TISIDB

Summary
Symbol	B3GNT3
Name	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
Aliases	B3GN-T3; beta3Gn-T3; HP10328; B3GNT-3; putative type II membrane protein; beta-1,3-N-acetylglucosaminyltrans ......
Chromosomal Location	19p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Golgi apparatus membrane Single-pass type II membrane protein
Domain	PF01762 Galactosyltransferase
Function	Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides (PubMed:11042166). Also acts as a core1-1,3-N-acetylglucosaminyltransferase (Core1-beta3GlcNAcT) to form the 6-sulfo sialyl Lewis x on extended core1 O-glycans (PubMed:11439191).

> Gene Ontology [ TOP ]
Biological Process	GO:0000271 polysaccharide biosynthetic process GO:0005976 polysaccharide metabolic process GO:0006022 aminoglycan metabolic process GO:0006023 aminoglycan biosynthetic process GO:0006024 glycosaminoglycan biosynthetic process GO:0006486 protein glycosylation GO:0006493 protein O-linked glycosylation GO:0006790 sulfur compound metabolic process GO:0009100 glycoprotein metabolic process GO:0009101 glycoprotein biosynthetic process GO:0016051 carbohydrate biosynthetic process GO:0016266 O-glycan processing GO:0018146 keratan sulfate biosynthetic process GO:0030203 glycosaminoglycan metabolic process GO:0030309 poly-N-acetyllactosamine metabolic process GO:0030311 poly-N-acetyllactosamine biosynthetic process GO:0033692 cellular polysaccharide biosynthetic process GO:0034637 cellular carbohydrate biosynthetic process GO:0042339 keratan sulfate metabolic process GO:0043413 macromolecule glycosylation GO:0044262 cellular carbohydrate metabolic process GO:0044264 cellular polysaccharide metabolic process GO:0044272 sulfur compound biosynthetic process GO:0044723 single-organism carbohydrate metabolic process GO:0070085 glycosylation GO:1903510 mucopolysaccharide metabolic process
Molecular Function	GO:0008194 UDP-glycosyltransferase activity GO:0008375 acetylglucosaminyltransferase activity GO:0008378 galactosyltransferase activity GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity GO:0016757 transferase activity, transferring glycosyl groups GO:0016758 transferase activity, transferring hexosyl groups GO:0035250 UDP-galactosyltransferase activity GO:0047223 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity GO:0048531 beta-1,3-galactosyltransferase activity
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series hsa01100 Metabolic pathways
Reactome	R-HSA-1630316: Glycosaminoglycan metabolism R-HSA-2022854: Keratan sulfate biosynthesis R-HSA-1638074: Keratan sulfate/keratin metabolism R-HSA-1430728: Metabolism R-HSA-71387: Metabolism of carbohydrates R-HSA-392499: Metabolism of proteins R-HSA-5173105: O-linked glycosylation R-HSA-913709: O-linked glycosylation of mucins R-HSA-597592: Post-translational protein modification

Summary
Symbol	B3GNT3
Name	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
Aliases	B3GN-T3; beta3Gn-T3; HP10328; B3GNT-3; putative type II membrane protein; beta-1,3-N-acetylglucosaminyltrans ......
Chromosomal Location	19p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between B3GNT3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

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Literatures describing the relation between B3GNT3 and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
29438695	Triple-Negative Breast Carcinoma	Inhibit immunity	Downregulation of B3GNT3 enhances cytotoxic T cell-mediated anti-tumor immunity.

Summary
Symbol	B3GNT3
Name	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
Aliases	B3GN-T3; beta3Gn-T3; HP10328; B3GNT-3; putative type II membrane protein; beta-1,3-N-acetylglucosaminyltrans ......
Chromosomal Location	19p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of B3GNT3 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	B3GNT3
Name	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
Aliases	B3GN-T3; beta3Gn-T3; HP10328; B3GNT-3; putative type II membrane protein; beta-1,3-N-acetylglucosaminyltrans ......
Chromosomal Location	19p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of B3GNT3 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.121	0.615
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.221	0.654
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.376	0.398
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.673	0.368
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.437	0.802
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.958	0.61
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.466	0.599
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	1.234	0.358
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.35	0.809
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.682	0.633
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-0.927	0.636
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.256	0.297

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of B3GNT3 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	0	0	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	0	0	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	5.9	-5.9	0.447
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	9.1	-9.1	0.458
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	2.6	3.7	-1.1	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	4.5	7.7	-3.2	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	B3GNT3
Name	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
Aliases	B3GN-T3; beta3Gn-T3; HP10328; B3GNT-3; putative type II membrane protein; beta-1,3-N-acetylglucosaminyltrans ......
Chromosomal Location	19p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of B3GNT3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	B3GNT3
Name	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
Aliases	B3GN-T3; beta3Gn-T3; HP10328; B3GNT-3; putative type II membrane protein; beta-1,3-N-acetylglucosaminyltrans ......
Chromosomal Location	19p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of B3GNT3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by B3GNT3. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	B3GNT3
Name	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
Aliases	B3GN-T3; beta3Gn-T3; HP10328; B3GNT-3; putative type II membrane protein; beta-1,3-N-acetylglucosaminyltrans ......
Chromosomal Location	19p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of B3GNT3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	B3GNT3
Name	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
Aliases	B3GN-T3; beta3Gn-T3; HP10328; B3GNT-3; putative type II membrane protein; beta-1,3-N-acetylglucosaminyltrans ......
Chromosomal Location	19p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of B3GNT3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	B3GNT3
Name	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
Aliases	B3GN-T3; beta3Gn-T3; HP10328; B3GNT-3; putative type II membrane protein; beta-1,3-N-acetylglucosaminyltrans ......
Chromosomal Location	19p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between B3GNT3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	B3GNT3
Name	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
Aliases	B3GN-T3; beta3Gn-T3; HP10328; B3GNT-3; putative type II membrane protein; beta-1,3-N-acetylglucosaminyltrans ......
Chromosomal Location	19p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting B3GNT3 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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