Browse BCHE

Summary
SymbolBCHE
Namebutyrylcholinesterase
Aliases CHE2; cholinesterase 1; cholinesterase (serum) 2; acylcholine acylhydrolase; butyrylcholine esterase; cholin ......
Chromosomal Location3q26.1-q26.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted
Domain PF08674 Acetylcholinesterase tetramerisation domain
PF00135 Carboxylesterase family
Function

Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.

> Gene Ontology
 
Biological Process GO:0001101 response to acid chemical
GO:0007584 response to nutrient
GO:0007611 learning or memory
GO:0007612 learning
GO:0009820 alkaloid metabolic process
GO:0009991 response to extracellular stimulus
GO:0014016 neuroblast differentiation
GO:0017144 drug metabolic process
GO:0019695 choline metabolic process
GO:0031667 response to nutrient levels
GO:0031960 response to corticosteroid
GO:0033273 response to vitamin
GO:0042493 response to drug
GO:0043279 response to alkaloid
GO:0044708 single-organism behavior
GO:0046448 tropane alkaloid metabolic process
GO:0048545 response to steroid hormone
GO:0048863 stem cell differentiation
GO:0050783 cocaine metabolic process
GO:0050804 modulation of synaptic transmission
GO:0050805 negative regulation of synaptic transmission
GO:0050890 cognition
GO:0051384 response to glucocorticoid
GO:0051593 response to folic acid
GO:0097164 ammonium ion metabolic process
Molecular Function GO:0001540 beta-amyloid binding
GO:0003990 acetylcholinesterase activity
GO:0004104 cholinesterase activity
GO:0033218 amide binding
GO:0033265 choline binding
GO:0042277 peptide binding
GO:0052689 carboxylic ester hydrolase activity
GO:0070405 ammonium ion binding
Cellular Component GO:0005635 nuclear envelope
GO:0005641 nuclear envelope lumen
GO:0005788 endoplasmic reticulum lumen
GO:0031970 organelle envelope lumen
GO:0072562 blood microparticle
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1483206: Glycerophospholipid biosynthesis
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-392499: Metabolism of proteins
R-HSA-112316: Neuronal System
R-HSA-112311: Neurotransmitter Clearance In The Synaptic Cleft
R-HSA-2980736: Peptide hormone metabolism
R-HSA-1483257: Phospholipid metabolism
R-HSA-1483191: Synthesis of PC
R-HSA-422085: Synthesis, secretion, and deacylation of Ghrelin
R-HSA-112315: Transmission across Chemical Synapses
Summary
SymbolBCHE
Namebutyrylcholinesterase
Aliases CHE2; cholinesterase 1; cholinesterase (serum) 2; acylcholine acylhydrolase; butyrylcholine esterase; cholin ......
Chromosomal Location3q26.1-q26.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between BCHE and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolBCHE
Namebutyrylcholinesterase
Aliases CHE2; cholinesterase 1; cholinesterase (serum) 2; acylcholine acylhydrolase; butyrylcholine esterase; cholin ......
Chromosomal Location3q26.1-q26.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of BCHE in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolBCHE
Namebutyrylcholinesterase
Aliases CHE2; cholinesterase 1; cholinesterase (serum) 2; acylcholine acylhydrolase; butyrylcholine esterase; cholin ......
Chromosomal Location3q26.1-q26.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of BCHE in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1260.885
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.1280.543
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)871.0510.452
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-1.5930.00768
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.5220.262
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.6950.218
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.4250.543
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.9070.562
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11121.9260.252
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-2.4210.0743
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.7750.621
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.4440.163
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of BCHE in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141721.411.89.60.636
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1033033.3-3.31
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277304.1-4.10.561
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275903.4-3.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolBCHE
Namebutyrylcholinesterase
Aliases CHE2; cholinesterase 1; cholinesterase (serum) 2; acylcholine acylhydrolase; butyrylcholine esterase; cholin ......
Chromosomal Location3q26.1-q26.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BCHE. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolBCHE
Namebutyrylcholinesterase
Aliases CHE2; cholinesterase 1; cholinesterase (serum) 2; acylcholine acylhydrolase; butyrylcholine esterase; cholin ......
Chromosomal Location3q26.1-q26.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BCHE. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BCHE.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolBCHE
Namebutyrylcholinesterase
Aliases CHE2; cholinesterase 1; cholinesterase (serum) 2; acylcholine acylhydrolase; butyrylcholine esterase; cholin ......
Chromosomal Location3q26.1-q26.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BCHE. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolBCHE
Namebutyrylcholinesterase
Aliases CHE2; cholinesterase 1; cholinesterase (serum) 2; acylcholine acylhydrolase; butyrylcholine esterase; cholin ......
Chromosomal Location3q26.1-q26.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of BCHE expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolBCHE
Namebutyrylcholinesterase
Aliases CHE2; cholinesterase 1; cholinesterase (serum) 2; acylcholine acylhydrolase; butyrylcholine esterase; cholin ......
Chromosomal Location3q26.1-q26.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between BCHE and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolBCHE
Namebutyrylcholinesterase
Aliases CHE2; cholinesterase 1; cholinesterase (serum) 2; acylcholine acylhydrolase; butyrylcholine esterase; cholin ......
Chromosomal Location3q26.1-q26.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting BCHE collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting BCHE.
ID Name Drug Type Targets #Targets
DB00122CholineSmall MoleculeACHE, BCHE, CHRNA7, PCYT1A, PCYT1B, PHOSPHO1, PLD1, PLD28
DB00382TacrineSmall MoleculeACHE, BCHE, CES13
DB00449DipivefrinSmall MoleculeACHE, ADRA1A, ADRA2A, ADRB2, BCHE5
DB00545PyridostigmineSmall MoleculeACHE, ALB, BCHE3
DB00674GalantamineSmall MoleculeACHE, BCHE, CHRNA1, CHRNA10, CHRNA2, CHRNA3, CHRNA4, CHRNA5, CHRNA ......18
DB00677IsoflurophateSmall MoleculeACHE, BCHE, TF3
DB00733PralidoximeSmall MoleculeACHE, BCHE2
DB00772MalathionSmall MoleculeBCHE1
DB00863RanitidineSmall MoleculeACHE, BCHE, HRH23
DB00941HexafluroniumSmall MoleculeBCHE1
DB00944DemecariumSmall MoleculeACHE, BCHE2
DB00989RivastigmineSmall MoleculeACHE, BCHE2
DB01010EdrophoniumSmall MoleculeACHE, BCHE2
DB01057EchothiophateSmall MoleculeBCHE1
DB01221KetamineSmall MoleculeBCHE, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD2, GRIN3A, HTR1A, HTR1 ......23
DB01226MivacuriumSmall MoleculeBCHE, CHRM2, CHRM3, CHRNA24
DB02811Diethylphosphono GroupSmall MoleculeBCHE1
DB02845Methylphosphinic AcidSmall MoleculeACHE, BCHE2
DB03568Butyric AcidSmall MoleculeBCHE1
DB036729-N-Phenylmethylamino-TacrineSmall MoleculeBCHE1
DB038142-(N-Morpholino)-Ethanesulfonic AcidSmall MoleculeACHE, ARL3, ASL, B4GALT1, BCHE, CMA1, GSTP1, HSD11B1, IRGC, L3MBTL ......13
DB03822Ethyl Dihydrogen PhosphateSmall MoleculeBCHE1
DB04250ButyrylthiocholineSmall MoleculeBCHE1
DB04892PhenserineSmall MoleculeACHE, APP, BCHE3
DB07681DODECANESULFONATE IONSmall MoleculeBCHE1
DB079409-(3-IODOBENZYLAMINO)-1,2,3,4-TETRAHYDROACRIDINESmall MoleculeBCHE1
DB08200(1R)-menthyl hexyl phosphonate groupSmall MoleculeBCHE1
DB08201(1S)-menthyl hexyl phosphonate groupSmall MoleculeBCHE1
DB08658ETHYL HYDROGEN DIETHYLAMIDOPHOSPHATESmall MoleculeBCHE1