Browse BAIAP2L1

Summary
SymbolBAIAP2L1
NameBAI1-associated protein 2-like 1
Aliases IRTKS; BAI1-associated protein 2-like protein 1; insulin receptor tyrosine kinase substrate; Brain-specific ......
Chromosomal Location7q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm, cytoskeleton Note=Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.
Domain PF08397 IRSp53/MIM homology domain
PF14604 Variant SH3 domain
Function

May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.

> Gene Ontology
 
Biological Process GO:0007009 plasma membrane organization
GO:0007015 actin filament organization
GO:0008064 regulation of actin polymerization or depolymerization
GO:0008154 actin polymerization or depolymerization
GO:0008286 insulin receptor signaling pathway
GO:0030041 actin filament polymerization
GO:0030832 regulation of actin filament length
GO:0030833 regulation of actin filament polymerization
GO:0030838 positive regulation of actin filament polymerization
GO:0031334 positive regulation of protein complex assembly
GO:0031532 actin cytoskeleton reorganization
GO:0032271 regulation of protein polymerization
GO:0032273 positive regulation of protein polymerization
GO:0032535 regulation of cellular component size
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0032956 regulation of actin cytoskeleton organization
GO:0032970 regulation of actin filament-based process
GO:0043254 regulation of protein complex assembly
GO:0043434 response to peptide hormone
GO:0044089 positive regulation of cellular component biogenesis
GO:0046626 regulation of insulin receptor signaling pathway
GO:0051017 actin filament bundle assembly
GO:0051258 protein polymerization
GO:0051493 regulation of cytoskeleton organization
GO:0051495 positive regulation of cytoskeleton organization
GO:0051764 actin crosslink formation
GO:0061572 actin filament bundle organization
GO:0071375 cellular response to peptide hormone stimulus
GO:0071417 cellular response to organonitrogen compound
GO:0090066 regulation of anatomical structure size
GO:1900076 regulation of cellular response to insulin stimulus
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:2000249 regulation of actin cytoskeleton reorganization
GO:2000251 positive regulation of actin cytoskeleton reorganization
Molecular Function GO:0003779 actin binding
GO:0008093 cytoskeletal adaptor activity
GO:0030674 protein binding, bridging
GO:0045296 cadherin binding
GO:0050839 cell adhesion molecule binding
GO:0060090 binding, bridging
GO:0070064 proline-rich region binding
GO:0098631 protein binding involved in cell adhesion
GO:0098632 protein binding involved in cell-cell adhesion
GO:0098641 cadherin binding involved in cell-cell adhesion
Cellular Component GO:0005913 cell-cell adherens junction
GO:0015629 actin cytoskeleton
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolBAIAP2L1
NameBAI1-associated protein 2-like 1
Aliases IRTKS; BAI1-associated protein 2-like protein 1; insulin receptor tyrosine kinase substrate; Brain-specific ......
Chromosomal Location7q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between BAIAP2L1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolBAIAP2L1
NameBAI1-associated protein 2-like 1
Aliases IRTKS; BAI1-associated protein 2-like protein 1; insulin receptor tyrosine kinase substrate; Brain-specific ......
Chromosomal Location7q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of BAIAP2L1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolBAIAP2L1
NameBAI1-associated protein 2-like 1
Aliases IRTKS; BAI1-associated protein 2-like protein 1; insulin receptor tyrosine kinase substrate; Brain-specific ......
Chromosomal Location7q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of BAIAP2L1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.4030.474
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.4220.72
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.3680.757
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3910.254
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.2820.893
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.5310.843
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1550.778
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.4470.709
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0390.978
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.480.654
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.6750.653
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0420.739
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of BAIAP2L1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.1011.10.0181
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.1011.10.0286
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolBAIAP2L1
NameBAI1-associated protein 2-like 1
Aliases IRTKS; BAI1-associated protein 2-like protein 1; insulin receptor tyrosine kinase substrate; Brain-specific ......
Chromosomal Location7q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BAIAP2L1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolBAIAP2L1
NameBAI1-associated protein 2-like 1
Aliases IRTKS; BAI1-associated protein 2-like protein 1; insulin receptor tyrosine kinase substrate; Brain-specific ......
Chromosomal Location7q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BAIAP2L1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BAIAP2L1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolBAIAP2L1
NameBAI1-associated protein 2-like 1
Aliases IRTKS; BAI1-associated protein 2-like protein 1; insulin receptor tyrosine kinase substrate; Brain-specific ......
Chromosomal Location7q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BAIAP2L1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolBAIAP2L1
NameBAI1-associated protein 2-like 1
Aliases IRTKS; BAI1-associated protein 2-like protein 1; insulin receptor tyrosine kinase substrate; Brain-specific ......
Chromosomal Location7q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of BAIAP2L1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolBAIAP2L1
NameBAI1-associated protein 2-like 1
Aliases IRTKS; BAI1-associated protein 2-like protein 1; insulin receptor tyrosine kinase substrate; Brain-specific ......
Chromosomal Location7q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between BAIAP2L1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolBAIAP2L1
NameBAI1-associated protein 2-like 1
Aliases IRTKS; BAI1-associated protein 2-like protein 1; insulin receptor tyrosine kinase substrate; Brain-specific ......
Chromosomal Location7q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting BAIAP2L1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.