Browse AXIN1

Summary
SymbolAXIN1
Nameaxin 1
Aliases PPP1R49; protein phosphatase 1, regulatory subunit 49; AXIN; axis inhibition protein 1; axis inhibitor 1; fu ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Nucleus Membrane Cell membrane Note=MACF1 is required for its translocation to cell membrane (By similarity). On UV irradiation, translocates to the nucleus and colocalizes with DAAX (PubMed:17210684).
Domain PF16646 Axin-1 tankyrase binding domain
PF08833 Axin beta-catenin binding domain
PF00778 DIX domain
PF00615 Regulator of G protein signaling domain
Function

Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684).

> Gene Ontology
 
Biological Process GO:0000187 activation of MAPK activity
GO:0000226 microtubule cytoskeleton organization
GO:0001501 skeletal system development
GO:0001654 eye development
GO:0001704 formation of primary germ layer
GO:0001707 mesoderm formation
GO:0001743 optic placode formation
GO:0001756 somitogenesis
GO:0003002 regionalization
GO:0006354 DNA-templated transcription, elongation
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006606 protein import into nucleus
GO:0006913 nucleocytoplasmic transport
GO:0007254 JNK cascade
GO:0007257 activation of JUN kinase activity
GO:0007368 determination of left/right symmetry
GO:0007369 gastrulation
GO:0007389 pattern specification process
GO:0007423 sensory organ development
GO:0007498 mesoderm development
GO:0009798 axis specification
GO:0009799 specification of symmetry
GO:0009855 determination of bilateral symmetry
GO:0009894 regulation of catabolic process
GO:0009896 positive regulation of catabolic process
GO:0009950 dorsal/ventral axis specification
GO:0009952 anterior/posterior pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0010498 proteasomal protein catabolic process
GO:0010799 regulation of peptidyl-threonine phosphorylation
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0016055 Wnt signaling pathway
GO:0017038 protein import
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0018209 peptidyl-serine modification
GO:0018210 peptidyl-threonine modification
GO:0021797 forebrain anterior/posterior pattern specification
GO:0021871 forebrain regionalization
GO:0021872 forebrain generation of neurons
GO:0021877 forebrain neuron fate commitment
GO:0021879 forebrain neuron differentiation
GO:0021881 Wnt-activated signaling pathway involved in forebrain neuron fate commitment
GO:0021898 commitment of multipotent stem cells to neuronal lineage in forebrain
GO:0021953 central nervous system neuron differentiation
GO:0021999 neural plate anterior/posterior regionalization
GO:0030111 regulation of Wnt signaling pathway
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030900 forebrain development
GO:0030910 olfactory placode formation
GO:0031098 stress-activated protein kinase signaling cascade
GO:0031122 cytoplasmic microtubule organization
GO:0031329 regulation of cellular catabolic process
GO:0031331 positive regulation of cellular catabolic process
GO:0031396 regulation of protein ubiquitination
GO:0031398 positive regulation of protein ubiquitination
GO:0032147 activation of protein kinase activity
GO:0032386 regulation of intracellular transport
GO:0032784 regulation of DNA-templated transcription, elongation
GO:0032785 negative regulation of DNA-templated transcription, elongation
GO:0032872 regulation of stress-activated MAPK cascade
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0032984 macromolecular complex disassembly
GO:0033135 regulation of peptidyl-serine phosphorylation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033157 regulation of intracellular protein transport
GO:0033674 positive regulation of kinase activity
GO:0034243 regulation of transcription elongation from RNA polymerase II promoter
GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter
GO:0034504 protein localization to nucleus
GO:0035282 segmentation
GO:0035411 catenin import into nucleus
GO:0035412 regulation of catenin import into nucleus
GO:0042176 regulation of protein catabolic process
GO:0042306 regulation of protein import into nucleus
GO:0042692 muscle cell differentiation
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043241 protein complex disassembly
GO:0043405 regulation of MAP kinase activity
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043506 regulation of JUN kinase activity
GO:0043507 positive regulation of JUN kinase activity
GO:0043584 nose development
GO:0044744 protein targeting to nucleus
GO:0045165 cell fate commitment
GO:0045444 fat cell differentiation
GO:0045598 regulation of fat cell differentiation
GO:0045599 negative regulation of fat cell differentiation
GO:0045732 positive regulation of protein catabolic process
GO:0045860 positive regulation of protein kinase activity
GO:0045862 positive regulation of proteolysis
GO:0046328 regulation of JNK cascade
GO:0046330 positive regulation of JNK cascade
GO:0046822 regulation of nucleocytoplasmic transport
GO:0048048 embryonic eye morphogenesis
GO:0048318 axial mesoderm development
GO:0048319 axial mesoderm morphogenesis
GO:0048320 axial mesoderm formation
GO:0048332 mesoderm morphogenesis
GO:0048562 embryonic organ morphogenesis
GO:0048568 embryonic organ development
GO:0048592 eye morphogenesis
GO:0048663 neuron fate commitment
GO:0048704 embryonic skeletal system morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0048706 embryonic skeletal system development
GO:0051169 nuclear transport
GO:0051170 nuclear import
GO:0051403 stress-activated MAPK cascade
GO:0051438 regulation of ubiquitin-protein transferase activity
GO:0051443 positive regulation of ubiquitin-protein transferase activity
GO:0055001 muscle cell development
GO:0060070 canonical Wnt signaling pathway
GO:0060272 embryonic skeletal joint morphogenesis
GO:0060541 respiratory system development
GO:0060788 ectodermal placode formation
GO:0060823 canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0060896 neural plate pattern specification
GO:0060897 neural plate regionalization
GO:0061053 somite development
GO:0070302 regulation of stress-activated protein kinase signaling cascade
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade
GO:0071407 cellular response to organic cyclic compound
GO:0071696 ectodermal placode development
GO:0071697 ectodermal placode morphogenesis
GO:0071698 olfactory placode development
GO:0071699 olfactory placode morphogenesis
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0072498 embryonic skeletal joint development
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090244 Wnt signaling pathway involved in somitogenesis
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0090596 sensory organ morphogenesis
GO:0198738 cell-cell signaling by wnt
GO:1900180 regulation of protein localization to nucleus
GO:1902593 single-organism nuclear import
GO:1903050 regulation of proteolysis involved in cellular protein catabolic process
GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process
GO:1903320 regulation of protein modification by small protein conjugation or removal
GO:1903322 positive regulation of protein modification by small protein conjugation or removal
GO:1903362 regulation of cellular protein catabolic process
GO:1903364 positive regulation of cellular protein catabolic process
GO:1903533 regulation of protein targeting
GO:1904589 regulation of protein import
GO:1904885 beta-catenin destruction complex assembly
GO:1904886 beta-catenin destruction complex disassembly
GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Molecular Function GO:0005096 GTPase activator activity
GO:0008013 beta-catenin binding
GO:0008047 enzyme activator activity
GO:0030159 receptor signaling complex scaffold activity
GO:0030695 GTPase regulator activity
GO:0031625 ubiquitin protein ligase binding
GO:0032947 protein complex scaffold
GO:0044389 ubiquitin-like protein ligase binding
GO:0046332 SMAD binding
GO:0060589 nucleoside-triphosphatase regulator activity
GO:0070016 armadillo repeat domain binding
GO:0070411 I-SMAD binding
Cellular Component GO:0005874 microtubule
GO:0005881 cytoplasmic microtubule
GO:0005938 cell cortex
GO:0014069 postsynaptic density
GO:0016328 lateral plasma membrane
GO:0030877 beta-catenin destruction complex
GO:0060076 excitatory synapse
GO:0098794 postsynapse
GO:0099568 cytoplasmic region
GO:0099572 postsynaptic specialization
> KEGG and Reactome Pathway
 
KEGG hsa04310 Wnt signaling pathway
hsa04390 Hippo signaling pathway
hsa04550 Signaling pathways regulating pluripotency of stem cells
Reactome R-HSA-4839748: AMER1 mutants destabilize the destruction complex
R-HSA-5467337: APC truncation mutants have impaired AXIN binding
R-HSA-5467340: AXIN missense mutants destabilize the destruction complex
R-HSA-4839735: AXIN mutants destabilize the destruction complex, activating WNT signaling
R-HSA-196299: Beta-catenin phosphorylation cascade
R-HSA-4641257: Degradation of AXIN
R-HSA-195253: Degradation of beta-catenin by the destruction complex
R-HSA-5467345: Deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
R-HSA-5688426: Deubiquitination
R-HSA-4641262: Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-392499: Metabolism of proteins
R-HSA-5339716: Misspliced GSK3beta mutants stabilize beta-catenin
R-HSA-597592: Post-translational protein modification
R-HSA-5358747: S33 mutants of beta-catenin aren't phosphorylated
R-HSA-5358749: S37 mutants of beta-catenin aren't phosphorylated
R-HSA-5358751: S45 mutants of beta-catenin aren't phosphorylated
R-HSA-162582: Signal Transduction
R-HSA-4791275: Signaling by WNT in cancer
R-HSA-195721: Signaling by Wnt
R-HSA-5358752: T41 mutants of beta-catenin aren't phosphorylated
R-HSA-201681: TCF dependent signaling in response to WNT
R-HSA-5467348: Truncations of AMER1 destabilize the destruction complex
R-HSA-5689880: Ub-specific processing proteases
R-HSA-4839743: phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
R-HSA-4839744: truncated APC mutants destabilize the destruction complex
Summary
SymbolAXIN1
Nameaxin 1
Aliases PPP1R49; protein phosphatase 1, regulatory subunit 49; AXIN; axis inhibition protein 1; axis inhibitor 1; fu ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between AXIN1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolAXIN1
Nameaxin 1
Aliases PPP1R49; protein phosphatase 1, regulatory subunit 49; AXIN; axis inhibition protein 1; axis inhibitor 1; fu ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of AXIN1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 STARS Score: 3.81; FDR: 0.041 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolAXIN1
Nameaxin 1
Aliases PPP1R49; protein phosphatase 1, regulatory subunit 49; AXIN; axis inhibition protein 1; axis inhibitor 1; fu ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of AXIN1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1050.633
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.3560.838
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0750.955
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0490.846
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.0960.964
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.0090.997
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0650.833
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.040.976
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1560.916
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0730.947
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.3650.812
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0360.537
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of AXIN1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.72.711
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.73.40.31
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382703.7-3.70.415
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolAXIN1
Nameaxin 1
Aliases PPP1R49; protein phosphatase 1, regulatory subunit 49; AXIN; axis inhibition protein 1; axis inhibitor 1; fu ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of AXIN1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolAXIN1
Nameaxin 1
Aliases PPP1R49; protein phosphatase 1, regulatory subunit 49; AXIN; axis inhibition protein 1; axis inhibitor 1; fu ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of AXIN1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by AXIN1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolAXIN1
Nameaxin 1
Aliases PPP1R49; protein phosphatase 1, regulatory subunit 49; AXIN; axis inhibition protein 1; axis inhibitor 1; fu ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of AXIN1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolAXIN1
Nameaxin 1
Aliases PPP1R49; protein phosphatase 1, regulatory subunit 49; AXIN; axis inhibition protein 1; axis inhibitor 1; fu ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of AXIN1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolAXIN1
Nameaxin 1
Aliases PPP1R49; protein phosphatase 1, regulatory subunit 49; AXIN; axis inhibition protein 1; axis inhibitor 1; fu ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between AXIN1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolAXIN1
Nameaxin 1
Aliases PPP1R49; protein phosphatase 1, regulatory subunit 49; AXIN; axis inhibition protein 1; axis inhibitor 1; fu ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting AXIN1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting AXIN1.
ID Name Drug Type Targets #Targets
DB044471,4-DithiothreitolSmall MoleculeALDH1A1, AXIN1, CAMK2A, GSTZ1, HMGCR, LGALS1, MSRA, PPIB, TPI1, TR ......10