Browse APOM

Summary
SymbolAPOM
Nameapolipoprotein M
Aliases G3a; NG20; HSPC336; apo-M; NG20-like protein; alternative name: G3a, NG20; protein G3a
Chromosomal Location6p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted Note=Present in high density lipoprotein (HDL) and to a lesser extent in triglyceride-rich lipoproteins (TGRLP) and low density lipoproteins (LDL).
Domain PF11032 ApoM domain
Function

Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.

> Gene Ontology
 
Biological Process GO:0001523 retinoid metabolic process
GO:0006720 isoprenoid metabolic process
GO:0006721 terpenoid metabolic process
GO:0006869 lipid transport
GO:0009636 response to toxic substance
GO:0009743 response to carbohydrate
GO:0009746 response to hexose
GO:0009749 response to glucose
GO:0010876 lipid localization
GO:0015850 organic hydroxy compound transport
GO:0015918 sterol transport
GO:0016101 diterpenoid metabolic process
GO:0030301 cholesterol transport
GO:0033344 cholesterol efflux
GO:0034284 response to monosaccharide
GO:0034367 macromolecular complex remodeling
GO:0034368 protein-lipid complex remodeling
GO:0034369 plasma lipoprotein particle remodeling
GO:0034375 high-density lipoprotein particle remodeling
GO:0034377 plasma lipoprotein particle assembly
GO:0034380 high-density lipoprotein particle assembly
GO:0034381 plasma lipoprotein particle clearance
GO:0034384 high-density lipoprotein particle clearance
GO:0034441 plasma lipoprotein particle oxidation
GO:0034442 regulation of lipoprotein oxidation
GO:0034443 negative regulation of lipoprotein oxidation
GO:0034444 regulation of plasma lipoprotein particle oxidation
GO:0034445 negative regulation of plasma lipoprotein particle oxidation
GO:0042157 lipoprotein metabolic process
GO:0042160 lipoprotein modification
GO:0042161 lipoprotein oxidation
GO:0042632 cholesterol homeostasis
GO:0043691 reverse cholesterol transport
GO:0050746 regulation of lipoprotein metabolic process
GO:0050748 negative regulation of lipoprotein metabolic process
GO:0055088 lipid homeostasis
GO:0055092 sterol homeostasis
GO:0065005 protein-lipid complex assembly
GO:0071825 protein-lipid complex subunit organization
GO:0071827 plasma lipoprotein particle organization
GO:0097006 regulation of plasma lipoprotein particle levels
GO:0098754 detoxification
GO:0098869 cellular oxidant detoxification
GO:1990748 cellular detoxification
Molecular Function GO:0005319 lipid transporter activity
GO:0005543 phospholipid binding
GO:0016209 antioxidant activity
Cellular Component GO:0032994 protein-lipid complex
GO:0034358 plasma lipoprotein particle
GO:0034361 very-low-density lipoprotein particle
GO:0034362 low-density lipoprotein particle
GO:0034364 high-density lipoprotein particle
GO:0034365 discoidal high-density lipoprotein particle
GO:0034366 spherical high-density lipoprotein particle
GO:0034385 triglyceride-rich lipoprotein particle
GO:1990777 lipoprotein particle
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1430728: Metabolism
R-HSA-6806667: Metabolism of fat-soluble vitamins
R-HSA-196854: Metabolism of vitamins and cofactors
R-HSA-975634: Retinoid metabolism and transport
R-HSA-162582: Signal Transduction
R-HSA-2187338: Visual phototransduction
Summary
SymbolAPOM
Nameapolipoprotein M
Aliases G3a; NG20; HSPC336; apo-M; NG20-like protein; alternative name: G3a, NG20; protein G3a
Chromosomal Location6p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between APOM and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolAPOM
Nameapolipoprotein M
Aliases G3a; NG20; HSPC336; apo-M; NG20-like protein; alternative name: G3a, NG20; protein G3a
Chromosomal Location6p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of APOM in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolAPOM
Nameapolipoprotein M
Aliases G3a; NG20; HSPC336; apo-M; NG20-like protein; alternative name: G3a, NG20; protein G3a
Chromosomal Location6p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of APOM in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.910.0204
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.7710.254
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)871.0180.0683
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2570.659
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2530.856
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.8940.571
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1050.832
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.8040.266
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.8420.282
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.4220.813
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.1180.962
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1590.223
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolAPOM
Nameapolipoprotein M
Aliases G3a; NG20; HSPC336; apo-M; NG20-like protein; alternative name: G3a, NG20; protein G3a
Chromosomal Location6p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of APOM. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolAPOM
Nameapolipoprotein M
Aliases G3a; NG20; HSPC336; apo-M; NG20-like protein; alternative name: G3a, NG20; protein G3a
Chromosomal Location6p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of APOM. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by APOM.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolAPOM
Nameapolipoprotein M
Aliases G3a; NG20; HSPC336; apo-M; NG20-like protein; alternative name: G3a, NG20; protein G3a
Chromosomal Location6p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of APOM. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolAPOM
Nameapolipoprotein M
Aliases G3a; NG20; HSPC336; apo-M; NG20-like protein; alternative name: G3a, NG20; protein G3a
Chromosomal Location6p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of APOM expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolAPOM
Nameapolipoprotein M
Aliases G3a; NG20; HSPC336; apo-M; NG20-like protein; alternative name: G3a, NG20; protein G3a
Chromosomal Location6p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between APOM and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolAPOM
Nameapolipoprotein M
Aliases G3a; NG20; HSPC336; apo-M; NG20-like protein; alternative name: G3a, NG20; protein G3a
Chromosomal Location6p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting APOM collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.