TISIDB

Summary
Symbol	ALDH6A1
Name	aldehyde dehydrogenase 6 family, member A1
Aliases	MMSDH; MMSADHA; malonate-semialdehyde dehydrogenase; mitochondrial acylating methylmalonate-semialdehyde deh ......
Chromosomal Location	14q24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Mitochondrion.
Domain	PF00171 Aldehyde dehydrogenase family
Function	Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.

> Gene Ontology [ TOP ]
Biological Process	GO:0006206 pyrimidine nucleobase metabolic process GO:0006208 pyrimidine nucleobase catabolic process GO:0006210 thymine catabolic process GO:0006520 cellular amino acid metabolic process GO:0006573 valine metabolic process GO:0006574 valine catabolic process GO:0009063 cellular amino acid catabolic process GO:0009081 branched-chain amino acid metabolic process GO:0009083 branched-chain amino acid catabolic process GO:0009112 nucleobase metabolic process GO:0016054 organic acid catabolic process GO:0019859 thymine metabolic process GO:0044270 cellular nitrogen compound catabolic process GO:0044282 small molecule catabolic process GO:0045444 fat cell differentiation GO:0046113 nucleobase catabolic process GO:0046395 carboxylic acid catabolic process GO:0046700 heterocycle catabolic process GO:0050873 brown fat cell differentiation GO:0072527 pyrimidine-containing compound metabolic process GO:0072529 pyrimidine-containing compound catabolic process GO:1901361 organic cyclic compound catabolic process GO:1901565 organonitrogen compound catabolic process
Molecular Function	GO:0000062 fatty-acyl-CoA binding GO:0004029 aldehyde dehydrogenase (NAD) activity GO:0004491 methylmalonate-semialdehyde dehydrogenase (acylating) activity GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors GO:0018478 malonate-semialdehyde dehydrogenase (acetylating) activity GO:0048037 cofactor binding GO:0050662 coenzyme binding GO:1901681 sulfur compound binding
Cellular Component	GO:0005759 mitochondrial matrix

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa00280 Valine, leucine and isoleucine degradation hsa00410 beta-Alanine metabolism hsa00562 Inositol phosphate metabolism hsa00640 Propanoate metabolism hsa01100 Metabolic pathways hsa01200 Carbon metabolism
Reactome	R-HSA-70895: Branched-chain amino acid catabolism R-HSA-1430728: Metabolism R-HSA-71291: Metabolism of amino acids and derivatives

Summary
Symbol	ALDH6A1
Name	aldehyde dehydrogenase 6 family, member A1
Aliases	MMSDH; MMSADHA; malonate-semialdehyde dehydrogenase; mitochondrial acylating methylmalonate-semialdehyde deh ......
Chromosomal Location	14q24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between ALDH6A1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	ALDH6A1
Name	aldehyde dehydrogenase 6 family, member A1
Aliases	MMSDH; MMSADHA; malonate-semialdehyde dehydrogenase; mitochondrial acylating methylmalonate-semialdehyde deh ......
Chromosomal Location	14q24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of ALDH6A1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	ALDH6A1
Name	aldehyde dehydrogenase 6 family, member A1
Aliases	MMSDH; MMSADHA; malonate-semialdehyde dehydrogenase; mitochondrial acylating methylmalonate-semialdehyde deh ......
Chromosomal Location	14q24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of ALDH6A1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.808	0.0303
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.775	0.552
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.831	0.412
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.302	0.351
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.196	0.912
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.924	0.652
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.205	0.611
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.59	0.591
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.304	0.817
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.346	0.784
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.491	0.77
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.003	0.971

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of ALDH6A1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	1.4	2.3	0.469
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	1.7	2	0.532
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	6.2	-6.2	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	2.6	3.7	-1.1	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	6.2	7.1	-0.9	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	7.7	-7.7	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	8.3	-8.3	1

Summary
Symbol	ALDH6A1
Name	aldehyde dehydrogenase 6 family, member A1
Aliases	MMSDH; MMSADHA; malonate-semialdehyde dehydrogenase; mitochondrial acylating methylmalonate-semialdehyde deh ......
Chromosomal Location	14q24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ALDH6A1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	ALDH6A1
Name	aldehyde dehydrogenase 6 family, member A1
Aliases	MMSDH; MMSADHA; malonate-semialdehyde dehydrogenase; mitochondrial acylating methylmalonate-semialdehyde deh ......
Chromosomal Location	14q24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ALDH6A1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ALDH6A1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	ALDH6A1
Name	aldehyde dehydrogenase 6 family, member A1
Aliases	MMSDH; MMSADHA; malonate-semialdehyde dehydrogenase; mitochondrial acylating methylmalonate-semialdehyde deh ......
Chromosomal Location	14q24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ALDH6A1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	ALDH6A1
Name	aldehyde dehydrogenase 6 family, member A1
Aliases	MMSDH; MMSADHA; malonate-semialdehyde dehydrogenase; mitochondrial acylating methylmalonate-semialdehyde deh ......
Chromosomal Location	14q24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of ALDH6A1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	ALDH6A1
Name	aldehyde dehydrogenase 6 family, member A1
Aliases	MMSDH; MMSADHA; malonate-semialdehyde dehydrogenase; mitochondrial acylating methylmalonate-semialdehyde deh ......
Chromosomal Location	14q24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between ALDH6A1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	ALDH6A1
Name	aldehyde dehydrogenase 6 family, member A1
Aliases	MMSDH; MMSADHA; malonate-semialdehyde dehydrogenase; mitochondrial acylating methylmalonate-semialdehyde deh ......
Chromosomal Location	14q24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting ALDH6A1 collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting ALDH6A1.

ID	Name	Drug Type	Targets	#Targets
DB00157	NADH	Small Molecule	AASS, ACADS, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH7, AKR1B1, AKR1C1 ......	144

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