Browse ANK3

Summary
SymbolANK3
Nameankyrin 3, node of Ranvier (ankyrin G)
Aliases ankyrin-3, node of Ranvier; ankyrin-G; MRT37; ankyrin G119; ANK-3; Ankyrin-3
Chromosomal Location10q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm, cytoskeleton Cell projection, axon Cell membrane, sarcolemma Cell junction, synapse, postsynaptic cell membrane Lysosome Note=In skeletal muscle, localized at costameres and neuromuscular junctions. In macrophages, associated with lysosomes. ; SUBCELLULAR LOCATION: Isoform 5: Cytoplasm, cytoskeleton Golgi apparatus
Domain PF12796 Ankyrin repeats (3 copies)
PF13606 Ankyrin repeat
PF00531 Death domain
PF00791 ZU5 domain
Function

In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). ; FUNCTION: Isoform 5: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin.

> Gene Ontology
 
Biological Process GO:0000281 mitotic cytokinesis
GO:0000910 cytokinesis
GO:0001508 action potential
GO:0002028 regulation of sodium ion transport
GO:0003254 regulation of membrane depolarization
GO:0006612 protein targeting to membrane
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0007009 plasma membrane organization
GO:0007016 cytoskeletal anchoring at plasma membrane
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007528 neuromuscular junction development
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0010644 cell communication by electrical coupling
GO:0010649 regulation of cell communication by electrical coupling
GO:0010650 positive regulation of cell communication by electrical coupling
GO:0010765 positive regulation of sodium ion transport
GO:0010959 regulation of metal ion transport
GO:0010960 magnesium ion homeostasis
GO:0015672 monovalent inorganic cation transport
GO:0019226 transmission of nerve impulse
GO:0019228 neuronal action potential
GO:0022407 regulation of cell-cell adhesion
GO:0022409 positive regulation of cell-cell adhesion
GO:0022898 regulation of transmembrane transporter activity
GO:0032026 response to magnesium ion
GO:0032386 regulation of intracellular transport
GO:0032388 positive regulation of intracellular transport
GO:0032409 regulation of transporter activity
GO:0032410 negative regulation of transporter activity
GO:0032411 positive regulation of transporter activity
GO:0032412 regulation of ion transmembrane transporter activity
GO:0032413 negative regulation of ion transmembrane transporter activity
GO:0032414 positive regulation of ion transmembrane transporter activity
GO:0032507 maintenance of protein location in cell
GO:0032844 regulation of homeostatic process
GO:0033157 regulation of intracellular protein transport
GO:0034109 homotypic cell-cell adhesion
GO:0034110 regulation of homotypic cell-cell adhesion
GO:0034112 positive regulation of homotypic cell-cell adhesion
GO:0034762 regulation of transmembrane transport
GO:0034763 negative regulation of transmembrane transport
GO:0034764 positive regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0034766 negative regulation of ion transmembrane transport
GO:0034767 positive regulation of ion transmembrane transport
GO:0035637 multicellular organismal signaling
GO:0035725 sodium ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0043001 Golgi to plasma membrane protein transport
GO:0043266 regulation of potassium ion transport
GO:0043267 negative regulation of potassium ion transport
GO:0043270 positive regulation of ion transport
GO:0043271 negative regulation of ion transport
GO:0044091 membrane biogenesis
GO:0045185 maintenance of protein location
GO:0045760 positive regulation of action potential
GO:0045785 positive regulation of cell adhesion
GO:0045838 positive regulation of membrane potential
GO:0048193 Golgi vesicle transport
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0050808 synapse organization
GO:0051051 negative regulation of transport
GO:0051222 positive regulation of protein transport
GO:0051235 maintenance of location
GO:0051651 maintenance of location in cell
GO:0051899 membrane depolarization
GO:0061564 axon development
GO:0061640 cytoskeleton-dependent cytokinesis
GO:0071241 cellular response to inorganic substance
GO:0071248 cellular response to metal ion
GO:0071286 cellular response to magnesium ion
GO:0071709 membrane assembly
GO:0071804 cellular potassium ion transport
GO:0071805 potassium ion transmembrane transport
GO:0072507 divalent inorganic cation homeostasis
GO:0072657 protein localization to membrane
GO:0072658 maintenance of protein location in membrane
GO:0072659 protein localization to plasma membrane
GO:0072660 maintenance of protein location in plasma membrane
GO:0072661 protein targeting to plasma membrane
GO:0086001 cardiac muscle cell action potential
GO:0086010 membrane depolarization during action potential
GO:0086012 membrane depolarization during cardiac muscle cell action potential
GO:0090002 establishment of protein localization to plasma membrane
GO:0090150 establishment of protein localization to membrane
GO:0090313 regulation of protein targeting to membrane
GO:0090314 positive regulation of protein targeting to membrane
GO:0090316 positive regulation of intracellular protein transport
GO:0097485 neuron projection guidance
GO:0098900 regulation of action potential
GO:0098901 regulation of cardiac muscle cell action potential
GO:0098902 regulation of membrane depolarization during action potential
GO:1900825 regulation of membrane depolarization during cardiac muscle cell action potential
GO:1900827 positive regulation of membrane depolarization during cardiac muscle cell action potential
GO:1901016 regulation of potassium ion transmembrane transporter activity
GO:1901017 negative regulation of potassium ion transmembrane transporter activity
GO:1901379 regulation of potassium ion transmembrane transport
GO:1901380 negative regulation of potassium ion transmembrane transport
GO:1902259 regulation of delayed rectifier potassium channel activity
GO:1902260 negative regulation of delayed rectifier potassium channel activity
GO:1902305 regulation of sodium ion transmembrane transport
GO:1902307 positive regulation of sodium ion transmembrane transport
GO:1903533 regulation of protein targeting
GO:1903817 negative regulation of voltage-gated potassium channel activity
GO:1903829 positive regulation of cellular protein localization
GO:1904062 regulation of cation transmembrane transport
GO:1904063 negative regulation of cation transmembrane transport
GO:1904064 positive regulation of cation transmembrane transport
GO:1904181 positive regulation of membrane depolarization
GO:1904951 positive regulation of establishment of protein localization
GO:1990778 protein localization to cell periphery
GO:2000021 regulation of ion homeostasis
GO:2000649 regulation of sodium ion transmembrane transporter activity
GO:2000651 positive regulation of sodium ion transmembrane transporter activity
GO:2001257 regulation of cation channel activity
GO:2001258 negative regulation of cation channel activity
GO:2001259 positive regulation of cation channel activity
Molecular Function GO:0005200 structural constituent of cytoskeleton
GO:0008093 cytoskeletal adaptor activity
GO:0030507 spectrin binding
GO:0030674 protein binding, bridging
GO:0044325 ion channel binding
GO:0045296 cadherin binding
GO:0050839 cell adhesion molecule binding
GO:0060090 binding, bridging
Cellular Component GO:0005923 bicellular tight junction
GO:0009925 basal plasma membrane
GO:0014704 intercalated disc
GO:0014731 spectrin-associated cytoskeleton
GO:0016323 basolateral plasma membrane
GO:0016328 lateral plasma membrane
GO:0016528 sarcoplasm
GO:0016529 sarcoplasmic reticulum
GO:0030016 myofibril
GO:0030017 sarcomere
GO:0030018 Z disc
GO:0030315 T-tubule
GO:0030424 axon
GO:0030425 dendrite
GO:0031594 neuromuscular junction
GO:0031674 I band
GO:0033267 axon part
GO:0033268 node of Ranvier
GO:0033270 paranode region of axon
GO:0042383 sarcolemma
GO:0043034 costamere
GO:0043194 axon initial segment
GO:0043292 contractile fiber
GO:0043296 apical junction complex
GO:0044291 cell-cell contact zone
GO:0044304 main axon
GO:0044449 contractile fiber part
GO:0045178 basal part of cell
GO:0045211 postsynaptic membrane
GO:0070160 occluding junction
GO:0097060 synaptic membrane
GO:0098794 postsynapse
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-446203: Asparagine N-linked glycosylation
R-HSA-422475: Axon guidance
R-HSA-6807878: COPI-mediated anterograde transport
R-HSA-1266738: Developmental Biology
R-HSA-199977: ER to Golgi Anterograde Transport
R-HSA-445095: Interaction between L1 and Ankyrins
R-HSA-373760: L1CAM interactions
R-HSA-199991: Membrane Trafficking
R-HSA-392499: Metabolism of proteins
R-HSA-597592: Post-translational protein modification
R-HSA-948021: Transport to the Golgi and subsequent modification
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolANK3
Nameankyrin 3, node of Ranvier (ankyrin G)
Aliases ankyrin-3, node of Ranvier; ankyrin-G; MRT37; ankyrin G119; ANK-3; Ankyrin-3
Chromosomal Location10q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ANK3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolANK3
Nameankyrin 3, node of Ranvier (ankyrin G)
Aliases ankyrin-3, node of Ranvier; ankyrin-G; MRT37; ankyrin G119; ANK-3; Ankyrin-3
Chromosomal Location10q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ANK3 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolANK3
Nameankyrin 3, node of Ranvier (ankyrin G)
Aliases ankyrin-3, node of Ranvier; ankyrin-G; MRT37; ankyrin G119; ANK-3; Ankyrin-3
Chromosomal Location10q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ANK3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.2650.567
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.8760.243
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.1780.783
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.20.561
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2460.925
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.1480.962
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2490.68
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.8740.367
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.4230.681
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.4380.769
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.2090.919
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0540.648
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ANK3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277348.121.926.20.0139
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275948.127.1210.0844
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211757.141.215.90.515
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)867533.341.70.277
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131146.245.50.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91633.312.520.80.312
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 594022.217.80.58
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 382726.322.24.10.777
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221322.715.47.30.689
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161431.228.62.61
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11139.109.10.458
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 512200200.294
Summary
SymbolANK3
Nameankyrin 3, node of Ranvier (ankyrin G)
Aliases ankyrin-3, node of Ranvier; ankyrin-G; MRT37; ankyrin G119; ANK-3; Ankyrin-3
Chromosomal Location10q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ANK3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolANK3
Nameankyrin 3, node of Ranvier (ankyrin G)
Aliases ankyrin-3, node of Ranvier; ankyrin-G; MRT37; ankyrin G119; ANK-3; Ankyrin-3
Chromosomal Location10q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ANK3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ANK3.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolANK3
Nameankyrin 3, node of Ranvier (ankyrin G)
Aliases ankyrin-3, node of Ranvier; ankyrin-G; MRT37; ankyrin G119; ANK-3; Ankyrin-3
Chromosomal Location10q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ANK3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolANK3
Nameankyrin 3, node of Ranvier (ankyrin G)
Aliases ankyrin-3, node of Ranvier; ankyrin-G; MRT37; ankyrin G119; ANK-3; Ankyrin-3
Chromosomal Location10q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ANK3 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolANK3
Nameankyrin 3, node of Ranvier (ankyrin G)
Aliases ankyrin-3, node of Ranvier; ankyrin-G; MRT37; ankyrin G119; ANK-3; Ankyrin-3
Chromosomal Location10q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ANK3 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolANK3
Nameankyrin 3, node of Ranvier (ankyrin G)
Aliases ankyrin-3, node of Ranvier; ankyrin-G; MRT37; ankyrin G119; ANK-3; Ankyrin-3
Chromosomal Location10q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ANK3 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.