Summary | |
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Symbol | AGBL1 |
Name | ATP/GTP binding protein-like 1 |
Aliases | FLJ32310; CCP4; cytosolic carboxypeptidase 4; FECD8; ATP/GTP-binding protein-like 1 |
Chromosomal Location | 15q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, cytosol |
Domain |
PF00246 Zinc carboxypeptidase |
Function |
Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. |
Biological Process |
GO:0018200 peptidyl-glutamic acid modification GO:0018410 C-terminal protein amino acid modification GO:0035608 protein deglutamylation GO:0035609 C-terminal protein deglutamylation GO:0035610 protein side chain deglutamylation GO:0043687 post-translational protein modification |
Molecular Function |
GO:0004180 carboxypeptidase activity GO:0004181 metallocarboxypeptidase activity GO:0008235 metalloexopeptidase activity GO:0008237 metallopeptidase activity GO:0008238 exopeptidase activity GO:0015631 tubulin binding |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | AGBL1 |
Name | ATP/GTP binding protein-like 1 |
Aliases | FLJ32310; CCP4; cytosolic carboxypeptidase 4; FECD8; ATP/GTP-binding protein-like 1 |
Chromosomal Location | 15q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between AGBL1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | AGBL1 |
Name | ATP/GTP binding protein-like 1 |
Aliases | FLJ32310; CCP4; cytosolic carboxypeptidase 4; FECD8; ATP/GTP-binding protein-like 1 |
Chromosomal Location | 15q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of AGBL1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | AGBL1 |
Name | ATP/GTP binding protein-like 1 |
Aliases | FLJ32310; CCP4; cytosolic carboxypeptidase 4; FECD8; ATP/GTP-binding protein-like 1 |
Chromosomal Location | 15q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of AGBL1 in various data sets.
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Points in the above scatter plot represent the mutation difference of AGBL1 in various data sets.
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Summary | |
---|---|
Symbol | AGBL1 |
Name | ATP/GTP binding protein-like 1 |
Aliases | FLJ32310; CCP4; cytosolic carboxypeptidase 4; FECD8; ATP/GTP-binding protein-like 1 |
Chromosomal Location | 15q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of AGBL1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | AGBL1 |
Name | ATP/GTP binding protein-like 1 |
Aliases | FLJ32310; CCP4; cytosolic carboxypeptidase 4; FECD8; ATP/GTP-binding protein-like 1 |
Chromosomal Location | 15q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of AGBL1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by AGBL1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | AGBL1 |
Name | ATP/GTP binding protein-like 1 |
Aliases | FLJ32310; CCP4; cytosolic carboxypeptidase 4; FECD8; ATP/GTP-binding protein-like 1 |
Chromosomal Location | 15q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of AGBL1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | AGBL1 |
Name | ATP/GTP binding protein-like 1 |
Aliases | FLJ32310; CCP4; cytosolic carboxypeptidase 4; FECD8; ATP/GTP-binding protein-like 1 |
Chromosomal Location | 15q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of AGBL1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | AGBL1 |
Name | ATP/GTP binding protein-like 1 |
Aliases | FLJ32310; CCP4; cytosolic carboxypeptidase 4; FECD8; ATP/GTP-binding protein-like 1 |
Chromosomal Location | 15q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between AGBL1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | AGBL1 |
Name | ATP/GTP binding protein-like 1 |
Aliases | FLJ32310; CCP4; cytosolic carboxypeptidase 4; FECD8; ATP/GTP-binding protein-like 1 |
Chromosomal Location | 15q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting AGBL1 collected from DrugBank database. |
There is no record. |