Browse AP1G2

Summary
SymbolAP1G2
Nameadaptor-related protein complex 1, gamma 2 subunit
Aliases G2AD; clathrin-associated/assembly/adaptor protein, large, gamma-2; gamma2-adaptin; AP-1 complex subunit gam ......
Chromosomal Location14q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Golgi apparatus membrane Peripheral membrane protein; Cytoplasmic side Cytoplasmic vesicle membrane Peripheral membrane protein. Endosome membrane Peripheral membrane protein. Note=Mainly localized to perinuclear vesicular structures (PubMed:9733768). Colocalizes with HBV major surface antigen L and HBV core protein C in CD63-containing compartments (PubMed:16867982). Colocalizes with HBV major surface antigen L to cis-Golgi-like structures (PubMed:11333915).
Domain PF01602 Adaptin N terminal region
PF02883 Adaptin C-terminal domain
Function

May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV).

> Gene Ontology
 
Biological Process -
Molecular Function GO:0008565 protein transporter activity
Cellular Component GO:0005798 Golgi-associated vesicle
GO:0010008 endosome membrane
GO:0012510 trans-Golgi network transport vesicle membrane
GO:0030117 membrane coat
GO:0030118 clathrin coat
GO:0030119 AP-type membrane coat adaptor complex
GO:0030120 vesicle coat
GO:0030121 AP-1 adaptor complex
GO:0030125 clathrin vesicle coat
GO:0030130 clathrin coat of trans-Golgi network vesicle
GO:0030131 clathrin adaptor complex
GO:0030133 transport vesicle
GO:0030135 coated vesicle
GO:0030136 clathrin-coated vesicle
GO:0030140 trans-Golgi network transport vesicle
GO:0030658 transport vesicle membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0030660 Golgi-associated vesicle membrane
GO:0030662 coated vesicle membrane
GO:0030665 clathrin-coated vesicle membrane
GO:0044440 endosomal part
GO:0048475 coated membrane
> KEGG and Reactome Pathway
 
KEGG hsa04142 Lysosome
Reactome R-HSA-421837: Clathrin derived vesicle budding
R-HSA-432720: Lysosome Vesicle Biogenesis
R-HSA-199991: Membrane Trafficking
R-HSA-5653656: Vesicle-mediated transport
R-HSA-199992: trans-Golgi Network Vesicle Budding
Summary
SymbolAP1G2
Nameadaptor-related protein complex 1, gamma 2 subunit
Aliases G2AD; clathrin-associated/assembly/adaptor protein, large, gamma-2; gamma2-adaptin; AP-1 complex subunit gam ......
Chromosomal Location14q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between AP1G2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolAP1G2
Nameadaptor-related protein complex 1, gamma 2 subunit
Aliases G2AD; clathrin-associated/assembly/adaptor protein, large, gamma-2; gamma2-adaptin; AP-1 complex subunit gam ......
Chromosomal Location14q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of AP1G2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolAP1G2
Nameadaptor-related protein complex 1, gamma 2 subunit
Aliases G2AD; clathrin-associated/assembly/adaptor protein, large, gamma-2; gamma2-adaptin; AP-1 complex subunit gam ......
Chromosomal Location14q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of AP1G2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.8310.0474
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.3260.829
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)871.2030.273
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.8220.0657
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.6810.799
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.0060.777
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2110.611
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.5390.721
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1710.92
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.620.728
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.0520.687
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0480.613
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of AP1G2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolAP1G2
Nameadaptor-related protein complex 1, gamma 2 subunit
Aliases G2AD; clathrin-associated/assembly/adaptor protein, large, gamma-2; gamma2-adaptin; AP-1 complex subunit gam ......
Chromosomal Location14q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of AP1G2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolAP1G2
Nameadaptor-related protein complex 1, gamma 2 subunit
Aliases G2AD; clathrin-associated/assembly/adaptor protein, large, gamma-2; gamma2-adaptin; AP-1 complex subunit gam ......
Chromosomal Location14q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of AP1G2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by AP1G2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolAP1G2
Nameadaptor-related protein complex 1, gamma 2 subunit
Aliases G2AD; clathrin-associated/assembly/adaptor protein, large, gamma-2; gamma2-adaptin; AP-1 complex subunit gam ......
Chromosomal Location14q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of AP1G2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolAP1G2
Nameadaptor-related protein complex 1, gamma 2 subunit
Aliases G2AD; clathrin-associated/assembly/adaptor protein, large, gamma-2; gamma2-adaptin; AP-1 complex subunit gam ......
Chromosomal Location14q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of AP1G2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolAP1G2
Nameadaptor-related protein complex 1, gamma 2 subunit
Aliases G2AD; clathrin-associated/assembly/adaptor protein, large, gamma-2; gamma2-adaptin; AP-1 complex subunit gam ......
Chromosomal Location14q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between AP1G2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolAP1G2
Nameadaptor-related protein complex 1, gamma 2 subunit
Aliases G2AD; clathrin-associated/assembly/adaptor protein, large, gamma-2; gamma2-adaptin; AP-1 complex subunit gam ......
Chromosomal Location14q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting AP1G2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.