Browse ASPM

Summary
SymbolASPM
Nameabnormal spindle microtubule assembly
Aliases Calmbp1; FLJ10517; FLJ10549; MCPH5; microcephaly, primary autosomal recessive 5; asp (abnormal spindle)-like ......
Chromosomal Location1q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Cytoplasm, cytoskeleton, spindle Nucleus Note=The nuclear-cytoplasmic distribution could be regulated by the availability of calmodulin (By similarity). Localizes to spindle poles during mitosis (PubMed:19690332). Associates with microtubule minus ends (By similarity).
Domain PF15780 Abnormal spindle-like microcephaly-assoc'd
PF00307 Calponin homology (CH) domain
PF00612 IQ calmodulin-binding motif
Function

Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis.

> Gene Ontology
 
Biological Process GO:0000226 microtubule cytoskeleton organization
GO:0001764 neuron migration
GO:0002052 positive regulation of neuroblast proliferation
GO:0007051 spindle organization
GO:0007067 mitotic nuclear division
GO:0007126 meiotic nuclear division
GO:0007281 germ cell development
GO:0007283 spermatogenesis
GO:0007292 female gamete generation
GO:0007405 neuroblast proliferation
GO:0007548 sex differentiation
GO:0008356 asymmetric cell division
GO:0008406 gonad development
GO:0008584 male gonad development
GO:0009786 regulation of asymmetric cell division
GO:0010720 positive regulation of cell development
GO:0010721 negative regulation of cell development
GO:0016055 Wnt signaling pathway
GO:0017145 stem cell division
GO:0019827 stem cell population maintenance
GO:0021537 telencephalon development
GO:0021543 pallium development
GO:0021872 forebrain generation of neurons
GO:0021873 forebrain neuroblast division
GO:0021987 cerebral cortex development
GO:0022412 cellular process involved in reproduction in multicellular organism
GO:0030111 regulation of Wnt signaling pathway
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030900 forebrain development
GO:0036445 neuronal stem cell division
GO:0045137 development of primary sexual characteristics
GO:0045665 negative regulation of neuron differentiation
GO:0045769 negative regulation of asymmetric cell division
GO:0046546 development of primary male sexual characteristics
GO:0046661 male sex differentiation
GO:0048103 somatic stem cell division
GO:0048232 male gamete generation
GO:0048477 oogenesis
GO:0048608 reproductive structure development
GO:0050768 negative regulation of neurogenesis
GO:0050769 positive regulation of neurogenesis
GO:0051225 spindle assembly
GO:0051235 maintenance of location
GO:0051302 regulation of cell division
GO:0051321 meiotic cell cycle
GO:0051445 regulation of meiotic cell cycle
GO:0051640 organelle localization
GO:0051642 centrosome localization
GO:0051651 maintenance of location in cell
GO:0051653 spindle localization
GO:0051657 maintenance of organelle location
GO:0051661 maintenance of centrosome location
GO:0051782 negative regulation of cell division
GO:0051961 negative regulation of nervous system development
GO:0051962 positive regulation of nervous system development
GO:0055057 neuroblast division
GO:0060070 canonical Wnt signaling pathway
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0061351 neural precursor cell proliferation
GO:0061458 reproductive system development
GO:0072089 stem cell proliferation
GO:0072091 regulation of stem cell proliferation
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0090306 spindle assembly involved in meiosis
GO:0097150 neuronal stem cell population maintenance
GO:0098727 maintenance of cell number
GO:0198738 cell-cell signaling by wnt
GO:1902692 regulation of neuroblast proliferation
GO:1903046 meiotic cell cycle process
GO:2000177 regulation of neural precursor cell proliferation
GO:2000179 positive regulation of neural precursor cell proliferation
GO:2000241 regulation of reproductive process
GO:2000648 positive regulation of stem cell proliferation
Molecular Function GO:0005516 calmodulin binding
Cellular Component GO:0000922 spindle pole
GO:0005819 spindle
GO:0005874 microtubule
GO:0030496 midbody
GO:0036449 microtubule minus-end
GO:0072686 mitotic spindle
GO:0072687 meiotic spindle
GO:0097431 mitotic spindle pole
GO:1990752 microtubule end
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolASPM
Nameabnormal spindle microtubule assembly
Aliases Calmbp1; FLJ10517; FLJ10549; MCPH5; microcephaly, primary autosomal recessive 5; asp (abnormal spindle)-like ......
Chromosomal Location1q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ASPM and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolASPM
Nameabnormal spindle microtubule assembly
Aliases Calmbp1; FLJ10517; FLJ10549; MCPH5; microcephaly, primary autosomal recessive 5; asp (abnormal spindle)-like ......
Chromosomal Location1q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ASPM in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolASPM
Nameabnormal spindle microtubule assembly
Aliases Calmbp1; FLJ10517; FLJ10549; MCPH5; microcephaly, primary autosomal recessive 5; asp (abnormal spindle)-like ......
Chromosomal Location1q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ASPM in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.6890.0182
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.6840.491
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.6930.359
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3580.509
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.6810.723
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.0410.988
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0180.967
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.7110.655
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.8720.588
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0470.945
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.0620.948
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.4590.0011
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ASPM in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141714.3014.30.196
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103200201
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277325.96.819.10.0153
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275925.98.517.40.0441
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.55.93.61
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.49.16.31
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.16.24.91
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.33.71.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolASPM
Nameabnormal spindle microtubule assembly
Aliases Calmbp1; FLJ10517; FLJ10549; MCPH5; microcephaly, primary autosomal recessive 5; asp (abnormal spindle)-like ......
Chromosomal Location1q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ASPM. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolASPM
Nameabnormal spindle microtubule assembly
Aliases Calmbp1; FLJ10517; FLJ10549; MCPH5; microcephaly, primary autosomal recessive 5; asp (abnormal spindle)-like ......
Chromosomal Location1q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ASPM. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ASPM.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolASPM
Nameabnormal spindle microtubule assembly
Aliases Calmbp1; FLJ10517; FLJ10549; MCPH5; microcephaly, primary autosomal recessive 5; asp (abnormal spindle)-like ......
Chromosomal Location1q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ASPM. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolASPM
Nameabnormal spindle microtubule assembly
Aliases Calmbp1; FLJ10517; FLJ10549; MCPH5; microcephaly, primary autosomal recessive 5; asp (abnormal spindle)-like ......
Chromosomal Location1q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ASPM expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolASPM
Nameabnormal spindle microtubule assembly
Aliases Calmbp1; FLJ10517; FLJ10549; MCPH5; microcephaly, primary autosomal recessive 5; asp (abnormal spindle)-like ......
Chromosomal Location1q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ASPM and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolASPM
Nameabnormal spindle microtubule assembly
Aliases Calmbp1; FLJ10517; FLJ10549; MCPH5; microcephaly, primary autosomal recessive 5; asp (abnormal spindle)-like ......
Chromosomal Location1q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ASPM collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.