Browse ABCC8

Summary
SymbolABCC8
NameATP-binding cassette, sub-family C (CFTR/MRP), member 8
Aliases SUR1; ABC36; HHF1; TNDM2; sulfonylurea receptor (hyperinsulinemia); SUR; HRINS; SUR1delta2; ATP-binding cass ......
Chromosomal Location11p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Multi-pass membrane protein
Domain PF00664 ABC transporter transmembrane region
PF00005 ABC transporter
Function

Subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release.

> Gene Ontology
 
Biological Process GO:0002237 response to molecule of bacterial origin
GO:0002790 peptide secretion
GO:0002791 regulation of peptide secretion
GO:0002792 negative regulation of peptide secretion
GO:0006813 potassium ion transport
GO:0006820 anion transport
GO:0009268 response to pH
GO:0009306 protein secretion
GO:0009914 hormone transport
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0010043 response to zinc ion
GO:0010817 regulation of hormone levels
GO:0010959 regulation of metal ion transport
GO:0015672 monovalent inorganic cation transport
GO:0015833 peptide transport
GO:0023061 signal release
GO:0030072 peptide hormone secretion
GO:0030073 insulin secretion
GO:0032496 response to lipopolysaccharide
GO:0032868 response to insulin
GO:0042493 response to drug
GO:0042886 amide transport
GO:0043266 regulation of potassium ion transport
GO:0043268 positive regulation of potassium ion transport
GO:0043270 positive regulation of ion transport
GO:0043434 response to peptide hormone
GO:0046676 negative regulation of insulin secretion
GO:0046879 hormone secretion
GO:0046883 regulation of hormone secretion
GO:0046888 negative regulation of hormone secretion
GO:0050708 regulation of protein secretion
GO:0050709 negative regulation of protein secretion
GO:0050796 regulation of insulin secretion
GO:0051048 negative regulation of secretion
GO:0051051 negative regulation of transport
GO:0051224 negative regulation of protein transport
GO:0071804 cellular potassium ion transport
GO:0071805 potassium ion transmembrane transport
GO:0090087 regulation of peptide transport
GO:0090276 regulation of peptide hormone secretion
GO:0090278 negative regulation of peptide hormone secretion
GO:0098656 anion transmembrane transport
GO:1901652 response to peptide
GO:1903531 negative regulation of secretion by cell
GO:1904950 negative regulation of establishment of protein localization
GO:1990267 response to transition metal nanoparticle
Molecular Function GO:0000149 SNARE binding
GO:0005216 ion channel activity
GO:0005242 inward rectifier potassium channel activity
GO:0005244 voltage-gated ion channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005261 cation channel activity
GO:0005267 potassium channel activity
GO:0008281 sulfonylurea receptor activity
GO:0008509 anion transmembrane transporter activity
GO:0015077 monovalent inorganic cation transmembrane transporter activity
GO:0015079 potassium ion transmembrane transporter activity
GO:0015267 channel activity
GO:0015272 ATP-activated inward rectifier potassium channel activity
GO:0015276 ligand-gated ion channel activity
GO:0015399 primary active transmembrane transporter activity
GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0016887 ATPase activity
GO:0019905 syntaxin binding
GO:0022803 passive transmembrane transporter activity
GO:0022804 active transmembrane transporter activity
GO:0022832 voltage-gated channel activity
GO:0022834 ligand-gated channel activity
GO:0022836 gated channel activity
GO:0022838 substrate-specific channel activity
GO:0022843 voltage-gated cation channel activity
GO:0022853 active ion transmembrane transporter activity
GO:0042623 ATPase activity, coupled
GO:0042625 ATPase coupled ion transmembrane transporter activity
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
GO:0043225 ATPase-coupled anion transmembrane transporter activity
GO:0043492 ATPase activity, coupled to movement of substances
GO:0044325 ion channel binding
GO:0046873 metal ion transmembrane transporter activity
Cellular Component GO:0008021 synaptic vesicle
GO:0008076 voltage-gated potassium channel complex
GO:0030133 transport vesicle
GO:0030658 transport vesicle membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0030672 synaptic vesicle membrane
GO:0034702 ion channel complex
GO:0034703 cation channel complex
GO:0034705 potassium channel complex
GO:0042383 sarcolemma
GO:0070382 exocytic vesicle
GO:0098793 presynapse
GO:0099501 exocytic vesicle membrane
GO:0099503 secretory vesicle
GO:1902495 transmembrane transporter complex
GO:1990351 transporter complex
> KEGG and Reactome Pathway
 
KEGG hsa02010 ABC transporters
hsa04911 Insulin secretion
Reactome R-HSA-5619084: ABC transporter disorders
R-HSA-382556: ABC-family proteins mediated transport
R-HSA-1296025: ATP sensitive Potassium channels
R-HSA-5683177: Defective ABCC8 can cause hypoglycemias and hyperglycemias
R-HSA-1643685: Disease
R-HSA-5619115: Disorders of transmembrane transporters
R-HSA-163685: Integration of energy metabolism
R-HSA-1296065: Inwardly rectifying K+ channels
R-HSA-1430728: Metabolism
R-HSA-112316: Neuronal System
R-HSA-1296071: Potassium Channels
R-HSA-422356: Regulation of insulin secretion
R-HSA-382551: Transmembrane transport of small molecules
Summary
SymbolABCC8
NameATP-binding cassette, sub-family C (CFTR/MRP), member 8
Aliases SUR1; ABC36; HHF1; TNDM2; sulfonylurea receptor (hyperinsulinemia); SUR; HRINS; SUR1delta2; ATP-binding cass ......
Chromosomal Location11p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ABCC8 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolABCC8
NameATP-binding cassette, sub-family C (CFTR/MRP), member 8
Aliases SUR1; ABC36; HHF1; TNDM2; sulfonylurea receptor (hyperinsulinemia); SUR; HRINS; SUR1delta2; ATP-binding cass ......
Chromosomal Location11p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ABCC8 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolABCC8
NameATP-binding cassette, sub-family C (CFTR/MRP), member 8
Aliases SUR1; ABC36; HHF1; TNDM2; sulfonylurea receptor (hyperinsulinemia); SUR; HRINS; SUR1delta2; ATP-binding cass ......
Chromosomal Location11p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ABCC8 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1280.581
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.5640.329
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.1870.666
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.6580.151
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.9020.505
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.3490.835
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.3270.66
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.7360.635
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2430.894
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.3390.456
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.6780.308
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0060.984
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ABCC8 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277322.24.118.10.011
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275922.23.418.80.0106
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21171923.5-4.51
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86250250.473
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.436.4-210.357
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916012.5-12.50.52
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59022.2-22.20.505
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.914.8-6.90.437
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.515.4-10.90.541
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161412.514.3-1.81
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolABCC8
NameATP-binding cassette, sub-family C (CFTR/MRP), member 8
Aliases SUR1; ABC36; HHF1; TNDM2; sulfonylurea receptor (hyperinsulinemia); SUR; HRINS; SUR1delta2; ATP-binding cass ......
Chromosomal Location11p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ABCC8. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolABCC8
NameATP-binding cassette, sub-family C (CFTR/MRP), member 8
Aliases SUR1; ABC36; HHF1; TNDM2; sulfonylurea receptor (hyperinsulinemia); SUR; HRINS; SUR1delta2; ATP-binding cass ......
Chromosomal Location11p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ABCC8. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ABCC8.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolABCC8
NameATP-binding cassette, sub-family C (CFTR/MRP), member 8
Aliases SUR1; ABC36; HHF1; TNDM2; sulfonylurea receptor (hyperinsulinemia); SUR; HRINS; SUR1delta2; ATP-binding cass ......
Chromosomal Location11p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ABCC8. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolABCC8
NameATP-binding cassette, sub-family C (CFTR/MRP), member 8
Aliases SUR1; ABC36; HHF1; TNDM2; sulfonylurea receptor (hyperinsulinemia); SUR; HRINS; SUR1delta2; ATP-binding cass ......
Chromosomal Location11p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ABCC8 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolABCC8
NameATP-binding cassette, sub-family C (CFTR/MRP), member 8
Aliases SUR1; ABC36; HHF1; TNDM2; sulfonylurea receptor (hyperinsulinemia); SUR; HRINS; SUR1delta2; ATP-binding cass ......
Chromosomal Location11p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ABCC8 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolABCC8
NameATP-binding cassette, sub-family C (CFTR/MRP), member 8
Aliases SUR1; ABC36; HHF1; TNDM2; sulfonylurea receptor (hyperinsulinemia); SUR; HRINS; SUR1delta2; ATP-binding cass ......
Chromosomal Location11p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ABCC8 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting ABCC8.
ID Name Drug Type Targets #Targets
DB00171ATPSmall MoleculeABCA1, ABCB1, ABCB11, ABCC1, ABCC2, ABCC4, ABCC6, ABCC8, ABCC9, AB ......42
DB00222GlimepirideSmall MoleculeABCC8, KCNJ1, KCNJ113
DB00672ChlorpropamideSmall MoleculeABCC81
DB00731NateglinideSmall MoleculeABCC8, PPARG2
DB00839TolazamideSmall MoleculeABCC8, KCNJ112
DB00912RepaglinideSmall MoleculeABCC8, PPARG2
DB01016GlyburideSmall MoleculeABCA1, ABCB11, ABCC8, ABCC9, CFTR, CPT1A, KCNJ11, KCNJ11, KCNJ5, K ......10
DB01067GlipizideSmall MoleculeABCC8, PPARG2
DB01120GliclazideSmall MoleculeABCC8, VEGFA2
DB01124TolbutamideSmall MoleculeABCC8, KCNJ12
DB01251GliquidoneSmall MoleculeABCC8, KCNJ82
DB01252MitiglinideSmall MoleculeABCC8, PPARG2
DB01382GlycodiazineSmall MoleculeABCC8, KCNJ12