TISIDB

Summary
Symbol	APOO
Name	apolipoprotein O
Aliases	MGC4825; My025; Mic23; MIC26; FAM121B; family with sequence similarity 121B; MICOS complex subunit MIC23; br ......
Chromosomal Location	Xp22.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Mitochondrion inner membrane Single-pass membrane protein Secreted Mitochondrion Golgi apparatus membrane Endoplasmic reticulum membrane Note=Exists in three distinct forms: a glycosylated and secreted form, an ER/Golgi-resident form and a non-glycosylated mitochondrial form.
Domain	PF09769 Apolipoprotein O
Function	Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:25764979). Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed:24743151). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (PubMed:16956892).

> Gene Ontology [ TOP ]
Biological Process	GO:0006869 lipid transport GO:0007006 mitochondrial membrane organization GO:0007007 inner mitochondrial membrane organization GO:0010876 lipid localization GO:0042407 cristae formation
Molecular Function	-
Cellular Component	GO:0005743 mitochondrial inner membrane GO:0031300 intrinsic component of organelle membrane GO:0031301 integral component of organelle membrane GO:0031304 intrinsic component of mitochondrial inner membrane GO:0031305 integral component of mitochondrial inner membrane GO:0032592 integral component of mitochondrial membrane GO:0032994 protein-lipid complex GO:0034358 plasma lipoprotein particle GO:0034361 very-low-density lipoprotein particle GO:0034362 low-density lipoprotein particle GO:0034364 high-density lipoprotein particle GO:0034385 triglyceride-rich lipoprotein particle GO:0044455 mitochondrial membrane part GO:0061617 MICOS complex GO:0098573 intrinsic component of mitochondrial membrane GO:0098798 mitochondrial protein complex GO:0098800 inner mitochondrial membrane protein complex GO:1990777 lipoprotein particle

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	APOO
Name	apolipoprotein O
Aliases	MGC4825; My025; Mic23; MIC26; FAM121B; family with sequence similarity 121B; MICOS complex subunit MIC23; br ......
Chromosomal Location	Xp22.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between APOO and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	APOO
Name	apolipoprotein O
Aliases	MGC4825; My025; Mic23; MIC26; FAM121B; family with sequence similarity 121B; MICOS complex subunit MIC23; br ......
Chromosomal Location	Xp22.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of APOO in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	Second most enriched score: 0.53	Sensitive to T cell-mediated killing
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	APOO
Name	apolipoprotein O
Aliases	MGC4825; My025; Mic23; MIC26; FAM121B; family with sequence similarity 121B; MICOS complex subunit MIC23; br ......
Chromosomal Location	Xp22.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of APOO in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.039	0.875
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.274	0.892
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.273	0.861
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.139	0.668
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.692	0.51
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.55	0.617
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.245	0.447
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.334	0.794
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.15	0.916
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.067	0.961
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.13	0.951
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.078	0.309

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of APOO in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	0	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	0	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	4.8	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	7.7	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	1

Summary
Symbol	APOO
Name	apolipoprotein O
Aliases	MGC4825; My025; Mic23; MIC26; FAM121B; family with sequence similarity 121B; MICOS complex subunit MIC23; br ......
Chromosomal Location	Xp22.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of APOO. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	APOO
Name	apolipoprotein O
Aliases	MGC4825; My025; Mic23; MIC26; FAM121B; family with sequence similarity 121B; MICOS complex subunit MIC23; br ......
Chromosomal Location	Xp22.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of APOO. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by APOO. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	APOO
Name	apolipoprotein O
Aliases	MGC4825; My025; Mic23; MIC26; FAM121B; family with sequence similarity 121B; MICOS complex subunit MIC23; br ......
Chromosomal Location	Xp22.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of APOO. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	APOO
Name	apolipoprotein O
Aliases	MGC4825; My025; Mic23; MIC26; FAM121B; family with sequence similarity 121B; MICOS complex subunit MIC23; br ......
Chromosomal Location	Xp22.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of APOO expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	APOO
Name	apolipoprotein O
Aliases	MGC4825; My025; Mic23; MIC26; FAM121B; family with sequence similarity 121B; MICOS complex subunit MIC23; br ......
Chromosomal Location	Xp22.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between APOO and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	APOO
Name	apolipoprotein O
Aliases	MGC4825; My025; Mic23; MIC26; FAM121B; family with sequence similarity 121B; MICOS complex subunit MIC23; br ......
Chromosomal Location	Xp22.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting APOO collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse APOO