TISIDB

Summary
Symbol	AQP5
Name	aquaporin 5
Aliases	AQP-5; PPKB; Aquaporin-5
Chromosomal Location	12q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Apical cell membrane Multi-pass membrane protein
Domain	PF00230 Major intrinsic protein
Function	Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. Required for TRPV4 activation by hypotonicity (PubMed:16571723). Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723).

> Gene Ontology [ TOP ]
Biological Process	GO:0001654 eye development GO:0006833 water transport GO:0006884 cell volume homeostasis GO:0007423 sensory organ development GO:0007586 digestion GO:0007588 excretion GO:0007589 body fluid secretion GO:0008361 regulation of cell size GO:0008643 carbohydrate transport GO:0009992 cellular water homeostasis GO:0015669 gas transport GO:0015670 carbon dioxide transport GO:0015791 polyol transport GO:0015793 glycerol transport GO:0015850 organic hydroxy compound transport GO:0019755 one-carbon compound transport GO:0022600 digestive system process GO:0030104 water homeostasis GO:0030157 pancreatic juice secretion GO:0032535 regulation of cellular component size GO:0032941 secretion by tissue GO:0042044 fluid transport GO:0042476 odontogenesis GO:0043010 camera-type eye development GO:0046541 saliva secretion GO:0048592 eye morphogenesis GO:0048593 camera-type eye morphogenesis GO:0050878 regulation of body fluid levels GO:0090066 regulation of anatomical structure size GO:0090596 sensory organ morphogenesis
Molecular Function	GO:0005372 water transmembrane transporter activity GO:0015144 carbohydrate transmembrane transporter activity GO:0015166 polyol transmembrane transporter activity GO:0015168 glycerol transmembrane transporter activity GO:0015250 water channel activity GO:0015254 glycerol channel activity GO:0015267 channel activity GO:0015665 alcohol transmembrane transporter activity GO:0022803 passive transmembrane transporter activity GO:0022838 substrate-specific channel activity GO:1901476 carbohydrate transporter activity GO:1901618 organic hydroxy compound transmembrane transporter activity
Cellular Component	GO:0005902 microvillus GO:0009925 basal plasma membrane GO:0016323 basolateral plasma membrane GO:0016324 apical plasma membrane GO:0045177 apical part of cell GO:0045178 basal part of cell GO:0098858 actin-based cell projection

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04970 Salivary secretion
Reactome	R-HSA-445717: Aquaporin-mediated transport R-HSA-432047: Passive transport by Aquaporins R-HSA-382551: Transmembrane transport of small molecules

Summary
Symbol	AQP5
Name	aquaporin 5
Aliases	AQP-5; PPKB; Aquaporin-5
Chromosomal Location	12q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between AQP5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	AQP5
Name	aquaporin 5
Aliases	AQP-5; PPKB; Aquaporin-5
Chromosomal Location	12q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of AQP5 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	AQP5
Name	aquaporin 5
Aliases	AQP-5; PPKB; Aquaporin-5
Chromosomal Location	12q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of AQP5 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.567	0.311
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.347	0.705
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	1.243	0.111
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	1.731	0.0467
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	1.133	0.38
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	2.478	0.0873
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.766	0.379
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-1.162	0.441
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.509	0.735
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0	1
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0	1
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.141	0.648

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of AQP5 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	3.7	0.27
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	3.7	0.314
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	1

Summary
Symbol	AQP5
Name	aquaporin 5
Aliases	AQP-5; PPKB; Aquaporin-5
Chromosomal Location	12q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of AQP5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	AQP5
Name	aquaporin 5
Aliases	AQP-5; PPKB; Aquaporin-5
Chromosomal Location	12q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of AQP5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by AQP5. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	AQP5
Name	aquaporin 5
Aliases	AQP-5; PPKB; Aquaporin-5
Chromosomal Location	12q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of AQP5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	AQP5
Name	aquaporin 5
Aliases	AQP-5; PPKB; Aquaporin-5
Chromosomal Location	12q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of AQP5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	AQP5
Name	aquaporin 5
Aliases	AQP-5; PPKB; Aquaporin-5
Chromosomal Location	12q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between AQP5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	AQP5
Name	aquaporin 5
Aliases	AQP-5; PPKB; Aquaporin-5
Chromosomal Location	12q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting AQP5 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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