Browse ACAT1

Summary
SymbolACAT1
Nameacetyl-CoA acetyltransferase 1
Aliases THIL; acetyl-Coenzyme A acetyltransferase 1; acetoacetyl-CoA thiolase; mitochondrial acetoacetyl-CoA thiolas ......
Chromosomal Location11q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Mitochondrion.
Domain PF02803 Thiolase
PF00108 Thiolase
Function

Plays a major role in ketone body metabolism.

> Gene Ontology
 
Biological Process GO:0001655 urogenital system development
GO:0001656 metanephros development
GO:0001822 kidney development
GO:0001889 liver development
GO:0006084 acetyl-CoA metabolic process
GO:0006085 acetyl-CoA biosynthetic process
GO:0006164 purine nucleotide biosynthetic process
GO:0006549 isoleucine metabolic process
GO:0006550 isoleucine catabolic process
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0006637 acyl-CoA metabolic process
GO:0006732 coenzyme metabolic process
GO:0006790 sulfur compound metabolic process
GO:0009062 fatty acid catabolic process
GO:0009081 branched-chain amino acid metabolic process
GO:0009083 branched-chain amino acid catabolic process
GO:0009108 coenzyme biosynthetic process
GO:0009109 coenzyme catabolic process
GO:0009116 nucleoside metabolic process
GO:0009119 ribonucleoside metabolic process
GO:0009150 purine ribonucleotide metabolic process
GO:0009152 purine ribonucleotide biosynthetic process
GO:0009163 nucleoside biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0009260 ribonucleotide biosynthetic process
GO:0009991 response to extracellular stimulus
GO:0015936 coenzyme A metabolic process
GO:0015937 coenzyme A biosynthetic process
GO:0016042 lipid catabolic process
GO:0016054 organic acid catabolic process
GO:0019395 fatty acid oxidation
GO:0030258 lipid modification
GO:0031667 response to nutrient levels
GO:0033865 nucleoside bisphosphate metabolic process
GO:0033866 nucleoside bisphosphate biosynthetic process
GO:0033875 ribonucleoside bisphosphate metabolic process
GO:0034030 ribonucleoside bisphosphate biosynthetic process
GO:0034032 purine nucleoside bisphosphate metabolic process
GO:0034033 purine nucleoside bisphosphate biosynthetic process
GO:0034440 lipid oxidation
GO:0035383 thioester metabolic process
GO:0035384 thioester biosynthetic process
GO:0042278 purine nucleoside metabolic process
GO:0042451 purine nucleoside biosynthetic process
GO:0042455 ribonucleoside biosynthetic process
GO:0042594 response to starvation
GO:0044242 cellular lipid catabolic process
GO:0044272 sulfur compound biosynthetic process
GO:0044273 sulfur compound catabolic process
GO:0044282 small molecule catabolic process
GO:0044283 small molecule biosynthetic process
GO:0046128 purine ribonucleoside metabolic process
GO:0046129 purine ribonucleoside biosynthetic process
GO:0046356 acetyl-CoA catabolic process
GO:0046390 ribose phosphate biosynthetic process
GO:0046395 carboxylic acid catabolic process
GO:0046950 cellular ketone body metabolic process
GO:0046951 ketone body biosynthetic process
GO:0046952 ketone body catabolic process
GO:0048732 gland development
GO:0051186 cofactor metabolic process
GO:0051187 cofactor catabolic process
GO:0051188 cofactor biosynthetic process
GO:0051259 protein oligomerization
GO:0051260 protein homooligomerization
GO:0060612 adipose tissue development
GO:0061008 hepaticobiliary system development
GO:0061326 renal tubule development
GO:0061448 connective tissue development
GO:0071616 acyl-CoA biosynthetic process
GO:0072001 renal system development
GO:0072006 nephron development
GO:0072009 nephron epithelium development
GO:0072014 proximal tubule development
GO:0072019 proximal convoluted tubule development
GO:0072073 kidney epithelium development
GO:0072080 nephron tubule development
GO:0072170 metanephric tubule development
GO:0072207 metanephric epithelium development
GO:0072229 metanephric proximal convoluted tubule development
GO:0072234 metanephric nephron tubule development
GO:0072237 metanephric proximal tubule development
GO:0072243 metanephric nephron epithelium development
GO:0072329 monocarboxylic acid catabolic process
GO:0072522 purine-containing compound biosynthetic process
GO:1901293 nucleoside phosphate biosynthetic process
GO:1901565 organonitrogen compound catabolic process
GO:1901605 alpha-amino acid metabolic process
GO:1901606 alpha-amino acid catabolic process
GO:1901657 glycosyl compound metabolic process
GO:1901659 glycosyl compound biosynthetic process
GO:1902224 ketone body metabolic process
GO:1902858 propionyl-CoA metabolic process
GO:1902860 propionyl-CoA biosynthetic process
Molecular Function GO:0003985 acetyl-CoA C-acetyltransferase activity
GO:0003988 acetyl-CoA C-acyltransferase activity
GO:0016407 acetyltransferase activity
GO:0016408 C-acyltransferase activity
GO:0016453 C-acetyltransferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0016829 lyase activity
GO:0016830 carbon-carbon lyase activity
GO:0016874 ligase activity
GO:0016885 ligase activity, forming carbon-carbon bonds
GO:0048037 cofactor binding
GO:0050662 coenzyme binding
Cellular Component GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
> KEGG and Reactome Pathway
 
KEGG hsa00071 Fatty acid degradation
hsa00072 Synthesis and degradation of ketone bodies
hsa00280 Valine, leucine and isoleucine degradation
hsa00310 Lysine degradation
hsa00380 Tryptophan metabolism
hsa00620 Pyruvate metabolism
hsa00630 Glyoxylate and dicarboxylate metabolism
hsa00640 Propanoate metabolism
hsa00650 Butanoate metabolism
hsa00900 Terpenoid backbone biosynthesis
hsa01100 Metabolic pathways
hsa01200 Carbon metabolism
hsa01212 Fatty acid metabolism
Reactome R-HSA-70895: Branched-chain amino acid catabolism
R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism
R-HSA-74182: Ketone body metabolism
R-HSA-1430728: Metabolism
R-HSA-71291: Metabolism of amino acids and derivatives
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-77111: Synthesis of Ketone Bodies
R-HSA-77108: Utilization of Ketone Bodies
Summary
SymbolACAT1
Nameacetyl-CoA acetyltransferase 1
Aliases THIL; acetyl-Coenzyme A acetyltransferase 1; acetoacetyl-CoA thiolase; mitochondrial acetoacetyl-CoA thiolas ......
Chromosomal Location11q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ACAT1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between ACAT1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
26982734MelanomaInhibit immunity (T cell function)ACAT1-deficient CD8(+) T cells were better than wild-type CD8(+) T cells at controlling melanoma growth and metastasis in mice.
Summary
SymbolACAT1
Nameacetyl-CoA acetyltransferase 1
Aliases THIL; acetyl-Coenzyme A acetyltransferase 1; acetoacetyl-CoA thiolase; mitochondrial acetoacetyl-CoA thiolas ......
Chromosomal Location11q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ACAT1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolACAT1
Nameacetyl-CoA acetyltransferase 1
Aliases THIL; acetyl-Coenzyme A acetyltransferase 1; acetoacetyl-CoA thiolase; mitochondrial acetoacetyl-CoA thiolas ......
Chromosomal Location11q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ACAT1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.2470.492
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.1920.933
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.570.73
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1960.542
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.6810.671
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.4180.837
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.2020.603
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1310.938
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.340.861
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.5580.792
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.4810.881
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0480.655
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolACAT1
Nameacetyl-CoA acetyltransferase 1
Aliases THIL; acetyl-Coenzyme A acetyltransferase 1; acetoacetyl-CoA thiolase; mitochondrial acetoacetyl-CoA thiolas ......
Chromosomal Location11q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ACAT1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolACAT1
Nameacetyl-CoA acetyltransferase 1
Aliases THIL; acetyl-Coenzyme A acetyltransferase 1; acetoacetyl-CoA thiolase; mitochondrial acetoacetyl-CoA thiolas ......
Chromosomal Location11q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ACAT1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ACAT1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolACAT1
Nameacetyl-CoA acetyltransferase 1
Aliases THIL; acetyl-Coenzyme A acetyltransferase 1; acetoacetyl-CoA thiolase; mitochondrial acetoacetyl-CoA thiolas ......
Chromosomal Location11q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ACAT1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolACAT1
Nameacetyl-CoA acetyltransferase 1
Aliases THIL; acetyl-Coenzyme A acetyltransferase 1; acetoacetyl-CoA thiolase; mitochondrial acetoacetyl-CoA thiolas ......
Chromosomal Location11q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ACAT1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolACAT1
Nameacetyl-CoA acetyltransferase 1
Aliases THIL; acetyl-Coenzyme A acetyltransferase 1; acetoacetyl-CoA thiolase; mitochondrial acetoacetyl-CoA thiolas ......
Chromosomal Location11q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ACAT1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolACAT1
Nameacetyl-CoA acetyltransferase 1
Aliases THIL; acetyl-Coenzyme A acetyltransferase 1; acetoacetyl-CoA thiolase; mitochondrial acetoacetyl-CoA thiolas ......
Chromosomal Location11q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ACAT1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting ACAT1.
ID Name Drug Type Targets #Targets
DB00795SulfasalazineSmall MoleculeACAT1, ALOX5, CHUK, IKBKB, PLA2G1B, PPARG, PTGS1, PTGS2, SLC7A11, ......10