TISIDB

Summary
Symbol	AMBP
Name	alpha-1-microglobulin/bikunin precursor
Aliases	UTI; EDC1; HI30; IATIL; ITILC; growth-inhibiting protein 19; uristatin; complex-forming glycoprotein heterog ......
Chromosomal Location	9q32-q33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Secreted.
Domain	PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain PF00061 Lipocalin / cytosolic fatty-acid binding protein family
Function	Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization. ; FUNCTION: Trypstatin is a trypsin inhibitor.

> Gene Ontology [ TOP ]
Biological Process	GO:0001933 negative regulation of protein phosphorylation GO:0002683 negative regulation of immune system process GO:0006778 porphyrin-containing compound metabolic process GO:0006787 porphyrin-containing compound catabolic process GO:0006898 receptor-mediated endocytosis GO:0007254 JNK cascade GO:0007565 female pregnancy GO:0010466 negative regulation of peptidase activity GO:0010951 negative regulation of endopeptidase activity GO:0018298 protein-chromophore linkage GO:0019439 aromatic compound catabolic process GO:0031098 stress-activated protein kinase signaling cascade GO:0032872 regulation of stress-activated MAPK cascade GO:0032873 negative regulation of stress-activated MAPK cascade GO:0033013 tetrapyrrole metabolic process GO:0033015 tetrapyrrole catabolic process GO:0042167 heme catabolic process GO:0042168 heme metabolic process GO:0042326 negative regulation of phosphorylation GO:0042440 pigment metabolic process GO:0043409 negative regulation of MAPK cascade GO:0044270 cellular nitrogen compound catabolic process GO:0044706 multi-multicellular organism process GO:0045861 negative regulation of proteolysis GO:0046149 pigment catabolic process GO:0046328 regulation of JNK cascade GO:0046329 negative regulation of JNK cascade GO:0046700 heterocycle catabolic process GO:0050777 negative regulation of immune response GO:0051186 cofactor metabolic process GO:0051187 cofactor catabolic process GO:0051346 negative regulation of hydrolase activity GO:0051403 stress-activated MAPK cascade GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0070302 regulation of stress-activated protein kinase signaling cascade GO:0070303 negative regulation of stress-activated protein kinase signaling cascade GO:1901361 organic cyclic compound catabolic process GO:1901565 organonitrogen compound catabolic process GO:1902532 negative regulation of intracellular signal transduction
Molecular Function	GO:0004857 enzyme inhibitor activity GO:0004866 endopeptidase inhibitor activity GO:0004867 serine-type endopeptidase inhibitor activity GO:0005246 calcium channel regulator activity GO:0008200 ion channel inhibitor activity GO:0016247 channel regulator activity GO:0016248 channel inhibitor activity GO:0019855 calcium channel inhibitor activity GO:0019862 IgA binding GO:0019865 immunoglobulin binding GO:0020037 heme binding GO:0030414 peptidase inhibitor activity GO:0046904 calcium oxalate binding GO:0046906 tetrapyrrole binding GO:0061134 peptidase regulator activity GO:0061135 endopeptidase regulator activity
Cellular Component	GO:0072562 blood microparticle

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-2173782: Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2168880: Scavenging of heme from plasma R-HSA-5653656: Vesicle-mediated transport

Summary
Symbol	AMBP
Name	alpha-1-microglobulin/bikunin precursor
Aliases	UTI; EDC1; HI30; IATIL; ITILC; growth-inhibiting protein 19; uristatin; complex-forming glycoprotein heterog ......
Chromosomal Location	9q32-q33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between AMBP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	AMBP
Name	alpha-1-microglobulin/bikunin precursor
Aliases	UTI; EDC1; HI30; IATIL; ITILC; growth-inhibiting protein 19; uristatin; complex-forming glycoprotein heterog ......
Chromosomal Location	9q32-q33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of AMBP in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	AMBP
Name	alpha-1-microglobulin/bikunin precursor
Aliases	UTI; EDC1; HI30; IATIL; ITILC; growth-inhibiting protein 19; uristatin; complex-forming glycoprotein heterog ......
Chromosomal Location	9q32-q33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of AMBP in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	1.329	0.16
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.097	0.949
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	2.257	0.0727
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.276	0.546
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.17	0.853
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.841	0.441
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.48	0.662
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.406	0.821
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.916	0.592
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.031	0.989
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.975	0.476
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.784	0.0291

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of AMBP in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	7.4	1.4	6	0.177
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	7.4	1.7	5.7	0.231
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	14.3	0	14.3	0.238
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	23.1	0	23.1	0.223
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	AMBP
Name	alpha-1-microglobulin/bikunin precursor
Aliases	UTI; EDC1; HI30; IATIL; ITILC; growth-inhibiting protein 19; uristatin; complex-forming glycoprotein heterog ......
Chromosomal Location	9q32-q33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of AMBP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	AMBP
Name	alpha-1-microglobulin/bikunin precursor
Aliases	UTI; EDC1; HI30; IATIL; ITILC; growth-inhibiting protein 19; uristatin; complex-forming glycoprotein heterog ......
Chromosomal Location	9q32-q33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of AMBP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by AMBP. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	AMBP
Name	alpha-1-microglobulin/bikunin precursor
Aliases	UTI; EDC1; HI30; IATIL; ITILC; growth-inhibiting protein 19; uristatin; complex-forming glycoprotein heterog ......
Chromosomal Location	9q32-q33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of AMBP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	AMBP
Name	alpha-1-microglobulin/bikunin precursor
Aliases	UTI; EDC1; HI30; IATIL; ITILC; growth-inhibiting protein 19; uristatin; complex-forming glycoprotein heterog ......
Chromosomal Location	9q32-q33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of AMBP expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	AMBP
Name	alpha-1-microglobulin/bikunin precursor
Aliases	UTI; EDC1; HI30; IATIL; ITILC; growth-inhibiting protein 19; uristatin; complex-forming glycoprotein heterog ......
Chromosomal Location	9q32-q33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between AMBP and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	AMBP
Name	alpha-1-microglobulin/bikunin precursor
Aliases	UTI; EDC1; HI30; IATIL; ITILC; growth-inhibiting protein 19; uristatin; complex-forming glycoprotein heterog ......
Chromosomal Location	9q32-q33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting AMBP collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting AMBP.

ID	Name	Drug Type	Targets	#Targets
DB00062	Human Serum Albumin	Biotech	AMBP, APOE, SAA1	3

Browse AMBP