Browse ATP1B1

Summary
SymbolATP1B1
NameATPase, Na+/K+ transporting, beta 1 polypeptide
Aliases sodium/potassium-transporting ATPase subunit beta-1; sodium pump subunit beta-1; sodium-potassium ATPase sub ......
Chromosomal Location1q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Single-pass type II membrane protein Cell membrane, sarcolemma Note=Colocalizes with OBSCN at the intercalated disk and sarcolemma in cardiomyocytes. Localizes in long striations at the level of Z and M lines.
Domain PF00287 Sodium / potassium ATPase beta chain
Function

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. ; FUNCTION: Involved in cell adhesion and establishing epithelial cell polarity.

> Gene Ontology
 
Biological Process GO:0001508 action potential
GO:0001666 response to hypoxia
GO:0002028 regulation of sodium ion transport
GO:0003012 muscle system process
GO:0003013 circulatory system process
GO:0003015 heart process
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0006883 cellular sodium ion homeostasis
GO:0006936 muscle contraction
GO:0006937 regulation of muscle contraction
GO:0006941 striated muscle contraction
GO:0006942 regulation of striated muscle contraction
GO:0007009 plasma membrane organization
GO:0008015 blood circulation
GO:0008016 regulation of heart contraction
GO:0009116 nucleoside metabolic process
GO:0009119 ribonucleoside metabolic process
GO:0009123 nucleoside monophosphate metabolic process
GO:0009126 purine nucleoside monophosphate metabolic process
GO:0009141 nucleoside triphosphate metabolic process
GO:0009144 purine nucleoside triphosphate metabolic process
GO:0009150 purine ribonucleotide metabolic process
GO:0009161 ribonucleoside monophosphate metabolic process
GO:0009167 purine ribonucleoside monophosphate metabolic process
GO:0009199 ribonucleoside triphosphate metabolic process
GO:0009205 purine ribonucleoside triphosphate metabolic process
GO:0010107 potassium ion import
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
GO:0010644 cell communication by electrical coupling
GO:0010765 positive regulation of sodium ion transport
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
GO:0010959 regulation of metal ion transport
GO:0015672 monovalent inorganic cation transport
GO:0019722 calcium-mediated signaling
GO:0019932 second-messenger-mediated signaling
GO:0022898 regulation of transmembrane transporter activity
GO:0030004 cellular monovalent inorganic cation homeostasis
GO:0030007 cellular potassium ion homeostasis
GO:0031647 regulation of protein stability
GO:0032409 regulation of transporter activity
GO:0032411 positive regulation of transporter activity
GO:0032412 regulation of ion transmembrane transporter activity
GO:0032414 positive regulation of ion transmembrane transporter activity
GO:0032594 protein transport within lipid bilayer
GO:0032596 protein transport into membrane raft
GO:0032781 positive regulation of ATPase activity
GO:0034762 regulation of transmembrane transport
GO:0034764 positive regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0034767 positive regulation of ion transmembrane transport
GO:0035637 multicellular organismal signaling
GO:0035725 sodium ion transmembrane transport
GO:0036293 response to decreased oxygen levels
GO:0036376 sodium ion export from cell
GO:0042278 purine nucleoside metabolic process
GO:0042391 regulation of membrane potential
GO:0043266 regulation of potassium ion transport
GO:0043268 positive regulation of potassium ion transport
GO:0043270 positive regulation of ion transport
GO:0043462 regulation of ATPase activity
GO:0044057 regulation of system process
GO:0044860 protein localization to plasma membrane raft
GO:0044861 protein transport into plasma membrane raft
GO:0046034 ATP metabolic process
GO:0046128 purine ribonucleoside metabolic process
GO:0050821 protein stabilization
GO:0050900 leukocyte migration
GO:0051668 localization within membrane
GO:0051924 regulation of calcium ion transport
GO:0051928 positive regulation of calcium ion transport
GO:0055067 monovalent inorganic cation homeostasis
GO:0055074 calcium ion homeostasis
GO:0055075 potassium ion homeostasis
GO:0055078 sodium ion homeostasis
GO:0055117 regulation of cardiac muscle contraction
GO:0055119 relaxation of cardiac muscle
GO:0060047 heart contraction
GO:0060048 cardiac muscle contraction
GO:0061337 cardiac conduction
GO:0070482 response to oxygen levels
GO:0070588 calcium ion transmembrane transport
GO:0070838 divalent metal ion transport
GO:0071436 sodium ion export
GO:0071804 cellular potassium ion transport
GO:0071805 potassium ion transmembrane transport
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072511 divalent inorganic cation transport
GO:0072657 protein localization to membrane
GO:0072659 protein localization to plasma membrane
GO:0086001 cardiac muscle cell action potential
GO:0086009 membrane repolarization
GO:0086011 membrane repolarization during action potential
GO:0086013 membrane repolarization during cardiac muscle cell action potential
GO:0086064 cell communication by electrical coupling involved in cardiac conduction
GO:0086065 cell communication involved in cardiac conduction
GO:0090002 establishment of protein localization to plasma membrane
GO:0090075 relaxation of muscle
GO:0090150 establishment of protein localization to membrane
GO:0090257 regulation of muscle system process
GO:0090662 ATP hydrolysis coupled transmembrane transport
GO:0098657 import into cell
GO:0098739 import across plasma membrane
GO:0099622 cardiac muscle cell membrane repolarization
GO:1901016 regulation of potassium ion transmembrane transporter activity
GO:1901018 positive regulation of potassium ion transmembrane transporter activity
GO:1901019 regulation of calcium ion transmembrane transporter activity
GO:1901021 positive regulation of calcium ion transmembrane transporter activity
GO:1901379 regulation of potassium ion transmembrane transport
GO:1901381 positive regulation of potassium ion transmembrane transport
GO:1901657 glycosyl compound metabolic process
GO:1902305 regulation of sodium ion transmembrane transport
GO:1902307 positive regulation of sodium ion transmembrane transport
GO:1903044 protein localization to membrane raft
GO:1903169 regulation of calcium ion transmembrane transport
GO:1903273 regulation of sodium ion export
GO:1903275 positive regulation of sodium ion export
GO:1903276 regulation of sodium ion export from cell
GO:1903278 positive regulation of sodium ion export from cell
GO:1903279 regulation of calcium:sodium antiporter activity
GO:1903281 positive regulation of calcium:sodium antiporter activity
GO:1903286 regulation of potassium ion import
GO:1903288 positive regulation of potassium ion import
GO:1903522 regulation of blood circulation
GO:1903779 regulation of cardiac conduction
GO:1904062 regulation of cation transmembrane transport
GO:1904064 positive regulation of cation transmembrane transport
GO:1904427 positive regulation of calcium ion transmembrane transport
GO:1990573 potassium ion import across plasma membrane
GO:1990778 protein localization to cell periphery
GO:2000649 regulation of sodium ion transmembrane transporter activity
GO:2000651 positive regulation of sodium ion transmembrane transporter activity
Molecular Function GO:0001671 ATPase activator activity
GO:0003823 antigen binding
GO:0005391 sodium:potassium-exchanging ATPase activity
GO:0008022 protein C-terminus binding
GO:0008047 enzyme activator activity
GO:0008144 drug binding
GO:0008556 potassium-transporting ATPase activity
GO:0015077 monovalent inorganic cation transmembrane transporter activity
GO:0015079 potassium ion transmembrane transporter activity
GO:0015081 sodium ion transmembrane transporter activity
GO:0015399 primary active transmembrane transporter activity
GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity
GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0016887 ATPase activity
GO:0019829 cation-transporting ATPase activity
GO:0022804 active transmembrane transporter activity
GO:0022853 active ion transmembrane transporter activity
GO:0023023 MHC protein complex binding
GO:0023026 MHC class II protein complex binding
GO:0030955 potassium ion binding
GO:0031402 sodium ion binding
GO:0031420 alkali metal ion binding
GO:0042623 ATPase activity, coupled
GO:0042625 ATPase coupled ion transmembrane transporter activity
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
GO:0043492 ATPase activity, coupled to movement of substances
GO:0046873 metal ion transmembrane transporter activity
GO:0051117 ATPase binding
GO:0060589 nucleoside-triphosphatase regulator activity
GO:0060590 ATPase regulator activity
Cellular Component GO:0005890 sodium:potassium-exchanging ATPase complex
GO:0005901 caveola
GO:0014704 intercalated disc
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0042383 sarcolemma
GO:0043209 myelin sheath
GO:0044291 cell-cell contact zone
GO:0044853 plasma membrane raft
GO:0045121 membrane raft
GO:0045177 apical part of cell
GO:0090533 cation-transporting ATPase complex
GO:0098533 ATPase dependent transmembrane transport complex
GO:0098589 membrane region
GO:0098857 membrane microdomain
GO:1902495 transmembrane transporter complex
GO:1904949 ATPase complex
GO:1990351 transporter complex
> KEGG and Reactome Pathway
 
KEGG hsa04022 cGMP-PKG signaling pathway
hsa04024 cAMP signaling pathway
hsa04260 Cardiac muscle contraction
hsa04261 Adrenergic signaling in cardiomyocytes
hsa04911 Insulin secretion
hsa04918 Thyroid hormone synthesis
hsa04919 Thyroid hormone signaling pathway
hsa04960 Aldosterone-regulated sodium reabsorption
hsa04961 Endocrine and other factor-regulated calcium reabsorption
hsa04964 Proximal tubule bicarbonate reclamation
hsa04970 Salivary secretion
hsa04971 Gastric acid secretion
hsa04972 Pancreatic secretion
hsa04973 Carbohydrate digestion and absorption
hsa04974 Protein digestion and absorption
hsa04976 Bile secretion
hsa04978 Mineral absorption
Reactome R-HSA-210991: Basigin interactions
R-HSA-5576891: Cardiac conduction
R-HSA-202733: Cell surface interactions at the vascular wall
R-HSA-109582: Hemostasis
R-HSA-983712: Ion channel transport
R-HSA-5578775: Ion homeostasis
R-HSA-936837: Ion transport by P-type ATPases
R-HSA-397014: Muscle contraction
R-HSA-382551: Transmembrane transport of small molecules
Summary
SymbolATP1B1
NameATPase, Na+/K+ transporting, beta 1 polypeptide
Aliases sodium/potassium-transporting ATPase subunit beta-1; sodium pump subunit beta-1; sodium-potassium ATPase sub ......
Chromosomal Location1q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ATP1B1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolATP1B1
NameATPase, Na+/K+ transporting, beta 1 polypeptide
Aliases sodium/potassium-transporting ATPase subunit beta-1; sodium pump subunit beta-1; sodium-potassium ATPase sub ......
Chromosomal Location1q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ATP1B1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolATP1B1
NameATPase, Na+/K+ transporting, beta 1 polypeptide
Aliases sodium/potassium-transporting ATPase subunit beta-1; sodium pump subunit beta-1; sodium-potassium ATPase sub ......
Chromosomal Location1q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ATP1B1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.7420.164
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.8980.708
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.6370.697
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9161.2940.00351
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 591.060.609
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.5840.517
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2760.64
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.1070.951
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.4750.803
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.7290.776
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.5410.895
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.2460.18
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ATP1B1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277302.7-2.71
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275903.4-3.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolATP1B1
NameATPase, Na+/K+ transporting, beta 1 polypeptide
Aliases sodium/potassium-transporting ATPase subunit beta-1; sodium pump subunit beta-1; sodium-potassium ATPase sub ......
Chromosomal Location1q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ATP1B1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolATP1B1
NameATPase, Na+/K+ transporting, beta 1 polypeptide
Aliases sodium/potassium-transporting ATPase subunit beta-1; sodium pump subunit beta-1; sodium-potassium ATPase sub ......
Chromosomal Location1q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ATP1B1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ATP1B1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolATP1B1
NameATPase, Na+/K+ transporting, beta 1 polypeptide
Aliases sodium/potassium-transporting ATPase subunit beta-1; sodium pump subunit beta-1; sodium-potassium ATPase sub ......
Chromosomal Location1q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ATP1B1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolATP1B1
NameATPase, Na+/K+ transporting, beta 1 polypeptide
Aliases sodium/potassium-transporting ATPase subunit beta-1; sodium pump subunit beta-1; sodium-potassium ATPase sub ......
Chromosomal Location1q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ATP1B1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolATP1B1
NameATPase, Na+/K+ transporting, beta 1 polypeptide
Aliases sodium/potassium-transporting ATPase subunit beta-1; sodium pump subunit beta-1; sodium-potassium ATPase sub ......
Chromosomal Location1q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ATP1B1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolATP1B1
NameATPase, Na+/K+ transporting, beta 1 polypeptide
Aliases sodium/potassium-transporting ATPase subunit beta-1; sodium pump subunit beta-1; sodium-potassium ATPase sub ......
Chromosomal Location1q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ATP1B1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.