TISIDB

Summary
Symbol	ATP11A
Name	ATPase, class VI, type 11A
Aliases	ATPIH; ATPIS; KIAA1021; potential phospholipid-transporting ATPase IH; phospholipid-translocating ATPase; P4 ......
Chromosomal Location	13q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cell membrane Multi-pass membrane protein Early endosome Recycling endosome Endoplasmic reticulum Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, predominantly located in the plasma membrane.
Domain	PF16212 Phospholipid-translocating P-type ATPase C-terminal PF16209 Phospholipid-translocating ATPase N-terminal
Function	Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib.

> Gene Ontology [ TOP ]
Biological Process	GO:0006869 lipid transport GO:0010876 lipid localization GO:0015748 organophosphate ester transport GO:0015914 phospholipid transport GO:0034204 lipid translocation GO:0045332 phospholipid translocation GO:0097035 regulation of membrane lipid distribution
Molecular Function	GO:0000287 magnesium ion binding GO:0004012 phospholipid-translocating ATPase activity GO:0005319 lipid transporter activity GO:0005548 phospholipid transporter activity GO:0016887 ATPase activity GO:0042623 ATPase activity, coupled GO:0043492 ATPase activity, coupled to movement of substances
Cellular Component	GO:0005765 lysosomal membrane GO:0005769 early endosome GO:0055037 recycling endosome GO:0098852 lytic vacuole membrane

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-983712: Ion channel transport R-HSA-936837: Ion transport by P-type ATPases R-HSA-6798695: Neutrophil degranulation R-HSA-382551: Transmembrane transport of small molecules

Summary
Symbol	ATP11A
Name	ATPase, class VI, type 11A
Aliases	ATPIH; ATPIS; KIAA1021; potential phospholipid-transporting ATPase IH; phospholipid-translocating ATPase; P4 ......
Chromosomal Location	13q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between ATP11A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	ATP11A
Name	ATPase, class VI, type 11A
Aliases	ATPIH; ATPIS; KIAA1021; potential phospholipid-transporting ATPase IH; phospholipid-translocating ATPase; P4 ......
Chromosomal Location	13q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of ATP11A in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	ATP11A
Name	ATPase, class VI, type 11A
Aliases	ATPIH; ATPIS; KIAA1021; potential phospholipid-transporting ATPase IH; phospholipid-translocating ATPase; P4 ......
Chromosomal Location	13q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of ATP11A in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.111	0.822
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.905	0.476
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.488	0.695
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.691	0.041
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.567	0.797
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.851	0.768
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.372	0.451
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	1.155	0.517
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.444	0.818
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.009	0.995
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.661	0.742
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.083	0.417

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of ATP11A in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	7.1	5.9	1.2	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	10	0	10	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	7.1	-7.1	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	1.4	-1.4	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	1.7	-1.7	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	0	11.1	0.36
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	25	0	25	0.364
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	ATP11A
Name	ATPase, class VI, type 11A
Aliases	ATPIH; ATPIS; KIAA1021; potential phospholipid-transporting ATPase IH; phospholipid-translocating ATPase; P4 ......
Chromosomal Location	13q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ATP11A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	ATP11A
Name	ATPase, class VI, type 11A
Aliases	ATPIH; ATPIS; KIAA1021; potential phospholipid-transporting ATPase IH; phospholipid-translocating ATPase; P4 ......
Chromosomal Location	13q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ATP11A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ATP11A. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	ATP11A
Name	ATPase, class VI, type 11A
Aliases	ATPIH; ATPIS; KIAA1021; potential phospholipid-transporting ATPase IH; phospholipid-translocating ATPase; P4 ......
Chromosomal Location	13q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ATP11A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	ATP11A
Name	ATPase, class VI, type 11A
Aliases	ATPIH; ATPIS; KIAA1021; potential phospholipid-transporting ATPase IH; phospholipid-translocating ATPase; P4 ......
Chromosomal Location	13q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of ATP11A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	ATP11A
Name	ATPase, class VI, type 11A
Aliases	ATPIH; ATPIS; KIAA1021; potential phospholipid-transporting ATPase IH; phospholipid-translocating ATPase; P4 ......
Chromosomal Location	13q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between ATP11A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	ATP11A
Name	ATPase, class VI, type 11A
Aliases	ATPIH; ATPIS; KIAA1021; potential phospholipid-transporting ATPase IH; phospholipid-translocating ATPase; P4 ......
Chromosomal Location	13q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting ATP11A collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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