Browse ARHGAP44

Summary
SymbolARHGAP44
NameRho GTPase activating protein 44
Aliases KIAA0672; RICH-2; RICH2; NPC-A-10; Rho-type GTPase-activating protein RICH2; RhoGAP interacting with CIP4 ho ......
Chromosomal Location17p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell projection, dendritic spine Recycling endosome Cell junction, synapse Note=In CA1 hippocampal synapses, detected at both presynaptic and postsynaptic sites.
Domain PF03114 BAR domain
PF00620 RhoGAP domain
Function

GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. May act as a GAP for CDC42 and RAC1. Endosomal recycling protein which, in association with SHANK3, is involved in synaptic plasticity. Promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation.

> Gene Ontology
 
Biological Process GO:0006887 exocytosis
GO:0051056 regulation of small GTPase mediated signal transduction
Molecular Function GO:0005096 GTPase activator activity
GO:0005543 phospholipid binding
GO:0008047 enzyme activator activity
GO:0030695 GTPase regulator activity
GO:0060589 nucleoside-triphosphatase regulator activity
Cellular Component GO:0030425 dendrite
GO:0031252 cell leading edge
GO:0031256 leading edge membrane
GO:0043197 dendritic spine
GO:0044309 neuron spine
GO:0055037 recycling endosome
GO:0098794 postsynapse
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-194840: Rho GTPase cycle
R-HSA-162582: Signal Transduction
R-HSA-194315: Signaling by Rho GTPases
Summary
SymbolARHGAP44
NameRho GTPase activating protein 44
Aliases KIAA0672; RICH-2; RICH2; NPC-A-10; Rho-type GTPase-activating protein RICH2; RhoGAP interacting with CIP4 ho ......
Chromosomal Location17p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ARHGAP44 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolARHGAP44
NameRho GTPase activating protein 44
Aliases KIAA0672; RICH-2; RICH2; NPC-A-10; Rho-type GTPase-activating protein RICH2; RhoGAP interacting with CIP4 ho ......
Chromosomal Location17p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ARHGAP44 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolARHGAP44
NameRho GTPase activating protein 44
Aliases KIAA0672; RICH-2; RICH2; NPC-A-10; Rho-type GTPase-activating protein RICH2; RhoGAP interacting with CIP4 ho ......
Chromosomal Location17p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ARHGAP44 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.3380.181
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.8620.0496
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0410.915
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.7750.0224
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 591.2510.429
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1740.93
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.9020.0234
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.7730.00399
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0940.892
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.8680.203
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.3530.14
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.2270.12
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ARHGAP44 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.817.6-12.80.307
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.727.3-19.60.3
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.33.71.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolARHGAP44
NameRho GTPase activating protein 44
Aliases KIAA0672; RICH-2; RICH2; NPC-A-10; Rho-type GTPase-activating protein RICH2; RhoGAP interacting with CIP4 ho ......
Chromosomal Location17p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ARHGAP44. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolARHGAP44
NameRho GTPase activating protein 44
Aliases KIAA0672; RICH-2; RICH2; NPC-A-10; Rho-type GTPase-activating protein RICH2; RhoGAP interacting with CIP4 ho ......
Chromosomal Location17p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ARHGAP44. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ARHGAP44.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolARHGAP44
NameRho GTPase activating protein 44
Aliases KIAA0672; RICH-2; RICH2; NPC-A-10; Rho-type GTPase-activating protein RICH2; RhoGAP interacting with CIP4 ho ......
Chromosomal Location17p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ARHGAP44. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolARHGAP44
NameRho GTPase activating protein 44
Aliases KIAA0672; RICH-2; RICH2; NPC-A-10; Rho-type GTPase-activating protein RICH2; RhoGAP interacting with CIP4 ho ......
Chromosomal Location17p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ARHGAP44 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolARHGAP44
NameRho GTPase activating protein 44
Aliases KIAA0672; RICH-2; RICH2; NPC-A-10; Rho-type GTPase-activating protein RICH2; RhoGAP interacting with CIP4 ho ......
Chromosomal Location17p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ARHGAP44 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolARHGAP44
NameRho GTPase activating protein 44
Aliases KIAA0672; RICH-2; RICH2; NPC-A-10; Rho-type GTPase-activating protein RICH2; RhoGAP interacting with CIP4 ho ......
Chromosomal Location17p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ARHGAP44 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.