miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-106b-5p PTEN -0.533221682375808 0.63001636555166 0.211623918553834 0.813084219088649 miRNAWalker2_validate;miRTarBase;miRNATAP -0.16345456792223 1.04711472843117e-06 24842611;24842611 MicroRNA-106b in cancer-associated fibroblasts from gastric cancer promotes cell migration and invasion by targeting PTEN;Here we have shown that miR-106b is up-regulated in cancer associated fibroblasts compared with normal fibroblasts established from patients with gastric cancer the expression level of miR-106b is associated with poor prognosis of patients and CAFs with down-regulated miR-106b could significantly inhibit gastric cancer cell migration and invasion by targeting PTEN invasion;cell migration;;worse prognosis;invasion;cell migration; stomach cancer;stomach cancer hsa-miR-141-3p PTEN -0.981483381227763 0.468559661528428 0.211623918553834 0.813084219088649 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.0913348859181185 1.0171688393833e-07 24742567;24742567 3 In typeIEC loss of PTEN was more frequent in the miR-141 or miR-200a up-regulated subgroups and the correlation between the PTEN and miR-200a status in typeItumors was statistically significant P < 0.05;PTEN might be a potential target of miR-141 and miR-200a in endometrial carcinogenesis ;tumorigenesis; endometrial cancer;endometrial cancer hsa-miR-144-3p PTEN -1.10022987352688 0.0200650348619594 0.211623918553834 0.813084219088649 miRNAWalker2_validate;miRNATAP -0.0527848746696556 0.00532148169400083 hsa-miR-17-5p PTEN -0.558487325347421 0.64971195714345 0.211623918553834 0.813084219088649 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.107223017801684 3.12017381951387e-05 23418359;25617127;24912422;24912422;24912422;24912422;23391506 The mature miR-17-5p exerted this function by repressing the expression of PTEN;The overexpressed PTENP1 decoyed oncomirs miR-17 miR-19b and miR-20a which would otherwise target PTEN PHLPP a negative AKT regulator and such autophagy genes as ULK1 ATG7 and p62 indicating that PTENP1 modulated the HCC cell behavior and gene networks by miRNA regulation;MicroRNA-17-5p promotes chemotherapeutic drug resistance and tumour metastasis of colorectal cancer by repressing PTEN expression;We found that PTEN was a target of miR-17-5p in the colon cancer cells and their context-specific interactions were responsible for multiple drug-resistance;Chemotherapy was found to increase the expression levels of miR-17-5p which further repressed PTEN levels contributing to the development of chemo-resistance;MiR-17-5p is a predictive factor for chemotherapy response and a prognostic factor for overall survival in CRC which is due to its regulation of PTEN expression;Stress response of glioblastoma cells mediated by miR-17-5p targeting PTEN and the passenger strand miR-17-3p targeting MDM2 ;;metastasis;drug resistance;;drug resistance;;drug resistance;;worse survival;drug resistance;;drug resistance; liver cancer;liver cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;glioblastoma hsa-miR-18a-5p PTEN -0.316704361017575 0.630157915881234 0.211623918553834 0.813084219088649 miRNAWalker2_validate;miRTarBase -0.100748931792874 1.71536361157568e-06 hsa-miR-193b-3p PTEN -0.0250523663856281 0.97400322410885 0.211623918553834 0.813084219088649 miRNAWalker2_validate;miRNATAP -0.0758545933973657 0.00947949810083512 hsa-miR-19a-3p PTEN -0.280997787303826 0.686768779097578 0.211623918553834 0.813084219088649 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.0981594277759158 4.95403486695813e-05 25107371;25107371;24831732 The target of miR-19a was identified by western blot and whether its regulatory role depends on its target was improved by a rescue experiment with miR-19a mimic and PTEN expression plasmid;Meanwhile gain or loss of function of miR-19a demonstrated that miR-19a can promote cell growth of bladder cancer cells and the further mechanism studies indicated that its oncogenic role was dependent on targeting PTEN;Meanwhile BPA-induced upregulation of oncogenic miR-19a and miR-19b and the dysregulated expression of miR-19-related downstream proteins including PTEN p-AKT p-MDM2 p53 and proliferating cell nuclear antigen were reversed by curcumin ;; bladder cancer;bladder cancer;breast cancer hsa-miR-19b-3p PTEN -0.48113833693056 0.629711866215103 0.211623918553834 0.813084219088649 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.132184212596985 9.17498922317951e-06 hsa-miR-20a-5p PTEN -0.370824373866068 0.745755382690979 0.211623918553834 0.813084219088649 miRNAWalker2_validate;miRTarBase;miRNATAP -0.0622055774471313 0.021223317812894 hsa-miR-221-3p PTEN -0.133767192385365 0.90845568941641 0.211623918553834 0.813084219088649 miRNAWalker2_validate;miRTarBase -0.0737277362420285 0.015887332059272 20618998;20618998;20618998;20618998;20618998 MicroRNA-221 and microRNA-222 regulate gastric carcinoma cell proliferation and radioresistance by targeting PTEN;Upregulation of miR-221 and miR-222 induced the malignant phenotype of SGC7901 cells whereas knockdown of miR-221 and miR-222 reversed this phenotype via induction of PTEN expression;Notably the seed sequence of miR-221 and miR-222 matched the 3'UTR of PTEN and introducing a PTEN cDNA without the 3'UTR into SGC7901 cells abrogated the miR-221 and miR-222-induced malignant phenotype;PTEN-3'UTR luciferase reporter assay confirmed PTEN as a direct target of miR-221 and miR-222;These results demonstrate that miR-221 and miR-222 regulate radiosensitivity and cell growth and invasion of SGC7901 cells possibly via direct modulation of PTEN expression drug resistance;;malignant trasformation;;malignant trasformation;;;invasion; stomach cancer;stomach cancer;stomach cancer;stomach cancer;stomach cancer hsa-miR-222-3p PTEN -0.275125633496205 0.764141762978043 0.211623918553834 0.813084219088649 miRNAWalker2_validate;miRTarBase -0.0884818232966669 0.000394749457260425 20618998;20618998;20618998;20618998;20618998 MicroRNA-221 and microRNA-222 regulate gastric carcinoma cell proliferation and radioresistance by targeting PTEN;Upregulation of miR-221 and miR-222 induced the malignant phenotype of SGC7901 cells whereas knockdown of miR-221 and miR-222 reversed this phenotype via induction of PTEN expression;Notably the seed sequence of miR-221 and miR-222 matched the 3'UTR of PTEN and introducing a PTEN cDNA without the 3'UTR into SGC7901 cells abrogated the miR-221 and miR-222-induced malignant phenotype;PTEN-3'UTR luciferase reporter assay confirmed PTEN as a direct target of miR-221 and miR-222;These results demonstrate that miR-221 and miR-222 regulate radiosensitivity and cell growth and invasion of SGC7901 cells possibly via direct modulation of PTEN expression drug resistance;;malignant trasformation;;malignant trasformation;;;invasion; stomach cancer;stomach cancer;stomach cancer;stomach cancer;stomach cancer hsa-miR-29b-3p PTEN -0.14654741438196 0.914512363365017 0.211623918553834 0.813084219088649 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.0651822697596678 0.0360008918062391 hsa-miR-93-5p PTEN -0.421956870962388 0.801507807077504 0.211623918553834 0.813084219088649 miRNAWalker2_validate;miRTarBase;miRNATAP -0.0669267562512349 0.0192745514364644 22465665 MiR-93 inversely correlates with PTEN expression in CDDP-resistant and sensitive human ovarian cancer tissues ovarian cancer hsa-miR-25-3p PTEN -0.405451202295515 0.822739342259655 0.211623918553834 0.813084219088649 miRTarBase;MirTarget;miRNATAP -0.178652318021824 4.2370489398595e-06 hsa-miR-130a-3p PTEN 0.912758034840175 0.270536220773922 0.211623918553834 0.813084219088649 MirTarget;miRNATAP -0.101878654607976 0.00170991786486828 24490491;24490491 Down-regulated miR-130a did not affect cell proliferations but enhanced the sensitivity of the cells to cisplatin inhibited the expressions of MDR1 mRNA and P-gp and increased the expression of PTEN proteins;MiR-130a inhibitor can reverse the cisplatin resistance by upregulating the expression of PTEN proteins and down-regulating P-gp in A2780 cell lines ;drug resistance; ovarian cancer;ovarian cancer hsa-miR-130b-3p PTEN -0.669489118333283 0.250443208990708 0.211623918553834 0.813084219088649 MirTarget;miRNATAP -0.134458037859614 3.36188015580824e-09 hsa-miR-142-5p PTEN 0.192037621024483 0.835157103136282 0.211623918553834 0.813084219088649 MirTarget;PITA -0.0733070861807257 0.00109836182472846 hsa-miR-148a-3p PTEN -0.538073533849548 0.803491246917593 0.211623918553834 0.813084219088649 MirTarget;miRNATAP -0.146210523100702 6.24373619920313e-10 hsa-miR-148b-3p PTEN -0.204415739147987 0.837649705534507 0.211623918553834 0.813084219088649 MirTarget;miRNATAP -0.194606896503993 7.38160514589378e-08 hsa-miR-16-1-3p PTEN -0.224089126619374 0.534015657060024 0.211623918553834 0.813084219088649 MirTarget -0.0898406032264613 0.00257578179742381 hsa-miR-188-5p PTEN -0.674377936527608 0.0703768807145046 0.211623918553834 0.813084219088649 MirTarget;PITA;miRNATAP -0.106744558901329 3.53640753468927e-06 hsa-miR-26b-5p PTEN -0.322530480957994 0.809498429728407 0.211623918553834 0.813084219088649 MirTarget;miRNATAP -0.125378744269599 0.000105346199903683 hsa-miR-301a-3p PTEN -0.142188825208656 0.733371789576573 0.211623918553834 0.813084219088649 MirTarget;miRNATAP -0.122199653496651 3.6327204236196e-05 hsa-miR-3065-3p PTEN -0.343964303723188 0.58997695203327 0.211623918553834 0.813084219088649 MirTarget;miRNATAP -0.0519035357155599 0.036536422255637 hsa-miR-30d-3p PTEN -0.633082082558245 0.0725006110111392 0.211623918553834 0.813084219088649 MirTarget;miRNATAP -0.081813457204846 0.042639412247598 hsa-miR-32-5p PTEN -0.501561664938467 0.484995849312329 0.211623918553834 0.813084219088649 MirTarget;miRNATAP -0.152764455120355 6.27851764346309e-07 23617834;23617834;23617834;23617834;23617834;23617834;24123284;24123284;24123284;24123284;24123284;24123284;25647261;25647261;25647261;25647261 MicroRNA-32 miR-32 regulates phosphatase and tensin homologue PTEN expression and promotes growth migration and invasion in colorectal carcinoma cells;The effect of miR-32 on PTEN expression was assessed in CRC cell lines with miR-32 mimics/inhibitor to increase/decrease miR-32 expression;Gain-of-function and loss-of-function studies showed that overexpression of miR-32 promoted SW480 cell proliferation migration and invasion reduced apoptosis and resulted in downregulation of PTEN at a posttranscriptional level;However miR-32 knock-down inhibited these processes in HCT-116 cells and enhanced the expression of PTEN protein;In addition we further identified PTEN as the functional downstream target of miR-32 by directly targeting the 3'-UTR of PTEN;Our results demonstrated that miR-32 was involved in tumorigenesis of CRC at least in part by suppression of PTEN;In this study we determined the levels of the correlation between and the clinical significance of the expression of miR-32 and phosphatase and tensin homologue PTEN a tumor suppressor targeted by miR-32 in CRC;The levels of miR-32 and PTEN gene expression in 35 colorectal carcinoma samples 35 corresponding cancer-adjacent tissue samples 27 colorectal adenoma samples and 16 normal tissue samples were quantified using real-time quantitative reverse transcriptase-polymerase chain reaction;The relationship between the miR-32 and PTEN protein expression and clinicopathological factors was analyzed;Significant upregulation of miR-32 expression and reduction of PTEN were identified in CRC tissues;An inverse relationship between miR-32 and PTEN protein expression was identified;MiR-32 and PTEN expression were inversely correlated and miR-32 may be associated with the development of CRC;MiR-32 induces cell proliferation migration and invasion in hepatocellular carcinoma by targeting PTEN;In the present study we found the expression of miR-32 was up-regulated in HCC tissue and cell lines inversely the expression of phosphatase and tensin homolog PTEN decreased;Besides miRNA-32 down-regulates PTEN through binding to 3'-UTR of PTEN mRNA from luciferase reporter assay and the expression level of miR-32 could affect the proliferation migration and invasion of liver cancer cell lines via PTEN/Akt signaling pathway;Down-expression of PTEN could significantly attenuate the inhibitory effects of knockdown miR-32 on the proliferation migration and invasion of liver cancer cells suggesting that miR-32 could be a potential target for HCC treatment invasion;;;invasion;;;;tumorigenesis;;;;;;;;invasion;;;invasion;;invasion; colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;liver cancer;liver cancer;liver cancer;liver cancer hsa-miR-320a PTEN -0.598485919184867 0.647848299879588 0.211623918553834 0.813084219088649 MirTarget;PITA;miRanda;miRNATAP -0.0920656477273229 0.0142560331096733 hsa-miR-320b PTEN -0.685659017948456 0.11661997693773 0.211623918553834 0.813084219088649 MirTarget;PITA;miRanda;miRNATAP -0.12161427323368 1.49456358558295e-06 hsa-miR-335-3p PTEN -0.169214904129289 0.843068527651354 0.211623918553834 0.813084219088649 MirTarget -0.0819672243289615 0.000302859220515411 hsa-miR-337-3p PTEN 0.352061355720659 0.60852454617983 0.211623918553834 0.813084219088649 MirTarget;PITA;miRNATAP -0.0955222476493067 0.00103565709913447 hsa-miR-374a-5p PTEN -0.0695450455350217 0.926845658374082 0.211623918553834 0.813084219088649 MirTarget;mirMAP -0.130082387021284 0.04507299232959 hsa-miR-374b-5p PTEN -0.0299307585385709 0.973404640000126 0.211623918553834 0.813084219088649 MirTarget;mirMAP;miRNATAP -0.156343467036307 0.00116859966891842 hsa-miR-454-3p PTEN -0.300936732801137 0.470359422266211 0.211623918553834 0.813084219088649 MirTarget;miRNATAP -0.152393297815498 5.04993881728631e-06 hsa-miR-495-3p PTEN 0.222220007860022 0.629853913825124 0.211623918553834 0.813084219088649 MirTarget;mirMAP -0.0803668642957159 0.0174400061331728 hsa-miR-589-3p PTEN -0.419735949896571 0.150668062082992 0.211623918553834 0.813084219088649 MirTarget;mirMAP -0.0816782963319813 0.00195167124937683 hsa-miR-590-3p PTEN -0.431990144467431 0.270449111739342 0.211623918553834 0.813084219088649 MirTarget;PITA;miRanda;mirMAP -0.151818853940952 5.93029314150585e-08 23803188;23803188 miR-590-3p was found to activate PI3K-AKT signaling pathway by down-regulating PTEN to promote AKT1-S473 phosphorylation;MiR-590 is an important tumorigenic factor for HCC and its two arms can both promote tumorigenesis by regulating the expression of their target tumor suppressor gene PDCD4 and PTEN to promote HCC cell proliferation and survival and activate the core tumor signal pathway PI3K-AKT ;tumorigenesis;worse survival; liver cancer;liver cancer hsa-miR-92a-3p PTEN -0.51165108055581 0.782286532728391 0.211623918553834 0.813084219088649 MirTarget;miRNATAP -0.138549364874388 1.36889903875543e-05 hsa-miR-92b-3p PTEN -0.137899617617282 0.880303492450285 0.211623918553834 0.813084219088649 MirTarget;miRNATAP -0.138633048696648 8.66595811770893e-05 24099768 Furthermore we found miR-92b could directly target PTEN a unique tumor suppressor gene which was downregulated in lung cancer tissues compared to the matched adjacent normal tissues lung cancer hsa-miR-193a-3p PTEN 0.131589391102775 0.775774798517621 0.211623918553834 0.813084219088649 PITA;miRanda -0.114092937728856 0.00316154947636919 hsa-miR-429 PTEN -1.23583609874326 0.276060321050978 0.211623918553834 0.813084219088649 PITA;miRanda;mirMAP;miRNATAP -0.077858686850075 1.8454133238878e-06 24866238 Furthermore we demonstrated that miR-429 down-regulates PTEN RASSF8 and TIMP2 expression by directly targeting the 3'-untranslated region of these target genes lung cancer hsa-miR-532-5p PTEN -0.512475701220444 0.712404312596663 0.211623918553834 0.813084219088649 PITA;mirMAP;miRNATAP -0.0875475040798495 0.00696843252354404 hsa-miR-542-3p PTEN -0.00589312050876245 0.995339247203977 0.211623918553834 0.813084219088649 PITA;miRanda;miRNATAP -0.091083272742702 0.0215137627647518 hsa-miR-577 PTEN -1.083093963605 0.118262612867653 0.211623918553834 0.813084219088649 PITA;mirMAP;miRNATAP -0.0624037952548563 9.86536316369099e-06 hsa-miR-200b-3p PTEN -1.05185956342893 0.474753978224675 0.211623918553834 0.813084219088649 TargetScan;mirMAP -0.0716609862015772 0.000146990223086574 hsa-miR-125a-3p PTEN -0.0441981234096132 0.891455076242211 0.211623918553834 0.813084219088649 miRanda -0.0853511874530766 0.00523153180406312 hsa-miR-362-3p PTEN -0.549301075641285 0.095329169888397 0.211623918553834 0.813084219088649 miRanda -0.0648545718152034 0.0167888011946157 hsa-miR-342-3p PTEN 0.672655250379988 0.473762037637412 0.211623918553834 0.813084219088649 miRanda -0.0768241970649771 0.00828301979897124 hsa-miR-455-5p PTEN -0.32296156815721 0.65135798446757 0.211623918553834 0.813084219088649 miRanda -0.0761793060279643 0.0112939086342541 hsa-miR-421 PTEN -0.45455783601547 0.0840936838285306 0.211623918553834 0.813084219088649 miRanda -0.104669444589397 0.000172701511747581 hsa-let-7a-3p PTEN -0.34220841423477 0.64143397496589 0.211623918553834 0.813084219088649 mirMAP -0.146036865570309 2.47608035669665e-05 hsa-let-7b-3p PTEN -0.373703674484226 0.568892234623274 0.211623918553834 0.813084219088649 mirMAP -0.140452087111016 0.00297615522145834 hsa-let-7f-1-3p PTEN -0.355901241355223 0.242795470103776 0.211623918553834 0.813084219088649 mirMAP -0.110568855525199 0.00207851466529083 hsa-miR-136-5p PTEN 0.560099026364262 0.381717458312323 0.211623918553834 0.813084219088649 mirMAP -0.0807748545067532 0.00442327347343771 hsa-miR-15b-3p PTEN -0.89376474912238 0.221232017699693 0.211623918553834 0.813084219088649 mirMAP -0.139710816683617 4.9085359801407e-08 hsa-miR-16-2-3p PTEN -0.545623185514255 0.259577195196569 0.211623918553834 0.813084219088649 mirMAP -0.119658150400376 8.79650090092113e-07 hsa-miR-182-5p PTEN -1.1625759408779 0.521820211699728 0.211623918553834 0.813084219088649 mirMAP -0.0883772515944835 2.06742734853855e-05 hsa-miR-186-5p PTEN -0.301903361876705 0.787201501300393 0.211623918553834 0.813084219088649 mirMAP;miRNATAP -0.213266547594836 4.02773910516678e-07 hsa-miR-200c-3p PTEN -1.05997568381159 0.558381466886993 0.211623918553834 0.813084219088649 mirMAP;miRNATAP -0.0948437221519353 1.1381687570055e-06 23869765;24682933;24682933;20716115;22637745;22637745 Moreover transfection of miR-20a or miR-200c led to corresponding reduction in endogenous PTEN protein while AKT1 and phosphate AKT1 levels were upregulated in miRNAs-transfected cells;The effects of silencing miR-200c expression were associated with upregulation of PTEN protein and p53 Ser15 phosphorylation levels in HCT-116 cells and PTEN protein expression in HT-29 cells;In conclusion miR-200c functions as an oncogene in colon cancer cells through regulating tumor cell apoptosis survival invasion and metastasis as well as xenograft tumor growth through inhibition of PTEN expression and p53 phosphorylation;Expression of zinc finger E-box binding homeobox ZEB1 and c-Myc targets of miR-200c as well as of p21 protein Cdc42/Rac-activated kinase PAK1 and phosphatase and tensin homologue deleted on chromosome 10 PTEN predicted targets of miR-222 were analysed;Forced over-expression or silencing of miR-200c followed by either CDF or BR-DIM treatment of MIAPaCa-2 cells altered the morphology of cells wound-healing capacity colony formation and the expression of MT1-MMP and PTEN;These results provide strong experimental evidence showing that the loss of miR-200 family and PTEN expression and increased level of MT1-MMP leads to aggressive behavior of PC cells which could be attenuated through re-expression of miR-200c by CDF and/or BR-DIM treatment suggesting that these agents could be useful for PC treatment ;;metastasis;worse survival;invasion;;;;invasion; ovarian cancer;colorectal cancer;colorectal cancer;ovarian cancer;pancreatic cancer;pancreatic cancer hsa-miR-26a-2-3p PTEN 0.0314316649326709 0.918442801541152 0.211623918553834 0.813084219088649 mirMAP -0.0910824802961814 0.0041055217432812 hsa-miR-30b-5p PTEN -0.435801387312985 0.718738450963105 0.211623918553834 0.813084219088649 mirMAP -0.0979415933773278 0.00438371023821841 hsa-miR-30e-5p PTEN -0.121671718124231 0.943974535461783 0.211623918553834 0.813084219088649 mirMAP -0.114747389715699 0.0150166664385482 hsa-miR-323a-3p PTEN 0.00677953912020546 0.985585302705434 0.211623918553834 0.813084219088649 mirMAP -0.056731204133355 0.0137110982446763 hsa-miR-452-5p PTEN -0.340758762003705 0.642989250432641 0.211623918553834 0.813084219088649 mirMAP -0.0808479482413263 0.00245299090765467 hsa-miR-493-5p PTEN 0.353064502800509 0.424878011727759 0.211623918553834 0.813084219088649 mirMAP -0.0984761594107992 0.000910954305332716 hsa-miR-508-3p PTEN -0.97710094677443 0.0218081263140875 0.211623918553834 0.813084219088649 mirMAP -0.0551706735312839 0.00347033261722327 hsa-miR-590-5p PTEN -0.517041757471599 0.342931336133633 0.211623918553834 0.813084219088649 mirMAP -0.135932396824307 2.90878704424935e-07 23803188;23803188 miR-590-3p was found to activate PI3K-AKT signaling pathway by down-regulating PTEN to promote AKT1-S473 phosphorylation;MiR-590 is an important tumorigenic factor for HCC and its two arms can both promote tumorigenesis by regulating the expression of their target tumor suppressor gene PDCD4 and PTEN to promote HCC cell proliferation and survival and activate the core tumor signal pathway PI3K-AKT ;tumorigenesis;worse survival; liver cancer;liver cancer hsa-miR-7-1-3p PTEN -0.858548928409762 0.237258315911497 0.211623918553834 0.813084219088649 mirMAP -0.137152983491268 1.75733109350449e-07 hsa-miR-106a-5p PTEN -0.185410723706807 0.712371139827219 0.211623918553834 0.813084219088649 miRNATAP -0.0704745010674372 0.0149064231119258 hsa-miR-3613-5p PTEN -0.548251470112128 0.27040580916196 0.211623918553834 0.813084219088649 miRNATAP -0.140518853170061 2.55621656914988e-08 hsa-miR-200a-3p PTEN -1.01559800252553 0.43063435969762 0.211623918553834 0.813084219088649 miRNATAP -0.0753272596770647 1.07827910446868e-05 24742567;24742567;22637745 3 In typeIEC loss of PTEN was more frequent in the miR-141 or miR-200a up-regulated subgroups and the correlation between the PTEN and miR-200a status in typeItumors was statistically significant P < 0.05;PTEN might be a potential target of miR-141 and miR-200a in endometrial carcinogenesis;We found loss of expression of miR-200a b and c in chemo-resistant PC cell lines which was correlated with loss of PTEN and over-expression of MT1-MMP ;tumorigenesis;; endometrial cancer;endometrial cancer;pancreatic cancer hsa-miR-744-3p PTEN -0.726956642019277 0.141573276661998 0.211623918553834 0.813084219088649 miRNATAP -0.112459867347004 2.90217921888435e-07 hsa-miR-484 PTEN -0.17537159278731 0.838388882691205 0.211623918553834 0.813084219088649 miRNATAP -0.128790875865172 4.14933898439673e-05 hsa-miR-212-3p PTEN 0.237396132621219 0.555736940240687 0.211623918553834 0.813084219088649 miRNATAP -0.0937206940285566 0.0123004108041004 hsa-miR-425-5p PTEN -0.625207713614229 0.563233760543381 0.211623918553834 0.813084219088649 miRNATAP -0.107180900918189 1.00947350170994e-05 25154996;25154996;24571667 IL-1β induced the up-regulation of miR-425 a negative expression regulator of phosphatase and tensin homolog PTEN;An increase in miR-425 depended upon IL-1β-induced NF-kappaB activation.Repression of PTEN by miR-425 promoted gastric cancer cell proliferation;NF-kappaB-dependent microRNA-425 upregulation promotes gastric cancer cell growth by targeting PTEN upon IL-1β induction ;; stomach cancer;stomach cancer;stomach cancer