TISIDB

Summary
Symbol	ANGPT2
Name	angiopoietin 2
Aliases	AGPT2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a; Angiopoietin-2
Chromosomal Location	8p23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Secreted.
Domain	PF00147 Fibrinogen beta and gamma chains
Function	Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.

> Gene Ontology [ TOP ]
Biological Process	GO:0001525 angiogenesis GO:0001655 urogenital system development GO:0001666 response to hypoxia GO:0001667 ameboidal-type cell migration GO:0001822 kidney development GO:0007162 negative regulation of cell adhesion GO:0007281 germ cell development GO:0007565 female pregnancy GO:0009314 response to radiation GO:0009612 response to mechanical stimulus GO:0009743 response to carbohydrate GO:0009746 response to hexose GO:0009749 response to glucose GO:0010594 regulation of endothelial cell migration GO:0010596 negative regulation of endothelial cell migration GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010633 negative regulation of epithelial cell migration GO:0010810 regulation of cell-substrate adhesion GO:0010812 negative regulation of cell-substrate adhesion GO:0014823 response to activity GO:0016525 negative regulation of angiogenesis GO:0022412 cellular process involved in reproduction in multicellular organism GO:0030336 negative regulation of cell migration GO:0031099 regeneration GO:0031100 animal organ regeneration GO:0031589 cell-substrate adhesion GO:0032102 negative regulation of response to external stimulus GO:0032835 glomerulus development GO:0034284 response to monosaccharide GO:0036293 response to decreased oxygen levels GO:0040013 negative regulation of locomotion GO:0043534 blood vessel endothelial cell migration GO:0043535 regulation of blood vessel endothelial cell migration GO:0043537 negative regulation of blood vessel endothelial cell migration GO:0043542 endothelial cell migration GO:0044706 multi-multicellular organism process GO:0045765 regulation of angiogenesis GO:0045766 positive regulation of angiogenesis GO:0048014 Tie signaling pathway GO:0048514 blood vessel morphogenesis GO:0050900 leukocyte migration GO:0050918 positive chemotaxis GO:0050920 regulation of chemotaxis GO:0050922 negative regulation of chemotaxis GO:0050926 regulation of positive chemotaxis GO:0050928 negative regulation of positive chemotaxis GO:0051271 negative regulation of cellular component movement GO:0060135 maternal process involved in female pregnancy GO:0061437 renal system vasculature development GO:0061440 kidney vasculature development GO:0070482 response to oxygen levels GO:0072001 renal system development GO:0072006 nephron development GO:0072012 glomerulus vasculature development GO:0090130 tissue migration GO:0090132 epithelium migration GO:1901342 regulation of vasculature development GO:1901343 negative regulation of vasculature development GO:1904018 positive regulation of vasculature development GO:2000146 negative regulation of cell motility GO:2000181 negative regulation of blood vessel morphogenesis
Molecular Function	GO:0030971 receptor tyrosine kinase binding GO:1990782 protein tyrosine kinase binding
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04014 Ras signaling pathway hsa04015 Rap1 signaling pathway hsa04066 HIF-1 signaling pathway hsa04151 PI3K-Akt signaling pathway
Reactome	R-HSA-202733: Cell surface interactions at the vascular wall R-HSA-109582: Hemostasis R-HSA-210993: Tie2 Signaling

Summary
Symbol	ANGPT2
Name	angiopoietin 2
Aliases	AGPT2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a; Angiopoietin-2
Chromosomal Location	8p23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between ANGPT2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	ANGPT2
Name	angiopoietin 2
Aliases	AGPT2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a; Angiopoietin-2
Chromosomal Location	8p23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of ANGPT2 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	ANGPT2
Name	angiopoietin 2
Aliases	AGPT2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a; Angiopoietin-2
Chromosomal Location	8p23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of ANGPT2 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.862	0.0276
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.82	0.349
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.893	0.193
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.048	0.875
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.016	0.993
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.091	0.967
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.397	0.449
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.087	0.944
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.968	0.467
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.732	0.583
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.444	0.432
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.123	0.333

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of ANGPT2 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	5.9	-5.9	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	7.1	-7.1	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	0	0	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	0	0	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	0	4.8	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	0	7.7	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	6.2	-6.2	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	3.7	-3.7	0.415
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	7.7	-7.7	0.371
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	9.1	0	9.1	0.458
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	20	0	20	0.294

Summary
Symbol	ANGPT2
Name	angiopoietin 2
Aliases	AGPT2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a; Angiopoietin-2
Chromosomal Location	8p23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ANGPT2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	ANGPT2
Name	angiopoietin 2
Aliases	AGPT2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a; Angiopoietin-2
Chromosomal Location	8p23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ANGPT2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ANGPT2. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	ANGPT2
Name	angiopoietin 2
Aliases	AGPT2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a; Angiopoietin-2
Chromosomal Location	8p23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ANGPT2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	ANGPT2
Name	angiopoietin 2
Aliases	AGPT2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a; Angiopoietin-2
Chromosomal Location	8p23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of ANGPT2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	ANGPT2
Name	angiopoietin 2
Aliases	AGPT2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a; Angiopoietin-2
Chromosomal Location	8p23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between ANGPT2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	ANGPT2
Name	angiopoietin 2
Aliases	AGPT2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a; Angiopoietin-2
Chromosomal Location	8p23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting ANGPT2 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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