Browse ATG13

Summary
SymbolATG13
Nameautophagy related 13
Aliases KIAA0652; ATG13 autophagy related 13 homolog (S. cerevisiae); PARATARG8; ATG13 autophagy related 13 homolog; ......
Chromosomal Location11p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm, cytosol Preautophagosomal structure Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation.
Domain PF10033 Autophagy-related protein 13
Function

Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.

> Gene Ontology
 
Biological Process GO:0000045 autophagosome assembly
GO:0000422 mitophagy
GO:0000423 macromitophagy
GO:0006626 protein targeting to mitochondrion
GO:0006839 mitochondrial transport
GO:0006914 autophagy
GO:0007033 vacuole organization
GO:0010821 regulation of mitochondrion organization
GO:0010822 positive regulation of mitochondrion organization
GO:0016236 macroautophagy
GO:0032386 regulation of intracellular transport
GO:0032388 positive regulation of intracellular transport
GO:0033157 regulation of intracellular protein transport
GO:0051222 positive regulation of protein transport
GO:0061726 mitochondrion disassembly
GO:0070585 protein localization to mitochondrion
GO:0072655 establishment of protein localization to mitochondrion
GO:0090316 positive regulation of intracellular protein transport
GO:0098779 mitophagy in response to mitochondrial depolarization
GO:0098780 response to mitochondrial depolarisation
GO:1903008 organelle disassembly
GO:1903214 regulation of protein targeting to mitochondrion
GO:1903533 regulation of protein targeting
GO:1903747 regulation of establishment of protein localization to mitochondrion
GO:1903749 positive regulation of establishment of protein localization to mitochondrion
GO:1903829 positive regulation of cellular protein localization
GO:1903955 positive regulation of protein targeting to mitochondrion
GO:1904951 positive regulation of establishment of protein localization
GO:1905037 autophagosome organization
Molecular Function -
Cellular Component GO:0000407 pre-autophagosomal structure
GO:0061695 transferase complex, transferring phosphorus-containing groups
GO:1902554 serine/threonine protein kinase complex
GO:1902911 protein kinase complex
GO:1990316 ATG1/ULK1 kinase complex
> KEGG and Reactome Pathway
 
KEGG hsa04140 Regulation of autophagy
Reactome R-HSA-2262752: Cellular responses to stress
R-HSA-1632852: Macroautophagy
Summary
SymbolATG13
Nameautophagy related 13
Aliases KIAA0652; ATG13 autophagy related 13 homolog (S. cerevisiae); PARATARG8; ATG13 autophagy related 13 homolog; ......
Chromosomal Location11p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ATG13 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolATG13
Nameautophagy related 13
Aliases KIAA0652; ATG13 autophagy related 13 homolog (S. cerevisiae); PARATARG8; ATG13 autophagy related 13 homolog; ......
Chromosomal Location11p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ATG13 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell logFC: -2.37; FDR: 0.04220 Resistant to T cell-mediated killing
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolATG13
Nameautophagy related 13
Aliases KIAA0652; ATG13 autophagy related 13 homolog (S. cerevisiae); PARATARG8; ATG13 autophagy related 13 homolog; ......
Chromosomal Location11p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ATG13 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1770.367
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.5170.778
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.070.958
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0310.887
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.050.979
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0090.997
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1320.738
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.4040.817
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.2050.918
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.890.618
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.0280.702
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0230.711
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ATG13 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.42.74.70.294
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.43.440.587
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolATG13
Nameautophagy related 13
Aliases KIAA0652; ATG13 autophagy related 13 homolog (S. cerevisiae); PARATARG8; ATG13 autophagy related 13 homolog; ......
Chromosomal Location11p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ATG13. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolATG13
Nameautophagy related 13
Aliases KIAA0652; ATG13 autophagy related 13 homolog (S. cerevisiae); PARATARG8; ATG13 autophagy related 13 homolog; ......
Chromosomal Location11p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ATG13. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ATG13.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolATG13
Nameautophagy related 13
Aliases KIAA0652; ATG13 autophagy related 13 homolog (S. cerevisiae); PARATARG8; ATG13 autophagy related 13 homolog; ......
Chromosomal Location11p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ATG13. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolATG13
Nameautophagy related 13
Aliases KIAA0652; ATG13 autophagy related 13 homolog (S. cerevisiae); PARATARG8; ATG13 autophagy related 13 homolog; ......
Chromosomal Location11p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ATG13 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolATG13
Nameautophagy related 13
Aliases KIAA0652; ATG13 autophagy related 13 homolog (S. cerevisiae); PARATARG8; ATG13 autophagy related 13 homolog; ......
Chromosomal Location11p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ATG13 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolATG13
Nameautophagy related 13
Aliases KIAA0652; ATG13 autophagy related 13 homolog (S. cerevisiae); PARATARG8; ATG13 autophagy related 13 homolog; ......
Chromosomal Location11p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ATG13 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.