Browse ATP2B1

Summary
SymbolATP2B1
NameATPase, Ca++ transporting, plasma membrane 1
Aliases PMCA1; plasma membrane calcium-transporting ATPase 1; PMCA1kb; Plasma membrane calcium pump isoform 1; Plasm ......
Chromosomal Location12q21.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane; Multi-pass membrane protein.
Domain PF12424 Plasma membrane calcium transporter ATPase C terminal
PF00689 Cation transporting ATPase
PF00690 Cation transporter/ATPase
Function

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.

> Gene Ontology
 
Biological Process GO:0001654 eye development
GO:0003013 circulatory system process
GO:0003015 heart process
GO:0003407 neural retina development
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0007423 sensory organ development
GO:0007568 aging
GO:0007584 response to nutrient
GO:0008015 blood circulation
GO:0008016 regulation of heart contraction
GO:0009266 response to temperature stimulus
GO:0009409 response to cold
GO:0009991 response to extracellular stimulus
GO:0031667 response to nutrient levels
GO:0031668 cellular response to extracellular stimulus
GO:0031669 cellular response to nutrient levels
GO:0031670 cellular response to nutrient
GO:0031960 response to corticosteroid
GO:0033273 response to vitamin
GO:0033280 response to vitamin D
GO:0035637 multicellular organismal signaling
GO:0043010 camera-type eye development
GO:0044057 regulation of system process
GO:0048545 response to steroid hormone
GO:0051384 response to glucocorticoid
GO:0051385 response to mineralocorticoid
GO:0051412 response to corticosterone
GO:0055074 calcium ion homeostasis
GO:0060041 retina development in camera-type eye
GO:0060047 heart contraction
GO:0061337 cardiac conduction
GO:0070588 calcium ion transmembrane transport
GO:0070838 divalent metal ion transport
GO:0071295 cellular response to vitamin
GO:0071305 cellular response to vitamin D
GO:0071383 cellular response to steroid hormone stimulus
GO:0071384 cellular response to corticosteroid stimulus
GO:0071385 cellular response to glucocorticoid stimulus
GO:0071386 cellular response to corticosterone stimulus
GO:0071389 cellular response to mineralocorticoid stimulus
GO:0071396 cellular response to lipid
GO:0071407 cellular response to organic cyclic compound
GO:0071496 cellular response to external stimulus
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072511 divalent inorganic cation transport
GO:1901654 response to ketone
GO:1901655 cellular response to ketone
GO:1901660 calcium ion export
GO:1903522 regulation of blood circulation
GO:1903779 regulation of cardiac conduction
Molecular Function GO:0005388 calcium-transporting ATPase activity
GO:0005516 calmodulin binding
GO:0015085 calcium ion transmembrane transporter activity
GO:0015399 primary active transmembrane transporter activity
GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity
GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0016887 ATPase activity
GO:0019829 cation-transporting ATPase activity
GO:0022804 active transmembrane transporter activity
GO:0022853 active ion transmembrane transporter activity
GO:0030165 PDZ domain binding
GO:0042623 ATPase activity, coupled
GO:0042625 ATPase coupled ion transmembrane transporter activity
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
GO:0043492 ATPase activity, coupled to movement of substances
GO:0046873 metal ion transmembrane transporter activity
GO:0072509 divalent inorganic cation transmembrane transporter activity
Cellular Component GO:0009898 cytoplasmic side of plasma membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0031252 cell leading edge
GO:0031253 cell projection membrane
GO:0031256 leading edge membrane
GO:0032589 neuron projection membrane
GO:0032590 dendrite membrane
GO:0032591 dendritic spine membrane
GO:0032809 neuronal cell body membrane
GO:0043025 neuronal cell body
GO:0044297 cell body
GO:0044298 cell body membrane
GO:0045121 membrane raft
GO:0045177 apical part of cell
GO:0097060 synaptic membrane
GO:0098552 side of membrane
GO:0098562 cytoplasmic side of membrane
GO:0098589 membrane region
GO:0098857 membrane microdomain
> KEGG and Reactome Pathway
 
KEGG hsa04020 Calcium signaling pathway
hsa04022 cGMP-PKG signaling pathway
hsa04024 cAMP signaling pathway
hsa04261 Adrenergic signaling in cardiomyocytes
hsa04961 Endocrine and other factor-regulated calcium reabsorption
hsa04970 Salivary secretion
hsa04972 Pancreatic secretion
hsa04978 Mineral absorption
Reactome R-HSA-5576891: Cardiac conduction
R-HSA-109582: Hemostasis
R-HSA-983712: Ion channel transport
R-HSA-5578775: Ion homeostasis
R-HSA-936837: Ion transport by P-type ATPases
R-HSA-397014: Muscle contraction
R-HSA-418360: Platelet calcium homeostasis
R-HSA-418346: Platelet homeostasis
R-HSA-418359: Reduction of cytosolic Ca++ levels
R-HSA-382551: Transmembrane transport of small molecules
Summary
SymbolATP2B1
NameATPase, Ca++ transporting, plasma membrane 1
Aliases PMCA1; plasma membrane calcium-transporting ATPase 1; PMCA1kb; Plasma membrane calcium pump isoform 1; Plasm ......
Chromosomal Location12q21.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ATP2B1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolATP2B1
NameATPase, Ca++ transporting, plasma membrane 1
Aliases PMCA1; plasma membrane calcium-transporting ATPase 1; PMCA1kb; Plasma membrane calcium pump isoform 1; Plasm ......
Chromosomal Location12q21.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ATP2B1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolATP2B1
NameATPase, Ca++ transporting, plasma membrane 1
Aliases PMCA1; plasma membrane calcium-transporting ATPase 1; PMCA1kb; Plasma membrane calcium pump isoform 1; Plasm ......
Chromosomal Location12q21.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ATP2B1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.340.393
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.1530.933
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.4770.726
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0770.815
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1410.948
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3510.897
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1130.818
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.3820.842
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.7340.718
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.7290.484
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.390.361
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0820.358
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ATP2B1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277314.81.413.40.0181
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275914.81.713.10.032
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.16.24.91
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 592011.18.91
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolATP2B1
NameATPase, Ca++ transporting, plasma membrane 1
Aliases PMCA1; plasma membrane calcium-transporting ATPase 1; PMCA1kb; Plasma membrane calcium pump isoform 1; Plasm ......
Chromosomal Location12q21.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ATP2B1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolATP2B1
NameATPase, Ca++ transporting, plasma membrane 1
Aliases PMCA1; plasma membrane calcium-transporting ATPase 1; PMCA1kb; Plasma membrane calcium pump isoform 1; Plasm ......
Chromosomal Location12q21.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ATP2B1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ATP2B1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolATP2B1
NameATPase, Ca++ transporting, plasma membrane 1
Aliases PMCA1; plasma membrane calcium-transporting ATPase 1; PMCA1kb; Plasma membrane calcium pump isoform 1; Plasm ......
Chromosomal Location12q21.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ATP2B1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolATP2B1
NameATPase, Ca++ transporting, plasma membrane 1
Aliases PMCA1; plasma membrane calcium-transporting ATPase 1; PMCA1kb; Plasma membrane calcium pump isoform 1; Plasm ......
Chromosomal Location12q21.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ATP2B1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolATP2B1
NameATPase, Ca++ transporting, plasma membrane 1
Aliases PMCA1; plasma membrane calcium-transporting ATPase 1; PMCA1kb; Plasma membrane calcium pump isoform 1; Plasm ......
Chromosomal Location12q21.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ATP2B1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolATP2B1
NameATPase, Ca++ transporting, plasma membrane 1
Aliases PMCA1; plasma membrane calcium-transporting ATPase 1; PMCA1kb; Plasma membrane calcium pump isoform 1; Plasm ......
Chromosomal Location12q21.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ATP2B1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.