Browse AGTR1

Summary
SymbolAGTR1
Nameangiotensin II receptor, type 1
Aliases AT2R1; AGTR1A; AT2R1A; HAT1R; AG2S; AT2R1B; AT1B; AGTR1B; angiotensin receptor 1B; AG2SB; AT1AR; AT1BR; AT1R ......
Chromosomal Location3q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane; Multi-pass membrane protein.
Domain PF00001 7 transmembrane receptor (rhodopsin family)
Function

Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

> Gene Ontology
 
Biological Process GO:0001558 regulation of cell growth
GO:0001655 urogenital system development
GO:0001822 kidney development
GO:0001990 regulation of systemic arterial blood pressure by hormone
GO:0002016 regulation of blood volume by renin-angiotensin
GO:0002018 renin-angiotensin regulation of aldosterone production
GO:0002034 regulation of blood vessel size by renin-angiotensin
GO:0003013 circulatory system process
GO:0003014 renal system process
GO:0003018 vascular process in circulatory system
GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal
GO:0003071 renal system process involved in regulation of systemic arterial blood pressure
GO:0003072 renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure
GO:0003073 regulation of systemic arterial blood pressure
GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin
GO:0006869 lipid transport
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007265 Ras protein signal transduction
GO:0007266 Rho protein signal transduction
GO:0007588 excretion
GO:0008015 blood circulation
GO:0008202 steroid metabolic process
GO:0008217 regulation of blood pressure
GO:0009914 hormone transport
GO:0010517 regulation of phospholipase activity
GO:0010518 positive regulation of phospholipase activity
GO:0010742 macrophage derived foam cell differentiation
GO:0010743 regulation of macrophage derived foam cell differentiation
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0010817 regulation of hormone levels
GO:0010872 regulation of cholesterol esterification
GO:0010873 positive regulation of cholesterol esterification
GO:0010876 lipid localization
GO:0015850 organic hydroxy compound transport
GO:0016049 cell growth
GO:0019216 regulation of lipid metabolic process
GO:0019218 regulation of steroid metabolic process
GO:0019229 regulation of vasoconstriction
GO:0019722 calcium-mediated signaling
GO:0019932 second-messenger-mediated signaling
GO:0023061 signal release
GO:0030258 lipid modification
GO:0031349 positive regulation of defense response
GO:0032103 positive regulation of response to external stimulus
GO:0032368 regulation of lipid transport
GO:0032429 regulation of phospholipase A2 activity
GO:0032430 positive regulation of phospholipase A2 activity
GO:0032844 regulation of homeostatic process
GO:0033860 regulation of NAD(P)H oxidase activity
GO:0033864 positive regulation of NAD(P)H oxidase activity
GO:0034367 macromolecular complex remodeling
GO:0034368 protein-lipid complex remodeling
GO:0034369 plasma lipoprotein particle remodeling
GO:0034374 low-density lipoprotein particle remodeling
GO:0034433 steroid esterification
GO:0034434 sterol esterification
GO:0034435 cholesterol esterification
GO:0035150 regulation of tube size
GO:0035812 renal sodium excretion
GO:0035813 regulation of renal sodium excretion
GO:0035929 steroid hormone secretion
GO:0035930 corticosteroid hormone secretion
GO:0035931 mineralocorticoid secretion
GO:0035932 aldosterone secretion
GO:0038166 angiotensin-activated signaling pathway
GO:0042310 vasoconstriction
GO:0042311 vasodilation
GO:0042312 regulation of vasodilation
GO:0043434 response to peptide hormone
GO:0044057 regulation of system process
GO:0044060 regulation of endocrine process
GO:0044062 regulation of excretion
GO:0045834 positive regulation of lipid metabolic process
GO:0045940 positive regulation of steroid metabolic process
GO:0046879 hormone secretion
GO:0046883 regulation of hormone secretion
GO:0050727 regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0050880 regulation of blood vessel size
GO:0050886 endocrine process
GO:0051341 regulation of oxidoreductase activity
GO:0051353 positive regulation of oxidoreductase activity
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0055067 monovalent inorganic cation homeostasis
GO:0055074 calcium ion homeostasis
GO:0055078 sodium ion homeostasis
GO:0060191 regulation of lipase activity
GO:0060193 positive regulation of lipase activity
GO:0060326 cell chemotaxis
GO:0060986 endocrine hormone secretion
GO:0071375 cellular response to peptide hormone stimulus
GO:0071417 cellular response to organonitrogen compound
GO:0071825 protein-lipid complex subunit organization
GO:0071827 plasma lipoprotein particle organization
GO:0072001 renal system development
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072593 reactive oxygen species metabolic process
GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway
GO:0090066 regulation of anatomical structure size
GO:0090077 foam cell differentiation
GO:0097006 regulation of plasma lipoprotein particle levels
GO:0098801 regulation of renal system process
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:1903522 regulation of blood circulation
GO:1904385 cellular response to angiotensin
GO:1990776 response to angiotensin
GO:2000021 regulation of ion homeostasis
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000831 regulation of steroid hormone secretion
GO:2000846 regulation of corticosteroid hormone secretion
GO:2000855 regulation of mineralocorticoid secretion
GO:2000858 regulation of aldosterone secretion
Molecular Function GO:0001595 angiotensin receptor activity
GO:0001596 angiotensin type I receptor activity
GO:0001653 peptide receptor activity
GO:0001664 G-protein coupled receptor binding
GO:0004945 angiotensin type II receptor activity
GO:0008528 G-protein coupled peptide receptor activity
GO:0031711 bradykinin receptor binding
GO:0046982 protein heterodimerization activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04020 Calcium signaling pathway
hsa04022 cGMP-PKG signaling pathway
hsa04080 Neuroactive ligand-receptor interaction
hsa04261 Adrenergic signaling in cardiomyocytes
hsa04270 Vascular smooth muscle contraction
hsa04614 Renin-angiotensin system
Reactome R-HSA-8856825: Cargo recognition for clathrin-mediated endocytosis
R-HSA-373076: Class A/1 (Rhodopsin-like receptors)
R-HSA-8856828: Clathrin-mediated endocytosis
R-HSA-416476: G alpha (q) signalling events
R-HSA-388396: GPCR downstream signaling
R-HSA-500792: GPCR ligand binding
R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-199991: Membrane Trafficking
R-HSA-375276: Peptide ligand-binding receptors
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolAGTR1
Nameangiotensin II receptor, type 1
Aliases AT2R1; AGTR1A; AT2R1A; HAT1R; AG2S; AT2R1B; AT1B; AGTR1B; angiotensin receptor 1B; AG2SB; AT1AR; AT1BR; AT1R ......
Chromosomal Location3q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between AGTR1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between AGTR1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
29034589Colon CarcinomaInhibit immunity (T cell function)Giving angiotensin II receptor blockers (ARB) to C57BL/6 mice bearing murine colon cancer cell line MC38 resulted in significant enhancement of tumor antigen gp70 specific T cells. ARB administration did not change the numbers of CD11b+ myeloid cells in tumors, but significantly reduced their T-cell inhibitory ability along with decreased production of various immunosuppressive factors including interleukin (IL)-6, IL-10, vascular endothelial growth factor (VEGF), and arginase by CD11b+ cells in tumors.
Summary
SymbolAGTR1
Nameangiotensin II receptor, type 1
Aliases AT2R1; AGTR1A; AT2R1A; HAT1R; AG2S; AT2R1B; AT1B; AGTR1B; angiotensin receptor 1B; AG2SB; AT1AR; AT1BR; AT1R ......
Chromosomal Location3q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of AGTR1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolAGTR1
Nameangiotensin II receptor, type 1
Aliases AT2R1; AGTR1A; AT2R1A; HAT1R; AG2S; AT2R1B; AT1B; AGTR1B; angiotensin receptor 1B; AG2SB; AT1AR; AT1BR; AT1R ......
Chromosomal Location3q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of AGTR1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.570.199
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.5670.0281
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.1630.795
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1470.754
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0720.953
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.2520.843
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.6210.482
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2360.851
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-1.2650.334
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.9150.367
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 282.3830.0555
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.8480.00333
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of AGTR1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.75.5-1.81
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.75.1-1.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.63.7-1.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.57.7-3.21
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolAGTR1
Nameangiotensin II receptor, type 1
Aliases AT2R1; AGTR1A; AT2R1A; HAT1R; AG2S; AT2R1B; AT1B; AGTR1B; angiotensin receptor 1B; AG2SB; AT1AR; AT1BR; AT1R ......
Chromosomal Location3q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of AGTR1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolAGTR1
Nameangiotensin II receptor, type 1
Aliases AT2R1; AGTR1A; AT2R1A; HAT1R; AG2S; AT2R1B; AT1B; AGTR1B; angiotensin receptor 1B; AG2SB; AT1AR; AT1BR; AT1R ......
Chromosomal Location3q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of AGTR1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by AGTR1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolAGTR1
Nameangiotensin II receptor, type 1
Aliases AT2R1; AGTR1A; AT2R1A; HAT1R; AG2S; AT2R1B; AT1B; AGTR1B; angiotensin receptor 1B; AG2SB; AT1AR; AT1BR; AT1R ......
Chromosomal Location3q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of AGTR1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolAGTR1
Nameangiotensin II receptor, type 1
Aliases AT2R1; AGTR1A; AT2R1A; HAT1R; AG2S; AT2R1B; AT1B; AGTR1B; angiotensin receptor 1B; AG2SB; AT1AR; AT1BR; AT1R ......
Chromosomal Location3q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of AGTR1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolAGTR1
Nameangiotensin II receptor, type 1
Aliases AT2R1; AGTR1A; AT2R1A; HAT1R; AG2S; AT2R1B; AT1B; AGTR1B; angiotensin receptor 1B; AG2SB; AT1AR; AT1BR; AT1R ......
Chromosomal Location3q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between AGTR1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolAGTR1
Nameangiotensin II receptor, type 1
Aliases AT2R1; AGTR1A; AT2R1A; HAT1R; AG2S; AT2R1B; AT1B; AGTR1B; angiotensin receptor 1B; AG2SB; AT1AR; AT1BR; AT1R ......
Chromosomal Location3q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting AGTR1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting AGTR1.
ID Name Drug Type Targets #Targets
DB00177ValsartanSmall MoleculeAGTR11
DB00275OlmesartanSmall MoleculeAGTR11
DB00678LosartanSmall MoleculeAGTR11
DB00796Candesartan cilexetilSmall MoleculeAGTR11
DB00876EprosartanSmall MoleculeAGTR11
DB00966TelmisartanSmall MoleculeAGTR1, PPARG2
DB01029IrbesartanSmall MoleculeAGTR1, JUN2
DB01342ForasartanSmall MoleculeAGTR11
DB01347SaprisartanSmall MoleculeAGTR11
DB01349TasosartanSmall MoleculeAGTR1, AGTR22
DB05739CYT006-AngQbBiotechAGTR1, AGTR22
DB08822Azilsartan medoxomilSmall MoleculeAGTR11
DB09279FimasartanSmall MoleculeAGTR11
DB11842Angiotensin IISmall MoleculeAGTR11
DB13919CandesartanSmall MoleculeAGTR11