Summary | |
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Symbol | ACTR3 |
Name | ARP3 actin-related protein 3 homolog (yeast) |
Aliases | ARP3 (actin-related protein 3, yeast) homolog; actin-like protein 3; Actin-related protein 3 |
Chromosomal Location | 2q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, cytoskeleton Cell projection Note=In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes) (PubMed:19109554). |
Domain |
PF00022 Actin |
Function |
Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis. |
Biological Process |
GO:0000910 cytokinesis GO:0002429 immune response-activating cell surface receptor signaling pathway GO:0002431 Fc receptor mediated stimulatory signaling pathway GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis GO:0002757 immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0006909 phagocytosis GO:0007015 actin filament organization GO:0007018 microtubule-based movement GO:0007059 chromosome segregation GO:0007126 meiotic nuclear division GO:0007163 establishment or maintenance of cell polarity GO:0008064 regulation of actin polymerization or depolymerization GO:0008154 actin polymerization or depolymerization GO:0008356 asymmetric cell division GO:0016344 meiotic chromosome movement towards spindle pole GO:0030041 actin filament polymerization GO:0030832 regulation of actin filament length GO:0030833 regulation of actin filament polymerization GO:0030838 positive regulation of actin filament polymerization GO:0031334 positive regulation of protein complex assembly GO:0032271 regulation of protein polymerization GO:0032273 positive regulation of protein polymerization GO:0032535 regulation of cellular component size GO:0032956 regulation of actin cytoskeleton organization GO:0032970 regulation of actin filament-based process GO:0033206 meiotic cytokinesis GO:0034314 Arp2/3 complex-mediated actin nucleation GO:0038093 Fc receptor signaling pathway GO:0038094 Fc-gamma receptor signaling pathway GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis GO:0043254 regulation of protein complex assembly GO:0044089 positive regulation of cellular component biogenesis GO:0045010 actin nucleation GO:0045132 meiotic chromosome segregation GO:0048013 ephrin receptor signaling pathway GO:0050000 chromosome localization GO:0051258 protein polymerization GO:0051303 establishment of chromosome localization GO:0051305 chromosome movement towards spindle pole GO:0051321 meiotic cell cycle GO:0051493 regulation of cytoskeleton organization GO:0051495 positive regulation of cytoskeleton organization GO:0051640 organelle localization GO:0051653 spindle localization GO:0051656 establishment of organelle localization GO:0060271 cilium morphogenesis GO:0061640 cytoskeleton-dependent cytokinesis GO:0090066 regulation of anatomical structure size GO:0098813 nuclear chromosome segregation GO:1903046 meiotic cell cycle process |
Molecular Function |
GO:0003779 actin binding GO:0005200 structural constituent of cytoskeleton GO:0051015 actin filament binding |
Cellular Component |
GO:0005885 Arp2/3 protein complex GO:0005903 brush border GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0015629 actin cytoskeleton GO:0030027 lamellipodium GO:0030055 cell-substrate junction GO:0031252 cell leading edge GO:0098862 cluster of actin-based cell projections |
KEGG |
hsa04530 Tight junction |
Reactome |
R-HSA-422475: Axon guidance R-HSA-8856828: Clathrin-mediated endocytosis R-HSA-1266738: Developmental Biology R-HSA-2682334: EPH-Ephrin signaling R-HSA-3928662: EPHB-mediated forward signaling R-HSA-2029480: Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-199991: Membrane Trafficking R-HSA-195258: RHO GTPase Effectors R-HSA-5663213: RHO GTPases Activate WASPs and WAVEs R-HSA-2029482: Regulation of actin dynamics for phagocytic cup formation R-HSA-162582: Signal Transduction R-HSA-194315: Signaling by Rho GTPases R-HSA-5653656: Vesicle-mediated transport |
Summary | |
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Symbol | ACTR3 |
Name | ARP3 actin-related protein 3 homolog (yeast) |
Aliases | ARP3 (actin-related protein 3, yeast) homolog; actin-like protein 3; Actin-related protein 3 |
Chromosomal Location | 2q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ACTR3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | ACTR3 |
Name | ARP3 actin-related protein 3 homolog (yeast) |
Aliases | ARP3 (actin-related protein 3, yeast) homolog; actin-like protein 3; Actin-related protein 3 |
Chromosomal Location | 2q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ACTR3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ACTR3 |
Name | ARP3 actin-related protein 3 homolog (yeast) |
Aliases | ARP3 (actin-related protein 3, yeast) homolog; actin-like protein 3; Actin-related protein 3 |
Chromosomal Location | 2q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ACTR3 in various data sets.
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Points in the above scatter plot represent the mutation difference of ACTR3 in various data sets.
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Summary | |
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Symbol | ACTR3 |
Name | ARP3 actin-related protein 3 homolog (yeast) |
Aliases | ARP3 (actin-related protein 3, yeast) homolog; actin-like protein 3; Actin-related protein 3 |
Chromosomal Location | 2q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ACTR3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ACTR3 |
Name | ARP3 actin-related protein 3 homolog (yeast) |
Aliases | ARP3 (actin-related protein 3, yeast) homolog; actin-like protein 3; Actin-related protein 3 |
Chromosomal Location | 2q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ACTR3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ACTR3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ACTR3 |
Name | ARP3 actin-related protein 3 homolog (yeast) |
Aliases | ARP3 (actin-related protein 3, yeast) homolog; actin-like protein 3; Actin-related protein 3 |
Chromosomal Location | 2q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ACTR3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ACTR3 |
Name | ARP3 actin-related protein 3 homolog (yeast) |
Aliases | ARP3 (actin-related protein 3, yeast) homolog; actin-like protein 3; Actin-related protein 3 |
Chromosomal Location | 2q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ACTR3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ACTR3 |
Name | ARP3 actin-related protein 3 homolog (yeast) |
Aliases | ARP3 (actin-related protein 3, yeast) homolog; actin-like protein 3; Actin-related protein 3 |
Chromosomal Location | 2q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ACTR3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ACTR3 |
Name | ARP3 actin-related protein 3 homolog (yeast) |
Aliases | ARP3 (actin-related protein 3, yeast) homolog; actin-like protein 3; Actin-related protein 3 |
Chromosomal Location | 2q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ACTR3 collected from DrugBank database. |
Details on drugs targeting ACTR3.
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