Browse ATP1A3

Summary
SymbolATP1A3
NameATPase, Na+/K+ transporting, alpha 3 polypeptide
Aliases sodium/potassium-transporting ATPase subunit alpha-3; sodium pump subunit alpha-3; sodium-potassium ATPase c ......
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Multi-pass membrane protein
Domain PF00689 Cation transporting ATPase
PF00690 Cation transporter/ATPase
Function

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

> Gene Ontology
 
Biological Process GO:0003012 muscle system process
GO:0003013 circulatory system process
GO:0003015 heart process
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0006818 hydrogen transport
GO:0006875 cellular metal ion homeostasis
GO:0006883 cellular sodium ion homeostasis
GO:0006936 muscle contraction
GO:0006941 striated muscle contraction
GO:0007215 glutamate receptor signaling pathway
GO:0007611 learning or memory
GO:0007612 learning
GO:0007613 memory
GO:0007626 locomotory behavior
GO:0007632 visual behavior
GO:0008015 blood circulation
GO:0008016 regulation of heart contraction
GO:0008306 associative learning
GO:0008344 adult locomotory behavior
GO:0008542 visual learning
GO:0009314 response to radiation
GO:0009416 response to light stimulus
GO:0010107 potassium ion import
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
GO:0010644 cell communication by electrical coupling
GO:0015672 monovalent inorganic cation transport
GO:0015988 energy coupled proton transmembrane transport, against electrochemical gradient
GO:0015991 ATP hydrolysis coupled proton transport
GO:0015992 proton transport
GO:0030004 cellular monovalent inorganic cation homeostasis
GO:0030007 cellular potassium ion homeostasis
GO:0030534 adult behavior
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035637 multicellular organismal signaling
GO:0035725 sodium ion transmembrane transport
GO:0036376 sodium ion export from cell
GO:0042391 regulation of membrane potential
GO:0042493 response to drug
GO:0044057 regulation of system process
GO:0044708 single-organism behavior
GO:0048545 response to steroid hormone
GO:0050890 cognition
GO:0055067 monovalent inorganic cation homeostasis
GO:0055075 potassium ion homeostasis
GO:0055078 sodium ion homeostasis
GO:0060047 heart contraction
GO:0060048 cardiac muscle contraction
GO:0061337 cardiac conduction
GO:0071383 cellular response to steroid hormone stimulus
GO:0071396 cellular response to lipid
GO:0071407 cellular response to organic cyclic compound
GO:0071436 sodium ion export
GO:0071804 cellular potassium ion transport
GO:0071805 potassium ion transmembrane transport
GO:0086036 regulation of cardiac muscle cell membrane potential
GO:0086064 cell communication by electrical coupling involved in cardiac conduction
GO:0086065 cell communication involved in cardiac conduction
GO:0090662 ATP hydrolysis coupled transmembrane transport
GO:1902600 hydrogen ion transmembrane transport
GO:1903416 response to glycoside
GO:1903522 regulation of blood circulation
GO:1903779 regulation of cardiac conduction
Molecular Function GO:0001664 G-protein coupled receptor binding
GO:0001948 glycoprotein binding
GO:0005391 sodium:potassium-exchanging ATPase activity
GO:0005496 steroid binding
GO:0008556 potassium-transporting ATPase activity
GO:0015077 monovalent inorganic cation transmembrane transporter activity
GO:0015079 potassium ion transmembrane transporter activity
GO:0015081 sodium ion transmembrane transporter activity
GO:0015399 primary active transmembrane transporter activity
GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity
GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0016887 ATPase activity
GO:0019829 cation-transporting ATPase activity
GO:0022804 active transmembrane transporter activity
GO:0022853 active ion transmembrane transporter activity
GO:0031748 D1 dopamine receptor binding
GO:0042562 hormone binding
GO:0042623 ATPase activity, coupled
GO:0042625 ATPase coupled ion transmembrane transporter activity
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
GO:0043394 proteoglycan binding
GO:0043395 heparan sulfate proteoglycan binding
GO:0043492 ATPase activity, coupled to movement of substances
GO:0046873 metal ion transmembrane transporter activity
GO:0050780 dopamine receptor binding
GO:0051087 chaperone binding
GO:0086037 sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential
GO:1901681 sulfur compound binding
GO:1990239 steroid hormone binding
Cellular Component GO:0005890 sodium:potassium-exchanging ATPase complex
GO:0030424 axon
GO:0030425 dendrite
GO:0042383 sarcolemma
GO:0043197 dendritic spine
GO:0043209 myelin sheath
GO:0044309 neuron spine
GO:0044326 dendritic spine neck
GO:0044327 dendritic spine head
GO:0090533 cation-transporting ATPase complex
GO:0098533 ATPase dependent transmembrane transport complex
GO:0098794 postsynapse
GO:1902495 transmembrane transporter complex
GO:1904949 ATPase complex
GO:1990351 transporter complex
> KEGG and Reactome Pathway
 
KEGG hsa04022 cGMP-PKG signaling pathway
hsa04024 cAMP signaling pathway
hsa04260 Cardiac muscle contraction
hsa04261 Adrenergic signaling in cardiomyocytes
hsa04911 Insulin secretion
hsa04918 Thyroid hormone synthesis
hsa04919 Thyroid hormone signaling pathway
hsa04960 Aldosterone-regulated sodium reabsorption
hsa04961 Endocrine and other factor-regulated calcium reabsorption
hsa04964 Proximal tubule bicarbonate reclamation
hsa04970 Salivary secretion
hsa04971 Gastric acid secretion
hsa04972 Pancreatic secretion
hsa04973 Carbohydrate digestion and absorption
hsa04974 Protein digestion and absorption
hsa04976 Bile secretion
hsa04978 Mineral absorption
Reactome R-HSA-5576891: Cardiac conduction
R-HSA-983712: Ion channel transport
R-HSA-5578775: Ion homeostasis
R-HSA-936837: Ion transport by P-type ATPases
R-HSA-397014: Muscle contraction
R-HSA-382551: Transmembrane transport of small molecules
Summary
SymbolATP1A3
NameATPase, Na+/K+ transporting, alpha 3 polypeptide
Aliases sodium/potassium-transporting ATPase subunit alpha-3; sodium pump subunit alpha-3; sodium-potassium ATPase c ......
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ATP1A3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolATP1A3
NameATPase, Na+/K+ transporting, alpha 3 polypeptide
Aliases sodium/potassium-transporting ATPase subunit alpha-3; sodium pump subunit alpha-3; sodium-potassium ATPase c ......
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ATP1A3 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolATP1A3
NameATPase, Na+/K+ transporting, alpha 3 polypeptide
Aliases sodium/potassium-transporting ATPase subunit alpha-3; sodium pump subunit alpha-3; sodium-potassium ATPase c ......
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ATP1A3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.2750.592
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.0080.992
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.480.499
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.90.183
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.8320.564
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.9790.546
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.8020.22
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.0330.282
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.670.527
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1540.79
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.210.785
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.5880.0106
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ATP1A3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.76.8-3.11
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.78.5-4.80.66
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.35.98.40.613
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86016.7-16.70.429
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131123.1023.10.223
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.112.5-1.41
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 592022.2-2.21
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382713.27.45.80.69
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221318.27.710.50.63
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.27.1-0.91
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolATP1A3
NameATPase, Na+/K+ transporting, alpha 3 polypeptide
Aliases sodium/potassium-transporting ATPase subunit alpha-3; sodium pump subunit alpha-3; sodium-potassium ATPase c ......
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ATP1A3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolATP1A3
NameATPase, Na+/K+ transporting, alpha 3 polypeptide
Aliases sodium/potassium-transporting ATPase subunit alpha-3; sodium pump subunit alpha-3; sodium-potassium ATPase c ......
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ATP1A3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ATP1A3.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolATP1A3
NameATPase, Na+/K+ transporting, alpha 3 polypeptide
Aliases sodium/potassium-transporting ATPase subunit alpha-3; sodium pump subunit alpha-3; sodium-potassium ATPase c ......
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ATP1A3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolATP1A3
NameATPase, Na+/K+ transporting, alpha 3 polypeptide
Aliases sodium/potassium-transporting ATPase subunit alpha-3; sodium pump subunit alpha-3; sodium-potassium ATPase c ......
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ATP1A3 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolATP1A3
NameATPase, Na+/K+ transporting, alpha 3 polypeptide
Aliases sodium/potassium-transporting ATPase subunit alpha-3; sodium pump subunit alpha-3; sodium-potassium ATPase c ......
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ATP1A3 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolATP1A3
NameATPase, Na+/K+ transporting, alpha 3 polypeptide
Aliases sodium/potassium-transporting ATPase subunit alpha-3; sodium pump subunit alpha-3; sodium-potassium ATPase c ......
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ATP1A3 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting ATP1A3.
ID Name Drug Type Targets #Targets
DB01092OuabainSmall MoleculeATP1A1, ATP1A2, ATP1A33