Browse ABCA7

Summary
SymbolABCA7
NameATP-binding cassette, sub-family A (ABC1), member 7
Aliases ABCX; ABCA-SSN; autoantigen SS-N; macrophage ABC transporter; ATP-binding cassette sub-family A member 7
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Multi-pass membrane protein Golgi apparatus membrane Multi-pass membrane protein Early endosome membrane Multi-pass membrane protein Note=Localizes to cell membrane ruffles and phagocytic cups of macrophages stimulated with C1q or apoptotic cells. Localizes to the cytoplasm of resting macrophages, probably in Golgi and endosomes. Localizes to the apical brush border of cells in the proximal tubules of kidney (By similarity). Isoform 2 may localize to the endoplasmic reticulum (PubMed:14592415).
Domain PF00005 ABC transporter
Function

Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation.

> Gene Ontology
 
Biological Process GO:0006869 lipid transport
GO:0006909 phagocytosis
GO:0006911 phagocytosis, engulfment
GO:0007611 learning or memory
GO:0007613 memory
GO:0009100 glycoprotein metabolic process
GO:0009101 glycoprotein biosynthetic process
GO:0010324 membrane invagination
GO:0010559 regulation of glycoprotein biosynthetic process
GO:0010561 negative regulation of glycoprotein biosynthetic process
GO:0010874 regulation of cholesterol efflux
GO:0010875 positive regulation of cholesterol efflux
GO:0010876 lipid localization
GO:0015748 organophosphate ester transport
GO:0015850 organic hydroxy compound transport
GO:0015914 phospholipid transport
GO:0015917 aminophospholipid transport
GO:0015918 sterol transport
GO:0018149 peptide cross-linking
GO:0030100 regulation of endocytosis
GO:0030301 cholesterol transport
GO:0032368 regulation of lipid transport
GO:0032370 positive regulation of lipid transport
GO:0032371 regulation of sterol transport
GO:0032373 positive regulation of sterol transport
GO:0032374 regulation of cholesterol transport
GO:0032376 positive regulation of cholesterol transport
GO:0033344 cholesterol efflux
GO:0033700 phospholipid efflux
GO:0034204 lipid translocation
GO:0034205 beta-amyloid formation
GO:0034248 regulation of cellular amide metabolic process
GO:0034249 negative regulation of cellular amide metabolic process
GO:0034377 plasma lipoprotein particle assembly
GO:0034380 high-density lipoprotein particle assembly
GO:0034504 protein localization to nucleus
GO:0038027 apolipoprotein A-I-mediated signaling pathway
GO:0042982 amyloid precursor protein metabolic process
GO:0042983 amyloid precursor protein biosynthetic process
GO:0042984 regulation of amyloid precursor protein biosynthetic process
GO:0042985 negative regulation of amyloid precursor protein biosynthetic process
GO:0042987 amyloid precursor protein catabolic process
GO:0043277 apoptotic cell clearance
GO:0043410 positive regulation of MAPK cascade
GO:0043652 engulfment of apoptotic cell
GO:0044708 single-organism behavior
GO:0045332 phospholipid translocation
GO:0045807 positive regulation of endocytosis
GO:0050435 beta-amyloid metabolic process
GO:0050764 regulation of phagocytosis
GO:0050766 positive regulation of phagocytosis
GO:0050890 cognition
GO:0060099 regulation of phagocytosis, engulfment
GO:0060100 positive regulation of phagocytosis, engulfment
GO:0060627 regulation of vesicle-mediated transport
GO:0065005 protein-lipid complex assembly
GO:0070371 ERK1 and ERK2 cascade
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071825 protein-lipid complex subunit organization
GO:0071827 plasma lipoprotein particle organization
GO:0097006 regulation of plasma lipoprotein particle levels
GO:0097035 regulation of membrane lipid distribution
GO:0097242 beta-amyloid clearance
GO:0099024 plasma membrane invagination
GO:1900221 regulation of beta-amyloid clearance
GO:1900223 positive regulation of beta-amyloid clearance
GO:1901074 regulation of engulfment of apoptotic cell
GO:1901076 positive regulation of engulfment of apoptotic cell
GO:1902003 regulation of beta-amyloid formation
GO:1902430 negative regulation of beta-amyloid formation
GO:1902991 regulation of amyloid precursor protein catabolic process
GO:1902992 negative regulation of amyloid precursor protein catabolic process
GO:1902994 regulation of phospholipid efflux
GO:1902995 positive regulation of phospholipid efflux
GO:1903018 regulation of glycoprotein metabolic process
GO:1903019 negative regulation of glycoprotein metabolic process
GO:1905153 regulation of membrane invagination
GO:1905155 positive regulation of membrane invagination
GO:2000425 regulation of apoptotic cell clearance
GO:2000427 positive regulation of apoptotic cell clearance
GO:2001138 regulation of phospholipid transport
GO:2001140 positive regulation of phospholipid transport
Molecular Function GO:0004012 phospholipid-translocating ATPase activity
GO:0005319 lipid transporter activity
GO:0005548 phospholipid transporter activity
GO:0008525 phosphatidylcholine transporter activity
GO:0015247 aminophospholipid transporter activity
GO:0015399 primary active transmembrane transporter activity
GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0016887 ATPase activity
GO:0022804 active transmembrane transporter activity
GO:0030226 apolipoprotein receptor activity
GO:0034188 apolipoprotein A-I receptor activity
GO:0042623 ATPase activity, coupled
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
GO:0043492 ATPase activity, coupled to movement of substances
GO:0090554 phosphatidylcholine-translocating ATPase activity
GO:0090556 phosphatidylserine-translocating ATPase activity
Cellular Component GO:0001726 ruffle
GO:0001891 phagocytic cup
GO:0005769 early endosome
GO:0010008 endosome membrane
GO:0016324 apical plasma membrane
GO:0031252 cell leading edge
GO:0031253 cell projection membrane
GO:0031256 leading edge membrane
GO:0031901 early endosome membrane
GO:0032587 ruffle membrane
GO:0043190 ATP-binding cassette (ABC) transporter complex
GO:0044440 endosomal part
GO:0045177 apical part of cell
GO:0098533 ATPase dependent transmembrane transport complex
GO:1902495 transmembrane transporter complex
GO:1904949 ATPase complex
GO:1990351 transporter complex
> KEGG and Reactome Pathway
 
KEGG hsa02010 ABC transporters
Reactome R-HSA-1369062: ABC transporters in lipid homeostasis
R-HSA-382556: ABC-family proteins mediated transport
R-HSA-382551: Transmembrane transport of small molecules
Summary
SymbolABCA7
NameATP-binding cassette, sub-family A (ABC1), member 7
Aliases ABCX; ABCA-SSN; autoantigen SS-N; macrophage ABC transporter; ATP-binding cassette sub-family A member 7
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ABCA7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolABCA7
NameATP-binding cassette, sub-family A (ABC1), member 7
Aliases ABCX; ABCA-SSN; autoantigen SS-N; macrophage ABC transporter; ATP-binding cassette sub-family A member 7
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ABCA7 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolABCA7
NameATP-binding cassette, sub-family A (ABC1), member 7
Aliases ABCX; ABCA-SSN; autoantigen SS-N; macrophage ABC transporter; ATP-binding cassette sub-family A member 7
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ABCA7 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1350.684
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.3890.69
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0490.95
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.6440.166
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.650.786
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.6370.833
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.6680.13
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.8690.413
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.4690.685
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.5390.596
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.7040.614
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1040.324
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ABCA7 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.15.91.21
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.15.55.60.384
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.16.84.30.673
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211728.6028.60.0241
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86250250.473
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131130.8030.80.0983
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916012.5-12.50.52
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59022.2-22.20.505
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolABCA7
NameATP-binding cassette, sub-family A (ABC1), member 7
Aliases ABCX; ABCA-SSN; autoantigen SS-N; macrophage ABC transporter; ATP-binding cassette sub-family A member 7
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ABCA7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolABCA7
NameATP-binding cassette, sub-family A (ABC1), member 7
Aliases ABCX; ABCA-SSN; autoantigen SS-N; macrophage ABC transporter; ATP-binding cassette sub-family A member 7
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ABCA7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ABCA7.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolABCA7
NameATP-binding cassette, sub-family A (ABC1), member 7
Aliases ABCX; ABCA-SSN; autoantigen SS-N; macrophage ABC transporter; ATP-binding cassette sub-family A member 7
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ABCA7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolABCA7
NameATP-binding cassette, sub-family A (ABC1), member 7
Aliases ABCX; ABCA-SSN; autoantigen SS-N; macrophage ABC transporter; ATP-binding cassette sub-family A member 7
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ABCA7 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolABCA7
NameATP-binding cassette, sub-family A (ABC1), member 7
Aliases ABCX; ABCA-SSN; autoantigen SS-N; macrophage ABC transporter; ATP-binding cassette sub-family A member 7
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ABCA7 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolABCA7
NameATP-binding cassette, sub-family A (ABC1), member 7
Aliases ABCX; ABCA-SSN; autoantigen SS-N; macrophage ABC transporter; ATP-binding cassette sub-family A member 7
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ABCA7 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.