Browse ABCA3

Summary
SymbolABCA3
NameATP-binding cassette, sub-family A (ABC1), member 3
Aliases ABC-C; EST111653; LBM180; ABC3; SMDP3; ABC transporter 3; ABC-C transporter; ATP-binding cassette transporte ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane Multi-pass membrane protein
Domain PF00005 ABC transporter
Function

Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol.

> Gene Ontology
 
Biological Process GO:0006869 lipid transport
GO:0010876 lipid localization
GO:0031960 response to corticosteroid
GO:0042493 response to drug
GO:0048545 response to steroid hormone
GO:0051384 response to glucocorticoid
Molecular Function GO:0005319 lipid transporter activity
GO:0015399 primary active transmembrane transporter activity
GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0016887 ATPase activity
GO:0022804 active transmembrane transporter activity
GO:0042623 ATPase activity, coupled
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
GO:0043492 ATPase activity, coupled to movement of substances
Cellular Component GO:0030141 secretory granule
GO:0030659 cytoplasmic vesicle membrane
GO:0030667 secretory granule membrane
GO:0042599 lamellar body
GO:0097208 alveolar lamellar body
GO:0097232 lamellar body membrane
GO:0097233 alveolar lamellar body membrane
GO:0099503 secretory vesicle
> KEGG and Reactome Pathway
 
KEGG hsa02010 ABC transporters
Reactome R-HSA-1369062: ABC transporters in lipid homeostasis
R-HSA-382556: ABC-family proteins mediated transport
R-HSA-392499: Metabolism of proteins
R-HSA-5683826: Surfactant metabolism
R-HSA-382551: Transmembrane transport of small molecules
Summary
SymbolABCA3
NameATP-binding cassette, sub-family A (ABC1), member 3
Aliases ABC-C; EST111653; LBM180; ABC3; SMDP3; ABC transporter 3; ABC-C transporter; ATP-binding cassette transporte ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ABCA3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolABCA3
NameATP-binding cassette, sub-family A (ABC1), member 3
Aliases ABC-C; EST111653; LBM180; ABC3; SMDP3; ABC transporter 3; ABC-C transporter; ATP-binding cassette transporte ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ABCA3 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolABCA3
NameATP-binding cassette, sub-family A (ABC1), member 3
Aliases ABC-C; EST111653; LBM180; ABC3; SMDP3; ABC transporter 3; ABC-C transporter; ATP-binding cassette transporte ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ABCA3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.7620.159
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.7670.572
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.7520.508
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.720.0431
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.5210.775
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.970.663
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0540.912
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.0690.386
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-1.2480.336
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.0460.975
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.8350.699
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1930.321
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ABCA3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.76.8-3.11
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.78.5-4.80.66
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.811.8-70.577
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.718.2-10.50.576
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.16.24.91
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 592011.18.91
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.37.4-2.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.115.4-6.30.618
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolABCA3
NameATP-binding cassette, sub-family A (ABC1), member 3
Aliases ABC-C; EST111653; LBM180; ABC3; SMDP3; ABC transporter 3; ABC-C transporter; ATP-binding cassette transporte ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ABCA3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolABCA3
NameATP-binding cassette, sub-family A (ABC1), member 3
Aliases ABC-C; EST111653; LBM180; ABC3; SMDP3; ABC transporter 3; ABC-C transporter; ATP-binding cassette transporte ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ABCA3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ABCA3.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolABCA3
NameATP-binding cassette, sub-family A (ABC1), member 3
Aliases ABC-C; EST111653; LBM180; ABC3; SMDP3; ABC transporter 3; ABC-C transporter; ATP-binding cassette transporte ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ABCA3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolABCA3
NameATP-binding cassette, sub-family A (ABC1), member 3
Aliases ABC-C; EST111653; LBM180; ABC3; SMDP3; ABC transporter 3; ABC-C transporter; ATP-binding cassette transporte ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ABCA3 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolABCA3
NameATP-binding cassette, sub-family A (ABC1), member 3
Aliases ABC-C; EST111653; LBM180; ABC3; SMDP3; ABC transporter 3; ABC-C transporter; ATP-binding cassette transporte ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ABCA3 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolABCA3
NameATP-binding cassette, sub-family A (ABC1), member 3
Aliases ABC-C; EST111653; LBM180; ABC3; SMDP3; ABC transporter 3; ABC-C transporter; ATP-binding cassette transporte ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ABCA3 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.