TISIDB

Summary
Symbol	ATP8A2
Name	ATPase, aminophospholipid transporter, class I, type 8A, member 2
Aliases	ATPIB; ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2; ATP; CAMRQ4; IB; P4-ATPase fl ......
Chromosomal Location	13q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Membrane Multi-pass membrane protein Golgi apparatus Endosome Cell projection, cilium, photoreceptor outer segment Cell membrane Note=Localizes to the Golgi and endosomes in photoreceptor cells. Localizes to disk membranes of rod photoreceptor outer segments (ROS) (By similarity).
Domain	PF16212 Phospholipid-translocating P-type ATPase C-terminal PF16209 Phospholipid-translocating ATPase N-terminal
Function	Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Involved in regulation of neurite outgrowth; acting in synergy with TMEM30A. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival.

> Gene Ontology [ TOP ]
Biological Process	GO:0001654 eye development GO:0003009 skeletal muscle contraction GO:0003011 involuntary skeletal muscle contraction GO:0003012 muscle system process GO:0003407 neural retina development GO:0006869 lipid transport GO:0006900 membrane budding GO:0006936 muscle contraction GO:0006941 striated muscle contraction GO:0007409 axonogenesis GO:0007423 sensory organ development GO:0007568 aging GO:0007601 visual perception GO:0007631 feeding behavior GO:0009314 response to radiation GO:0009416 response to light stimulus GO:0009581 detection of external stimulus GO:0009582 detection of abiotic stimulus GO:0009583 detection of light stimulus GO:0009584 detection of visible light GO:0009612 response to mechanical stimulus GO:0010720 positive regulation of cell development GO:0010842 retina layer formation GO:0010876 lipid localization GO:0010975 regulation of neuron projection development GO:0010976 positive regulation of neuron projection development GO:0010996 response to auditory stimulus GO:0015748 organophosphate ester transport GO:0015914 phospholipid transport GO:0016050 vesicle organization GO:0031346 positive regulation of cell projection organization GO:0032368 regulation of lipid transport GO:0032370 positive regulation of lipid transport GO:0034204 lipid translocation GO:0035264 multicellular organism growth GO:0040014 regulation of multicellular organism growth GO:0040018 positive regulation of multicellular organism growth GO:0042471 ear morphogenesis GO:0042472 inner ear morphogenesis GO:0042755 eating behavior GO:0043010 camera-type eye development GO:0043583 ear development GO:0043588 skin development GO:0045103 intermediate filament-based process GO:0045104 intermediate filament cytoskeleton organization GO:0045332 phospholipid translocation GO:0045666 positive regulation of neuron differentiation GO:0045927 positive regulation of growth GO:0048193 Golgi vesicle transport GO:0048194 Golgi vesicle budding GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048592 eye morphogenesis GO:0048593 camera-type eye morphogenesis GO:0048638 regulation of developmental growth GO:0048639 positive regulation of developmental growth GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048839 inner ear development GO:0050769 positive regulation of neurogenesis GO:0050879 multicellular organismal movement GO:0050881 musculoskeletal movement GO:0050884 neuromuscular process controlling posture GO:0050905 neuromuscular process GO:0050908 detection of light stimulus involved in visual perception GO:0050953 sensory perception of light stimulus GO:0050962 detection of light stimulus involved in sensory perception GO:0051962 positive regulation of nervous system development GO:0060041 retina development in camera-type eye GO:0060042 retina morphogenesis in camera-type eye GO:0060052 neurofilament cytoskeleton organization GO:0061091 regulation of phospholipid translocation GO:0061092 positive regulation of phospholipid translocation GO:0061564 axon development GO:0090596 sensory organ morphogenesis GO:0097035 regulation of membrane lipid distribution GO:2001138 regulation of phospholipid transport GO:2001140 positive regulation of phospholipid transport
Molecular Function	GO:0000287 magnesium ion binding GO:0004012 phospholipid-translocating ATPase activity GO:0005319 lipid transporter activity GO:0005548 phospholipid transporter activity GO:0016887 ATPase activity GO:0042623 ATPase activity, coupled GO:0043492 ATPase activity, coupled to movement of substances
Cellular Component	GO:0001750 photoreceptor outer segment GO:0005802 trans-Golgi network GO:0005929 cilium GO:0031513 nonmotile primary cilium GO:0031984 organelle subcompartment GO:0072372 primary cilium GO:0098791 Golgi subcompartment

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-983712: Ion channel transport R-HSA-936837: Ion transport by P-type ATPases R-HSA-382551: Transmembrane transport of small molecules

Summary
Symbol	ATP8A2
Name	ATPase, aminophospholipid transporter, class I, type 8A, member 2
Aliases	ATPIB; ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2; ATP; CAMRQ4; IB; P4-ATPase fl ......
Chromosomal Location	13q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between ATP8A2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	ATP8A2
Name	ATPase, aminophospholipid transporter, class I, type 8A, member 2
Aliases	ATPIB; ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2; ATP; CAMRQ4; IB; P4-ATPase fl ......
Chromosomal Location	13q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of ATP8A2 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	ATP8A2
Name	ATPase, aminophospholipid transporter, class I, type 8A, member 2
Aliases	ATPIB; ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2; ATP; CAMRQ4; IB; P4-ATPase fl ......
Chromosomal Location	13q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of ATP8A2 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	1.025	0.00561
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.91	0.159
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	1.108	0.0393
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.006	0.992
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.216	0.86
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.261	0.855
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.641	0.361
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-1.426	0.181
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.483	0.644
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.39	0.341
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.412	0.457
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.169	0.446

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of ATP8A2 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	11.1	2.7	8.4	0.12
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	11.1	3.4	7.7	0.176
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	14.3	0	14.3	0.238
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	12.5	0	12.5	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	15.4	0	15.4	0.482
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	6.2	4.9	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	25	0	25	0.364
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	ATP8A2
Name	ATPase, aminophospholipid transporter, class I, type 8A, member 2
Aliases	ATPIB; ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2; ATP; CAMRQ4; IB; P4-ATPase fl ......
Chromosomal Location	13q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ATP8A2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	ATP8A2
Name	ATPase, aminophospholipid transporter, class I, type 8A, member 2
Aliases	ATPIB; ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2; ATP; CAMRQ4; IB; P4-ATPase fl ......
Chromosomal Location	13q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ATP8A2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ATP8A2. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	ATP8A2
Name	ATPase, aminophospholipid transporter, class I, type 8A, member 2
Aliases	ATPIB; ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2; ATP; CAMRQ4; IB; P4-ATPase fl ......
Chromosomal Location	13q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ATP8A2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	ATP8A2
Name	ATPase, aminophospholipid transporter, class I, type 8A, member 2
Aliases	ATPIB; ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2; ATP; CAMRQ4; IB; P4-ATPase fl ......
Chromosomal Location	13q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of ATP8A2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	ATP8A2
Name	ATPase, aminophospholipid transporter, class I, type 8A, member 2
Aliases	ATPIB; ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2; ATP; CAMRQ4; IB; P4-ATPase fl ......
Chromosomal Location	13q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between ATP8A2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	ATP8A2
Name	ATPase, aminophospholipid transporter, class I, type 8A, member 2
Aliases	ATPIB; ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2; ATP; CAMRQ4; IB; P4-ATPase fl ......
Chromosomal Location	13q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting ATP8A2 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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