Browse ADNP

Summary
SymbolADNP
Nameactivity-dependent neuroprotector homeobox
Aliases KIAA0784; ADNP1; ADNP homeobox 1; activity-dependent neuroprotector; HVDAS; MRD28; activity-dependent neurop ......
Chromosomal Location20q13.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain PF00046 Homeobox domain
Function

Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation.

> Gene Ontology
 
Biological Process GO:0001558 regulation of cell growth
GO:0006140 regulation of nucleotide metabolic process
GO:0006164 purine nucleotide biosynthetic process
GO:0006182 cGMP biosynthetic process
GO:0006471 protein ADP-ribosylation
GO:0006486 protein glycosylation
GO:0007409 axonogenesis
GO:0007416 synapse assembly
GO:0007611 learning or memory
GO:0007613 memory
GO:0007614 short-term memory
GO:0008361 regulation of cell size
GO:0009100 glycoprotein metabolic process
GO:0009101 glycoprotein biosynthetic process
GO:0009150 purine ribonucleotide metabolic process
GO:0009152 purine ribonucleotide biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0009187 cyclic nucleotide metabolic process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0009260 ribonucleotide biosynthetic process
GO:0009743 response to carbohydrate
GO:0009991 response to extracellular stimulus
GO:0010035 response to inorganic substance
GO:0010559 regulation of glycoprotein biosynthetic process
GO:0010720 positive regulation of cell development
GO:0010769 regulation of cell morphogenesis involved in differentiation
GO:0010770 positive regulation of cell morphogenesis involved in differentiation
GO:0010835 regulation of protein ADP-ribosylation
GO:0010975 regulation of neuron projection development
GO:0010976 positive regulation of neuron projection development
GO:0016049 cell growth
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0018212 peptidyl-tyrosine modification
GO:0022604 regulation of cell morphogenesis
GO:0030307 positive regulation of cell growth
GO:0030516 regulation of axon extension
GO:0030799 regulation of cyclic nucleotide metabolic process
GO:0030801 positive regulation of cyclic nucleotide metabolic process
GO:0030802 regulation of cyclic nucleotide biosynthetic process
GO:0030804 positive regulation of cyclic nucleotide biosynthetic process
GO:0030808 regulation of nucleotide biosynthetic process
GO:0030810 positive regulation of nucleotide biosynthetic process
GO:0030823 regulation of cGMP metabolic process
GO:0030825 positive regulation of cGMP metabolic process
GO:0030826 regulation of cGMP biosynthetic process
GO:0030828 positive regulation of cGMP biosynthetic process
GO:0031346 positive regulation of cell projection organization
GO:0031668 cellular response to extracellular stimulus
GO:0032091 negative regulation of protein binding
GO:0032147 activation of protein kinase activity
GO:0032535 regulation of cellular component size
GO:0033483 gas homeostasis
GO:0033484 nitric oxide homeostasis
GO:0033674 positive regulation of kinase activity
GO:0042698 ovulation cycle
GO:0043393 regulation of protein binding
GO:0043413 macromolecule glycosylation
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0044089 positive regulation of cellular component biogenesis
GO:0044708 single-organism behavior
GO:0044849 estrous cycle
GO:0045666 positive regulation of neuron differentiation
GO:0045773 positive regulation of axon extension
GO:0045860 positive regulation of protein kinase activity
GO:0045927 positive regulation of growth
GO:0045981 positive regulation of nucleotide metabolic process
GO:0046068 cGMP metabolic process
GO:0046390 ribose phosphate biosynthetic process
GO:0048511 rhythmic process
GO:0048588 developmental cell growth
GO:0048638 regulation of developmental growth
GO:0048639 positive regulation of developmental growth
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048675 axon extension
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050769 positive regulation of neurogenesis
GO:0050770 regulation of axonogenesis
GO:0050772 positive regulation of axonogenesis
GO:0050803 regulation of synapse structure or activity
GO:0050804 modulation of synaptic transmission
GO:0050805 negative regulation of synaptic transmission
GO:0050807 regulation of synapse organization
GO:0050808 synapse organization
GO:0050890 cognition
GO:0051098 regulation of binding
GO:0051100 negative regulation of binding
GO:0051402 neuron apoptotic process
GO:0051962 positive regulation of nervous system development
GO:0051963 regulation of synapse assembly
GO:0051965 positive regulation of synapse assembly
GO:0052652 cyclic purine nucleotide metabolic process
GO:0060049 regulation of protein glycosylation
GO:0060560 developmental growth involved in morphogenesis
GO:0061387 regulation of extent of cell growth
GO:0061564 axon development
GO:0070085 glycosylation
GO:0070997 neuron death
GO:0071496 cellular response to external stimulus
GO:0072522 purine-containing compound biosynthetic process
GO:0090066 regulation of anatomical structure size
GO:1900371 regulation of purine nucleotide biosynthetic process
GO:1900373 positive regulation of purine nucleotide biosynthetic process
GO:1900542 regulation of purine nucleotide metabolic process
GO:1900544 positive regulation of purine nucleotide metabolic process
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:1901293 nucleoside phosphate biosynthetic process
GO:1903018 regulation of glycoprotein metabolic process
GO:1990138 neuron projection extension
Molecular Function GO:0003682 chromatin binding
GO:0005507 copper ion binding
GO:0015631 tubulin binding
GO:0033218 amide binding
GO:0042277 peptide binding
GO:0048487 beta-tubulin binding
Cellular Component GO:0030424 axon
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0044297 cell body
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolADNP
Nameactivity-dependent neuroprotector homeobox
Aliases KIAA0784; ADNP1; ADNP homeobox 1; activity-dependent neuroprotector; HVDAS; MRD28; activity-dependent neurop ......
Chromosomal Location20q13.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ADNP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolADNP
Nameactivity-dependent neuroprotector homeobox
Aliases KIAA0784; ADNP1; ADNP homeobox 1; activity-dependent neuroprotector; HVDAS; MRD28; activity-dependent neurop ......
Chromosomal Location20q13.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ADNP in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 STARS Score: 4.53; FDR: 0.008 Resistant to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX STARS Score: 5.21; FDR: 0.003 Resistant to T cell-mediated killing
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolADNP
Nameactivity-dependent neuroprotector homeobox
Aliases KIAA0784; ADNP1; ADNP homeobox 1; activity-dependent neuroprotector; HVDAS; MRD28; activity-dependent neurop ......
Chromosomal Location20q13.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ADNP in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1220.571
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.0140.995
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2050.893
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1210.763
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1290.96
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.4410.898
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0220.96
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0020.999
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1120.958
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2410.856
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.6270.756
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0270.67
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ADNP in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.41.460.177
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.41.75.70.231
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916012.5-12.50.52
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolADNP
Nameactivity-dependent neuroprotector homeobox
Aliases KIAA0784; ADNP1; ADNP homeobox 1; activity-dependent neuroprotector; HVDAS; MRD28; activity-dependent neurop ......
Chromosomal Location20q13.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ADNP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolADNP
Nameactivity-dependent neuroprotector homeobox
Aliases KIAA0784; ADNP1; ADNP homeobox 1; activity-dependent neuroprotector; HVDAS; MRD28; activity-dependent neurop ......
Chromosomal Location20q13.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ADNP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ADNP.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolADNP
Nameactivity-dependent neuroprotector homeobox
Aliases KIAA0784; ADNP1; ADNP homeobox 1; activity-dependent neuroprotector; HVDAS; MRD28; activity-dependent neurop ......
Chromosomal Location20q13.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ADNP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolADNP
Nameactivity-dependent neuroprotector homeobox
Aliases KIAA0784; ADNP1; ADNP homeobox 1; activity-dependent neuroprotector; HVDAS; MRD28; activity-dependent neurop ......
Chromosomal Location20q13.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ADNP expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolADNP
Nameactivity-dependent neuroprotector homeobox
Aliases KIAA0784; ADNP1; ADNP homeobox 1; activity-dependent neuroprotector; HVDAS; MRD28; activity-dependent neurop ......
Chromosomal Location20q13.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ADNP and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolADNP
Nameactivity-dependent neuroprotector homeobox
Aliases KIAA0784; ADNP1; ADNP homeobox 1; activity-dependent neuroprotector; HVDAS; MRD28; activity-dependent neurop ......
Chromosomal Location20q13.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ADNP collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.