Browse ADRA1A

Summary
SymbolADRA1A
Nameadrenoceptor alpha 1A
Aliases ADRA1L1; ADRA1C; ALPHA1AAR; G protein coupled receptor; adrenergic, alpha-1A-, receptor variant 1; adrenergi ......
Chromosomal Location8p21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus membrane; Multi-pass membrane protein. Cell membrane Multi-pass membrane protein Cytoplasm Membrane, caveola Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.
Domain PF00001 7 transmembrane receptor (rhodopsin family)
Function

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.

> Gene Ontology
 
Biological Process GO:0001508 action potential
GO:0001976 neurological system process involved in regulation of systemic arterial blood pressure
GO:0001978 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback
GO:0001983 baroreceptor response to increased systemic arterial blood pressure
GO:0001985 negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
GO:0001993 regulation of systemic arterial blood pressure by norepinephrine-epinephrine
GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine
GO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine
GO:0002026 regulation of the force of heart contraction
GO:0002027 regulation of heart rate
GO:0003012 muscle system process
GO:0003013 circulatory system process
GO:0003014 renal system process
GO:0003015 heart process
GO:0003018 vascular process in circulatory system
GO:0003025 regulation of systemic arterial blood pressure by baroreceptor feedback
GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal
GO:0003057 regulation of the force of heart contraction by chemical signal
GO:0003073 regulation of systemic arterial blood pressure
GO:0003084 positive regulation of systemic arterial blood pressure
GO:0003085 negative regulation of systemic arterial blood pressure
GO:0003099 positive regulation of the force of heart contraction by chemical signal
GO:0003321 positive regulation of blood pressure by epinephrine-norepinephrine
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0006936 muscle contraction
GO:0006937 regulation of muscle contraction
GO:0006939 smooth muscle contraction
GO:0006940 regulation of smooth muscle contraction
GO:0006941 striated muscle contraction
GO:0006942 regulation of striated muscle contraction
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007265 Ras protein signal transduction
GO:0007266 Rho protein signal transduction
GO:0007270 neuron-neuron synaptic transmission
GO:0007507 heart development
GO:0007512 adult heart development
GO:0007568 aging
GO:0007588 excretion
GO:0008015 blood circulation
GO:0008016 regulation of heart contraction
GO:0008217 regulation of blood pressure
GO:0010459 negative regulation of heart rate
GO:0010460 positive regulation of heart rate
GO:0010517 regulation of phospholipase activity
GO:0010518 positive regulation of phospholipase activity
GO:0010863 positive regulation of phospholipase C activity
GO:0016049 cell growth
GO:0019229 regulation of vasoconstriction
GO:0032228 regulation of synaptic transmission, GABAergic
GO:0032230 positive regulation of synaptic transmission, GABAergic
GO:0035023 regulation of Rho protein signal transduction
GO:0035024 negative regulation of Rho protein signal transduction
GO:0035150 regulation of tube size
GO:0035265 organ growth
GO:0042310 vasoconstriction
GO:0042391 regulation of membrane potential
GO:0042493 response to drug
GO:0043410 positive regulation of MAPK cascade
GO:0044057 regulation of system process
GO:0045760 positive regulation of action potential
GO:0045776 negative regulation of blood pressure
GO:0045777 positive regulation of blood pressure
GO:0045822 negative regulation of heart contraction
GO:0045823 positive regulation of heart contraction
GO:0045907 positive regulation of vasoconstriction
GO:0045933 positive regulation of muscle contraction
GO:0045987 positive regulation of smooth muscle contraction
GO:0045989 positive regulation of striated muscle contraction
GO:0046578 regulation of Ras protein signal transduction
GO:0046580 negative regulation of Ras protein signal transduction
GO:0050804 modulation of synaptic transmission
GO:0050806 positive regulation of synaptic transmission
GO:0050880 regulation of blood vessel size
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051058 negative regulation of small GTPase mediated signal transduction
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051932 synaptic transmission, GABAergic
GO:0055074 calcium ion homeostasis
GO:0055117 regulation of cardiac muscle contraction
GO:0060004 reflex
GO:0060047 heart contraction
GO:0060048 cardiac muscle contraction
GO:0060073 micturition
GO:0060191 regulation of lipase activity
GO:0060193 positive regulation of lipase activity
GO:0060401 cytosolic calcium ion transport
GO:0060402 calcium ion transport into cytosol
GO:0060452 positive regulation of cardiac muscle contraction
GO:0070371 ERK1 and ERK2 cascade
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070528 protein kinase C signaling
GO:0070838 divalent metal ion transport
GO:0071875 adrenergic receptor signaling pathway
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072511 divalent inorganic cation transport
GO:0090036 regulation of protein kinase C signaling
GO:0090037 positive regulation of protein kinase C signaling
GO:0090066 regulation of anatomical structure size
GO:0090257 regulation of muscle system process
GO:0097195 pilomotor reflex
GO:0098900 regulation of action potential
GO:1900274 regulation of phospholipase C activity
GO:1902532 negative regulation of intracellular signal transduction
GO:1903522 regulation of blood circulation
GO:1903523 negative regulation of blood circulation
GO:1903524 positive regulation of blood circulation
Molecular Function GO:0004935 adrenergic receptor activity
GO:0004936 alpha-adrenergic receptor activity
GO:0004937 alpha1-adrenergic receptor activity
GO:0008227 G-protein coupled amine receptor activity
GO:0046982 protein heterodimerization activity
Cellular Component GO:0005635 nuclear envelope
GO:0030016 myofibril
GO:0030017 sarcomere
GO:0030018 Z disc
GO:0030315 T-tubule
GO:0031674 I band
GO:0031965 nuclear membrane
GO:0042383 sarcolemma
GO:0043292 contractile fiber
GO:0044449 contractile fiber part
> KEGG and Reactome Pathway
 
KEGG hsa04020 Calcium signaling pathway
hsa04022 cGMP-PKG signaling pathway
hsa04080 Neuroactive ligand-receptor interaction
hsa04152 AMPK signaling pathway
hsa04261 Adrenergic signaling in cardiomyocytes
hsa04270 Vascular smooth muscle contraction
hsa04970 Salivary secretion
Reactome R-HSA-390696: Adrenoceptors
R-HSA-375280: Amine ligand-binding receptors
R-HSA-373076: Class A/1 (Rhodopsin-like receptors)
R-HSA-416482: G alpha (12/13) signalling events
R-HSA-416476: G alpha (q) signalling events
R-HSA-388396: GPCR downstream signaling
R-HSA-500792: GPCR ligand binding
R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
Summary
SymbolADRA1A
Nameadrenoceptor alpha 1A
Aliases ADRA1L1; ADRA1C; ALPHA1AAR; G protein coupled receptor; adrenergic, alpha-1A-, receptor variant 1; adrenergi ......
Chromosomal Location8p21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ADRA1A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolADRA1A
Nameadrenoceptor alpha 1A
Aliases ADRA1L1; ADRA1C; ALPHA1AAR; G protein coupled receptor; adrenergic, alpha-1A-, receptor variant 1; adrenergi ......
Chromosomal Location8p21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ADRA1A in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolADRA1A
Nameadrenoceptor alpha 1A
Aliases ADRA1L1; ADRA1C; ALPHA1AAR; G protein coupled receptor; adrenergic, alpha-1A-, receptor variant 1; adrenergi ......
Chromosomal Location8p21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ADRA1A in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.2890.367
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.0130.983
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.4950.347
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.8990.0989
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.9190.548
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.8780.621
729033130MelanomaallAnti-PD-1 (nivolumab) 26231.3470.127
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.8670.216
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.7560.636
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.3660.645
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.1420.895
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.6830.0333
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ADRA1A in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277305.5-5.50.572
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275906.8-6.80.304
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.55.93.61
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.49.16.31
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59200200.357
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolADRA1A
Nameadrenoceptor alpha 1A
Aliases ADRA1L1; ADRA1C; ALPHA1AAR; G protein coupled receptor; adrenergic, alpha-1A-, receptor variant 1; adrenergi ......
Chromosomal Location8p21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ADRA1A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolADRA1A
Nameadrenoceptor alpha 1A
Aliases ADRA1L1; ADRA1C; ALPHA1AAR; G protein coupled receptor; adrenergic, alpha-1A-, receptor variant 1; adrenergi ......
Chromosomal Location8p21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ADRA1A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ADRA1A.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolADRA1A
Nameadrenoceptor alpha 1A
Aliases ADRA1L1; ADRA1C; ALPHA1AAR; G protein coupled receptor; adrenergic, alpha-1A-, receptor variant 1; adrenergi ......
Chromosomal Location8p21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ADRA1A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolADRA1A
Nameadrenoceptor alpha 1A
Aliases ADRA1L1; ADRA1C; ALPHA1AAR; G protein coupled receptor; adrenergic, alpha-1A-, receptor variant 1; adrenergi ......
Chromosomal Location8p21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ADRA1A expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolADRA1A
Nameadrenoceptor alpha 1A
Aliases ADRA1L1; ADRA1C; ALPHA1AAR; G protein coupled receptor; adrenergic, alpha-1A-, receptor variant 1; adrenergi ......
Chromosomal Location8p21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ADRA1A and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolADRA1A
Nameadrenoceptor alpha 1A
Aliases ADRA1L1; ADRA1C; ALPHA1AAR; G protein coupled receptor; adrenergic, alpha-1A-, receptor variant 1; adrenergi ......
Chromosomal Location8p21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ADRA1A collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting ADRA1A.
ID Name Drug Type Targets #Targets
DB00182AmphetamineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB ......19
DB00211MidodrineSmall MoleculeADRA1A, ADRA1B, ADRA1D3
DB00215CitalopramSmall MoleculeADRA1A, CHRM1, HRH1, HTR2C, SLC6A45
DB00246ZiprasidoneSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM3, CHRM4 ......25
DB00248CabergolineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, DRD1 ......22
DB00298DapiprazoleSmall MoleculeADRA1A, ADRA1B, ADRA1D3
DB00321AmitriptylineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, ......35
DB00334OlanzapineSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1 ......50
DB00346AlfuzosinSmall MoleculeADRA1A, ADRA1B, ADRA1D, KCNH24
DB00363ClozapineSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, CALY, CHRM1, CHRM2, CHRM3, ......27
DB00368NorepinephrineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB ......12
DB00370MirtazapineSmall MoleculeADRA1A, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, DRD1 ......23
DB00370MirtazapineSmall MoleculeADRA1A, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, DRD1 ......23
DB00388PhenylephrineSmall MoleculeADRA1A, ADRA1B, ADRA1D3
DB00408LoxapineSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, CHRM1, CHRM2, CHRM3 ......34
DB00420PromazineSmall MoleculeADRA1A, ADRA1B, ADRA1D, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, D ......14
DB00449DipivefrinSmall MoleculeACHE, ADRA1A, ADRA2A, ADRB2, BCHE5
DB00450DroperidolSmall MoleculeADRA1A, DRD22
DB00457PrazosinSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, KCNH2, KCNH6, KCNH78
DB00458ImipramineSmall MoleculeADRA1A, ADRA1B, ADRA1D, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, D ......25
DB00477ChlorpromazineSmall MoleculeADRA1A, ADRA1A, ADRA1B, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CH ......31
DB00477ChlorpromazineSmall MoleculeADRA1A, ADRA1A, ADRA1B, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CH ......31
DB00540NortriptylineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB ......24
DB00543AmoxapineSmall MoleculeADRA1A, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2A, ADRA2B, ADRA2C, CH ......48
DB00543AmoxapineSmall MoleculeADRA1A, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2A, ADRA2B, ADRA2C, CH ......48
DB00555LamotrigineSmall MoleculeADORA1, ADORA2A, ADRA1A, ADRA2A, ADRB1, CACNA1E, CHRM1, CHRM2, CHR ......44
DB00575ClonidineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C6
DB00590DoxazosinSmall MoleculeADRA1A, ADRA1B, ADRA1D, KCNH2, KCNH6, KCNH76
DB00598LabetalolSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB25
DB00610MetaraminolSmall MoleculeADRA1A1
DB00622NicardipineSmall MoleculeADRA1A, ADRA1B, ADRA1D, CACNA1C, CACNA1D, CACNA2D1, CACNB2, CHRM1, ......14
DB00656TrazodoneSmall MoleculeADRA1A, ADRA2A, HRH1, HTR1A, HTR2A, HTR2C, SLC6A47
DB00661VerapamilSmall MoleculeADRA1A, ADRA1B, ADRA1D, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1 ......19
DB00668EpinephrineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB ......12
DB00679ThioridazineSmall MoleculeADRA1A, ADRA1B, DRD1, DRD2, HTR2A, KCNH26
DB00692PhentolamineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A4
DB00696ErgotamineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, DRD1, DRD2, DRD5, HTR1A, H ......16
DB00699NicergolineSmall MoleculeADRA1A1
DB00706TamsulosinSmall MoleculeADRA1A, ADRA1B, ADRA1D3
DB00723MethoxamineSmall MoleculeADRA1A, ADRA1B, ADRA1D3
DB00726TrimipramineSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, ......24
DB00734RisperidoneSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, DRD4, HR ......15
DB00751EpinastineSmall MoleculeADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR76
DB00777PropiomazineSmall MoleculeADRA1A, ADRA1B, ADRA1D, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, D ......14
DB00797TolazolineSmall MoleculeADRA1A, ADRA2A, ADRA2B, ADRA2C, HRH1, HRH26
DB00800FenoldopamSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD58
DB00831TrifluoperazineSmall MoleculeADRA1A, CALY, DRD2, S100A4, TNNC15
DB00852PseudoephedrineSmall MoleculeADRA1A, ADRA2A, ADRB1, ADRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATF6, ......20
DB00865BenzphetamineSmall MoleculeADRA1A, ADRA2A, SLC18A2, SLC6A34
DB00875FlupentixolSmall MoleculeADRA1A, CHRM1, DRD1, DRD2, HTR2A5
DB00908QuinidineSmall MoleculeADRA1A, ADRA1B, ADRA1D, KCNH2, KCNK1, KCNK6, SCN5A7
DB00925PhenoxybenzamineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB27
DB00934MaprotilineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM ......17
DB00935OxymetazolineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C6
DB00964ApraclonidineSmall MoleculeADRA1A, ADRA2A, ADRA2B3
DB01049Ergoloid mesylateSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, GABRA1 ......41
DB01069PromethazineSmall MoleculeADRA1A, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD2, HRH1, HRH2, HTR2A10
DB01136CarvedilolSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, GJA1 ......17
DB01142DoxepinSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM ......23
DB01149NefazodoneSmall MoleculeADRA1A, ADRA1B, ADRA2A, HTR1A, HTR2A, HTR2C, KCNH2, SLC6A2, SLC6A3 ......10
DB01151DesipramineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, CHRM ......21
DB01162TerazosinSmall MoleculeADRA1A, ADRA1B, ADRA1D, KCNH2, KCNH6, KCNH76
DB01175EscitalopramSmall MoleculeADRA1A, CHRM1, HRH1, SLC6A2, SLC6A3, SLC6A46
DB01186PergolideSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, ......17
DB01200BromocriptineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, ......18
DB01224QuetiapineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM ......26
DB01238AripiprazoleSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM3, CHRM4 ......25
DB01253ErgonovineSmall MoleculeADRA1A1
DB01267PaliperidoneSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, CYP2D6, CYP3A4, CYP3A5, DR ......18
DB01295BevantololSmall MoleculeADRA1A, ADRB1, ADRB23
DB01364EphedrineSmall MoleculeACHE, ADRA1A, SLC18A2, SLC6A24
DB01365MephentermineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB ......9
DB01403MethotrimeprazineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM ......19
DB014724-MethoxyamphetamineSmall MoleculeADRA1A, ADRA2A, MAOA, MAOB, SLC18A2, SLC6A3, SLC6A47
DB01576DextroamphetamineSmall MoleculeADRA1A, ADRA1B, SLC18A2, SLC6A2, SLC6A3, TAAR16
DB01579PhendimetrazineSmall MoleculeADRA1A, ADRA1B, SLC6A23
DB01614AcepromazineSmall MoleculeADRA1A, ADRA1B, DRD1, DRD2, HTR1A, HTR2A6
DB01622ThioproperazineSmall MoleculeADRA1A, ADRA1B, DRD1, DRD2, HTR1A, HTR2A6
DB01624ZuclopenthixolSmall MoleculeADRA1A, ADRA2A, DRD1, DRD2, DRD5, HRH1, HTR2A7
DB04855DronedaroneSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, CACNA1C, CA ......18
DB04946IloperidoneSmall MoleculeADRA1A, ADRA2C, DRD1, DRD2, DRD3, DRD4, HRH1, HTR1A, HTR2A, HTR6, ......11
DB05469R450Small MoleculeADRA1A, ADRA1B, ADRA1D3
DB05492Epicept NP-1Small MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, HRH1, HTR2A, HTR2B ......12
DB06144SertindoleSmall MoleculeADRA1A, ADRA1B, ADRA1D, DRD2, HTR2A, HTR2C, HTR6, KCNH28
DB06148MianserinSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, ......23
DB06207SilodosinSmall MoleculeADRA1A, ADRA1B, ADRA1D3
DB06216AsenapineSmall MoleculeADRA1A, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, DRD1, DRD2, DRD3, DR ......20
DB06229OcaperidoneSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, DRD2, HRH1, HTR2A, ......11
DB06262DroxidopaSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB ......10
DB06694XylometazolineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C6
DB06706IsomethepteneSmall MoleculeADRA1A, SLC18A22
DB06711NaphazolineSmall MoleculeADRA1A, ADRA2A2
DB06764TetryzolineSmall MoleculeADRA1A1
DB08922PerospironeSmall MoleculeADRA1A, ADRA1B, ADRA1D, DRD2, DRD4, HRH1, HTR1A, HTR2A8
DB08950IndoraminSmall MoleculeADRA1A1
DB09167DosulepinSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM ......16
DB09194EtoperidoneSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM ......15
DB09195LorpiprazoleSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, HRH1, HTR2A, HTR2C ......10
DB09202CirazolineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C6
DB09203SynephrineSmall MoleculeADRA1A, ADRA1B, ADRA1D3
DB09204ArotinololSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB25
DB09205MoxisylyteSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C6
DB09229AranidipineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CACNA1C, CACNA1D, ......10
DB09239NiguldipineSmall MoleculeADRA1A1
DB09286PipamperoneSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, DRD1, DRD2, DRD3, DRD4, HTR2A, HTR ......10
DB11124RacepinephrineSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB27
DB13025TiaprideSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, DRD2, DRD3, HRH1, ......25