Browse ALAD

Summary
SymbolALAD
Nameaminolevulinate dehydratase
Aliases ALADH; PBGS; porphobilinogen synthase; aminolevulinate, delta-, dehydratase; Delta-aminolevulinic acid dehyd ......
Chromosomal Location9q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF00490 Delta-aminolevulinic acid dehydratase
Function

Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.

> Gene Ontology
 
Biological Process GO:0001101 response to acid chemical
GO:0001666 response to hypoxia
GO:0002237 response to molecule of bacterial origin
GO:0006778 porphyrin-containing compound metabolic process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0006783 heme biosynthetic process
GO:0006979 response to oxidative stress
GO:0007584 response to nutrient
GO:0009314 response to radiation
GO:0009635 response to herbicide
GO:0009636 response to toxic substance
GO:0009991 response to extracellular stimulus
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0010039 response to iron ion
GO:0010043 response to zinc ion
GO:0010044 response to aluminum ion
GO:0010212 response to ionizing radiation
GO:0010266 response to vitamin B1
GO:0010269 response to selenium ion
GO:0010288 response to lead ion
GO:0014823 response to activity
GO:0031667 response to nutrient levels
GO:0031960 response to corticosteroid
GO:0032025 response to cobalt ion
GO:0032496 response to lipopolysaccharide
GO:0033013 tetrapyrrole metabolic process
GO:0033014 tetrapyrrole biosynthetic process
GO:0033197 response to vitamin E
GO:0033273 response to vitamin
GO:0036293 response to decreased oxygen levels
GO:0042168 heme metabolic process
GO:0042440 pigment metabolic process
GO:0042493 response to drug
GO:0043200 response to amino acid
GO:0045471 response to ethanol
GO:0046148 pigment biosynthetic process
GO:0046501 protoporphyrinogen IX metabolic process
GO:0046685 response to arsenic-containing substance
GO:0046686 response to cadmium ion
GO:0046689 response to mercury ion
GO:0048545 response to steroid hormone
GO:0051186 cofactor metabolic process
GO:0051188 cofactor biosynthetic process
GO:0051259 protein oligomerization
GO:0051260 protein homooligomerization
GO:0051384 response to glucocorticoid
GO:0051597 response to methylmercury
GO:0070482 response to oxygen levels
GO:0070541 response to platinum ion
GO:0070542 response to fatty acid
GO:0070670 response to interleukin-4
GO:0071241 cellular response to inorganic substance
GO:0071248 cellular response to metal ion
GO:0071284 cellular response to lead ion
GO:0071353 cellular response to interleukin-4
GO:0097305 response to alcohol
GO:1990267 response to transition metal nanoparticle
Molecular Function GO:0004655 porphobilinogen synthase activity
GO:0016829 lyase activity
GO:0016835 carbon-oxygen lyase activity
GO:0016836 hydro-lyase activity
GO:0032791 lead ion binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa00860 Porphyrin and chlorophyll metabolism
hsa01100 Metabolic pathways
Reactome R-HSA-189451: Heme biosynthesis
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-1430728: Metabolism
R-HSA-189445: Metabolism of porphyrins
R-HSA-6798695: Neutrophil degranulation
Summary
SymbolALAD
Nameaminolevulinate dehydratase
Aliases ALADH; PBGS; porphobilinogen synthase; aminolevulinate, delta-, dehydratase; Delta-aminolevulinic acid dehyd ......
Chromosomal Location9q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ALAD and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolALAD
Nameaminolevulinate dehydratase
Aliases ALADH; PBGS; porphobilinogen synthase; aminolevulinate, delta-, dehydratase; Delta-aminolevulinic acid dehyd ......
Chromosomal Location9q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ALAD in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell logFC: 1.38; FDR: 0.000381 Sensitive to T cell-mediated killing
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolALAD
Nameaminolevulinate dehydratase
Aliases ALADH; PBGS; porphobilinogen synthase; aminolevulinate, delta-, dehydratase; Delta-aminolevulinic acid dehyd ......
Chromosomal Location9q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ALAD in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1060.609
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.0070.997
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.1820.891
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.4320.157
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.4780.765
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3760.858
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0250.944
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.240.877
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.2680.881
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2990.831
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.20.543
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1250.0938
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ALAD in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916012.5-12.50.52
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolALAD
Nameaminolevulinate dehydratase
Aliases ALADH; PBGS; porphobilinogen synthase; aminolevulinate, delta-, dehydratase; Delta-aminolevulinic acid dehyd ......
Chromosomal Location9q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ALAD. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolALAD
Nameaminolevulinate dehydratase
Aliases ALADH; PBGS; porphobilinogen synthase; aminolevulinate, delta-, dehydratase; Delta-aminolevulinic acid dehyd ......
Chromosomal Location9q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ALAD. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ALAD.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolALAD
Nameaminolevulinate dehydratase
Aliases ALADH; PBGS; porphobilinogen synthase; aminolevulinate, delta-, dehydratase; Delta-aminolevulinic acid dehyd ......
Chromosomal Location9q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ALAD. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolALAD
Nameaminolevulinate dehydratase
Aliases ALADH; PBGS; porphobilinogen synthase; aminolevulinate, delta-, dehydratase; Delta-aminolevulinic acid dehyd ......
Chromosomal Location9q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ALAD expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolALAD
Nameaminolevulinate dehydratase
Aliases ALADH; PBGS; porphobilinogen synthase; aminolevulinate, delta-, dehydratase; Delta-aminolevulinic acid dehyd ......
Chromosomal Location9q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ALAD and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolALAD
Nameaminolevulinate dehydratase
Aliases ALADH; PBGS; porphobilinogen synthase; aminolevulinate, delta-, dehydratase; Delta-aminolevulinic acid dehyd ......
Chromosomal Location9q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ALAD collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting ALAD.
ID Name Drug Type Targets #Targets
DB00855Aminolevulinic acidSmall MoleculeALAD1
DB02068Delta-Amino Valeric AcidSmall MoleculeALAD, GATM2
DB02239Laevulinic AcidSmall MoleculeALAD1
DB022604-Oxosebacic AcidSmall MoleculeALAD1
DB02272PorphobilinogenSmall MoleculeALAD1
DB028783-(2-Aminoethyl)-4-(Aminomethyl)Heptanedioic AcidSmall MoleculeALAD1
DB045604,7-Dioxosebacic AcidSmall MoleculeALAD1
DB047815-hydroxyvaleric acidSmall MoleculeALAD1