Browse AICDA

Summary
SymbolAICDA
Nameactivation-induced cytidine deaminase
Aliases HIGM2; CDA2; AID; epididymis secretory protein Li 284; integrated into Burkitt's lymphoma cell line Ramos; S ......
Chromosomal Location12p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Cytoplasm Note=Predominantly cytoplasmic but shuttles between the nucleus and the cytoplasm.
Domain PF08210 APOBEC-like N-terminal domain
Function

Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894).

> Gene Ontology
 
Biological Process GO:0002200 somatic diversification of immune receptors
GO:0002204 somatic recombination of immunoglobulin genes involved in immune response
GO:0002208 somatic diversification of immunoglobulins involved in immune response
GO:0002237 response to molecule of bacterial origin
GO:0002250 adaptive immune response
GO:0002263 cell activation involved in immune response
GO:0002285 lymphocyte activation involved in immune response
GO:0002312 B cell activation involved in immune response
GO:0002366 leukocyte activation involved in immune response
GO:0002377 immunoglobulin production
GO:0002381 immunoglobulin production involved in immunoglobulin mediated immune response
GO:0002440 production of molecular mediator of immune response
GO:0002443 leukocyte mediated immunity
GO:0002449 lymphocyte mediated immunity
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0002521 leukocyte differentiation
GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus
GO:0002566 somatic diversification of immune receptors via somatic mutation
GO:0006213 pyrimidine nucleoside metabolic process
GO:0006216 cytidine catabolic process
GO:0006304 DNA modification
GO:0006310 DNA recombination
GO:0006342 chromatin silencing
GO:0006346 methylation-dependent chromatin silencing
GO:0006397 mRNA processing
GO:0009116 nucleoside metabolic process
GO:0009119 ribonucleoside metabolic process
GO:0009164 nucleoside catabolic process
GO:0009972 cytidine deamination
GO:0016064 immunoglobulin mediated immune response
GO:0016444 somatic cell DNA recombination
GO:0016445 somatic diversification of immunoglobulins
GO:0016446 somatic hypermutation of immunoglobulin genes
GO:0016447 somatic recombination of immunoglobulin gene segments
GO:0016458 gene silencing
GO:0019439 aromatic compound catabolic process
GO:0019724 B cell mediated immunity
GO:0030098 lymphocyte differentiation
GO:0030183 B cell differentiation
GO:0031935 regulation of chromatin silencing
GO:0031936 negative regulation of chromatin silencing
GO:0032496 response to lipopolysaccharide
GO:0034655 nucleobase-containing compound catabolic process
GO:0035510 DNA dealkylation
GO:0040029 regulation of gene expression, epigenetic
GO:0042113 B cell activation
GO:0042454 ribonucleoside catabolic process
GO:0044270 cellular nitrogen compound catabolic process
GO:0044728 DNA methylation or demethylation
GO:0045190 isotype switching
GO:0045814 negative regulation of gene expression, epigenetic
GO:0045815 positive regulation of gene expression, epigenetic
GO:0046087 cytidine metabolic process
GO:0046131 pyrimidine ribonucleoside metabolic process
GO:0046133 pyrimidine ribonucleoside catabolic process
GO:0046135 pyrimidine nucleoside catabolic process
GO:0046700 heterocycle catabolic process
GO:0051052 regulation of DNA metabolic process
GO:0051053 negative regulation of DNA metabolic process
GO:0060968 regulation of gene silencing
GO:0060969 negative regulation of gene silencing
GO:0070988 demethylation
GO:0071216 cellular response to biotic stimulus
GO:0071219 cellular response to molecule of bacterial origin
GO:0071222 cellular response to lipopolysaccharide
GO:0071396 cellular response to lipid
GO:0072527 pyrimidine-containing compound metabolic process
GO:0072529 pyrimidine-containing compound catabolic process
GO:0080111 DNA demethylation
GO:0090308 regulation of methylation-dependent chromatin silencing
GO:0090310 negative regulation of methylation-dependent chromatin silencing
GO:1901136 carbohydrate derivative catabolic process
GO:1901361 organic cyclic compound catabolic process
GO:1901565 organonitrogen compound catabolic process
GO:1901657 glycosyl compound metabolic process
GO:1901658 glycosyl compound catabolic process
GO:1902275 regulation of chromatin organization
GO:1905268 negative regulation of chromatin organization
Molecular Function GO:0004126 cytidine deaminase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
GO:0019239 deaminase activity
GO:0031625 ubiquitin protein ligase binding
GO:0044389 ubiquitin-like protein ligase binding
Cellular Component GO:0000178 exosome (RNase complex)
GO:1905354 exoribonuclease complex
> KEGG and Reactome Pathway
 
KEGG hsa04672 Intestinal immune network for IgA production
Reactome -
Summary
SymbolAICDA
Nameactivation-induced cytidine deaminase
Aliases HIGM2; CDA2; AID; epididymis secretory protein Li 284; integrated into Burkitt's lymphoma cell line Ramos; S ......
Chromosomal Location12p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between AICDA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolAICDA
Nameactivation-induced cytidine deaminase
Aliases HIGM2; CDA2; AID; epididymis secretory protein Li 284; integrated into Burkitt's lymphoma cell line Ramos; S ......
Chromosomal Location12p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of AICDA in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolAICDA
Nameactivation-induced cytidine deaminase
Aliases HIGM2; CDA2; AID; epididymis secretory protein Li 284; integrated into Burkitt's lymphoma cell line Ramos; S ......
Chromosomal Location12p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of AICDA in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.2930.342
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.6860.311
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.7060.157
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.6580.475
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.7750.438
729033130MelanomaallAnti-PD-1 (nivolumab) 26231.910.0143
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.4440.345
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11122.5030.138
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1560.714
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.0560.924
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1830.527
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of AICDA in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86016.7-16.70.429
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.907.90.26
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161412.5012.50.485
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolAICDA
Nameactivation-induced cytidine deaminase
Aliases HIGM2; CDA2; AID; epididymis secretory protein Li 284; integrated into Burkitt's lymphoma cell line Ramos; S ......
Chromosomal Location12p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of AICDA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolAICDA
Nameactivation-induced cytidine deaminase
Aliases HIGM2; CDA2; AID; epididymis secretory protein Li 284; integrated into Burkitt's lymphoma cell line Ramos; S ......
Chromosomal Location12p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of AICDA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by AICDA.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolAICDA
Nameactivation-induced cytidine deaminase
Aliases HIGM2; CDA2; AID; epididymis secretory protein Li 284; integrated into Burkitt's lymphoma cell line Ramos; S ......
Chromosomal Location12p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of AICDA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolAICDA
Nameactivation-induced cytidine deaminase
Aliases HIGM2; CDA2; AID; epididymis secretory protein Li 284; integrated into Burkitt's lymphoma cell line Ramos; S ......
Chromosomal Location12p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of AICDA expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolAICDA
Nameactivation-induced cytidine deaminase
Aliases HIGM2; CDA2; AID; epididymis secretory protein Li 284; integrated into Burkitt's lymphoma cell line Ramos; S ......
Chromosomal Location12p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between AICDA and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolAICDA
Nameactivation-induced cytidine deaminase
Aliases HIGM2; CDA2; AID; epididymis secretory protein Li 284; integrated into Burkitt's lymphoma cell line Ramos; S ......
Chromosomal Location12p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting AICDA collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.