Summary | |
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Symbol | ADRA2C |
Name | adrenoceptor alpha 2C |
Aliases | ADRARL2; ADRA2L2; ADRA2RL2; adrenergic, alpha-2C-, receptor; ALPHA2CAR; alpha-2 adrenergic receptor subtype ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Domain |
PF00001 7 transmembrane receptor (rhodopsin family) |
Function |
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. |
Biological Process |
GO:0000187 activation of MAPK activity GO:0002790 peptide secretion GO:0002791 regulation of peptide secretion GO:0003012 muscle system process GO:0003013 circulatory system process GO:0003018 vascular process in circulatory system GO:0006936 muscle contraction GO:0006937 regulation of muscle contraction GO:0006939 smooth muscle contraction GO:0006940 regulation of smooth muscle contraction GO:0007173 epidermal growth factor receptor signaling pathway GO:0007176 regulation of epidermal growth factor-activated receptor activity GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007565 female pregnancy GO:0007596 blood coagulation GO:0007599 hemostasis GO:0008015 blood circulation GO:0009306 protein secretion GO:0009914 hormone transport GO:0010469 regulation of receptor activity GO:0010700 negative regulation of norepinephrine secretion GO:0010720 positive regulation of cell development GO:0010817 regulation of hormone levels GO:0014060 regulation of epinephrine secretion GO:0014061 regulation of norepinephrine secretion GO:0015833 peptide transport GO:0015837 amine transport GO:0015844 monoamine transport GO:0015850 organic hydroxy compound transport GO:0015874 norepinephrine transport GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0019229 regulation of vasoconstriction GO:0019233 sensory perception of pain GO:0023061 signal release GO:0030072 peptide hormone secretion GO:0030073 insulin secretion GO:0030168 platelet activation GO:0031644 regulation of neurological system process GO:0032147 activation of protein kinase activity GO:0032148 activation of protein kinase B activity GO:0032811 negative regulation of epinephrine secretion GO:0033604 negative regulation of catecholamine secretion GO:0033674 positive regulation of kinase activity GO:0035150 regulation of tube size GO:0035624 receptor transactivation GO:0035625 epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway GO:0038127 ERBB signaling pathway GO:0042058 regulation of epidermal growth factor receptor signaling pathway GO:0042310 vasoconstriction GO:0042886 amide transport GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0044057 regulation of system process GO:0044706 multi-multicellular organism process GO:0045666 positive regulation of neuron differentiation GO:0045741 positive regulation of epidermal growth factor-activated receptor activity GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway GO:0045860 positive regulation of protein kinase activity GO:0045907 positive regulation of vasoconstriction GO:0045932 negative regulation of muscle contraction GO:0045986 negative regulation of smooth muscle contraction GO:0046879 hormone secretion GO:0046883 regulation of hormone secretion GO:0046888 negative regulation of hormone secretion GO:0048241 epinephrine transport GO:0048242 epinephrine secretion GO:0048243 norepinephrine secretion GO:0050432 catecholamine secretion GO:0050433 regulation of catecholamine secretion GO:0050708 regulation of protein secretion GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050769 positive regulation of neurogenesis GO:0050796 regulation of insulin secretion GO:0050817 coagulation GO:0050878 regulation of body fluid levels GO:0050880 regulation of blood vessel size GO:0051048 negative regulation of secretion GO:0051051 negative regulation of transport GO:0051930 regulation of sensory perception of pain GO:0051931 regulation of sensory perception GO:0051937 catecholamine transport GO:0051952 regulation of amine transport GO:0051953 negative regulation of amine transport GO:0051962 positive regulation of nervous system development GO:0061097 regulation of protein tyrosine kinase activity GO:0061098 positive regulation of protein tyrosine kinase activity GO:0070471 uterine smooth muscle contraction GO:0070472 regulation of uterine smooth muscle contraction GO:0070473 negative regulation of uterine smooth muscle contraction GO:0071875 adrenergic receptor signaling pathway GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0090066 regulation of anatomical structure size GO:0090087 regulation of peptide transport GO:0090257 regulation of muscle system process GO:0090276 regulation of peptide hormone secretion GO:1901184 regulation of ERBB signaling pathway GO:1901186 positive regulation of ERBB signaling pathway GO:1903522 regulation of blood circulation GO:1903524 positive regulation of blood circulation GO:1903531 negative regulation of secretion by cell GO:2000273 positive regulation of receptor activity |
Molecular Function |
GO:0001664 G-protein coupled receptor binding GO:0004935 adrenergic receptor activity GO:0004936 alpha-adrenergic receptor activity GO:0004938 alpha2-adrenergic receptor activity GO:0008227 G-protein coupled amine receptor activity GO:0031690 adrenergic receptor binding GO:0031694 alpha-2A adrenergic receptor binding GO:0046982 protein heterodimerization activity GO:0051379 epinephrine binding GO:1901338 catecholamine binding |
Cellular Component |
GO:0030424 axon GO:0033267 axon part GO:0043679 axon terminus GO:0044306 neuron projection terminus |
KEGG |
hsa04022 cGMP-PKG signaling pathway hsa04080 Neuroactive ligand-receptor interaction |
Reactome |
R-HSA-392023: Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-400042: Adrenaline,noradrenaline inhibits insulin secretion R-HSA-390696: Adrenoceptors R-HSA-375280: Amine ligand-binding receptors R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-418594: G alpha (i) signalling events R-HSA-418597: G alpha (z) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-109582: Hemostasis R-HSA-163685: Integration of energy metabolism R-HSA-1430728: Metabolism R-HSA-392499: Metabolism of proteins R-HSA-76009: Platelet Aggregation (Plug Formation) R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-422356: Regulation of insulin secretion R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR R-HSA-5683826: Surfactant metabolism |
Summary | |
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Symbol | ADRA2C |
Name | adrenoceptor alpha 2C |
Aliases | ADRARL2; ADRA2L2; ADRA2RL2; adrenergic, alpha-2C-, receptor; ALPHA2CAR; alpha-2 adrenergic receptor subtype ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ADRA2C and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | ADRA2C |
Name | adrenoceptor alpha 2C |
Aliases | ADRARL2; ADRA2L2; ADRA2RL2; adrenergic, alpha-2C-, receptor; ALPHA2CAR; alpha-2 adrenergic receptor subtype ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ADRA2C in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ADRA2C |
Name | adrenoceptor alpha 2C |
Aliases | ADRARL2; ADRA2L2; ADRA2RL2; adrenergic, alpha-2C-, receptor; ALPHA2CAR; alpha-2 adrenergic receptor subtype ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ADRA2C in various data sets.
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Points in the above scatter plot represent the mutation difference of ADRA2C in various data sets.
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Summary | |
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Symbol | ADRA2C |
Name | adrenoceptor alpha 2C |
Aliases | ADRARL2; ADRA2L2; ADRA2RL2; adrenergic, alpha-2C-, receptor; ALPHA2CAR; alpha-2 adrenergic receptor subtype ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ADRA2C. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ADRA2C |
Name | adrenoceptor alpha 2C |
Aliases | ADRARL2; ADRA2L2; ADRA2RL2; adrenergic, alpha-2C-, receptor; ALPHA2CAR; alpha-2 adrenergic receptor subtype ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ADRA2C. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ADRA2C. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ADRA2C |
Name | adrenoceptor alpha 2C |
Aliases | ADRARL2; ADRA2L2; ADRA2RL2; adrenergic, alpha-2C-, receptor; ALPHA2CAR; alpha-2 adrenergic receptor subtype ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ADRA2C. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ADRA2C |
Name | adrenoceptor alpha 2C |
Aliases | ADRARL2; ADRA2L2; ADRA2RL2; adrenergic, alpha-2C-, receptor; ALPHA2CAR; alpha-2 adrenergic receptor subtype ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ADRA2C expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ADRA2C |
Name | adrenoceptor alpha 2C |
Aliases | ADRARL2; ADRA2L2; ADRA2RL2; adrenergic, alpha-2C-, receptor; ALPHA2CAR; alpha-2 adrenergic receptor subtype ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ADRA2C and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ADRA2C |
Name | adrenoceptor alpha 2C |
Aliases | ADRARL2; ADRA2L2; ADRA2RL2; adrenergic, alpha-2C-, receptor; ALPHA2CAR; alpha-2 adrenergic receptor subtype ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ADRA2C collected from DrugBank database. |
Details on drugs targeting ADRA2C.
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