Browse ADCY8

Summary
SymbolADCY8
Nameadenylate cyclase 8 (brain)
Aliases HBAC1; AC8; ATP pyrophosphate-lyase 8; adenylate cyclase type VIII; adenylyl cyclase 8; adenylyl cyclase-8, ......
Chromosomal Location8q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane; Multi-pass membrane protein.
Domain PF16214 Adenylyl cyclase N-terminal extracellular and transmembrane region
PF06327 Domain of Unknown Function (DUF1053)
PF00211 Adenylate and Guanylate cyclase catalytic domain
Function

This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity).

> Gene Ontology
 
Biological Process GO:0003014 renal system process
GO:0003091 renal water homeostasis
GO:0006140 regulation of nucleotide metabolic process
GO:0006164 purine nucleotide biosynthetic process
GO:0006171 cAMP biosynthetic process
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007611 learning or memory
GO:0007613 memory
GO:0007616 long-term memory
GO:0009150 purine ribonucleotide metabolic process
GO:0009152 purine ribonucleotide biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0009187 cyclic nucleotide metabolic process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0009260 ribonucleotide biosynthetic process
GO:0019932 second-messenger-mediated signaling
GO:0019933 cAMP-mediated signaling
GO:0019935 cyclic-nucleotide-mediated signaling
GO:0030104 water homeostasis
GO:0030799 regulation of cyclic nucleotide metabolic process
GO:0030801 positive regulation of cyclic nucleotide metabolic process
GO:0030802 regulation of cyclic nucleotide biosynthetic process
GO:0030804 positive regulation of cyclic nucleotide biosynthetic process
GO:0030808 regulation of nucleotide biosynthetic process
GO:0030810 positive regulation of nucleotide biosynthetic process
GO:0030814 regulation of cAMP metabolic process
GO:0030816 positive regulation of cAMP metabolic process
GO:0030817 regulation of cAMP biosynthetic process
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0031279 regulation of cyclase activity
GO:0031281 positive regulation of cyclase activity
GO:0032147 activation of protein kinase activity
GO:0033674 positive regulation of kinase activity
GO:0033762 response to glucagon
GO:0034199 activation of protein kinase A activity
GO:0043434 response to peptide hormone
GO:0044708 single-organism behavior
GO:0045761 regulation of adenylate cyclase activity
GO:0045762 positive regulation of adenylate cyclase activity
GO:0045860 positive regulation of protein kinase activity
GO:0045981 positive regulation of nucleotide metabolic process
GO:0046058 cAMP metabolic process
GO:0046390 ribose phosphate biosynthetic process
GO:0048871 multicellular organismal homeostasis
GO:0050878 regulation of body fluid levels
GO:0050890 cognition
GO:0050891 multicellular organismal water homeostasis
GO:0051339 regulation of lyase activity
GO:0051349 positive regulation of lyase activity
GO:0052652 cyclic purine nucleotide metabolic process
GO:0071375 cellular response to peptide hormone stimulus
GO:0071377 cellular response to glucagon stimulus
GO:0071417 cellular response to organonitrogen compound
GO:0072522 purine-containing compound biosynthetic process
GO:1900371 regulation of purine nucleotide biosynthetic process
GO:1900373 positive regulation of purine nucleotide biosynthetic process
GO:1900542 regulation of purine nucleotide metabolic process
GO:1900544 positive regulation of purine nucleotide metabolic process
GO:1901293 nucleoside phosphate biosynthetic process
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
Molecular Function GO:0004016 adenylate cyclase activity
GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity
GO:0009975 cyclase activity
GO:0016829 lyase activity
GO:0016849 phosphorus-oxygen lyase activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04015 Rap1 signaling pathway
hsa04020 Calcium signaling pathway
hsa04022 cGMP-PKG signaling pathway
hsa04024 cAMP signaling pathway
hsa04062 Chemokine signaling pathway
hsa04114 Oocyte meiosis
hsa04261 Adrenergic signaling in cardiomyocytes
hsa04270 Vascular smooth muscle contraction
hsa04540 Gap junction
hsa04611 Platelet activation
hsa04713 Circadian entrainment
hsa04720 Long-term potentiation
hsa04723 Retrograde endocannabinoid signaling
hsa04724 Glutamatergic synapse
hsa04725 Cholinergic synapse
hsa04727 GABAergic synapse
hsa04742 Taste transduction
hsa04750 Inflammatory mediator regulation of TRP channels
hsa04911 Insulin secretion
hsa04912 GnRH signaling pathway
hsa04913 Ovarian steroidogenesis
hsa04914 Progesterone-mediated oocyte maturation
hsa04915 Estrogen signaling pathway
hsa04916 Melanogenesis
hsa04918 Thyroid hormone synthesis
hsa04921 Oxytocin signaling pathway
hsa04970 Salivary secretion
hsa04971 Gastric acid secretion
hsa04972 Pancreatic secretion
hsa04976 Bile secretion
hsa00230 Purine metabolism
Reactome R-HSA-991365: Activation of GABAB receptors
R-HSA-442755: Activation of NMDA receptor upon glutamate binding and postsynaptic events
R-HSA-170660: Adenylate cyclase activating pathway
R-HSA-170670: Adenylate cyclase inhibitory pathway
R-HSA-445717: Aquaporin-mediated transport
R-HSA-442720: CREB phosphorylation through the activation of Adenylate Cyclase
R-HSA-111996: Ca-dependent events
R-HSA-111997: CaM pathway
R-HSA-111933: Calmodulin induced events
R-HSA-1489509: DAG and IP3 signaling
R-HSA-2172127: DAP12 interactions
R-HSA-2424491: DAP12 signaling
R-HSA-186763: Downstream signal transduction
R-HSA-212718: EGFR interacts with phospholipase C-gamma
R-HSA-418594: G alpha (i) signalling events
R-HSA-418555: G alpha (s) signalling events
R-HSA-418597: G alpha (z) signalling events
R-HSA-112040: G-protein mediated events
R-HSA-977444: GABA B receptor activation
R-HSA-977443: GABA receptor activation
R-HSA-388396: GPCR downstream signaling
R-HSA-163359: Glucagon signaling in metabolic regulation
R-HSA-381676: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-5610787: Hedgehog 'off' state
R-HSA-168256: Immune System
R-HSA-997269: Inhibition of adenylate cyclase pathway
R-HSA-168249: Innate Immune System
R-HSA-163685: Integration of energy metabolism
R-HSA-1430728: Metabolism
R-HSA-187037: NGF signalling via TRKA from the plasma membrane
R-HSA-112316: Neuronal System
R-HSA-112314: Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
R-HSA-111885: Opioid Signalling
R-HSA-163615: PKA activation
R-HSA-164378: PKA activation in glucagon signalling
R-HSA-111931: PKA-mediated phosphorylation of CREB
R-HSA-112043: PLC beta mediated events
R-HSA-167021: PLC-gamma1 signalling
R-HSA-438064: Post NMDA receptor activation events
R-HSA-422356: Regulation of insulin secretion
R-HSA-162582: Signal Transduction
R-HSA-177929: Signaling by EGFR
R-HSA-372790: Signaling by GPCR
R-HSA-5358351: Signaling by Hedgehog
R-HSA-186797: Signaling by PDGF
R-HSA-166520: Signalling by NGF
R-HSA-382551: Transmembrane transport of small molecules
R-HSA-112315: Transmission across Chemical Synapses
R-HSA-432040: Vasopressin regulates renal water homeostasis via Aquaporins
Summary
SymbolADCY8
Nameadenylate cyclase 8 (brain)
Aliases HBAC1; AC8; ATP pyrophosphate-lyase 8; adenylate cyclase type VIII; adenylyl cyclase 8; adenylyl cyclase-8, ......
Chromosomal Location8q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ADCY8 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolADCY8
Nameadenylate cyclase 8 (brain)
Aliases HBAC1; AC8; ATP pyrophosphate-lyase 8; adenylate cyclase type VIII; adenylyl cyclase 8; adenylyl cyclase-8, ......
Chromosomal Location8q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ADCY8 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolADCY8
Nameadenylate cyclase 8 (brain)
Aliases HBAC1; AC8; ATP pyrophosphate-lyase 8; adenylate cyclase type VIII; adenylyl cyclase 8; adenylyl cyclase-8, ......
Chromosomal Location8q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ADCY8 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.3870.337
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.0860.905
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.6020.34
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.10.86
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.2210.863
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.0580.968
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1930.829
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0980.951
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.3430.841
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1150.893
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.2140.261
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1290.537
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ADCY8 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141714.3014.30.196
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 414250250.222
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277314.89.65.20.482
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275914.811.92.90.735
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211733.317.615.70.46
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8637.516.720.80.58
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131130.818.212.60.649
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382715.8015.80.037
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221327.3027.30.0645
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolADCY8
Nameadenylate cyclase 8 (brain)
Aliases HBAC1; AC8; ATP pyrophosphate-lyase 8; adenylate cyclase type VIII; adenylyl cyclase 8; adenylyl cyclase-8, ......
Chromosomal Location8q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ADCY8. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolADCY8
Nameadenylate cyclase 8 (brain)
Aliases HBAC1; AC8; ATP pyrophosphate-lyase 8; adenylate cyclase type VIII; adenylyl cyclase 8; adenylyl cyclase-8, ......
Chromosomal Location8q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ADCY8. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ADCY8.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolADCY8
Nameadenylate cyclase 8 (brain)
Aliases HBAC1; AC8; ATP pyrophosphate-lyase 8; adenylate cyclase type VIII; adenylyl cyclase 8; adenylyl cyclase-8, ......
Chromosomal Location8q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ADCY8. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolADCY8
Nameadenylate cyclase 8 (brain)
Aliases HBAC1; AC8; ATP pyrophosphate-lyase 8; adenylate cyclase type VIII; adenylyl cyclase 8; adenylyl cyclase-8, ......
Chromosomal Location8q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ADCY8 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolADCY8
Nameadenylate cyclase 8 (brain)
Aliases HBAC1; AC8; ATP pyrophosphate-lyase 8; adenylate cyclase type VIII; adenylyl cyclase 8; adenylyl cyclase-8, ......
Chromosomal Location8q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ADCY8 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolADCY8
Nameadenylate cyclase 8 (brain)
Aliases HBAC1; AC8; ATP pyrophosphate-lyase 8; adenylate cyclase type VIII; adenylyl cyclase 8; adenylyl cyclase-8, ......
Chromosomal Location8q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ADCY8 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.