e-05 -2.66414079745014 1.18516559618196e-30 miRNAWalker2_validate;miRTarBase -0.331477790277974 0.00288454680059085 NA NA NA hsa-miR-330-5p IGFBP2 1.44960468659754 2.12131210588035e-45 -2.66414079745014 1.18516559618196e-30 miRanda -0.82573160315326 8.95939494644396e-13 NA NA NA hsa-miR-423-3p IGFBP2 0.460506077888547 3.44680149368459e-09 -2.66414079745014 1.18516559618196e-30 PITA -0.919322365832175 1.65905786593559e-07 NA NA NA hsa-miR-486-5p IGFBP2 1.16748143760361 1.68410465883829e-08 -2.66414079745014 1.18516559618196e-30 PITA;miRanda;miRNATAP -0.205891978780222 0.0019037343327036 NA NA NA hsa-miR-592 IGFBP2 2.6404220268798 8.81369998128794e-32 -2.66414079745014 1.18516559618196e-30 PITA;miRNATAP -0.337323153847513 1.33482745347739e-09 NA NA NA hsa-miR-125a-5p IGFBP3 -0.561874059994802 7.3931856356891e-13 3.48729574947195 8.32683985774644e-56 miRanda -1.02047231351068 1.01227328587369e-08 NA NA NA hsa-miR-374b-5p IGFBP3 0.0804104684417872 0.365593963035077 3.48729574947195 8.32683985774644e-56 MirTarget -0.493802861332429 0.00288337522928547 NA NA NA hsa-miR-375 IGFBP3 -1.46468479447701 9.20596529469647e-07 3.48729574947195 8.32683985774644e-56 miRNAWalker2_validate -0.229076503160393 1.34783828747569e-06 NA NA NA hsa-miR-9-5p IGFBP3 -2.23538606210968 1.28143998950751e-12 3.48729574947195 8.32683985774644e-56 MirTarget;miRNATAP -0.121289042431336 0.00650460243457003 NA NA NA hsa-miR-532-3p IGFBP4 -1.759223962964 7.9077916669414e-40 0.860428742735603 1.82176656701785e-15 miRNATAP -0.243580864435368 1.82075217740267e-09 NA NA NA hsa-miR-130a-3p IL15 -0.667386596699886 1.34029167767774e-10 0.837916006433949 2.57016399328188e-16 MirTarget -0.201076415386713 0.000281578691062943 NA NA NA hsa-miR-139-5p IL15 -0.704802495091118 2.36904108453776e-06 0.837916006433949 2.57016399328188e-16 miRanda -0.128880941563601 0.000942686122514287 NA NA NA hsa-miR-429 IL15 -2.16569233119434 2.66862243626443e-37 0.837916006433949 2.57016399328188e-16 miRanda -0.155631216226153 3.56832525354193e-07 NA NA NA hsa-miR-493-5p IL15 -1.03936667688502 3.71842205277243e-08 0.837916006433949 2.57016399328188e-16 MirTarget -0.109347146838506 0.000537907025258782 NA NA NA hsa-miR-107 IL6 0.140046250553248 0.0943611632552367 -0.432551704985806 0.174200627733491 miRanda -0.626802809840839 0.00308751628926532 NA NA NA hsa-miR-139-5p IL6 -0.704802495091118 2.36904108453776e-06 -0.432551704985806 0.174200627733491 miRanda -0.314265848732322 0.00673546049087722 NA NA NA hsa-miR-338-5p IL6 0.628429807914222 1.27575140717947e-06 -0.432551704985806 0.174200627733491 MirTarget;PITA -0.580992506147854 1.66390019671047e-05 NA NA NA hsa-miR-10a-3p INHBA -1.40380922426511 3.42207767326254e-23 0.676794081295144 0.000383267539361987 mirMAP -0.282272546085035 7.01917976344773e-05 NA NA NA hsa-miR-200b-3p INHBA -1.70383252137161 2.38979336321755e-30 0.676794081295144 0.000383267539361987 TargetScan -0.362244116588901 1.2189090292543e-08 NA NA NA hsa-miR-30a-5p INHBA -0.778411951775343 2.73322451127932e-16 0.676794081295144 0.000383267539361987 mirMAP -0.765038178012175 1.16396155713743e-13 NA NA NA hsa-miR-30b-5p INHBA -1.18330589477119 6.8341618466966e-27 0.676794081295144 0.000383267539361987 mirMAP -0.53051971043374 9.80045787171572e-10 NA NA NA hsa-miR-30c-5p INHBA -1.08783070774238 2.02505402525786e-24 0.676794081295144 0.000383267539361987 mirMAP -0.525639215658958 6.8521413124538e-09 NA NA NA hsa-miR-30d-5p INHBA -0.202727675788184 0.00659067084745794 0.676794081295144 0.000383267539361987 mirMAP -0.932518857068309 2.35643197591404e-11 NA NA NA hsa-miR-30e-5p INHBA -0.0905907245198101 0.21196704484334 0.676794081295144 0.000383267539361987 mirMAP -0.745923989848458 3.45205649288139e-07 NA NA NA hsa-miR-577 INHBA -1.48881999472397 7.03080165111147e-10 0.676794081295144 0.000383267539361987 mirMAP -0.155213065827597 0.000278724146645866 NA NA NA hsa-miR-103a-3p ITGA2 0.779373475434461 7.37867196796994e-20 -1.08388449508643 1.56728724217302e-16 miRNAWalker2_validate;MirTarget;miRNATAP -0.419895180265999 4.91303588784847e-07 NA NA NA hsa-miR-107 ITGA2 0.140046250553248 0.0943611632552367 -1.08388449508643 1.56728724217302e-16 MirTarget;miRanda;miRNATAP -0.39500807003267 1.45081117707125e-05 NA NA NA hsa-miR-130b-3p ITGA2 1.12788913578446 2.939369462276e-16 -1.08388449508643 1.56728724217302e-16 mirMAP -0.301078183289923 5.74875888533156e-09 NA NA NA hsa-miR-142-3p ITGA2 1.88928758773299 2.72985643829893e-22 -1.08388449508643 1.56728724217302e-16 miRanda -0.181925006393419 4.35157712604764e-07 NA NA NA hsa-miR-15a-5p ITGA2 1.42663930007845 1.36006952074963e-57 -1.08388449508643 1.56728724217302e-16 MirTarget;miRNATAP -0.550597246380852 1.03193099020898e-15 NA NA NA hsa-miR-15b-5p ITGA2 0.773001494057531 1.71784656078957e-16 -1.08388449508643 1.56728724217302e-16 MirTarget;miRNATAP -0.401580517439157 1.59762423415028e-07 NA NA NA hsa-miR-16-5p ITGA2 0.934012514027655 4.85417898318515e-24 -1.08388449508643 1.56728724217302e-16 miRNAWalker2_validate;MirTarget;miRNATAP -0.45864815574881 1.14236037377433e-09 NA NA NA hsa-miR-181a-5p ITGA2 1.11111114875339 3.97880443756442e-29 -1.08388449508643 1.56728724217302e-16 MirTarget -0.240540213003525 0.000614026393391858 NA NA NA hsa-miR-181b-5p ITGA2 1.49054296272357 3.69051660739368e-41 -1.08388449508643 1.56728724217302e-16 MirTarget -0.260977698431527 1.3381994160642e-05 NA NA NA hsa-miR-185-5p ITGA2 1.05056378692621 1.31174187880682e-22 -1.08388449508643 1.56728724217302e-16 miRNATAP -0.440454395431351 8.40284340534913e-12 NA NA NA hsa-miR-186-5p ITGA2 0.507217561043443 9.04455748270995e-10 -1.08388449508643 1.56728724217302e-16 mirMAP -0.315820034560473 0.000458722104915937 NA NA NA hsa-miR-18a-5p ITGA2 0.936704393213466 1.05064580570579e-10 -1.08388449508643 1.56728724217302e-16 MirTarget -0.269671283120125 7.74562619345101e-08 NA NA NA hsa-miR-19a-3p ITGA2 0.722913586880779 2.76301458932381e-10 -1.08388449508643 1.56728724217302e-16 MirTarget -0.188951928102935 0.00355080009303547 NA NA NA hsa-miR-330-5p ITGA2 1.44960468659754 2.12131210588035e-45 -1.08388449508643 1.56728724217302e-16 PITA -0.273200724643208 2.02579830641045e-05 NA NA NA hsa-miR-340-5p ITGA2 1.14479851941741 2.91936881701444e-15 -1.08388449508643 1.56728724217302e-16 mirMAP -0.182858378643398 0.000255888563223987 NA NA NA hsa-miR-374a-5p ITGA2 0.543061152108237 2.19403097299769e-14 -1.08388449508643 1.56728724217302e-16 MirTarget -0.420504545654072 4.84584405234286e-05 NA NA NA hsa-miR-374b-5p ITGA2 0.0804104684417872 0.365593963035077 -1.08388449508643 1.56728724217302e-16 MirTarget -0.371842793300295 1.46801328770967e-05 NA NA NA hsa-miR-590-3p ITGA2 1.13702599385212 3.53435739887793e-22 -1.08388449508643 1.56728724217302e-16 MirTarget;miRanda;mirMAP -0.354910578826915 2.56472998666883e-09 NA NA NA hsa-miR-590-5p ITGA2 0.709763558412506 1.11883921359361e-11 -1.08388449508643 1.56728724217302e-16 miRanda -0.382977146193393 3.76588814581367e-08 NA NA NA hsa-miR-183-5p ITGA5 -1.21596931064487 1.31473205758898e-08 2.04116263996683 7.34474138145585e-47 miRNAWalker2_validate -0.168509641988799 4.28263649045998e-05 NA NA NA hsa-miR-27b-3p ITGA5 -0.699527231242518 1.07356023759234e-15 2.04116263996683 7.34474138145585e-47 miRNATAP -0.665011188256571 8.42719111597212e-12 NA NA NA hsa-miR-3065-3p ITGA5 -1.64500070417457 9.57561660036697e-16 2.04116263996683 7.34474138145585e-47 miRNATAP -0.336097070488892 8.38394013805882e-17 NA NA NA hsa-miR-30a-5p ITGA5 -0.778411951775343 2.73322451127932e-16 2.04116263996683 7.34474138145585e-47 miRNATAP -0.963193438692052 8.11656677667882e-31 NA NA NA hsa-miR-30c-5p ITGA5 -1.08783070774238 2.02505402525786e-24 2.04116263996683 7.34474138145585e-47 miRNATAP -0.80466770180918 2.23719209001784e-28 NA NA NA hsa-miR-30d-5p ITGA5 -0.202727675788184 0.00659067084745794 2.04116263996683 7.34474138145585e-47 miRNATAP -0.832879085803553 2.90046596941365e-12 NA NA NA hsa-miR-429 ITGA5 -2.16569233119434 2.66862243626443e-37 2.04116263996683 7.34474138145585e-47 miRNATAP -0.500173657300576 8.56440818684276e-31 NA NA NA hsa-let-7a-3p ITGAV 0.0677487960013088 0.460458477653989 -0.361899844330413 0.00011347300913332 MirTarget -0.188911001850044 0.000960608483582614 NA NA NA hsa-miR-25-3p ITGAV 1.12016166564779 3.79069348635778e-48 -0.361899844330413 0.00011347300913332 MirTarget;miRNATAP -0.157237225581948 0.00757909498068144 NA NA NA hsa-miR-32-5p ITGAV 0.407826130035097 7.26884631998646e-06 -0.361899844330413 0.00011347300913332 miRNAWalker2_validate;MirTarget;miRNATAP -0.167851835458867 0.00323387736288527 NA NA NA hsa-miR-361-5p ITGAV 0.0514169367202078 0.382929376393199 -0.361899844330413 0.00011347300913332 MirTarget;miRanda -0.292428262269443 0.00126336908744253 NA NA NA hsa-miR-374b-5p ITGAV 0.0804104684417872 0.365593963035077 -0.361899844330413 0.00011347300913332 mirMAP -0.157261944769125 0.00800336422382721 NA NA NA hsa-miR-29a-3p ITGB1 -0.431613225927952 4.10166815070288e-08 0.513228143004044 1.7455234981606e-12 MirTarget;miRNATAP -0.266903360917896 2.1799173467495e-07 26903137 hTERT mediates gastric cancer metastasis partially through the indirect targeting of ITGB1 by microRNA 29a; We found that the up-regulation of hTERT in gastric cancer cells could inhibit the expression of miR-29a and enhance the expression of Integrin β1 ITGB1; Our study also found that the restoration of miR-29a suppressed the expression of ITGB1 and inhibited GC cell metastasis both in vitro and in vivo metastasis gastric cancer hsa-miR-29b-3p ITGB1 -0.228125979913806 0.0271621721891603 0.513228143004044 1.7455234981606e-12 MirTarget;miRNATAP -0.141683516314429 0.000421065810916977 NA NA NA hsa-miR-29c-3p ITGB1 -0.238671318446745 0.0141475322347596 0.513228143004044 1.7455234981606e-12 MirTarget;miRNATAP -0.250688699199018 2.20527026177669e-09 26766915 MiR 29c inhibits cell growth invasion and migration of pancreatic cancer by targeting ITGB1; Further analysis revealed that ITGB1 is one of the functional target genes of miR-29c and knockdown of ITGB1 inhibited the proliferation migration and invasion of PC cells which was similar to the effects of overexpression of miR-29c pancreatic cancer hsa-miR-429 ITGB1 -2.16569233119434 2.66862243626443e-37 0.513228143004044 1.7455234981606e-12 miRanda -0.159357819397413 2.51619184392234e-14 NA NA NA hsa-miR-185-5p ITGB3 1.05056378692621 1.31174187880682e-22 -1.16876127262302 4.47213898532844e-13 MirTarget -0.380827888713313 1.80757978703474e-06 NA NA NA hsa-miR-186-5p ITGB3 0.507217561043443 9.04455748270995e-10 -1.16876127262302 4.47213898532844e-13 mirMAP -0.287450613176695 0.00895994676850249 NA NA NA hsa-miR-28-5p ITGB3 0.461962042257226 3.32424690573327e-11 -1.16876127262302 4.47213898532844e-13 miRanda -0.618026759980789 1.73519014813362e-06 NA NA NA hsa-miR-589-5p ITGB3 0.696241532021631 5.26958362886071e-16 -1.16876127262302 4.47213898532844e-13 MirTarget -0.791365193458178 1.60125046389991e-15 NA NA NA hsa-miR-590-3p ITGB3 1.13702599385212 3.53435739887793e-22 -1.16876127262302 4.47213898532844e-13 PITA;miRanda -0.320338883173731 1.2408606013794e-05 NA NA NA hsa-miR-590-5p ITGB3 0.709763558412506 1.11883921359361e-11 -1.16876127262302 4.47213898532844e-13 miRanda -0.378575696987631 9.00644743494825e-06 NA NA NA hsa-miR-374a-3p ITGB5 1.13863935833993 2.79089304015401e-44 -0.251981418555273 0.000366030910909779 MirTarget -0.125509807214839 0.0028566990547544 NA NA NA hsa-miR-30a-5p JUN -0.778411951775343 2.73322451127932e-16 0.299129375328292 0.0179949924502712 miRNAWalker2_validate -0.220689109507382 0.00170903222537552 NA NA NA hsa-miR-146b-5p LAMA2 1.40714170253819 2.9559871816487e-12 -2.4271590687032 5.37760256830424e-23 miRanda -0.211187780161961 0.00241983525398163 NA NA NA hsa-miR-590-3p LAMA2 1.13702599385212 3.53435739887793e-22 -2.4271590687032 5.37760256830424e-23 miRanda -0.6633279491368 6.24057756600592e-09 NA NA NA hsa-miR-125a-3p LAMA3 -0.372794471295036 0.000941729459601642 0.577410935053985 8.68292293363872e-05 miRanda -0.191972986583435 0.00830423746226377 NA NA NA hsa-miR-107 LAMC1 0.140046250553248 0.0943611632552367 0.635416495630585 3.74602393524152e-13 miRanda -0.356998455033202 1.51354896546459e-09 NA NA NA hsa-miR-188-5p LAMC1 -1.74586655806628 1.50431624674552e-28 0.635416495630585 3.74602393524152e-13 MirTarget -0.233399116501937 4.14059870201399e-16 NA NA NA hsa-miR-193b-3p LAMC1 -0.273325765316079 0.104328826585392 0.635416495630585 3.74602393524152e-13 MirTarget -0.109330671932415 0.000220228840950065 NA NA NA hsa-miR-200b-3p LAMC1 -1.70383252137161 2.38979336321755e-30 0.635416495630585 3.74602393524152e-13 MirTarget;TargetScan -0.196024438912367 4.56764179933925e-11 NA NA NA hsa-miR-22-3p LAMC1 0.198460552200729 0.00761005672059428 0.635416495630585 3.74602393524152e-13 MirTarget;miRNATAP -0.277437526606205 4.00267627669617e-05 26052614 The identification of laminin gamma 1 LAMC1 and myeloid cell leukemia 1 MCL1 as direct targets of miR-22 and miR-29a respectively suggested a tumor-suppressive role of these miRNAs prostate cancer hsa-miR-29a-3p LAMC1 -0.431613225927952 4.10166815070288e-08 0.635416495630585 3.74602393524152e-13 MirTarget;miRNATAP -0.28682179968968 4.28193030377521e-06 26052614 The identification of laminin gamma 1 LAMC1 and myeloid cell leukemia 1 MCL1 as direct targets of miR-22 and miR-29a respectively suggested a tumor-suppressive role of these miRNAs prostate cancer hsa-miR-29b-3p LAMC1 -0.228125979913806 0.0271621721891603 0.635416495630585 3.74602393524152e-13 MirTarget;miRNATAP -0.20056094366702 3.27529894162567e-05 NA NA NA hsa-miR-29c-3p LAMC1 -0.238671318446745 0.0141475322347596 0.635416495630585 3.74602393524152e-13 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.333942940925805 2.97674000981545e-11 NA NA NA hsa-miR-362-3p LAMC1 -0.753214251798232 3.0025661608035e-07 0.635416495630585 3.74602393524152e-13 miRanda -0.214832155546576 1.75815413222915e-10 NA NA NA hsa-miR-374b-5p LAMC1 0.0804104684417872 0.365593963035077 0.635416495630585 3.74602393524152e-13 mirMAP -0.182761708008844 0.00128421088165845 NA NA NA hsa-miR-429 LAMC1 -2.16569233119434 2.66862243626443e-37 0.635416495630585 3.74602393524152e-13 MirTarget;PITA;miRanda;miRNATAP -0.194389787205348 1.21390474944864e-14 NA NA NA hsa-miR-148b-3p LAMC2 0.346011252093377 4.27203463315056e-06 -2.46092405865136 1.8652143818936e-17 miRNAWalker2_validate -0.66664092810126 0.00285317312072829 NA NA NA hsa-miR-338-3p LAMC2 0.906250377628867 2.76970900371139e-15 -2.46092405865136 1.8652143818936e-17 miRanda -0.805513316218237 5.37762850839552e-09 NA NA NA hsa-miR-338-5p LAMC2 0.628429807914222 1.27575140717947e-06 -2.46092405865136 1.8652143818936e-17 mirMAP -0.4632654300985 0.000364208008352244 NA NA NA hsa-miR-342-3p LAMC2 1.4124432570595 1.07208971556131e-28 -2.46092405865136 1.8652143818936e-17 miRanda -0.524757063210548 1.30108235280438e-05 NA NA NA hsa-miR-590-3p LAMC2 1.13702599385212 3.53435739887793e-22 -2.46092405865136 1.8652143818936e-17 miRanda;mirMAP -0.737606678200318 2.44235870305358e-08 NA NA NA hsa-miR-590-5p LAMC2 0.709763558412506 1.11883921359361e-11 -2.46092405865136 1.8652143818936e-17 miRanda -0.743355453275857 1.58765147817913e-06 NA NA NA hsa-miR-149-5p LOX -1.95790336710741 8.46371715052367e-27 3.54705883871106 5.47525922936558e-34 miRNATAP -0.517578209269183 5.18620278375575e-09 NA NA NA hsa-miR-199a-3p LOX -1.61607426368083 1.97964980193147e-26 3.54705883871106 5.47525922936558e-34 miRNATAP -0.465410900363682 1.60731140290047e-05 NA NA NA hsa-miR-199b-3p LOX -1.61804389801139 1.97668652730486e-26 3.54705883871106 5.47525922936558e-34 miRNATAP -0.464924779445245 1.6018047841261e-05 NA NA NA hsa-miR-200b-3p LOX -1.70383252137161 2.38979336321755e-30 3.54705883871106 5.47525922936558e-34 TargetScan -1.02893078986961 7.73820469360607e-24 NA NA NA hsa-miR-27b-3p LOX -0.699527231242518 1.07356023759234e-15 3.54705883871106 5.47525922936558e-34 miRNATAP -1.51992586895695 1.09900584971456e-15 NA NA NA hsa-miR-29a-3p LOX -0.431613225927952 4.10166815070288e-08 3.54705883871106 5.47525922936558e-34 miRNATAP -0.946294683393552 2.43724722188785e-05 25153510 Second the direct interaction between one of the upregulated mRNA target the LOX gene which is an EMT key player and a downregulated miRNA the miR-29a was experimentally validated by a luciferase assay in HEK cell thyroid cancer hsa-miR-29c-3p LOX -0.238671318446745 0.0141475322347596 3.54705883871106 5.47525922936558e-34 miRNATAP -0.789587119335493 1.70752284765663e-05 NA NA NA hsa-miR-3065-3p LOX -1.64500070417457 9.57561660036697e-16 3.54705883871106 5.47525922936558e-34 miRNATAP -0.567888149232707 2.2016984603509e-12 NA NA NA hsa-miR-30a-5p LOX -0.778411951775343 2.73322451127932e-16 3.54705883871106 5.47525922936558e-34 miRNATAP -1.59608976478461 6.91869744122507e-21 NA NA NA hsa-miR-30c-5p LOX -1.08783070774238 2.02505402525786e-24 3.54705883871106 5.47525922936558e-34 miRNATAP -1.30174853003599 1.9678935944116e-18 NA NA NA hsa-miR-30d-5p LOX -0.202727675788184 0.00659067084745794 3.54705883871106 5.47525922936558e-34 miRNATAP -0.939944008343792 9.95687120618472e-05 NA NA NA hsa-miR-335-5p LOX -2.09515619961552 1.03765771499548e-25 3.54705883871106 5.47525922936558e-34 miRNAWalker2_validate -0.427810941450406 2.08820656939295e-07 NA NA NA hsa-miR-429 LOX -2.16569233119434 2.66862243626443e-37 3.54705883871106 5.47525922936558e-34 miRanda;miRNATAP -0.849367954123017 5.42271240159557e-22 NA NA NA hsa-miR-508-3p LOX -3.41433288024917 3.47699261121175e-37 3.54705883871106 5.47525922936558e-34 mirMAP -0.273380803835145 3.57416243889334e-06 NA NA NA hsa-miR-577 LOX -1.48881999472397 7.03080165111147e-10 3.54705883871106 5.47525922936558e-34 mirMAP -0.419028874306532 3.77018472874674e-09 NA NA NA hsa-miR-148b-3p LOXL1 0.346011252093377 4.27203463315056e-06 -0.673550410194676 0.000524869641251125 miRNAWalker2_validate -0.575594860782647 5.3322339872464e-05 NA NA NA hsa-miR-199a-5p LOXL2 -1.64658415208633 1.01615659358973e-23 2.94341140013829 3.83026855500917e-46 miRanda -0.23695911147452 0.00148691762472074 NA NA NA hsa-miR-199b-5p LOXL2 -2.39483476763681 1.04659509514884e-17 2.94341140013829 3.83026855500917e-46 miRanda -0.132621953963858 0.00369755797296497 NA NA NA hsa-miR-200b-3p LRP1 -1.70383252137161 2.38979336321755e-30 0.915425791127509 7.07859984312477e-15 TargetScan -0.243005293879506 2.05165749011994e-09 NA NA NA hsa-miR-429 LRP1 -2.16569233119434 2.66862243626443e-37 0.915425791127509 7.07859984312477e-15 PITA;miRanda;miRNATAP -0.227355407953716 4.63710701563213e-11 NA NA NA hsa-miR-200a-3p LRRC15 -1.43409013664263 2.00188483717828e-20 0.0490123344754854 0.886529102381126 mirMAP -0.555550702509304 9.79971501579237e-07 NA NA NA hsa-miR-30a-5p LRRC15 -0.778411951775343 2.73322451127932e-16 0.0490123344754854 0.886529102381126 mirMAP -1.21540554143247 6.10921720716782e-11 NA NA NA hsa-miR-30c-5p LRRC15 -1.08783070774238 2.02505402525786e-24 0.0490123344754854 0.886529102381126 mirMAP -0.768691125980201 2.55091119819504e-06 NA NA NA hsa-miR-30d-5p LRRC15 -0.202727675788184 0.00659067084745794 0.0490123344754854 0.886529102381126 mirMAP -1.14802411168972 6.107176615448e-06 NA NA NA hsa-miR-30e-5p LRRC15 -0.0905907245198101 0.21196704484334 0.0490123344754854 0.886529102381126 mirMAP -0.962774393887957 0.000263852659527166 NA NA NA hsa-miR-590-3p LUM 1.13702599385212 3.53435739887793e-22 -2.79075276019434 2.36114136467187e-17 miRanda;mirMAP -0.646554275023498 2.08130356636958e-05 NA NA NA hsa-miR-590-5p LUM 0.709763558412506 1.11883921359361e-11 -2.79075276019434 2.36114136467187e-17 MirTarget;PITA;miRanda -0.502423359948147 0.00480925793988215 NA NA NA hsa-miR-7-1-3p LUM 0.544601828025304 5.33830451326047e-07 -2.79075276019434 2.36114136467187e-17 mirMAP -0.550444366030477 0.00154319668556642 NA NA NA hsa-miR-140-5p MAGEE1 0.504309496243674 3.09884038729031e-11 -0.776073020888316 1.046003313689e-23 miRanda -0.207778183648273 0.000428090163912354 NA NA NA hsa-miR-146b-5p MAGEE1 1.40714170253819 2.9559871816487e-12 -0.776073020888316 1.046003313689e-23 miRanda -0.120772141877368 1.99316101794826e-08 NA NA NA hsa-miR-193a-3p MAGEE1 0.849206638484406 3.68101781083335e-14 -0.776073020888316 1.046003313689e-23 miRanda -0.213949938094008 3.30103187551362e-08 NA NA NA hsa-miR-330-3p MAGEE1 0.912906550436308 3.35037014057665e-13 -0.776073020888316 1.046003313689e-23 miRNATAP -0.146736518488359 4.07337253517422e-05 NA NA NA hsa-miR-590-3p MAGEE1 1.13702599385212 3.53435739887793e-22 -0.776073020888316 1.046003313689e-23 miRanda -0.288378070119931 1.65800055841923e-16 NA NA NA hsa-miR-671-5p MAGEE1 0.740296481994777 8.07053661008188e-07 -0.776073020888316 1.046003313689e-23 MirTarget -0.142529887921238 2.1043814088083e-06 NA NA NA hsa-miR-21-5p MATN2 2.51462371613332 3.30620591950316e-66 -1.3607828056579 2.12688088741606e-20 miRNATAP -0.432795687093735 7.09997487464926e-22 NA NA NA hsa-miR-486-5p MATN2 1.16748143760361 1.68410465883829e-08 -1.3607828056579 2.12688088741606e-20 miRanda -0.16431582009823 4.91638429475226e-05 NA NA NA hsa-miR-590-3p MATN2 1.13702599385212 3.53435739887793e-22 -1.3607828056579 2.12688088741606e-20 miRanda;mirMAP;miRNATAP -0.520858063121616 3.73958738575225e-15 NA NA NA hsa-miR-590-5p MATN2 0.709763558412506 1.11883921359361e-11 -1.3607828056579 2.12688088741606e-20 PITA;miRanda;miRNATAP -0.424661055272424 7.73844196238581e-08 NA NA NA hsa-miR-126-5p MATN3 0.785607261431085 5.77058629454465e-13 -1.37367792768589 1.11171632270735e-11 mirMAP;miRNATAP -0.284574585921404 0.00545601070484673 NA NA NA hsa-miR-148b-3p MATN3 0.346011252093377 4.27203463315056e-06 -1.37367792768589 1.11171632270735e-11 miRNAWalker2_validate;MirTarget -0.441116419604586 0.00397980298462162 NA NA NA hsa-miR-374b-3p MATN3 0.611842481331529 3.85718194756943e-07 -1.37367792768589 1.11171632270735e-11 MirTarget -0.285229799110286 0.00348251852991264 NA NA NA hsa-miR-584-5p MATN3 2.09455345496517 1.01738783798409e-51 -1.37367792768589 1.11171632270735e-11 MirTarget -0.34220613748753 1.01863649654039e-06 NA NA NA hsa-miR-590-3p MATN3 1.13702599385212 3.53435739887793e-22 -1.37367792768589 1.11171632270735e-11 miRanda;mirMAP -0.313020816444461 0.000665429371185024 NA NA NA hsa-miR-107 MEST 0.140046250553248 0.0943611632552367 -2.02567211734204 7.14205959466748e-20 miRanda -0.514969856662342 0.0010197263384819 NA NA NA hsa-miR-144-5p MEST 1.47329317992706 4.31620137156824e-12 -2.02567211734204 7.14205959466748e-20 MirTarget -0.180307877043099 0.00223669811963667 NA NA NA hsa-miR-151a-5p MEST 0.27443050816043 9.61242939867036e-05 -2.02567211734204 7.14205959466748e-20 MirTarget -0.598996791373384 0.0012703081831711 NA NA NA hsa-miR-155-5p MEST 3.26274490570809 5.06841441826518e-51 -2.02567211734204 7.14205959466748e-20 miRNAWalker2_validate -0.220902101838767 1.23459900309176e-05 NA NA NA hsa-miR-28-5p MEST 0.461962042257226 3.32424690573327e-11 -2.02567211734204 7.14205959466748e-20 miRanda -0.716014646540878 9.09797317776202e-05 NA NA NA hsa-miR-330-5p MEST 1.44960468659754 2.12131210588035e-45 -2.02567211734204 7.14205959466748e-20 miRanda;miRNATAP -0.514131277307711 2.55152501392477e-06 NA NA NA hsa-miR-455-5p MEST 0.773674551205946 2.12957541541474e-09 -2.02567211734204 7.14205959466748e-20 miRanda -0.384263080568271 8.6351143836733e-05 NA NA NA hsa-miR-590-3p MEST 1.13702599385212 3.53435739887793e-22 -2.02567211734204 7.14205959466748e-20 PITA;miRanda -0.440543109707293 1.98003238876381e-05 NA NA NA hsa-miR-200b-3p MFAP5 -1.70383252137161 2.38979336321755e-30 0.0637644875226712 0.857057155398804 TargetScan -0.378418361788314 0.00147960314838589 NA NA NA hsa-miR-361-5p MFAP5 0.0514169367202078 0.382929376393199 0.0637644875226712 0.857057155398804 miRanda -0.995474338480793 0.00339853256728022 NA NA NA hsa-miR-429 MFAP5 -2.16569233119434 2.66862243626443e-37 0.0637644875226712 0.857057155398804 miRanda;miRNATAP -0.296650748141935 0.00367523175284287 NA NA NA hsa-miR-361-5p MMP1 0.0514169367202078 0.382929376393199 0.59529463847907 0.0782653493007861 miRanda -0.886804885568312 0.00645757310274782 NA NA NA hsa-miR-125a-5p MMP14 -0.561874059994802 7.3931856356891e-13 1.45576792917467 4.76591517386002e-34 mirMAP -0.446433926374357 7.63598806302783e-07 NA NA NA hsa-miR-125b-5p MMP14 -0.825456421494266 2.13029877878434e-15 1.45576792917467 4.76591517386002e-34 mirMAP -0.187702305312085 0.00564893299250127 NA NA NA hsa-miR-29b-2-5p MMP14 -0.297854154636098 0.00260919277325581 1.45576792917467 4.76591517386002e-34 mirMAP -0.211660218204352 0.00441668202545254 NA NA NA hsa-miR-3065-3p MMP14 -1.64500070417457 9.57561660036697e-16 1.45576792917467 4.76591517386002e-34 miRNATAP -0.173016156804977 2.87770461358945e-07 NA NA NA hsa-miR-335-5p MMP14 -2.09515619961552 1.03765771499548e-25 1.45576792917467 4.76591517386002e-34 miRNAWalker2_validate -0.121942972915983 0.000352980843725998 NA NA NA hsa-miR-532-3p MMP14 -1.759223962964 7.9077916669414e-40 1.45576792917467 4.76591517386002e-34 miRNATAP -0.374508473964473 1.01980403874363e-15 NA NA NA hsa-miR-3065-3p MMP2 -1.64500070417457 9.57561660036697e-16 0.13580087878588 0.38751266836232 miRNATAP -0.115381318247002 0.00418325017588526 NA NA NA hsa-miR-188-5p MSX1 -1.74586655806628 1.50431624674552e-28 1.2839389844607 8.25632815848827e-26 PITA;miRNATAP -0.262479638281833 8.64979783806551e-10 NA NA NA hsa-miR-101-3p MXRA5 0.683973909682285 2.88573524246948e-15 -1.4744169485692 3.23145833048095e-14 miRNATAP -0.900011418906255 6.19333361135522e-14 NA NA NA hsa-miR-144-3p MXRA5 1.4617706700291 9.18139413836375e-11 -1.4744169485692 3.23145833048095e-14 MirTarget;miRNATAP -0.214697369689622 6.60308887344892e-06 NA NA NA hsa-miR-185-5p MXRA5 1.05056378692621 1.31174187880682e-22 -1.4744169485692 3.23145833048095e-14 MirTarget -0.68137435470112 4.9502850791894e-13 NA NA NA hsa-miR-30d-5p MXRA5 -0.202727675788184 0.00659067084745794 -1.4744169485692 3.23145833048095e-14 miRNATAP -0.576676619734327 0.000128472285484964 NA NA NA hsa-miR-590-3p MXRA5 1.13702599385212 3.53435739887793e-22 -1.4744169485692 3.23145833048095e-14 MirTarget;PITA;miRanda -0.491050117549984 2.20746063356126e-08 NA NA NA hsa-miR-107 MYLK 0.140046250553248 0.0943611632552367 -0.423571925277193 7.29455025396978e-05 miRanda -0.234284935692046 0.00106584274248417 NA NA NA hsa-miR-15a-5p MYLK 1.42663930007845 1.36006952074963e-57 -0.423571925277193 7.29455025396978e-05 MirTarget;miRNATAP -0.255060893186151 4.10351440775616e-06 NA NA NA hsa-miR-340-5p MYLK 1.14479851941741 2.91936881701444e-15 -0.423571925277193 7.29455025396978e-05 MirTarget;mirMAP -0.104017811994037 0.00804628742884491 NA NA NA hsa-miR-501-5p MYLK -1.1103073934745 1.81589804886553e-16 -0.423571925277193 7.29455025396978e-05 MirTarget;PITA;miRNATAP -0.125410455218387 0.0028301508946485 NA NA NA hsa-miR-590-3p MYLK 1.13702599385212 3.53435739887793e-22 -0.423571925277193 7.29455025396978e-05 MirTarget;miRanda;mirMAP -0.208364986262526 9.67877196283988e-06 NA NA NA hsa-miR-590-5p MYLK 0.709763558412506 1.11883921359361e-11 -0.423571925277193 7.29455025396978e-05 miRanda -0.194648605505565 0.0004126585730679 NA NA NA hsa-miR-30a-5p NID2 -0.778411951775343 2.73322451127932e-16 0.774599671668371 5.98406189060363e-09 miRNATAP -0.450624821607918 1.23367548291158e-09 NA NA NA hsa-miR-30c-5p NID2 -1.08783070774238 2.02505402525786e-24 0.774599671668371 5.98406189060363e-09 miRNATAP -0.289163643147727 8.79128390510847e-06 NA NA NA hsa-miR-30d-5p NID2 -0.202727675788184 0.00659067084745794 0.774599671668371 5.98406189060363e-09 miRNATAP -0.401094666639935 7.43684458508544e-05 NA NA NA hsa-miR-508-3p NID2 -3.41433288024917 3.47699261121175e-37 0.774599671668371 5.98406189060363e-09 PITA;miRNATAP -0.142219828712848 6.49392573857702e-09 NA NA NA hsa-miR-107 NOTCH2 0.140046250553248 0.0943611632552367 -0.0700565047087798 0.430301832782032 miRNAWalker2_validate;MirTarget;miRanda;miRNATAP -0.216729873257326 0.000221205695030684 NA NA NA hsa-miR-148a-5p NOTCH2 0.415500302855613 0.000691460831436767 -0.0700565047087798 0.430301832782032 MirTarget -0.143491957776434 0.000286489906009164 NA NA NA hsa-miR-27b-3p NOTCH2 -0.699527231242518 1.07356023759234e-15 -0.0700565047087798 0.430301832782032 miRNAWalker2_validate -0.180231909266313 0.000799391316908958 NA NA NA hsa-miR-29c-3p NOTCH2 -0.238671318446745 0.0141475322347596 -0.0700565047087798 0.430301832782032 MirTarget -0.193946527828871 0.000109529287102852 NA NA NA hsa-miR-30b-5p NOTCH2 -1.18330589477119 6.8341618466966e-27 -0.0700565047087798 0.430301832782032 mirMAP -0.217052941504026 6.92142665594373e-08 NA NA NA hsa-miR-30a-5p NT5E -0.778411951775343 2.73322451127932e-16 0.70786558393759 1.38593879531102e-06 miRNAWalker2_validate;miRNATAP -0.325852288046334 7.6277840687483e-05 NA NA NA hsa-miR-30c-5p NT5E -1.08783070774238 2.02505402525786e-24 0.70786558393759 1.38593879531102e-06 miRNATAP -0.272455969995521 0.000134892676615073 NA NA NA hsa-miR-30d-5p NT5E -0.202727675788184 0.00659067084745794 0.70786558393759 1.38593879531102e-06 miRNATAP -0.345310032526859 0.00189123335108555 NA NA NA hsa-miR-188-5p NTM -1.74586655806628 1.50431624674552e-28 1.21431426722444 1.40378945258265e-06 miRNATAP -0.354434043931924 2.42807365096853e-05 NA NA NA hsa-miR-30a-5p NTM -0.778411951775343 2.73322451127932e-16 1.21431426722444 1.40378945258265e-06 miRNATAP -0.974973587820985 1.50584789564217e-12 NA NA NA hsa-miR-30b-3p NTM -1.64703050862226 1.89878531036464e-31 1.21431426722444 1.40378945258265e-06 MirTarget -0.48186009140146 8.15686764852572e-08 NA NA NA hsa-miR-30c-5p NTM -1.08783070774238 2.02505402525786e-24 1.21431426722444 1.40378945258265e-06 miRNATAP -0.654253576409895 6.77858492469753e-08 NA NA NA hsa-miR-30d-5p NTM -0.202727675788184 0.00659067084745794 1.21431426722444 1.40378945258265e-06 miRNATAP -1.14260506565252 9.73841258155933e-10 NA NA NA hsa-miR-429 NTM -2.16569233119434 2.66862243626443e-37 1.21431426722444 1.40378945258265e-06 miRanda;miRNATAP -0.389181109247977 8.87410849131412e-08 NA NA NA hsa-miR-29c-3p OXTR -0.238671318446745 0.0141475322347596 0.164526871438408 0.343373979328859 miRNATAP -0.297143685895982 0.00260236687038667 NA NA NA hsa-miR-30a-3p OXTR -0.955360819934585 1.97009535429185e-20 0.164526871438408 0.343373979328859 mirMAP -0.460906222077828 9.04820300024539e-08 NA NA NA hsa-miR-30d-3p OXTR -0.249777194282131 0.00235356711813496 0.164526871438408 0.343373979328859 mirMAP -0.501293832286666 1.61475830375642e-05 NA NA NA hsa-miR-30e-3p OXTR -0.205602546270795 0.00132666419729688 0.164526871438408 0.343373979328859 mirMAP -0.580579326335093 0.000118157918909913 NA NA NA hsa-miR-182-5p PCOLCE2 -0.608710746044567 0.0025264935278104 0.283126153274692 0.358627711299993 miRNAWalker2_validate -0.441482802357903 8.79109322667463e-08 NA NA NA hsa-miR-29a-3p PDGFRB -0.431613225927952 4.10166815070288e-08 0.733059789264273 9.08256836273142e-08 miRNATAP -0.452409180680295 2.53894645761997e-06 NA NA NA hsa-miR-29b-3p PDGFRB -0.228125979913806 0.0271621721891603 0.733059789264273 9.08256836273142e-08 miRNATAP -0.473479216745421 9.29300376624436e-11 NA NA NA hsa-miR-29c-3p PDGFRB -0.238671318446745 0.0141475322347596 0.733059789264273 9.08256836273142e-08 miRNATAP -0.358531848837518 5.48317704341144e-06 NA NA NA hsa-miR-664a-3p PDGFRB -0.019312777079624 0.825861598748857 0.733059789264273 9.08256836273142e-08 MirTarget -0.347941365487638 8.25629516369049e-05 NA NA NA hsa-miR-324-5p PDLIM4 -0.487750893426456 3.74472736457965e-05 -0.314234469134278 0.153589708034528 miRanda -0.282834990715931 0.00551735199600282 NA NA NA hsa-miR-330-5p PDLIM4 1.44960468659754 2.12131210588035e-45 -0.314234469134278 0.153589708034528 miRanda -0.274768470292014 0.00774863102847658 NA NA NA hsa-miR-106b-5p PFN2 1.07509411417907 2.11739194181878e-36 -1.63992192214666 1.17713010569586e-28 miRNATAP -0.745708124937389 8.56893499428546e-17 NA NA NA hsa-miR-140-5p PFN2 0.504309496243674 3.09884038729031e-11 -1.63992192214666 1.17713010569586e-28 PITA;miRanda -0.737505627772089 4.79318718634293e-11 NA NA NA hsa-miR-142-3p PFN2 1.88928758773299 2.72985643829893e-22 -1.63992192214666 1.17713010569586e-28 miRanda -0.276741264384201 2.74553332083619e-11 NA NA NA hsa-miR-150-5p PFN2 1.00371863159681 1.09871676395528e-09 -1.63992192214666 1.17713010569586e-28 miRNATAP -0.292697988845054 1.54195432938498e-08 NA NA NA hsa-miR-151a-3p PFN2 0.657909055193034 1.46651056355997e-25 -1.63992192214666 1.17713010569586e-28 miRNATAP -0.799131479330082 8.34181847826779e-10 NA NA NA hsa-miR-15b-3p PFN2 1.49422666971434 5.44139893275088e-29 -1.63992192214666 1.17713010569586e-28 miRNATAP -0.340337747066031 1.36112383730142e-08 NA NA NA hsa-miR-17-5p PFN2 0.494260110870015 3.8348005261e-09 -1.63992192214666 1.17713010569586e-28 TargetScan;miRNATAP -0.46052965321824 9.0469101121905e-06 NA NA NA hsa-miR-194-5p PFN2 0.62222617402691 0.00659826803316099 -1.63992192214666 1.17713010569586e-28 miRNATAP -0.237209641107608 3.38478573809004e-10 NA NA NA hsa-miR-19a-3p PFN2 0.722913586880779 2.76301458932381e-10 -1.63992192214666 1.17713010569586e-28 miRNATAP -0.359578518938359 1.65288715042343e-06 NA NA NA hsa-miR-19b-3p PFN2 0.195940928879427 0.0300512922542325 -1.63992192214666 1.17713010569586e-28 miRNATAP -0.281465573775607 0.00460343988719459 NA NA NA hsa-miR-20a-5p PFN2 0.702602695798242 4.06372887613329e-13 -1.63992192214666 1.17713010569586e-28 miRNATAP -0.400602654072678 5.69545585862988e-06 NA NA NA hsa-miR-2355-5p PFN2 1.57515081110162 3.54962327490702e-48 -1.63992192214666 1.17713010569586e-28 miRNATAP -0.635279699041508 1.98936275258019e-21 NA NA NA hsa-miR-320a PFN2 0.412740558379182 2.02929519701706e-05 -1.63992192214666 1.17713010569586e-28 miRanda -0.436275467070834 1.41845408224827e-06 NA NA NA hsa-miR-320b PFN2 0.300497419754843 0.0245219177384172 -1.63992192214666 1.17713010569586e-28 miRanda -0.273213476514872 3.69531413242049e-05 NA NA NA hsa-miR-338-3p PFN2 0.906250377628867 2.76970900371139e-15 -1.63992192214666 1.17713010569586e-28 miRanda -0.507513265142829 2.08672179463206e-12 NA NA NA hsa-miR-340-5p PFN2 1.14479851941741 2.91936881701444e-15 -1.63992192214666 1.17713010569586e-28 mirMAP -0.30513633360546 1.37207738965911e-07 NA NA NA hsa-miR-342-3p PFN2 1.4124432570595 1.07208971556131e-28 -1.63992192214666 1.17713010569586e-28 miRanda;miRNATAP -0.44410786701224 9.03036450556609e-13 NA NA NA hsa-miR-486-5p PFN2 1.16748143760361 1.68410465883829e-08 -1.63992192214666 1.17713010569586e-28 miRanda -0.156449274862226 0.000186241268475073 NA NA NA hsa-miR-590-3p PFN2 1.13702599385212 3.53435739887793e-22 -1.63992192214666 1.17713010569586e-28 PITA;miRanda;mirMAP -0.426598863861955 9.04013612345797e-10 NA NA NA hsa-miR-590-5p PFN2 0.709763558412506 1.11883921359361e-11 -1.63992192214666 1.17713010569586e-28 PITA;miRanda -0.396863125567773 1.27135500928983e-06 NA NA NA hsa-miR-93-5p PFN2 1.37365940377595 2.37567548683245e-46 -1.63992192214666 1.17713010569586e-28 miRNATAP -0.602256175555856 6.9996134785627e-15 NA NA NA hsa-miR-139-5p PLAUR -0.704802495091118 2.36904108453776e-06 1.55095977915837 2.68391327004948e-21 miRanda -0.545480715890399 1.24895249427869e-19 NA NA NA hsa-miR-204-5p PLAUR -1.67490789640238 9.14741888352476e-10 1.55095977915837 2.68391327004948e-21 miRNAWalker2_validate -0.273410914493141 5.96250850859845e-17 NA NA NA hsa-miR-149-5p PLOD1 -1.95790336710741 8.46371715052367e-27 1.27750253938659 2.62721049709363e-28 miRNAWalker2_validate -0.103039620846306 0.00336877092900527 NA NA NA hsa-miR-23b-3p PLOD1 -0.533749586990474 2.46924776953771e-10 1.27750253938659 2.62721049709363e-28 miRNAWalker2_validate -0.390668322824604 1.11005465591227e-06 NA NA NA hsa-miR-335-5p PLOD1 -2.09515619961552 1.03765771499548e-25 1.27750253938659 2.62721049709363e-28 MirTarget -0.118281165889311 0.000260285020078053 NA NA NA hsa-miR-429 PLOD1 -2.16569233119434 2.66862243626443e-37 1.27750253938659 2.62721049709363e-28 miRNATAP -0.234354903912978 4.38085454063323e-11 NA NA NA hsa-miR-26a-5p PLOD2 -0.202091714279613 0.00166918288801054 1.60660415176902 1.04870269435404e-28 MirTarget;miRNATAP -0.586025495210756 1.79028879274647e-05 26983694;27310702 Thus our data showed that two genes promoting metastasis LOXL2 and PLOD2 were epigenetically regulated by tumor-suppressive microRNAs miR-26a and miR-26b providing important insights into the molecular mechanisms of RCC metastasis;The gene encoding procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 PLOD2 a collagen crosslinking enzyme was directly regulated by miR-26a-5p and miR-26b-5p; PLOD2 which is associated with the stiffness of the extracellular matrix was directly regulated by miR-26a-5p and miR-26b-5p and may be a good prognostic marker in patients with BC metastasis; kidney renal cell cancer;bladder cancer hsa-miR-429 PLOD2 -2.16569233119434 2.66862243626443e-37 1.60660415176902 1.04870269435404e-28 miRanda -0.346581713515533 2.65225650724216e-15 NA NA NA hsa-miR-10a-3p PMEPA1 -1.40380922426511 3.42207767326254e-23 1.57938736295483 2.56957043305956e-26 mirMAP -0.408477828059627 2.25003692981952e-12 NA NA NA hsa-miR-10a-5p PMEPA1 -1.17164272592931 4.86621098042279e-24 1.57938736295483 2.56957043305956e-26 mirMAP -0.476855805230305 6.94188037776344e-12 NA NA NA hsa-miR-335-5p PMEPA1 -2.09515619961552 1.03765771499548e-25 1.57938736295483 2.56957043305956e-26 mirMAP -0.180027646952921 1.24155327109638e-05 NA NA NA hsa-miR-429 PMEPA1 -2.16569233119434 2.66862243626443e-37 1.57938736295483 2.56957043305956e-26 miRNATAP -0.358974853663907 9.90903234296632e-16 NA NA NA hsa-miR-514a-3p PMEPA1 -3.60916038800272 7.44698991540685e-35 1.57938736295483 2.56957043305956e-26 mirMAP -0.140971316670026 1.55818030098551e-07 NA NA NA hsa-miR-532-3p PMEPA1 -1.759223962964 7.9077916669414e-40 1.57938736295483 2.56957043305956e-26 mirMAP -0.610958755280502 1.19145196461532e-29 NA NA NA hsa-miR-9-5p PMEPA1 -2.23538606210968 1.28143998950751e-12 1.57938736295483 2.56957043305956e-26 mirMAP -0.105247959926993 0.000100858652937793 NA NA NA hsa-miR-96-5p PMEPA1 -1.00223771166604 3.91564621567028e-06 1.57938736295483 2.56957043305956e-26 TargetScan -0.253825307691808 4.54194582046203e-10 NA NA NA hsa-miR-29a-3p PMP22 -0.431613225927952 4.10166815070288e-08 0.917926597051454 7.75183948792991e-17 MirTarget;miRNATAP -0.434775456779395 3.82611087193536e-08 NA NA NA hsa-miR-29b-3p PMP22 -0.228125979913806 0.0271621721891603 0.917926597051454 7.75183948792991e-17 MirTarget;miRNATAP -0.250299855707951 4.91988486858507e-05 NA NA NA hsa-miR-29c-3p PMP22 -0.238671318446745 0.0141475322347596 0.917926597051454 7.75183948792991e-17 MirTarget;miRNATAP -0.357417056661396 3.43748300176202e-08 NA NA NA hsa-miR-30b-3p PMP22 -1.64703050862226 1.89878531036464e-31 0.917926597051454 7.75183948792991e-17 MirTarget -0.354288980926516 1.12516140315581e-19 NA NA NA hsa-miR-361-5p PMP22 0.0514169367202078 0.382929376393199 0.917926597051454 7.75183948792991e-17 miRanda -0.309105493804457 0.00548844537731804 NA NA NA hsa-miR-429 PMP22 -2.16569233119434 2.66862243626443e-37 0.917926597051454 7.75183948792991e-17 PITA;miRanda;miRNATAP -0.253485066461568 2.78772107846121e-15 NA NA NA hsa-miR-10b-3p PRRX1 -0.8205021989966 7.84331443044781e-21 0.879417629803063 8.60048203449821e-05 miRNATAP -0.449172972908936 0.000830357916501737 NA NA NA hsa-miR-200b-5p PRRX1 -1.46985752435972 3.43232443788022e-27 0.879417629803063 8.60048203449821e-05 mirMAP -0.448017687333553 8.42537292407904e-08 NA NA NA hsa-miR-204-5p PRRX1 -1.67490789640238 9.14741888352476e-10 0.879417629803063 8.60048203449821e-05 MirTarget;miRNATAP -0.311567375145941 3.56745386492138e-13 NA NA NA hsa-miR-20b-5p PRRX1 -1.30218163823367 6.87172815978149e-17 0.879417629803063 8.60048203449821e-05 MirTarget;miRNATAP -0.20140079537745 0.00830680238741008 NA NA NA hsa-miR-26a-1-3p PRRX1 -1.56107117111696 6.75439319582901e-15 0.879417629803063 8.60048203449821e-05 MirTarget -0.159021077380887 0.0093382579996213 NA NA NA hsa-miR-500a-5p PRRX1 -1.28374735824553 1.95870374809798e-20 0.879417629803063 8.60048203449821e-05 mirMAP -0.442715941086158 1.1832704457988e-07 NA NA NA hsa-miR-106a-5p PTHLH -0.830908656792615 2.67547872901508e-10 4.82134706868762 9.61208237234467e-36 MirTarget;miRNATAP -0.721145398888336 4.00247439098286e-05 NA NA NA hsa-miR-139-5p PTHLH -0.704802495091118 2.36904108453776e-06 4.82134706868762 9.61208237234467e-36 miRanda -1.02855240114979 1.89817962818072e-11 NA NA NA hsa-miR-190a-5p PTHLH -0.286268924946003 0.017120414883133 4.82134706868762 9.61208237234467e-36 MirTarget -0.694038326049064 0.000466883800643381 NA NA NA hsa-miR-199a-5p PTHLH -1.64658415208633 1.01615659358973e-23 4.82134706868762 9.61208237234467e-36 miRanda -0.537493472811632 6.40827626608416e-05 NA NA NA hsa-miR-200b-3p PTHLH -1.70383252137161 2.38979336321755e-30 4.82134706868762 9.61208237234467e-36 MirTarget;TargetScan -1.09805318649959 4.74099416499695e-15 NA NA NA hsa-miR-200c-3p PTHLH -5.40303134829523 2.74173143360645e-94 4.82134706868762 9.61208237234467e-36 MirTarget -0.651373443804392 8.14067480833699e-25 NA NA NA hsa-miR-20b-5p PTHLH -1.30218163823367 6.87172815978149e-17 4.82134706868762 9.61208237234467e-36 MirTarget -0.952456671948629 1.8485149349644e-11 NA NA NA hsa-miR-29a-3p PTHLH -0.431613225927952 4.10166815070288e-08 4.82134706868762 9.61208237234467e-36 MirTarget -0.901145127460364 0.00271454471962896 NA NA NA hsa-miR-29c-3p PTHLH -0.238671318446745 0.0141475322347596 4.82134706868762 9.61208237234467e-36 MirTarget -0.860054602766939 0.000463245677000312 NA NA NA hsa-miR-3065-3p PTHLH -1.64500070417457 9.57561660036697e-16 4.82134706868762 9.61208237234467e-36 MirTarget;miRNATAP -0.951639498124316 1.36070854505061e-19 NA NA NA hsa-miR-33a-5p PTHLH -1.59840463890997 1.13487952314403e-18 4.82134706868762 9.61208237234467e-36 miRNAWalker2_validate -0.636478243285129 2.46975208603042e-07 23458685 We have found that miR-33a which is downregulated in lung cancer cells directly targets PTHrP parathyroid hormone-related protein a potent stimulator of osteoclastic bone resorption leading to decreased osteolytic bone metastasis; We also found that miR-33a levels are inversely correlated with PTHrP expression between human normal bronchial cell line and lung cancer cell lines; These findings have led us to conclude that miR-33a may be a potent tumor suppressor which inhibits direct and indirect osteoclastogenesis through repression of PTHrP miR-33a may even predict a poor prognosis for lung cancer patients metastasis;worse prognosis lung cancer hsa-miR-429 PTHLH -2.16569233119434 2.66862243626443e-37 4.82134706868762 9.61208237234467e-36 MirTarget;PITA;miRanda -1.01752023671975 1.26177398284264e-17 NA NA NA hsa-miR-101-3p PTX3 0.683973909682285 2.88573524246948e-15 -1.01213952478721 4.59443946645769e-06 miRNATAP -0.940986648177783 1.67878241853451e-12 NA NA NA hsa-miR-27b-5p PVR -0.660506646244576 2.52529588436758e-11 0.128394237121102 0.0701849223639705 mirMAP -0.181439922107299 1.74923612339372e-06 NA NA NA hsa-miR-101-5p QSOX1 -0.710089604234471 1.19159750684491e-09 0.532710271015096 7.3465338130413e-06 mirMAP -0.37626830683168 2.86865707097659e-12 NA NA NA hsa-miR-106a-5p QSOX1 -0.830908656792615 2.67547872901508e-10 0.532710271015096 7.3465338130413e-06 mirMAP -0.168259163298923 0.000596130845619362 NA NA NA hsa-miR-135a-5p QSOX1 -2.13422485001223 6.29449029671498e-14 0.532710271015096 7.3465338130413e-06 mirMAP -0.107795681104217 2.03836510456772e-06 NA NA NA hsa-miR-188-5p QSOX1 -1.74586655806628 1.50431624674552e-28 0.532710271015096 7.3465338130413e-06 mirMAP -0.191649409600674 1.08805104829291e-06 NA NA NA hsa-miR-192-3p QSOX1 0.156650099616707 0.483496040900362 0.532710271015096 7.3465338130413e-06 mirMAP -0.123180032022756 3.26728508674072e-05 NA NA NA hsa-miR-192-5p QSOX1 0.442478872410106 0.0669238175123954 0.532710271015096 7.3465338130413e-06 mirMAP -0.130908999307746 1.35599434390689e-06 NA NA NA hsa-miR-20b-5p QSOX1 -1.30218163823367 6.87172815978149e-17 0.532710271015096 7.3465338130413e-06 mirMAP -0.216892831532136 5.40950682673165e-08 NA NA NA hsa-miR-23b-3p QSOX1 -0.533749586990474 2.46924776953771e-10 0.532710271015096 7.3465338130413e-06 mirMAP -0.588633435387899 1.94954304589972e-15 NA NA NA hsa-miR-26a-1-3p QSOX1 -1.56107117111696 6.75439319582901e-15 0.532710271015096 7.3465338130413e-06 mirMAP -0.152275097805093 2.17381577756521e-06 NA NA NA hsa-miR-27b-5p QSOX1 -0.660506646244576 2.52529588436758e-11 0.532710271015096 7.3465338130413e-06 mirMAP -0.464235232118241 1.87771535002883e-13 NA NA NA hsa-miR-362-3p QSOX1 -0.753214251798232 3.0025661608035e-07 0.532710271015096 7.3465338130413e-06 MirTarget;miRanda;miRNATAP -0.143899303984043 0.00165386805514878 NA NA NA hsa-miR-362-5p QSOX1 -2.72767654824605 1.34821749679113e-49 0.532710271015096 7.3465338130413e-06 TargetScan;mirMAP -0.18705933540854 5.00652548451653e-10 NA NA NA hsa-miR-378a-3p QSOX1 0.287244802401236 0.0501155019984562 0.532710271015096 7.3465338130413e-06 mirMAP -0.151236916623338 0.000810831071017574 NA NA NA hsa-miR-378a-5p QSOX1 0.0656803477649888 0.671175582876016 0.532710271015096 7.3465338130413e-06 mirMAP -0.122290563728114 0.00445790708733351 NA NA NA hsa-miR-378c QSOX1 0.755048315231594 3.56147090439556e-06 0.532710271015096 7.3465338130413e-06 mirMAP -0.13654185379511 0.000732145370673857 NA NA NA hsa-miR-455-3p QSOX1 0.171798655137046 0.261841668213493 0.532710271015096 7.3465338130413e-06 mirMAP -0.146330007324599 0.000728100285639701 NA NA NA hsa-miR-107 RGS4 0.140046250553248 0.0943611632552367 0.0843438864400425 0.642451781771009 MirTarget;miRanda;miRNATAP -0.510534394494541 2.03658568420685e-05 NA NA NA hsa-miR-30b-3p RGS4 -1.64703050862226 1.89878531036464e-31 0.0843438864400425 0.642451781771009 MirTarget -0.187912684716165 0.00367395536958569 NA NA NA hsa-miR-455-5p RGS4 0.773674551205946 2.12957541541474e-09 0.0843438864400425 0.642451781771009 PITA;miRanda -0.328415241507748 1.19867603436001e-05 NA NA NA hsa-miR-183-5p RHOB -1.21596931064487 1.31473205758898e-08 0.710319193425473 5.78451706449585e-08 miRNATAP -0.27513581947755 7.92983201440772e-18 NA NA NA hsa-miR-335-5p RHOB -2.09515619961552 1.03765771499548e-25 0.710319193425473 5.78451706449585e-08 miRNAWalker2_validate -0.173098618768939 3.25064231075658e-07 NA NA NA hsa-miR-362-3p RHOB -0.753214251798232 3.0025661608035e-07 0.710319193425473 5.78451706449585e-08 miRanda -0.221974399391274 1.06227805010839e-05 NA NA NA hsa-miR-429 RHOB -2.16569233119434 2.66862243626443e-37 0.710319193425473 5.78451706449585e-08 miRNATAP -0.135600527357895 0.000423089493746635 NA NA NA hsa-miR-139-5p SAT1 -0.704802495091118 2.36904108453776e-06 -0.102135468370909 0.289005672394289 miRanda -0.196845430317836 9.7257267259699e-09 NA NA NA hsa-miR-320a SAT1 0.412740558379182 2.02929519701706e-05 -0.102135468370909 0.289005672394289 miRanda;miRNATAP -0.155271536364817 0.00433701732592694 NA NA NA hsa-miR-320b SAT1 0.300497419754843 0.0245219177384172 -0.102135468370909 0.289005672394289 miRanda;miRNATAP -0.115178518605024 0.0036695763103162 NA NA NA hsa-miR-338-3p SAT1 0.906250377628867 2.76970900371139e-15 -0.102135468370909 0.289005672394289 miRanda -0.171028438042527 0.000104493226246176 NA NA NA hsa-miR-455-3p SAT1 0.171798655137046 0.261841668213493 -0.102135468370909 0.289005672394289 miRNAWalker2_validate -0.141471657572818 3.9739442426463e-05 NA NA NA hsa-miR-139-5p SCG2 -0.704802495091118 2.36904108453776e-06 2.71104718714967 9.61632836039922e-24 miRanda -0.494662515874392 2.29131044433504e-06 NA NA NA hsa-miR-30b-3p SCG2 -1.64703050862226 1.89878531036464e-31 2.71104718714967 9.61632836039922e-24 MirTarget -0.832717802045336 3.68205882229305e-17 NA NA NA hsa-miR-362-3p SCG2 -0.753214251798232 3.0025661608035e-07 2.71104718714967 9.61632836039922e-24 miRanda -0.458370253145477 2.99968204349115e-05 NA NA NA hsa-miR-18a-5p SDC1 0.936704393213466 1.05064580570579e-10 -1.15893099367259 3.8876347011693e-12 mirMAP -0.212957990187073 0.00083466500957972 NA NA NA hsa-miR-19a-3p SDC1 0.722913586880779 2.76301458932381e-10 -1.15893099367259 3.8876347011693e-12 MirTarget;miRNATAP -0.358261408522632 8.55973586207988e-06 NA NA NA hsa-miR-19b-1-5p SDC1 0.66692013055553 1.55789130176287e-09 -1.15893099367259 3.8876347011693e-12 MirTarget -0.260527041733695 0.00206353712398786 NA NA NA hsa-miR-28-5p SDC1 0.461962042257226 3.32424690573327e-11 -1.15893099367259 3.8876347011693e-12 miRanda;miRNATAP -0.579182408278005 1.4729968703483e-05 NA NA NA hsa-miR-330-3p SDC1 0.912906550436308 3.35037014057665e-13 -1.15893099367259 3.8876347011693e-12 mirMAP -0.298631603816921 6.12995030777628e-05 NA NA NA hsa-miR-338-3p SDC1 0.906250377628867 2.76970900371139e-15 -1.15893099367259 3.8876347011693e-12 miRanda -0.324151221777973 4.27252008557238e-05 NA NA NA hsa-miR-342-3p SDC1 1.4124432570595 1.07208971556131e-28 -1.15893099367259 3.8876347011693e-12 miRanda;mirMAP -0.325529993240885 1.66255335571806e-06 NA NA NA hsa-miR-486-5p SDC1 1.16748143760361 1.68410465883829e-08 -1.15893099367259 3.8876347011693e-12 miRanda -0.196681137835454 1.04048340941689e-05 NA NA NA hsa-miR-589-5p SDC1 0.696241532021631 5.26958362886071e-16 -1.15893099367259 3.8876347011693e-12 mirMAP -0.361328415765218 0.000692963622361748 NA NA NA hsa-miR-130b-3p SDC4 1.12788913578446 2.939369462276e-16 -0.679873358696346 7.69363194451398e-13 MirTarget -0.168584086931865 5.87792929960659e-06 NA NA NA hsa-miR-140-3p SDC4 0.989350547007025 6.14964028267239e-25 -0.679873358696346 7.69363194451398e-13 MirTarget -0.245425863301965 2.43186459545273e-06 NA NA NA hsa-miR-142-3p SDC4 1.88928758773299 2.72985643829893e-22 -0.679873358696346 7.69363194451398e-13 miRanda -0.127829801587372 6.33598003044732e-07 NA NA NA hsa-miR-16-1-3p SDC4 1.51429140700091 3.17219833254498e-37 -0.679873358696346 7.69363194451398e-13 MirTarget -0.255061400411043 2.54989292364331e-10 NA NA NA hsa-miR-18a-5p SDC4 0.936704393213466 1.05064580570579e-10 -0.679873358696346 7.69363194451398e-13 MirTarget -0.128161487499522 0.000400683730764958 NA NA NA hsa-miR-224-5p SDC4 2.84654230414912 3.0480927226395e-47 -0.679873358696346 7.69363194451398e-13 MirTarget -0.117432883932985 4.96019580914017e-07 NA NA NA hsa-miR-301a-3p SDC4 0.259400847075798 0.0216890736701418 -0.679873358696346 7.69363194451398e-13 MirTarget -0.151548244420837 0.00159708405407945 NA NA NA hsa-miR-454-3p SDC4 0.68285296887698 1.17407812677787e-08 -0.679873358696346 7.69363194451398e-13 MirTarget -0.13447944522439 0.00243655897994855 NA NA NA hsa-miR-629-5p SDC4 1.73389921851483 5.39614356468007e-48 -0.679873358696346 7.69363194451398e-13 MirTarget -0.18528494069632 1.7586630993144e-06 NA NA NA hsa-miR-942-5p SDC4 0.978672610596303 3.12802933163696e-12 -0.679873358696346 7.69363194451398e-13 MirTarget -0.130447698725591 0.000470064628639832 NA NA NA hsa-miR-204-5p SERPINE1 -1.67490789640238 9.14741888352476e-10 1.92970249364449 2.84437942656963e-16 miRNAWalker2_validate -0.36894574634153 2.36125358098929e-15 NA NA NA hsa-miR-30a-5p SERPINE1 -0.778411951775343 2.73322451127932e-16 1.92970249364449 2.84437942656963e-16 miRNATAP -1.43022749865242 6.79980385354922e-30 NA NA NA hsa-miR-30b-5p SERPINE1 -1.18330589477119 6.8341618466966e-27 1.92970249364449 2.84437942656963e-16 MirTarget -0.898818015759768 2.15911007917366e-16 25170877 miR-30b may function as a novel tumor suppressor gene in gastric cancer by targeting PAI-1 and regulating the apoptosis of cancer cells gastric cancer hsa-miR-30c-5p SERPINE1 -1.08783070774238 2.02505402525786e-24 1.92970249364449 2.84437942656963e-16 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -1.08355371642794 3.40127651324715e-22 NA NA NA hsa-miR-30d-5p SERPINE1 -0.202727675788184 0.00659067084745794 1.92970249364449 2.84437942656963e-16 miRNATAP -1.30372212824368 3.11670391718996e-13 NA NA NA hsa-miR-514a-3p SERPINE1 -3.60916038800272 7.44698991540685e-35 1.92970249364449 2.84437942656963e-16 MirTarget -0.254217949872863 4.98891418851513e-10 NA NA NA hsa-miR-99a-5p SERPINE1 -0.609395142445514 1.66643233447031e-07 1.92970249364449 2.84437942656963e-16 miRNAWalker2_validate -0.700232387065003 5.61135213392081e-10 NA NA NA hsa-miR-30a-5p SERPINE2 -0.778411951775343 2.73322451127932e-16 0.861372048386008 6.65102975230085e-07 miRNAWalker2_validate -0.674304441096192 1.20975222718134e-12 NA NA NA hsa-miR-429 SERPINE2 -2.16569233119434 2.66862243626443e-37 0.861372048386008 6.65102975230085e-07 miRanda -0.220873664994398 1.21712523244945e-05 NA NA NA hsa-miR-29a-3p SERPINH1 -0.431613225927952 4.10166815070288e-08 1.52445101251399 3.62888622027088e-43 miRNATAP -0.243269668844667 0.00578574096589866 27488440 Regulation of LOXL2 and SERPINH1 by antitumor microRNA 29a in lung cancer with idiopathic pulmonary fibrosis; Downregulation of miR-29a caused overexpression of LOXL2 and SERPINH1 in lung cancer and IPF suggesting that these genes are involved in the pathogenesis of these two diseases.Journal of Human Genetics advance online publication 4 August 2016; doi:10.1038/jhg.2016.99 staging lung cancer hsa-miR-29c-3p SERPINH1 -0.238671318446745 0.0141475322347596 1.52445101251399 3.62888622027088e-43 miRNATAP -0.365287476735699 2.89364556280389e-07 NA NA NA hsa-miR-3065-3p SERPINH1 -1.64500070417457 9.57561660036697e-16 1.52445101251399 3.62888622027088e-43 miRNATAP -0.222031840760096 1.94634960468846e-12 NA NA NA hsa-miR-429 SERPINH1 -2.16569233119434 2.66862243626443e-37 1.52445101251399 3.62888622027088e-43 miRanda -0.36972034215183 5.02400330807532e-28 NA NA NA hsa-miR-1271-5p SFRP1 0.900599702972936 3.07963385418853e-10 -6.72745240941721 1.9741325361747e-76 mirMAP -0.935571391893478 3.9719556764976e-08 NA NA NA hsa-miR-1301-3p SFRP1 0.393537638993954 0.000390498879474539 -6.72745240941721 1.9741325361747e-76 MirTarget -0.814199430842928 0.000353545491558244 NA NA NA hsa-miR-144-3p SFRP1 1.4617706700291 9.18139413836375e-11 -6.72745240941721 1.9741325361747e-76 MirTarget;miRNATAP -0.547752901720784 4.06383036099132e-07 NA NA NA hsa-miR-146a-5p SFRP1 1.04938133739924 7.51013231709992e-12 -6.72745240941721 1.9741325361747e-76 MirTarget -0.946895365400288 1.77064009262476e-09 NA NA NA hsa-miR-146b-5p SFRP1 1.40714170253819 2.9559871816487e-12 -6.72745240941721 1.9741325361747e-76 MirTarget -0.843390207692544 8.51250295462547e-13 NA NA NA hsa-miR-16-1-3p SFRP1 1.51429140700091 3.17219833254498e-37 -6.72745240941721 1.9741325361747e-76 MirTarget -1.75055415502597 7.31488845345297e-22 NA NA NA hsa-miR-19b-1-5p SFRP1 0.66692013055553 1.55789130176287e-09 -6.72745240941721 1.9741325361747e-76 MirTarget -1.12753811318698 4.3219412563047e-07 NA NA NA hsa-miR-27a-3p SFRP1 0.558934437526245 1.44256383086177e-12 -6.72745240941721 1.9741325361747e-76 MirTarget;miRNATAP -1.88566378766955 8.96268932831741e-10 NA NA NA hsa-miR-484 SFRP1 0.571987778099603 9.67278224458421e-10 -6.72745240941721 1.9741325361747e-76 MirTarget -1.27789179412824 1.28983947669007e-06 NA NA NA hsa-miR-486-5p SFRP1 1.16748143760361 1.68410465883829e-08 -6.72745240941721 1.9741325361747e-76 MirTarget;miRanda -0.572465876933945 1.44794265463149e-06 NA NA NA hsa-miR-576-5p SFRP1 1.06681109513983 5.69294424466526e-24 -6.72745240941721 1.9741325361747e-76 MirTarget;PITA -1.9117524322024 2.63414907936094e-19 NA NA NA hsa-miR-7-1-3p SFRP1 0.544601828025304 5.33830451326047e-07 -6.72745240941721 1.9741325361747e-76 MirTarget;mirMAP -1.10265418660015 1.44645692623341e-06 NA NA NA hsa-miR-429 SFRP4 -2.16569233119434 2.66862243626443e-37 0.407466742313577 0.0618304568350401 miRanda -0.263094136413292 2.67416497460191e-05 NA NA NA hsa-miR-532-5p SFRP4 -1.09700348358668 8.34836230254408e-26 0.407466742313577 0.0618304568350401 MirTarget -0.388701882820144 0.000263635488674725 NA NA NA hsa-miR-182-5p SGCB -0.608710746044567 0.0025264935278104 0.514943504370333 8.30943332786584e-09 mirMAP -0.163592679463885 1.19679122494042e-11 NA NA NA hsa-miR-199a-5p SGCB -1.64658415208633 1.01615659358973e-23 0.514943504370333 8.30943332786584e-09 miRanda -0.13075307134445 3.6830289046238e-06 NA NA NA hsa-miR-199b-5p SGCB -2.39483476763681 1.04659509514884e-17 0.514943504370333 8.30943332786584e-09 miRanda -0.128747132612185 1.82013502496262e-14 NA NA NA hsa-miR-335-3p SGCB -1.36498175550207 6.84287752180534e-13 0.514943504370333 8.30943332786584e-09 mirMAP -0.177053727229928 8.22433442472022e-13 NA NA NA hsa-miR-429 SGCB -2.16569233119434 2.66862243626443e-37 0.514943504370333 8.30943332786584e-09 miRanda;miRNATAP -0.117028517314282 7.56818531022496e-06 NA NA NA hsa-miR-106b-5p SGCD 1.07509411417907 2.11739194181878e-36 -1.24100323719584 3.3942177379357e-07 mirMAP -0.554184577402394 0.000109205443588971 NA NA NA hsa-miR-15a-5p SGCD 1.42663930007845 1.36006952074963e-57 -1.24100323719584 3.3942177379357e-07 miRNATAP -0.495958470084736 0.000106417528109032 NA NA NA hsa-miR-15b-5p SGCD 0.773001494057531 1.71784656078957e-16 -1.24100323719584 3.3942177379357e-07 miRNATAP -0.473100566799125 0.000685154554247539 NA NA NA hsa-miR-16-5p SGCD 0.934012514027655 4.85417898318515e-24 -1.24100323719584 3.3942177379357e-07 miRNATAP -0.459711005880193 0.000867551270258172 NA NA NA hsa-miR-17-5p SGCD 0.494260110870015 3.8348005261e-09 -1.24100323719584 3.3942177379357e-07 mirMAP -0.694215103504386 1.30895479264473e-05 NA NA NA hsa-miR-19a-3p SGCD 0.722913586880779 2.76301458932381e-10 -1.24100323719584 3.3942177379357e-07 mirMAP -0.416203713503942 0.000334465143652247 NA NA NA hsa-miR-20a-5p SGCD 0.702602695798242 4.06372887613329e-13 -1.24100323719584 3.3942177379357e-07 mirMAP -0.563356140488101 3.3548279730083e-05 NA NA NA hsa-miR-25-3p SGCD 1.12016166564779 3.79069348635778e-48 -1.24100323719584 3.3942177379357e-07 mirMAP -0.471429274130212 0.00223121702407238 NA NA NA hsa-miR-32-5p SGCD 0.407826130035097 7.26884631998646e-06 -1.24100323719584 3.3942177379357e-07 mirMAP -0.464054984648261 0.00189568355191101 NA NA NA hsa-miR-576-5p SGCD 1.06681109513983 5.69294424466526e-24 -1.24100323719584 3.3942177379357e-07 mirMAP -0.552288065220424 3.78163841121197e-06 NA NA NA hsa-miR-590-3p SGCD 1.13702599385212 3.53435739887793e-22 -1.24100323719584 3.3942177379357e-07 PITA;miRanda;mirMAP;miRNATAP -0.442153521775011 4.65409839886704e-05 NA NA NA hsa-miR-590-5p SGCD 0.709763558412506 1.11883921359361e-11 -1.24100323719584 3.3942177379357e-07 miRanda -0.436713445499392 0.000574307340907417 NA NA NA hsa-miR-616-5p SGCD 0.913426384742148 3.78418389333709e-09 -1.24100323719584 3.3942177379357e-07 miRNATAP -0.336498995889961 0.000111668308066889 NA NA NA hsa-miR-7-1-3p SGCD 0.544601828025304 5.33830451326047e-07 -1.24100323719584 3.3942177379357e-07 mirMAP -0.44575130091397 0.000318091648401585 NA NA NA hsa-miR-92a-3p SGCD 0.178194888895831 0.0088835082650834 -1.24100323719584 3.3942177379357e-07 mirMAP -0.536703143836395 0.0084727690178615 NA NA NA hsa-miR-93-5p SGCD 1.37365940377595 2.37567548683245e-46 -1.24100323719584 3.3942177379357e-07 mirMAP -0.51153996992319 3.03814070351179e-05 NA NA NA hsa-miR-149-5p SLC6A8 -1.95790336710741 8.46371715052367e-27 1.57083924134325 2.1391454953582e-20 miRNATAP -0.212084692756851 2.10003260652818e-05 NA NA NA hsa-miR-218-5p SLC6A8 -0.81077534785501 3.0631582201951e-08 1.57083924134325 2.1391454953582e-20 mirMAP -0.201658248619327 0.00247698293626569 NA NA NA hsa-miR-429 SLC6A8 -2.16569233119434 2.66862243626443e-37 1.57083924134325 2.1391454953582e-20 miRNATAP -0.175010472719928 0.00077705154791365 NA NA NA hsa-miR-330-3p SLIT2 0.912906550436308 3.35037014057665e-13 -2.23814872142923 1.21595775707376e-16 miRNAWalker2_validate -0.551003738161637 6.41672843493442e-06 NA NA NA hsa-miR-576-5p SLIT2 1.06681109513983 5.69294424466526e-24 -2.23814872142923 1.21595775707376e-16 mirMAP -0.68504672237668 5.30748891966363e-07 NA NA NA hsa-miR-590-3p SLIT2 1.13702599385212 3.53435739887793e-22 -2.23814872142923 1.21595775707376e-16 miRanda -0.64031234919011 2.18074033796618e-07 NA NA NA hsa-miR-664a-3p SLIT2 -0.019312777079624 0.825861598748857 -2.23814872142923 1.21595775707376e-16 mirMAP -0.679172763315979 0.000157887516563659 NA NA NA hsa-miR-148a-5p SLIT3 0.415500302855613 0.000691460831436767 -0.0780976222318266 0.598613445176202 MirTarget;miRNATAP -0.266587145653805 5.3904183803817e-05 NA NA NA hsa-miR-148b-5p SLIT3 0.269550343699955 0.0383631776794927 -0.0780976222318266 0.598613445176202 mirMAP -0.252184598581052 9.10725119436779e-05 NA NA NA hsa-miR-188-5p SLIT3 -1.74586655806628 1.50431624674552e-28 -0.0780976222318266 0.598613445176202 mirMAP -0.183591197700746 0.00016496091500475 NA NA NA hsa-miR-1976 SLIT3 0.343475600930938 0.000360243844871748 -0.0780976222318266 0.598613445176202 mirMAP -0.313906343872168 0.000199697596520333 NA NA NA hsa-miR-362-3p SLIT3 -0.753214251798232 3.0025661608035e-07 -0.0780976222318266 0.598613445176202 miRanda -0.184623252791347 0.00102862294455604 NA NA NA hsa-miR-362-5p SLIT3 -2.72767654824605 1.34821749679113e-49 -0.0780976222318266 0.598613445176202 TargetScan -0.130332380779288 0.000560577703291292 NA NA NA hsa-miR-3913-5p SLIT3 0.136365354811444 0.24239516424369 -0.0780976222318266 0.598613445176202 mirMAP -0.205078696244712 0.00554058026147008 NA NA NA hsa-miR-500a-5p SLIT3 -1.28374735824553 1.95870374809798e-20 -0.0780976222318266 0.598613445176202 mirMAP -0.20634444616426 0.000190744790240121 NA NA NA hsa-miR-589-3p SLIT3 -0.0184909376114044 0.903149951095234 -0.0780976222318266 0.598613445176202 mirMAP -0.186966660422394 0.000641989654619015 NA NA NA hsa-miR-590-3p SLIT3 1.13702599385212 3.53435739887793e-22 -0.0780976222318266 0.598613445176202 miRanda;mirMAP -0.238884585653094 0.000239015616274335 NA NA NA hsa-miR-590-5p SLIT3 0.709763558412506 1.11883921359361e-11 -0.0780976222318266 0.598613445176202 miRanda -0.272188849953041 0.000324344242272176 NA NA NA hsa-miR-616-5p SLIT3 0.913426384742148 3.78418389333709e-09 -0.0780976222318266 0.598613445176202 mirMAP -0.303821789346449 3.03705722125784e-09 NA NA NA hsa-miR-625-5p SLIT3 0.153090549230629 0.330314026509869 -0.0780976222318266 0.598613445176202 mirMAP -0.316097921050682 1.10030578490138e-08 NA NA NA hsa-miR-96-5p SLIT3 -1.00223771166604 3.91564621567028e-06 -0.0780976222318266 0.598613445176202 TargetScan -0.107217467697844 0.00502697777393995 NA NA NA hsa-miR-107 SNAI2 0.140046250553248 0.0943611632552367 -0.356427634692673 0.0129979444851688 miRanda -0.306761793705569 0.00133520032495645 NA NA NA hsa-miR-148b-3p SNAI2 0.346011252093377 4.27203463315056e-06 -0.356427634692673 0.0129979444851688 miRNAWalker2_validate -0.344852018746948 0.00104190652326892 NA NA NA hsa-miR-200b-3p SNAI2 -1.70383252137161 2.38979336321755e-30 -0.356427634692673 0.0129979444851688 TargetScan -0.228745245252803 1.8598022178794e-06 NA NA NA hsa-miR-429 SNAI2 -2.16569233119434 2.66862243626443e-37 -0.356427634692673 0.0129979444851688 PITA;miRanda;miRNATAP -0.159866688950626 0.000110424269096433 NA NA NA hsa-miR-532-5p SNAI2 -1.09700348358668 8.34836230254408e-26 -0.356427634692673 0.0129979444851688 PITA -0.190823518677431 0.00678741605783006 NA NA NA hsa-miR-142-5p SNTB1 1.88417391525707 1.2096808039882e-27 -0.314769066298097 0.00804232556042109 mirMAP -0.163460619642494 2.09120777052181e-06 NA NA NA hsa-miR-16-1-3p SNTB1 1.51429140700091 3.17219833254498e-37 -0.314769066298097 0.00804232556042109 MirTarget;mirMAP -0.201169247498677 5.2691975275751e-05 NA NA NA hsa-miR-24-3p SNTB1 0.173813044685099 0.00565259443420961 -0.314769066298097 0.00804232556042109 miRNAWalker2_validate -0.283256045471134 0.00784875966694686 NA NA NA hsa-miR-361-5p SNTB1 0.0514169367202078 0.382929376393199 -0.314769066298097 0.00804232556042109 miRanda -0.315324499471889 0.00591261685555708 NA NA NA hsa-miR-421 SNTB1 0.313155739887734 0.020433534776003 -0.314769066298097 0.00804232556042109 miRanda -0.166363316840536 0.000896928715300608 NA NA NA hsa-miR-450b-5p SNTB1 0.404819502355575 0.00357671373841274 -0.314769066298097 0.00804232556042109 mirMAP -0.125886558273907 0.00760233570872954 NA NA NA hsa-miR-625-5p SNTB1 0.153090549230629 0.330314026509869 -0.314769066298097 0.00804232556042109 MirTarget -0.188192716678065 2.89265320477779e-05 NA NA NA hsa-miR-664a-3p SNTB1 -0.019312777079624 0.825861598748857 -0.314769066298097 0.00804232556042109 MirTarget -0.297704183745612 7.59603056086665e-05 NA NA NA hsa-miR-10a-5p SPARC -1.17164272592931 4.86621098042279e-24 1.90824549118881 4.78957289029292e-49 miRNAWalker2_validate -0.522600156218231 4.06184393477277e-16 NA NA NA hsa-miR-203a-3p SPARC -2.25533513338731 1.77332845294014e-21 1.90824549118881 4.78957289029292e-49 MirTarget -0.223959432460199 2.28434485779251e-12 NA NA NA hsa-miR-204-5p SPARC -1.67490789640238 9.14741888352476e-10 1.90824549118881 4.78957289029292e-49 miRNATAP -0.124481322112408 2.35853090452438e-05 NA NA NA hsa-miR-29a-3p SPARC -0.431613225927952 4.10166815070288e-08 1.90824549118881 4.78957289029292e-49 miRNAWalker2_validate;miRTarBase;miRNATAP -0.653673137258382 1.890924265469e-10 23023935 microRNA 29a suppresses cell proliferation by targeting SPARC in hepatocellular carcinoma; Dual-luciferase reporter assays indicated that the SPARC mRNA 3'UTR was directly targeted by miR-29a since the mutated 3'UTR was not affected; Silencing SPARC expression by RNAi knockdown resulted in a similar effect as miR-29a overexpression on hepatocellular carcinoma HCC cell growth regulation liver cancer hsa-miR-29b-3p SPARC -0.228125979913806 0.0271621721891603 1.90824549118881 4.78957289029292e-49 miRNATAP -0.410350382657506 2.95908042169467e-07 NA NA NA hsa-miR-29c-3p SPARC -0.238671318446745 0.0141475322347596 1.90824549118881 4.78957289029292e-49 miRNAWalker2_validate;miRTarBase;miRNATAP -0.407625819822862 1.7269687783901e-06 NA NA NA hsa-miR-335-3p SPARC -1.36498175550207 6.84287752180534e-13 1.90824549118881 4.78957289029292e-49 MirTarget -0.148341763618501 0.00044552341923798 NA NA NA hsa-miR-345-5p SPARC -0.953479075875024 8.95459389953487e-14 1.90824549118881 4.78957289029292e-49 MirTarget -0.236627645528092 0.000155652519707974 NA NA NA hsa-miR-362-5p SPARC -2.72767654824605 1.34821749679113e-49 1.90824549118881 4.78957289029292e-49 TargetScan -0.424094251741842 6.35419534966911e-34 NA NA NA hsa-miR-532-3p SPARC -1.759223962964 7.9077916669414e-40 1.90824549118881 4.78957289029292e-49 miRNATAP -0.577489751576625 3.04405470463404e-30 NA NA NA hsa-miR-139-5p SPOCK1 -0.704802495091118 2.36904108453776e-06 -1.78381279475344 1.54901966475558e-09 PITA;miRanda;miRNATAP -0.369683279876138 0.00079050111792097 NA NA NA hsa-miR-16-1-3p SPOCK1 1.51429140700091 3.17219833254498e-37 -1.78381279475344 1.54901966475558e-09 MirTarget -0.565292254318652 7.67397863008789e-06 NA NA NA hsa-miR-452-5p SPOCK1 2.05325688842141 2.82238393643084e-40 -1.78381279475344 1.54901966475558e-09 mirMAP -0.2804393689937 0.00325586185773754 NA NA NA hsa-miR-139-5p SPP1 -0.704802495091118 2.36904108453776e-06 -0.534175644251711 0.00146073730596245 miRanda -0.232080239064456 0.000148526247285292 NA NA NA hsa-miR-128-3p TAGLN 0.475045893035043 2.6255647468e-06 -0.0489724437906505 0.772219438657184 miRNAWalker2_validate -0.28372927894276 0.00186101205391498 NA NA NA hsa-miR-126-5p TFPI2 0.785607261431085 5.77058629454465e-13 -0.190390061005853 0.463952965590108 MirTarget -0.51737783463048 4.18930177311103e-05 NA NA NA hsa-miR-23b-3p TFPI2 -0.533749586990474 2.46924776953771e-10 -0.190390061005853 0.463952965590108 MirTarget;miRNATAP -0.804518712617898 1.03869262102148e-06 NA NA NA hsa-miR-139-5p TGFB1 -0.704802495091118 2.36904108453776e-06 1.54700279831576 2.78812914754058e-38 miRanda -0.229663915619583 2.28216718397939e-06 NA NA NA hsa-miR-744-5p TGFB1 -0.348985243196771 0.000187889982228835 1.54700279831576 2.78812914754058e-38 miRNAWalker2_validate;miRNATAP -0.399940904532963 3.45780106724256e-07 NA NA NA hsa-miR-30a-5p TGFBI -0.778411951775343 2.73322451127932e-16 2.7877722726408 1.32579964762946e-20 miRNAWalker2_validate -1.86379292735307 1.09567862374019e-30 NA NA NA hsa-miR-362-3p TGFBI -0.753214251798232 3.0025661608035e-07 2.7877722726408 1.32579964762946e-20 miRanda -0.879506184856691 5.98233967862363e-14 NA NA NA hsa-miR-429 TGFBI -2.16569233119434 2.66862243626443e-37 2.7877722726408 1.32579964762946e-20 miRanda -0.701971751252258 2.1313677743869e-15 NA NA NA hsa-let-7b-5p TGFBR3 0.770868211539597 6.63408323707647e-21 -1.57245582743475 8.42471350231223e-38 MirTarget -0.319834106397516 0.00024758608339899 NA NA NA hsa-let-7i-5p TGFBR3 0.911372377723717 7.11483853341932e-31 -1.57245582743475 8.42471350231223e-38 MirTarget -0.755744537132936 1.57463365077216e-19 NA NA NA hsa-miR-103a-3p TGFBR3 0.779373475434461 7.37867196796994e-20 -1.57245582743475 8.42471350231223e-38 MirTarget;miRNATAP -0.503340582878597 1.13549702449542e-09 NA NA NA hsa-miR-15a-5p TGFBR3 1.42663930007845 1.36006952074963e-57 -1.57245582743475 8.42471350231223e-38 MirTarget;miRNATAP -0.55103001652561 9.11798473862567e-16 NA NA NA hsa-miR-15b-5p TGFBR3 0.773001494057531 1.71784656078957e-16 -1.57245582743475 8.42471350231223e-38 MirTarget;miRNATAP -0.495702844427736 5.68887973645524e-11 NA NA NA hsa-miR-16-2-3p TGFBR3 1.3046118743965 4.17207934608428e-19 -1.57245582743475 8.42471350231223e-38 mirMAP -0.33198494010436 3.33562428718567e-12 NA NA NA hsa-miR-16-5p TGFBR3 0.934012514027655 4.85417898318515e-24 -1.57245582743475 8.42471350231223e-38 MirTarget;miRNATAP -0.443185509215413 4.17675451211971e-09 NA NA NA hsa-miR-181a-5p TGFBR3 1.11111114875339 3.97880443756442e-29 -1.57245582743475 8.42471350231223e-38 miRNAWalker2_validate;mirMAP;miRNATAP -0.331635516623544 1.87095456483716e-06 NA NA NA hsa-miR-181b-5p TGFBR3 1.49054296272357 3.69051660739368e-41 -1.57245582743475 8.42471350231223e-38 mirMAP -0.3928729293488 2.22983292307128e-11 NA NA NA hsa-miR-182-5p TGFBR3 -0.608710746044567 0.0025264935278104 -1.57245582743475 8.42471350231223e-38 miRNATAP -0.137621875224013 0.000227355156819408 NA NA NA hsa-miR-185-3p TGFBR3 0.993379985307475 2.62011454953707e-13 -1.57245582743475 8.42471350231223e-38 MirTarget;miRNATAP -0.303490341109223 1.63057544848852e-08 NA NA NA hsa-miR-186-5p TGFBR3 0.507217561043443 9.04455748270995e-10 -1.57245582743475 8.42471350231223e-38 MirTarget -0.326408691574756 0.000286697033118517 NA NA NA hsa-miR-18a-5p TGFBR3 0.936704393213466 1.05064580570579e-10 -1.57245582743475 8.42471350231223e-38 MirTarget -0.26690352365531 1.03514087602482e-07 NA NA NA hsa-miR-193a-3p TGFBR3 0.849206638484406 3.68101781083335e-14 -1.57245582743475 8.42471350231223e-38 MirTarget;miRanda;miRNATAP -0.364598156589893 1.37153863725981e-08 NA NA NA hsa-miR-21-5p TGFBR3 2.51462371613332 3.30620591950316e-66 -1.57245582743475 8.42471350231223e-38 miRNAWalker2_validate -0.485920953664702 3.04471690655492e-38 NA NA NA hsa-miR-222-5p TGFBR3 0.345754786636279 0.0500394455965523 -1.57245582743475 8.42471350231223e-38 MirTarget -0.126068873385686 0.00408519674719402 NA NA NA hsa-miR-223-3p TGFBR3 1.23291409735619 1.07767240442694e-17 -1.57245582743475 8.42471350231223e-38 MirTarget -0.273365825008074 2.88648655670509e-08 NA NA NA hsa-miR-23a-3p TGFBR3 0.761438723382355 4.09310879199257e-27 -1.57245582743475 8.42471350231223e-38 MirTarget;mirMAP -0.632459260245655 9.95125102366945e-11 NA NA NA hsa-miR-27a-3p TGFBR3 0.558934437526245 1.44256383086177e-12 -1.57245582743475 8.42471350231223e-38 MirTarget;miRNATAP -0.466455044939739 4.92579434392472e-07 NA NA NA hsa-miR-339-5p TGFBR3 0.322848334531193 0.0117281778821612 -1.57245582743475 8.42471350231223e-38 miRanda -0.173765113435527 0.00338518356337332 NA NA NA hsa-miR-340-5p TGFBR3 1.14479851941741 2.91936881701444e-15 -1.57245582743475 8.42471350231223e-38 mirMAP -0.204805915669402 3.95638080260634e-05 NA NA NA hsa-miR-34a-5p TGFBR3 1.07544567720768 1.81510842038009e-20 -1.57245582743475 8.42471350231223e-38 miRNATAP -0.352331378789618 6.04024250971825e-09 NA NA NA hsa-miR-361-3p TGFBR3 1.08992546227594 1.13197240706704e-36 -1.57245582743475 8.42471350231223e-38 MirTarget;miRNATAP -0.669429161279383 4.67297707045364e-19 NA NA NA hsa-miR-484 TGFBR3 0.571987778099603 9.67278224458421e-10 -1.57245582743475 8.42471350231223e-38 MirTarget;miRNATAP -0.232322165248572 0.00356430125213643 NA NA NA hsa-miR-590-3p TGFBR3 1.13702599385212 3.53435739887793e-22 -1.57245582743475 8.42471350231223e-38 MirTarget;miRanda;mirMAP -0.459417807683317 3.42476405933133e-15 NA NA NA hsa-miR-590-5p TGFBR3 0.709763558412506 1.11883921359361e-11 -1.57245582743475 8.42471350231223e-38 miRanda -0.373843239536119 7.90131643482662e-08 NA NA NA hsa-miR-106a-5p TGM2 -0.830908656792615 2.67547872901508e-10 1.34247709707941 5.2396523432174e-18 MirTarget -0.316198422332058 1.77872407454926e-06 NA NA NA hsa-miR-20b-5p TGM2 -1.30218163823367 6.87172815978149e-17 1.34247709707941 5.2396523432174e-18 MirTarget -0.30907688418323 1.18984076806534e-08 NA NA NA hsa-miR-30a-5p TGM2 -0.778411951775343 2.73322451127932e-16 1.34247709707941 5.2396523432174e-18 miRNAWalker2_validate -0.714961277596458 2.36225259946136e-16 NA NA NA hsa-miR-30b-3p TGM2 -1.64703050862226 1.89878531036464e-31 1.34247709707941 5.2396523432174e-18 mirMAP -0.537100415078008 9.66215726529549e-23 NA NA NA hsa-miR-324-3p TGM2 -0.197662887871899 0.0298845059559819 1.34247709707941 5.2396523432174e-18 MirTarget -0.390043142906133 9.05876311490008e-05 NA NA NA hsa-miR-590-3p THBS1 1.13702599385212 3.53435739887793e-22 -0.422350939168091 0.00203641360708328 miRanda -0.199102332423063 0.00100744242039509 NA NA NA hsa-miR-671-5p THBS1 0.740296481994777 8.07053661008188e-07 -0.422350939168091 0.00203641360708328 MirTarget -0.195692881132597 9.34674725383135e-05 NA NA NA hsa-miR-139-5p THBS2 -0.704802495091118 2.36904108453776e-06 0.895321867056393 0.000269222765203446 miRanda -0.327278957005627 0.000272140669897031 NA NA NA hsa-miR-20b-5p THBS2 -1.30218163823367 6.87172815978149e-17 0.895321867056393 0.000269222765203446 MirTarget -0.271490377299147 0.00112875670067071 NA NA NA hsa-miR-29c-3p THBS2 -0.238671318446745 0.0141475322347596 0.895321867056393 0.000269222765203446 MirTarget -0.583050087821529 3.18134128753791e-05 NA NA NA hsa-miR-185-3p THY1 0.993379985307475 2.62011454953707e-13 -0.279651276772514 0.0335562515963486 MirTarget -0.231519291353066 7.91751558046572e-06 NA NA NA hsa-miR-103a-3p TIMP3 0.779373475434461 7.37867196796994e-20 -0.749486925113811 5.5926307765176e-08 miRNAWalker2_validate;miRTarBase -0.366761926703984 1.85590169692259e-05 22783422 miR-103 inhibitor transfection increased the activity of the luciferase reporter assay containing the TIMP-3 3'-untranslated region UTR construct and increased the levels of the TIMP-3 protein but not its mRNA in endometrial cancer cell lines; Our data suggested that miR-103 post-transcriptionally downregulates the expression of the tumor suppressor TIMP-3 and stimulates growth and invasion in endometrial cancer cell lines endometrial cancer hsa-miR-106b-5p TIMP3 1.07509411417907 2.11739194181878e-36 -0.749486925113811 5.5926307765176e-08 miRNATAP -0.540609495851175 1.0224976142682e-11 NA NA NA hsa-miR-148a-5p TIMP3 0.415500302855613 0.000691460831436767 -0.749486925113811 5.5926307765176e-08 mirMAP -0.284001593407252 5.66184655114125e-06 NA NA NA hsa-miR-16-1-3p TIMP3 1.51429140700091 3.17219833254498e-37 -0.749486925113811 5.5926307765176e-08 mirMAP -0.245570015301944 2.94374151513078e-05 NA NA NA hsa-miR-16-5p TIMP3 0.934012514027655 4.85417898318515e-24 -0.749486925113811 5.5926307765176e-08 miRNAWalker2_validate -0.348947015540826 7.46618299487207e-06 NA NA NA hsa-miR-20a-5p TIMP3 0.702602695798242 4.06372887613329e-13 -0.749486925113811 5.5926307765176e-08 miRNATAP -0.274997519031374 0.000383500155206658 NA NA NA hsa-miR-21-5p TIMP3 2.51462371613332 3.30620591950316e-66 -0.749486925113811 5.5926307765176e-08 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.391861183791146 3.6598264609275e-22 21820586;23936642;25720799;20346171;25587717 The effect of TIMP3 on miR-21-induced cell survival was determined by transfection with TIMP3 lacking 3' untranslated region and miR-21;Genetic heterogeneity of breast cancer metastasis may be related to miR 21 regulation of TIMP 3 in translation; The aim of this study is to determine whether microRNA-21 miR-21 a specific microRNA implicated in multiple aspects of carcinogenesis promoted breast cancer metastasis by regulating the tissue inhibitor of metalloproteinase 3 TIMP-3 gene; Correlation analysis was performed between miR-21 and TIMP-3; There was significantly inverse correlation between miR-21 and TIMP-3 extracted from tissue;We verified that HMGB1-induced expression of miR-21 in HCC provides a posttranscriptional repression of the matrix metalloproteinase MMP inhibitors RECK and TIMP3 which are known to impact HCC progression and metastases; Finally we found that inhibition of miR-21 in murine HMGB1-overexpressing HCC xenografts led to reduced tumor MMP activity through released repression of the miR-21 targets RECK and TIMP3 which ultimately impeded tumor progression;The aim of this study was to determine whether microRNA-21 miR-21 a specific microRNA implicated in multiple aspects of carcinogenesis impacts breast cancer invasion by regulating the tissue inhibitor of metalloproteinase 3 TIMP3 gene; In addition the regulation of tissue inhibitor of metalloproteinase 3 TIMP3 by miR-21 was evaluated by western blotting and luciferase assays; Evaluation of TIMP3 protein levels a peptidase involved in extarcellular matrix degredation inversely correlated with miR-21 expression; As knockdown of miR-21 increased TIMP3 protein expression and luciferase reporter activity our data suggests that miR-21 could promote invasion in breast cancer cells via its regulation of TIMP3;It was previously shown by our group that miR-21 a potential regulator of TIMP3 is over-expressed in cutaneous melanoma; It was therefore hypothesized that increased levels of miR-21 expression would lead to decreased expression of TIMP3 and thereby enhance the invasiveness of melanoma cells; Reduced expression of TIMP3 was achieved by siRNA knockdown and significantly enhanced invasion of melanoma cell lines mimicking the effects of miR-21 over-expression; Treatment of tumor cells with a linked nucleic acid antagomir to miR-21 inhibited tumor growth and increased tumor expression of TIMP3 in vivo in 01B74 Athymic NCr-nu/nu mice; This data shows that increased expression of miR-21 enhanced the invasive potential of melanoma cell lines through TIMP3 inhibition poor survival;metastasis;tumorigenesis;metastasis;progression;tumorigenesis; kidney renal cell cancer;breast cancer;liver cancer;breast cancer;melanoma hsa-miR-221-3p TIMP3 0.337895669520713 0.0136448974691037 -0.749486925113811 5.5926307765176e-08 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.369376962980952 1.9708285263517e-11 27077469 MiR 221 Exacerbate Cell Proliferation and Invasion by Targeting TIMP3 in Papillary Thyroid Carcinoma; The results indicated that miR-221 exacerbated PTC by downregulating the expression of TIMP3; The effects of miR-221 and TIMP3 in vivo were also confirmed by human PTC-bearing mice models which suggest consistent results with those in vitro studies thyroid cancer hsa-miR-222-3p TIMP3 0.214811008033524 0.0965295551752457 -0.749486925113811 5.5926307765176e-08 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.325182489201269 3.97465111697589e-08 NA NA NA hsa-miR-452-3p TIMP3 1.72039996672257 1.35748079442153e-22 -0.749486925113811 5.5926307765176e-08 MirTarget -0.11316042798628 0.0071608507047525 NA NA NA hsa-miR-452-5p TIMP3 2.05325688842141 2.82238393643084e-40 -0.749486925113811 5.5926307765176e-08 MirTarget;miRNATAP -0.121618567501321 0.0060335637185035 NA NA NA hsa-miR-589-3p TIMP3 -0.0184909376114044 0.903149951095234 -0.749486925113811 5.5926307765176e-08 mirMAP -0.200643954833282 0.000112668197986033 NA NA NA hsa-miR-590-3p TIMP3 1.13702599385212 3.53435739887793e-22 -0.749486925113811 5.5926307765176e-08 PITA;miRanda;miRNATAP -0.404716711161305 2.03145379616411e-11 NA NA NA hsa-miR-590-5p TIMP3 0.709763558412506 1.11883921359361e-11 -0.749486925113811 5.5926307765176e-08 MirTarget;PITA;miRanda;miRNATAP -0.378297993740156 1.05896777770094e-07 NA NA NA hsa-miR-616-5p TIMP3 0.913426384742148 3.78418389333709e-09 -0.749486925113811 5.5926307765176e-08 mirMAP -0.310274640400615 1.59778927050467e-10 NA NA NA hsa-miR-486-5p TNC 1.16748143760361 1.68410465883829e-08 -1.02056823197306 4.71471488735119e-07 PITA;miRanda -0.149577632469242 0.00534754730223606 NA NA NA hsa-miR-590-3p TNC 1.13702599385212 3.53435739887793e-22 -1.02056823197306 4.71471488735119e-07 miRanda -0.33734412499211 0.000194178786973807 NA NA NA hsa-let-7e-5p TNFAIP3 -0.727009689927955 1.30690859412163e-11 1.38030173354281 6.4639950782351e-32 miRNATAP -0.273445839868814 2.09785896344318e-05 NA NA NA hsa-let-7g-5p TNFAIP3 -0.739744008507763 1.07979566264383e-14 1.38030173354281 6.4639950782351e-32 miRNATAP -0.223767595834218 0.00188581235715797 NA NA NA hsa-miR-125a-5p TNFAIP3 -0.561874059994802 7.3931856356891e-13 1.38030173354281 6.4639950782351e-32 miRNAWalker2_validate;miRTarBase;miRanda -0.511011460691663 4.82163639567302e-09 NA NA NA hsa-miR-125b-5p TNFAIP3 -0.825456421494266 2.13029877878434e-15 1.38030173354281 6.4639950782351e-32 miRNAWalker2_validate;miRTarBase;miRNATAP -0.383403013728774 3.10786690825287e-09 24901050 miR 125b controls apoptosis and temozolomide resistance by targeting TNFAIP3 and NKIRAS2 in glioblastomas; GBM cells overexpressing TNFAIP3 and NKIRAS2 were refractory to miR-125b-induced apoptosis resistance as well as TMZ resistance indicating that both genes are relevant targets of miR-125b drug resistance glioblastoma hsa-miR-141-3p TNFAIP3 -5.87110686537457 1.20877726722907e-85 1.38030173354281 6.4639950782351e-32 TargetScan -0.188303983358912 6.07622530070826e-29 NA NA NA hsa-miR-23b-3p TNFAIP3 -0.533749586990474 2.46924776953771e-10 1.38030173354281 6.4639950782351e-32 miRNATAP -0.268192829355823 0.0012560426364318 NA NA NA hsa-miR-27b-5p TNFAIP3 -0.660506646244576 2.52529588436758e-11 1.38030173354281 6.4639950782351e-32 miRNATAP -0.320053543170784 4.47088555663971e-06 NA NA NA hsa-miR-29a-3p TNFAIP3 -0.431613225927952 4.10166815070288e-08 1.38030173354281 6.4639950782351e-32 miRNAWalker2_validate;miRTarBase -0.377105855310913 2.50795180649657e-05 NA NA NA hsa-miR-362-3p TNFAIP3 -0.753214251798232 3.0025661608035e-07 1.38030173354281 6.4639950782351e-32 miRanda -0.248430124827238 3.38389317075442e-07 NA NA NA hsa-miR-429 TNFAIP3 -2.16569233119434 2.66862243626443e-37 1.38030173354281 6.4639950782351e-32 miRanda -0.309625602657189 3.53901064958812e-18 NA NA NA hsa-miR-181a-5p TNFRSF11B 1.11111114875339 3.97880443756442e-29 -1.55107104161658 8.94169567208543e-16 miRNATAP -0.506400586364229 6.7307586069377e-07 NA NA NA hsa-miR-181b-5p TNFRSF11B 1.49054296272357 3.69051660739368e-41 -1.55107104161658 8.94169567208543e-16 miRNATAP -0.458048533115685 1.54029922143735e-07 NA NA NA hsa-miR-181c-5p TNFRSF11B 0.762784646696248 4.48373118147729e-10 -1.55107104161658 8.94169567208543e-16 miRNATAP -0.271051845887462 0.00229171670132079 NA NA NA hsa-miR-21-5p TNFRSF11B 2.51462371613332 3.30620591950316e-66 -1.55107104161658 8.94169567208543e-16 miRNAWalker2_validate -0.353412211416595 6.13772933203379e-09 NA NA NA hsa-miR-338-3p TNFRSF11B 0.906250377628867 2.76970900371139e-15 -1.55107104161658 8.94169567208543e-16 miRanda -0.460505360173555 5.70689726906944e-07 NA NA NA hsa-miR-576-5p TNFRSF11B 1.06681109513983 5.69294424466526e-24 -1.55107104161658 8.94169567208543e-16 PITA -0.350538021357503 0.000353562512025795 NA NA NA hsa-miR-590-3p TNFRSF11B 1.13702599385212 3.53435739887793e-22 -1.55107104161658 8.94169567208543e-16 miRanda -0.473946398324169 6.6051850072584e-08 NA NA NA hsa-miR-590-5p TNFRSF11B 0.709763558412506 1.11883921359361e-11 -1.55107104161658 8.94169567208543e-16 PITA;miRanda;miRNATAP -0.522698884194442 3.28244289135801e-07 NA NA NA hsa-miR-107 TPM1 0.140046250553248 0.0943611632552367 0.880006370733445 1.11468289382848e-18 PITA;miRanda -0.243882349232229 0.000491041152390551 NA NA NA hsa-miR-29a-3p TPM1 -0.431613225927952 4.10166815070288e-08 0.880006370733445 1.11468289382848e-18 miRNATAP -0.521756348824963 1.61430579927058e-13 NA NA NA hsa-miR-29b-3p TPM1 -0.228125979913806 0.0271621721891603 0.880006370733445 1.11468289382848e-18 miRNATAP -0.264791174112867 2.18375164138686e-06 NA NA NA hsa-miR-29c-3p TPM1 -0.238671318446745 0.0141475322347596 0.880006370733445 1.11468289382848e-18 miRNATAP -0.223731006465321 0.000181068592773151 NA NA NA hsa-miR-429 TPM1 -2.16569233119434 2.66862243626443e-37 0.880006370733445 1.11468289382848e-18 miRNATAP -0.151244580801009 4.87106822320685e-07 NA NA NA hsa-miR-192-5p TPM4 0.442478872410106 0.0669238175123954 -0.224704625772311 0.0302901755805405 miRNAWalker2_validate -0.175323760682295 1.24428754007104e-14 NA NA NA hsa-miR-215-5p TPM4 1.57223951497888 6.18833867819653e-10 -0.224704625772311 0.0302901755805405 miRNAWalker2_validate -0.112016752457541 2.15215325701925e-07 NA NA NA hsa-miR-30a-5p TPM4 -0.778411951775343 2.73322451127932e-16 -0.224704625772311 0.0302901755805405 miRNATAP -0.364460264227768 9.16801380152892e-11 NA NA NA hsa-miR-30c-5p TPM4 -1.08783070774238 2.02505402525786e-24 -0.224704625772311 0.0302901755805405 miRNATAP -0.155367470558748 0.00185097086569274 NA NA NA hsa-miR-30d-5p TPM4 -0.202727675788184 0.00659067084745794 -0.224704625772311 0.0302901755805405 miRNATAP -0.558094413285548 8.33907746386186e-14 NA NA NA hsa-miR-107 VCAN 0.140046250553248 0.0943611632552367 1.91334401481166 4.39794071153042e-18 MirTarget;miRanda;miRNATAP -0.456276053762339 0.00328447552052593 NA NA NA hsa-miR-135a-5p VCAN -2.13422485001223 6.29449029671498e-14 1.91334401481166 4.39794071153042e-18 MirTarget;miRNATAP -0.153602274502858 0.000532708460436805 NA NA NA hsa-miR-141-3p VCAN -5.87110686537457 1.20877726722907e-85 1.91334401481166 4.39794071153042e-18 MirTarget;TargetScan;miRNATAP -0.252083215137438 1.92503431308421e-15 NA NA NA hsa-miR-200a-3p VCAN -1.43409013664263 2.00188483717828e-20 1.91334401481166 4.39794071153042e-18 MirTarget;miRNATAP -0.397059037241056 2.51597457122074e-07 NA NA NA hsa-miR-203a-3p VCAN -2.25533513338731 1.77332845294014e-21 1.91334401481166 4.39794071153042e-18 MirTarget -0.146966312480016 0.00377023099340187 NA NA NA hsa-miR-23b-3p VCAN -0.533749586990474 2.46924776953771e-10 1.91334401481166 4.39794071153042e-18 MirTarget;miRNATAP -0.509671740359726 0.000641764045875706 NA NA NA hsa-miR-33a-5p VCAN -1.59840463890997 1.13487952314403e-18 1.91334401481166 4.39794071153042e-18 MirTarget -0.409062011006316 5.29410892756515e-10 NA NA NA hsa-miR-429 VCAN -2.16569233119434 2.66862243626443e-37 1.91334401481166 4.39794071153042e-18 miRanda -0.473164903959668 3.74277969432673e-13 NA NA NA hsa-miR-1-3p VEGFA -1.38047704190737 9.11649491260066e-13 3.1902151031465 4.32161998112301e-60 MirTarget -0.377004508862683 2.92409820832604e-09 24966896 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL bladder cancer hsa-miR-106a-5p VEGFA -0.830908656792615 2.67547872901508e-10 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRTarBase -0.565883993248695 1.96742640916183e-09 NA NA NA hsa-miR-125a-5p VEGFA -0.561874059994802 7.3931856356891e-13 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRanda -0.691987422405189 1.65186087473265e-05 22768249 Ectopic expression of MiR 125a inhibits the proliferation and metastasis of hepatocellular carcinoma by targeting MMP11 and VEGF; Furthermore miR-125a expression was inversely correlated with both MMP11 and VEGF-A expression in HCC tissues; MiR-125a inhibits the proliferation and metastasis of HCC by targeting MMP11 and VEGF-A metastasis liver cancer hsa-miR-133a-3p VEGFA -1.27121745308165 9.16266399887975e-11 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate -0.334559517340425 1.60041057990039e-07 NA NA NA hsa-miR-134-5p VEGFA -0.940639322366899 1.24417590236773e-06 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRTarBase;MirTarget -0.273283677460691 3.09936265314409e-05 NA NA NA hsa-miR-199a-5p VEGFA -1.64658415208633 1.01615659358973e-23 3.1902151031465 4.32161998112301e-60 miRanda;miRNATAP -0.582562369754787 1.33420730972332e-16 25444917 In addition co-transfection with miR-199a mimic reversed the CCL5-mediated VEGF expression and angiogenesis in vitro and in vivo sarcoma hsa-miR-199b-5p VEGFA -2.39483476763681 1.04659509514884e-17 3.1902151031465 4.32161998112301e-60 miRanda -0.388055722385546 8.86533920644866e-20 NA NA NA hsa-miR-200b-3p VEGFA -1.70383252137161 2.38979336321755e-30 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.652162092625576 6.74456951743668e-18 20420713;22904162;25301739 We also found strong anti-correlation between VEGFA and the miR-200 family of microRNA: miR-200a* 200b 200c and miR-141;In contrast a positive correlation was observed between VEGF-A and miR-200b and -210;CCL5 promotes VEGF dependent angiogenesis by down regulating miR 200b through PI3K/Akt signaling pathway in human chondrosarcoma cells; We also demonstrated CCL5 inhibiting miR-200b expression and miR-200b mimic reversing the CCL5-enhanced VEGF expression and angiogenesis ;; kidney renal cell cancer;endometrial cancer;sarcoma hsa-miR-200c-3p VEGFA -5.40303134829523 2.74173143360645e-94 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRTarBase;MirTarget -0.482839305599163 5.43978252023974e-53 24205206;25445393 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway;Analysis revealed a negative correlation between miR-200c and VEGFA expressions r=-468 ; lung squamous cell cancer;breast cancer hsa-miR-20b-5p VEGFA -1.30218163823367 6.87172815978149e-17 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRTarBase -0.658858628437659 2.63194222583861e-18 22901144;20232316;26612965 Correlation analysis showed that the key miRNAs miR-20a and miR-20b negatively correlated with the target proteins VEGF-A and HIF-1alpha;We investigated whether and how miR-20b can regulate the expression of vascular endothelial growth factor VEGF in MCF-7 breast cancer cells under normoxic and hypoxia-mimicking conditions CoCl2 exposure; Using immunoblotting ELISA and quantitative real-time PCR we demonstrated that miR-20b decreased VEGF protein levels at 4 and 24 h following CoCl2 treatment and VEGF mRNA at 4 h of treatment; In addition miR-20b reduced VEGF protein expression in untreated cells;Clinicopathological Significance of MicroRNA 20b Expression in Hepatocellular Carcinoma and Regulation of HIF 1α and VEGF Effect on Cell Biological Behaviour; Meanwhile the HIF-1α and VEGF targets of miR-20b have been confirmed; We found not only miR-20b regulation of HIF-1α and VEGF in normal but also regulation of miR-20b in hypoxia; The whole study suggests that miR-20b HIF-1α and VEGF serve as a potential therapeutic agent for hepatocellular carcinoma ;; breast cancer;breast cancer;liver cancer hsa-miR-29a-3p VEGFA -0.431613225927952 4.10166815070288e-08 3.1902151031465 4.32161998112301e-60 MirTarget -1.19030784245849 4.8715212353082e-14 24209632 miR 29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF A; Furthermore western blot combined with the luciferase reporter assays demonstrate that vascular endothelial growth factor A VEGF-A is direct target of miR-29a; This is the first time miR-29a was found to suppress the tumor microvessel density in gastric cancer by targeting VEGF-A gastric cancer hsa-miR-29b-2-5p VEGFA -0.297854154636098 0.00260919277325581 3.1902151031465 4.32161998112301e-60 MirTarget -0.376634138151447 0.00423612473269059 NA NA NA hsa-miR-29b-3p VEGFA -0.228125979913806 0.0271621721891603 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRTarBase;MirTarget -0.569482283980511 5.47301472525388e-06 26155940;22815235 Moreover miR-29b inhibits angiogenesis by attenuating tube formation and the expression of VEGF and Ang-2 and stemness maintenance in GBM cells as demonstrated by decreasing neurosphere formation and cancer stem cell marker protein expression;Additionally for two genes that are deregulated in PCa heterogeneous nuclear ribonucleoprotein K hnRNP-K and vascular endothelial growth factor A VEGF-A we identified two regulatory miRNAs miR-205 and miR-29b ; glioblastoma;prostate cancer hsa-miR-335-5p VEGFA -2.09515619961552 1.03765771499548e-25 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate -0.560731405851007 4.75077750352693e-23 NA NA NA hsa-miR-362-3p VEGFA -0.753214251798232 3.0025661608035e-07 3.1902151031465 4.32161998112301e-60 miRanda -0.478977237100648 5.87028343678109e-08 NA NA NA hsa-miR-429 VEGFA -2.16569233119434 2.66862243626443e-37 3.1902151031465 4.32161998112301e-60 MirTarget;miRanda;miRNATAP -0.567681641585143 1.7112668371199e-18 NA NA NA hsa-miR-9-5p VEGFA -2.23538606210968 1.28143998950751e-12 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate -0.222102357667036 1.24335781156383e-08 NA NA NA hsa-miR-127-5p VIM -1.33574359249785 5.73079880594981e-13 2.6073355889954 2.70476758072894e-78 miRNATAP -0.175666547723753 0.000533935769876531 NA NA NA hsa-miR-30a-5p VIM -0.778411951775343 2.73322451127932e-16 2.6073355889954 2.70476758072894e-78 miRNAWalker2_validate;miRNATAP -0.974084806991323 1.32810630325801e-26 25409297;24447545;22476851;27212164 Furthermore low-expression levels of miR-30a and high-expression levels of Vimentin and Twist1 were observed in the high-risk group;RUNX3 regulates vimentin expression via miR 30a during epithelial mesenchymal transition in gastric cancer cells; miR-30a inhibitor abrogated RUNX3-mediated inhibition of cell invasion and downregulation of vimentin; Thus RUNX3 suppressed gastric cancer cell invasion and vimentin expression by activating miR-30a; In gastric cancer patients levels of RUNX3 were positively correlated with miR-30a and negatively associated with the levels of vimentin;MicroRNA 30a inhibits cell migration and invasion by downregulating vimentin expression and is a potential prognostic marker in breast cancer; The functional interaction between the candidate miRNA miR-30a and the target gene Vim which codes for vimentin a protein involved in epithelial-mesenchymal transition was examined using the luciferase reporter assay western blotting and migration and invasion assays; miR-30a negatively regulated vimentin expression by binding to the 3'-untranslated region of Vim; The finding that miR-30a downmodulates vimentin expression might provide a therapeutic target for the treatment of breast cancer;Knockdown of endogenous miR-30a promoted the elongated fibroblast-like morphologic alteration of SGC-7901 cells and also enhanced Snail and Vimentin expression; MiR-30a overexpression induced morphological changes from an extended fibroblast-like morphology to more epithelial-like morphology in SGC-7901/DDP cells and decreased Snail and Vimentin level ;;cell migration; prostate cancer;gastric cancer;breast cancer;gastric cancer hsa-miR-30c-5p VIM -1.08783070774238 2.02505402525786e-24 2.6073355889954 2.70476758072894e-78 miRNAWalker2_validate;miRNATAP -0.855184674071634 1.85998833118894e-27 NA NA NA hsa-miR-30d-5p VIM -0.202727675788184 0.00659067084745794 2.6073355889954 2.70476758072894e-78 miRNATAP -0.748922935992898 8.69659708418083e-09 NA NA NA hsa-miR-615-3p VIM -0.777370544471479 2.08193713560545e-08 2.6073355889954 2.70476758072894e-78 miRNAWalker2_validate -0.181635842051917 0.00872795028163409 NA NA NA hsa-miR-9-5p VIM -2.23538606210968 1.28143998950751e-12 2.6073355889954 2.70476758072894e-78 miRNAWalker2_validate -0.125548159892399 2.35797272114025e-05 25086633 Expression of miR-9 was also higher in tumors showing the CD44+/CD24- phenotype vimentin expression and E-cadherin loss breast cancer hsa-miR-125a-3p WIPF1 -0.372794471295036 0.000941729459601642 1.52799538548924 1.94695012738459e-49 miRanda -0.163637112162426 0.00563670817155269 NA NA NA hsa-miR-141-3p WIPF1 -5.87110686537457 1.20877726722907e-85 1.52799538548924 1.94695012738459e-49 MirTarget;TargetScan;miRNATAP -0.201258863205754 2.22663790936004e-40 NA NA NA hsa-miR-200a-3p WIPF1 -1.43409013664263 2.00188483717828e-20 1.52799538548924 1.94695012738459e-49 MirTarget;miRNATAP -0.301007115381353 9.93967164310582e-15 NA NA NA hsa-miR-200b-3p WIPF1 -1.70383252137161 2.38979336321755e-30 1.52799538548924 1.94695012738459e-49 MirTarget;TargetScan -0.393621106975577 2.04656794069104e-25 NA NA NA hsa-miR-200c-3p WIPF1 -5.40303134829523 2.74173143360645e-94 1.52799538548924 1.94695012738459e-49 MirTarget;miRNATAP -0.228164253022584 1.2846727764912e-42 NA NA NA hsa-miR-26a-1-3p WIPF1 -1.56107117111696 6.75439319582901e-15 1.52799538548924 1.94695012738459e-49 mirMAP -0.171764933954315 8.92041896287977e-08 NA NA NA hsa-miR-29a-5p WIPF1 -0.519003718107105 1.03351148282116e-06 1.52799538548924 1.94695012738459e-49 MirTarget -0.174823890856167 0.00482157548527796 NA NA NA hsa-miR-30a-5p WIPF1 -0.778411951775343 2.73322451127932e-16 1.52799538548924 1.94695012738459e-49 MirTarget;miRNATAP -0.449741707636947 5.26405673317594e-12 NA NA NA hsa-miR-30b-5p WIPF1 -1.18330589477119 6.8341618466966e-27 1.52799538548924 1.94695012738459e-49 MirTarget -0.414378965116618 1.15658553661671e-14 NA NA NA hsa-miR-30c-5p WIPF1 -1.08783070774238 2.02505402525786e-24 1.52799538548924 1.94695012738459e-49 MirTarget;miRNATAP -0.423124361605938 4.36270844101439e-14 NA NA NA hsa-miR-30d-5p WIPF1 -0.202727675788184 0.00659067084745794 1.52799538548924 1.94695012738459e-49 MirTarget;miRNATAP -0.315615859738353 0.000450017837884522 NA NA NA hsa-miR-429 WIPF1 -2.16569233119434 2.66862243626443e-37 1.52799538548924 1.94695012738459e-49 MirTarget;PITA;miRanda;miRNATAP -0.331105664651687 2.09479426140908e-24 NA NA NA hsa-miR-577 WIPF1 -1.48881999472397 7.03080165111147e-10 1.52799538548924 1.94695012738459e-49 mirMAP -0.17025894129697 9.16541030283236e-11 NA NA NA hsa-miR-664a-5p WIPF1 -0.618481839889218 7.01961389909184e-09 1.52799538548924 1.94695012738459e-49 MirTarget -0.253659980126654 3.00955009574363e-05 NA NA NA hsa-miR-9-5p WIPF1 -2.23538606210968 1.28143998950751e-12 1.52799538548924 1.94695012738459e-49 miRNATAP -0.113504532215616 1.33577120995554e-08 NA NA NA hsa-miR-96-5p WIPF1 -1.00223771166604 3.91564621567028e-06 1.52799538548924 1.94695012738459e-49 miRNATAP -0.123975641055019 6.29982405384508e-05 NA NA NA hsa-miR-126-5p WNT5A 0.785607261431085 5.77058629454465e-13 -1.25649996580397 2.97982315334721e-13 mirMAP -0.497609550494676 7.01940069035601e-09 NA NA NA hsa-miR-140-3p WNT5A 0.989350547007025 6.14964028267239e-25 -1.25649996580397 2.97982315334721e-13 MirTarget;miRNATAP -0.410982799593669 1.53927981205954e-05 NA NA NA hsa-miR-144-5p WNT5A 1.47329317992706 4.31620137156824e-12 -1.25649996580397 2.97982315334721e-13 mirMAP -0.181231886000792 4.64255738631183e-05 NA NA NA hsa-miR-155-5p WNT5A 3.26274490570809 5.06841441826518e-51 -1.25649996580397 2.97982315334721e-13 miRNAWalker2_validate;mirMAP -0.111728607814617 0.00384447853284572 NA NA NA hsa-miR-16-5p WNT5A 0.934012514027655 4.85417898318515e-24 -1.25649996580397 2.97982315334721e-13 miRNAWalker2_validate -0.292442381918752 0.00341475986146058 NA NA NA hsa-miR-195-3p WNT5A 0.808592887366705 6.8151241038711e-09 -1.25649996580397 2.97982315334721e-13 MirTarget;mirMAP;miRNATAP -0.237857210411741 0.000625989364005096 NA NA NA hsa-miR-374b-5p WNT5A 0.0804104684417872 0.365593963035077 -1.25649996580397 2.97982315334721e-13 MirTarget;miRNATAP -0.306774236271591 0.00629832209619688 NA NA NA hsa-miR-455-5p WNT5A 0.773674551205946 2.12957541541474e-09 -1.25649996580397 2.97982315334721e-13 miRanda -0.326532956746668 1.02604153763706e-05 NA NA NA hsa-miR-590-3p WNT5A 1.13702599385212 3.53435739887793e-22 -1.25649996580397 2.97982315334721e-13 miRanda;mirMAP;miRNATAP -0.245049075980974 0.00188051767367072 NA NA NA