TISIDB

Summary
Symbol	ACOX2
Name	acyl-CoA oxidase 2, branched chain
Aliases	BRCOX; THCCox; trihydroxycoprostanoyl-CoA oxidase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-C ......
Chromosomal Location	3p14.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Peroxisome
Domain	PF01756 Acyl-CoA oxidase PF02770 Acyl-CoA dehydrogenase PF14749 Acyl-coenzyme A oxidase N-terminal
Function	Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids.

> Gene Ontology [ TOP ]
Biological Process	GO:0006631 fatty acid metabolic process GO:0006635 fatty acid beta-oxidation GO:0006694 steroid biosynthetic process GO:0006699 bile acid biosynthetic process GO:0008202 steroid metabolic process GO:0008206 bile acid metabolic process GO:0009062 fatty acid catabolic process GO:0016042 lipid catabolic process GO:0016053 organic acid biosynthetic process GO:0016054 organic acid catabolic process GO:0019395 fatty acid oxidation GO:0030258 lipid modification GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase GO:0034440 lipid oxidation GO:0044242 cellular lipid catabolic process GO:0044282 small molecule catabolic process GO:0044283 small molecule biosynthetic process GO:0046394 carboxylic acid biosynthetic process GO:0046395 carboxylic acid catabolic process GO:0055088 lipid homeostasis GO:0072329 monocarboxylic acid catabolic process GO:0072330 monocarboxylic acid biosynthetic process
Molecular Function	GO:0000062 fatty-acyl-CoA binding GO:0003995 acyl-CoA dehydrogenase activity GO:0003997 acyl-CoA oxidase activity GO:0009055 electron carrier activity GO:0016402 pristanoyl-CoA oxidase activity GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor GO:0016725 oxidoreductase activity, acting on CH or CH2 groups GO:0033791 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity GO:0048037 cofactor binding GO:0050660 flavin adenine dinucleotide binding GO:0050662 coenzyme binding GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor GO:1901681 sulfur compound binding
Cellular Component	GO:0005777 peroxisome GO:0005782 peroxisomal matrix GO:0031907 microbody lumen GO:0042579 microbody GO:0044438 microbody part GO:0044439 peroxisomal part

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa03320 PPAR signaling pathway hsa04146 Peroxisome hsa00120 Primary bile acid biosynthesis hsa01100 Metabolic pathways
Reactome	R-HSA-389887: Beta-oxidation of pristanoyl-CoA R-HSA-194068: Bile acid and bile salt metabolism R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-390918: Peroxisomal lipid metabolism R-HSA-192105: Synthesis of bile acids and bile salts R-HSA-193368: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

Summary
Symbol	ACOX2
Name	acyl-CoA oxidase 2, branched chain
Aliases	BRCOX; THCCox; trihydroxycoprostanoyl-CoA oxidase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-C ......
Chromosomal Location	3p14.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between ACOX2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	ACOX2
Name	acyl-CoA oxidase 2, branched chain
Aliases	BRCOX; THCCox; trihydroxycoprostanoyl-CoA oxidase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-C ......
Chromosomal Location	3p14.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of ACOX2 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	ACOX2
Name	acyl-CoA oxidase 2, branched chain
Aliases	BRCOX; THCCox; trihydroxycoprostanoyl-CoA oxidase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-C ......
Chromosomal Location	3p14.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of ACOX2 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.477	0.294
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.888	0.263
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.175	0.792
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.085	0.879
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.374	0.797
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.664	0.712
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.154	0.801
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.1	0.913
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.345	0.734
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.352	0.742
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.155	0.919
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.592	0.00222

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of ACOX2 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	2.7	1	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	3.4	0.3	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	22.2	6.2	16	0.53
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	20	0	20	0.357
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	25	14.3	10.7	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	ACOX2
Name	acyl-CoA oxidase 2, branched chain
Aliases	BRCOX; THCCox; trihydroxycoprostanoyl-CoA oxidase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-C ......
Chromosomal Location	3p14.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ACOX2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	ACOX2
Name	acyl-CoA oxidase 2, branched chain
Aliases	BRCOX; THCCox; trihydroxycoprostanoyl-CoA oxidase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-C ......
Chromosomal Location	3p14.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ACOX2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ACOX2. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	ACOX2
Name	acyl-CoA oxidase 2, branched chain
Aliases	BRCOX; THCCox; trihydroxycoprostanoyl-CoA oxidase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-C ......
Chromosomal Location	3p14.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ACOX2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	ACOX2
Name	acyl-CoA oxidase 2, branched chain
Aliases	BRCOX; THCCox; trihydroxycoprostanoyl-CoA oxidase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-C ......
Chromosomal Location	3p14.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of ACOX2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	ACOX2
Name	acyl-CoA oxidase 2, branched chain
Aliases	BRCOX; THCCox; trihydroxycoprostanoyl-CoA oxidase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-C ......
Chromosomal Location	3p14.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between ACOX2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	ACOX2
Name	acyl-CoA oxidase 2, branched chain
Aliases	BRCOX; THCCox; trihydroxycoprostanoyl-CoA oxidase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-C ......
Chromosomal Location	3p14.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting ACOX2 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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