TISIDB

Summary
Symbol	ADCY1
Name	adenylate cyclase 1 (brain)
Aliases	ATP pyrophosphate-lyase 1; adenyl cyclase; adenylate cyclase type I; adenylyl cyclase 1; Adenylate cyclase t ......
Chromosomal Location	7p12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein Cytoplasm Membrane raft Note=Expressed in the cytoplasm of supporting cells and hair cells of the cochlea vestibule, as well as to the cochlear hair cell nuclei and stereocilia.
Domain	PF16214 Adenylyl cyclase N-terminal extracellular and transmembrane region PF00211 Adenylate and Guanylate cyclase catalytic domain
Function	Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels (By similarity). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity).

> Gene Ontology [ TOP ]
Biological Process	GO:0003014 renal system process GO:0003091 renal water homeostasis GO:0006140 regulation of nucleotide metabolic process GO:0006164 purine nucleotide biosynthetic process GO:0006171 cAMP biosynthetic process GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007190 activation of adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007409 axonogenesis GO:0007611 learning or memory GO:0007613 memory GO:0007616 long-term memory GO:0007623 circadian rhythm GO:0009150 purine ribonucleotide metabolic process GO:0009152 purine ribonucleotide biosynthetic process GO:0009165 nucleotide biosynthetic process GO:0009187 cyclic nucleotide metabolic process GO:0009190 cyclic nucleotide biosynthetic process GO:0009260 ribonucleotide biosynthetic process GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010226 response to lithium ion GO:0019932 second-messenger-mediated signaling GO:0019933 cAMP-mediated signaling GO:0019935 cyclic-nucleotide-mediated signaling GO:0030104 water homeostasis GO:0030799 regulation of cyclic nucleotide metabolic process GO:0030801 positive regulation of cyclic nucleotide metabolic process GO:0030802 regulation of cyclic nucleotide biosynthetic process GO:0030804 positive regulation of cyclic nucleotide biosynthetic process GO:0030808 regulation of nucleotide biosynthetic process GO:0030810 positive regulation of nucleotide biosynthetic process GO:0030814 regulation of cAMP metabolic process GO:0030816 positive regulation of cAMP metabolic process GO:0030817 regulation of cAMP biosynthetic process GO:0030819 positive regulation of cAMP biosynthetic process GO:0031279 regulation of cyclase activity GO:0031281 positive regulation of cyclase activity GO:0032147 activation of protein kinase activity GO:0033674 positive regulation of kinase activity GO:0033762 response to glucagon GO:0034199 activation of protein kinase A activity GO:0042493 response to drug GO:0042752 regulation of circadian rhythm GO:0043434 response to peptide hormone GO:0044708 single-organism behavior GO:0045761 regulation of adenylate cyclase activity GO:0045762 positive regulation of adenylate cyclase activity GO:0045860 positive regulation of protein kinase activity GO:0045981 positive regulation of nucleotide metabolic process GO:0046058 cAMP metabolic process GO:0046390 ribose phosphate biosynthetic process GO:0048511 rhythmic process GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048871 multicellular organismal homeostasis GO:0050878 regulation of body fluid levels GO:0050890 cognition GO:0050891 multicellular organismal water homeostasis GO:0051339 regulation of lyase activity GO:0051349 positive regulation of lyase activity GO:0051592 response to calcium ion GO:0052652 cyclic purine nucleotide metabolic process GO:0061564 axon development GO:0071241 cellular response to inorganic substance GO:0071248 cellular response to metal ion GO:0071277 cellular response to calcium ion GO:0071375 cellular response to peptide hormone stimulus GO:0071377 cellular response to glucagon stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0072522 purine-containing compound biosynthetic process GO:1900371 regulation of purine nucleotide biosynthetic process GO:1900373 positive regulation of purine nucleotide biosynthetic process GO:1900542 regulation of purine nucleotide metabolic process GO:1900544 positive regulation of purine nucleotide metabolic process GO:1901293 nucleoside phosphate biosynthetic process GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1901654 response to ketone GO:1901655 cellular response to ketone GO:1904321 response to forskolin GO:1904322 cellular response to forskolin
Molecular Function	GO:0004016 adenylate cyclase activity GO:0005516 calmodulin binding GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity GO:0009975 cyclase activity GO:0016829 lyase activity GO:0016849 phosphorus-oxygen lyase activity
Cellular Component	GO:0045121 membrane raft GO:0098589 membrane region GO:0098857 membrane microdomain

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04015 Rap1 signaling pathway hsa04020 Calcium signaling pathway hsa04022 cGMP-PKG signaling pathway hsa04024 cAMP signaling pathway hsa04062 Chemokine signaling pathway hsa04114 Oocyte meiosis hsa04261 Adrenergic signaling in cardiomyocytes hsa04270 Vascular smooth muscle contraction hsa04540 Gap junction hsa04611 Platelet activation hsa04713 Circadian entrainment hsa04720 Long-term potentiation hsa04723 Retrograde endocannabinoid signaling hsa04724 Glutamatergic synapse hsa04725 Cholinergic synapse hsa04727 GABAergic synapse hsa04750 Inflammatory mediator regulation of TRP channels hsa04911 Insulin secretion hsa04912 GnRH signaling pathway hsa04913 Ovarian steroidogenesis hsa04914 Progesterone-mediated oocyte maturation hsa04915 Estrogen signaling pathway hsa04916 Melanogenesis hsa04918 Thyroid hormone synthesis hsa04921 Oxytocin signaling pathway hsa04970 Salivary secretion hsa04971 Gastric acid secretion hsa04972 Pancreatic secretion hsa04976 Bile secretion hsa00230 Purine metabolism
Reactome	R-HSA-991365: Activation of GABAB receptors R-HSA-442755: Activation of NMDA receptor upon glutamate binding and postsynaptic events R-HSA-170660: Adenylate cyclase activating pathway R-HSA-170670: Adenylate cyclase inhibitory pathway R-HSA-445717: Aquaporin-mediated transport R-HSA-442720: CREB phosphorylation through the activation of Adenylate Cyclase R-HSA-111996: Ca-dependent events R-HSA-111997: CaM pathway R-HSA-111933: Calmodulin induced events R-HSA-1489509: DAG and IP3 signaling R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-186763: Downstream signal transduction R-HSA-212718: EGFR interacts with phospholipase C-gamma R-HSA-418594: G alpha (i) signalling events R-HSA-418555: G alpha (s) signalling events R-HSA-418597: G alpha (z) signalling events R-HSA-112040: G-protein mediated events R-HSA-977444: GABA B receptor activation R-HSA-977443: GABA receptor activation R-HSA-388396: GPCR downstream signaling R-HSA-163359: Glucagon signaling in metabolic regulation R-HSA-5610787: Hedgehog 'off' state R-HSA-168256: Immune System R-HSA-997269: Inhibition of adenylate cyclase pathway R-HSA-168249: Innate Immune System R-HSA-163685: Integration of energy metabolism R-HSA-1430728: Metabolism R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-112316: Neuronal System R-HSA-112314: Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell R-HSA-111885: Opioid Signalling R-HSA-163615: PKA activation R-HSA-164378: PKA activation in glucagon signalling R-HSA-111931: PKA-mediated phosphorylation of CREB R-HSA-112043: PLC beta mediated events R-HSA-167021: PLC-gamma1 signalling R-HSA-438064: Post NMDA receptor activation events R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-372790: Signaling by GPCR R-HSA-5358351: Signaling by Hedgehog R-HSA-186797: Signaling by PDGF R-HSA-166520: Signalling by NGF R-HSA-382551: Transmembrane transport of small molecules R-HSA-112315: Transmission across Chemical Synapses R-HSA-432040: Vasopressin regulates renal water homeostasis via Aquaporins

> KEGG and Reactome Pathway

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KEGG

hsa04015 Rap1 signaling pathway
hsa04020 Calcium signaling pathway
hsa04022 cGMP-PKG signaling pathway
hsa04024 cAMP signaling pathway
hsa04062 Chemokine signaling pathway
hsa04114 Oocyte meiosis
hsa04261 Adrenergic signaling in cardiomyocytes
hsa04270 Vascular smooth muscle contraction
hsa04540 Gap junction
hsa04611 Platelet activation
hsa04713 Circadian entrainment
hsa04720 Long-term potentiation
hsa04723 Retrograde endocannabinoid signaling
hsa04724 Glutamatergic synapse
hsa04725 Cholinergic synapse
hsa04727 GABAergic synapse
hsa04750 Inflammatory mediator regulation of TRP channels
hsa04911 Insulin secretion
hsa04912 GnRH signaling pathway
hsa04913 Ovarian steroidogenesis
hsa04914 Progesterone-mediated oocyte maturation
hsa04915 Estrogen signaling pathway
hsa04916 Melanogenesis
hsa04918 Thyroid hormone synthesis
hsa04921 Oxytocin signaling pathway
hsa04970 Salivary secretion
hsa04971 Gastric acid secretion
hsa04972 Pancreatic secretion
hsa04976 Bile secretion
hsa00230 Purine metabolism

Reactome

R-HSA-991365: Activation of GABAB receptors
R-HSA-442755: Activation of NMDA receptor upon glutamate binding and postsynaptic events
R-HSA-170660: Adenylate cyclase activating pathway
R-HSA-170670: Adenylate cyclase inhibitory pathway
R-HSA-445717: Aquaporin-mediated transport
R-HSA-442720: CREB phosphorylation through the activation of Adenylate Cyclase
R-HSA-111996: Ca-dependent events
R-HSA-111997: CaM pathway
R-HSA-111933: Calmodulin induced events
R-HSA-1489509: DAG and IP3 signaling
R-HSA-2172127: DAP12 interactions
R-HSA-2424491: DAP12 signaling
R-HSA-186763: Downstream signal transduction
R-HSA-212718: EGFR interacts with phospholipase C-gamma
R-HSA-418594: G alpha (i) signalling events
R-HSA-418555: G alpha (s) signalling events
R-HSA-418597: G alpha (z) signalling events
R-HSA-112040: G-protein mediated events
R-HSA-977444: GABA B receptor activation
R-HSA-977443: GABA receptor activation
R-HSA-388396: GPCR downstream signaling
R-HSA-163359: Glucagon signaling in metabolic regulation
R-HSA-5610787: Hedgehog 'off' state
R-HSA-168256: Immune System
R-HSA-997269: Inhibition of adenylate cyclase pathway
R-HSA-168249: Innate Immune System
R-HSA-163685: Integration of energy metabolism
R-HSA-1430728: Metabolism
R-HSA-187037: NGF signalling via TRKA from the plasma membrane
R-HSA-112316: Neuronal System
R-HSA-112314: Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
R-HSA-111885: Opioid Signalling
R-HSA-163615: PKA activation
R-HSA-164378: PKA activation in glucagon signalling
R-HSA-111931: PKA-mediated phosphorylation of CREB
R-HSA-112043: PLC beta mediated events
R-HSA-167021: PLC-gamma1 signalling
R-HSA-438064: Post NMDA receptor activation events
R-HSA-162582: Signal Transduction
R-HSA-177929: Signaling by EGFR
R-HSA-372790: Signaling by GPCR
R-HSA-5358351: Signaling by Hedgehog
R-HSA-186797: Signaling by PDGF
R-HSA-166520: Signalling by NGF
R-HSA-382551: Transmembrane transport of small molecules
R-HSA-112315: Transmission across Chemical Synapses
R-HSA-432040: Vasopressin regulates renal water homeostasis via Aquaporins

Summary
Symbol	ADCY1
Name	adenylate cyclase 1 (brain)
Aliases	ATP pyrophosphate-lyase 1; adenyl cyclase; adenylate cyclase type I; adenylyl cyclase 1; Adenylate cyclase t ......
Chromosomal Location	7p12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between ADCY1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	ADCY1
Name	adenylate cyclase 1 (brain)
Aliases	ATP pyrophosphate-lyase 1; adenyl cyclase; adenylate cyclase type I; adenylyl cyclase 1; Adenylate cyclase t ......
Chromosomal Location	7p12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of ADCY1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	ADCY1
Name	adenylate cyclase 1 (brain)
Aliases	ATP pyrophosphate-lyase 1; adenyl cyclase; adenylate cyclase type I; adenylyl cyclase 1; Adenylate cyclase t ......
Chromosomal Location	7p12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of ADCY1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.688	0.311
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	1.788	0.178
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.124	0.916
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.842	0.0203
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.837	0.565
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.841	0.612
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.549	0.442
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.297	0.85
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.837	0.625
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.096	0.889
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.927	0.283
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.397	0.0532

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of ADCY1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	7.1	0	7.1	0.452
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	10	0	10	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	7.4	4.1	3.3	0.61
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	7.4	5.1	2.3	0.647
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	14.3	23.5	-9.2	0.678
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	12.5	33.3	-20.8	0.538
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	15.4	18.2	-2.8	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	6.2	-6.2	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	14.3	-14.3	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	7.9	0	7.9	0.26
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	13.6	0	13.6	0.279
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	7.7	-7.7	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	8.3	-8.3	1

Summary
Symbol	ADCY1
Name	adenylate cyclase 1 (brain)
Aliases	ATP pyrophosphate-lyase 1; adenyl cyclase; adenylate cyclase type I; adenylyl cyclase 1; Adenylate cyclase t ......
Chromosomal Location	7p12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ADCY1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	ADCY1
Name	adenylate cyclase 1 (brain)
Aliases	ATP pyrophosphate-lyase 1; adenyl cyclase; adenylate cyclase type I; adenylyl cyclase 1; Adenylate cyclase t ......
Chromosomal Location	7p12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ADCY1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ADCY1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	ADCY1
Name	adenylate cyclase 1 (brain)
Aliases	ATP pyrophosphate-lyase 1; adenyl cyclase; adenylate cyclase type I; adenylyl cyclase 1; Adenylate cyclase t ......
Chromosomal Location	7p12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ADCY1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	ADCY1
Name	adenylate cyclase 1 (brain)
Aliases	ATP pyrophosphate-lyase 1; adenyl cyclase; adenylate cyclase type I; adenylyl cyclase 1; Adenylate cyclase t ......
Chromosomal Location	7p12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of ADCY1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	ADCY1
Name	adenylate cyclase 1 (brain)
Aliases	ATP pyrophosphate-lyase 1; adenyl cyclase; adenylate cyclase type I; adenylyl cyclase 1; Adenylate cyclase t ......
Chromosomal Location	7p12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between ADCY1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	ADCY1
Name	adenylate cyclase 1 (brain)
Aliases	ATP pyrophosphate-lyase 1; adenyl cyclase; adenylate cyclase type I; adenylyl cyclase 1; Adenylate cyclase t ......
Chromosomal Location	7p12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting ADCY1 collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting ADCY1.

ID	Name	Drug Type	Targets	#Targets
DB00131	Adenosine monophosphate	Small Molecule	ACSL1, ACSS1, ACSS2, ADCY1, ADK, CREB1, FBP1, HINT1, PDE4B, PDE4D, ......	15
DB00171	ATP	Small Molecule	ABCA1, ABCB1, ABCB11, ABCC1, ABCC2, ABCC4, ABCC6, ABCC8, ABCC9, AB ......	42
DB09121	Aurothioglucose	Small Molecule	ADCY1, ADCY2, ADCY5	3

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