Browse BCL2

Summary
SymbolBCL2
NameB-cell CLL/lymphoma 2
Aliases Bcl-2; PPP1R50; protein phosphatase 1, regulatory subunit 50; Apoptosis regulator Bcl-2
Chromosomal Location18q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Mitochondrion outer membrane Single-pass membrane protein Nucleus membrane Single-pass membrane protein Endoplasmic reticulum membrane Single-pass membrane protein
Domain PF00452 Apoptosis regulator proteins
PF02180 Bcl-2 homology region 4
Function

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).

> Gene Ontology
 
Biological Process GO:0000082 G1/S transition of mitotic cell cycle
GO:0000209 protein polyubiquitination
GO:0000302 response to reactive oxygen species
GO:0001503 ossification
GO:0001541 ovarian follicle development
GO:0001558 regulation of cell growth
GO:0001654 eye development
GO:0001655 urogenital system development
GO:0001656 metanephros development
GO:0001657 ureteric bud development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001662 behavioral fear response
GO:0001666 response to hypoxia
GO:0001763 morphogenesis of a branching structure
GO:0001776 leukocyte homeostasis
GO:0001782 B cell homeostasis
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0001836 release of cytochrome c from mitochondria
GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0001894 tissue homeostasis
GO:0001942 hair follicle development
GO:0001952 regulation of cell-matrix adhesion
GO:0002209 behavioral defense response
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002260 lymphocyte homeostasis
GO:0002320 lymphoid progenitor cell differentiation
GO:0002326 B cell lineage commitment
GO:0002360 T cell lineage commitment
GO:0002363 alpha-beta T cell lineage commitment
GO:0002429 immune response-activating cell surface receptor signaling pathway
GO:0002521 leukocyte differentiation
GO:0002694 regulation of leukocyte activation
GO:0002696 positive regulation of leukocyte activation
GO:0002757 immune response-activating signal transduction
GO:0002764 immune response-regulating signaling pathway
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0002931 response to ischemia
GO:0003014 renal system process
GO:0003254 regulation of membrane depolarization
GO:0006470 protein dephosphorylation
GO:0006582 melanin metabolic process
GO:0006808 regulation of nitrogen utilization
GO:0006816 calcium ion transport
GO:0006839 mitochondrial transport
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0006885 regulation of pH
GO:0006914 autophagy
GO:0006959 humoral immune response
GO:0006979 response to oxidative stress
GO:0007006 mitochondrial membrane organization
GO:0007015 actin filament organization
GO:0007044 cell-substrate junction assembly
GO:0007045 cell-substrate adherens junction assembly
GO:0007159 leukocyte cell-cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007281 germ cell development
GO:0007292 female gamete generation
GO:0007346 regulation of mitotic cell cycle
GO:0007409 axonogenesis
GO:0007423 sensory organ development
GO:0007517 muscle organ development
GO:0007519 skeletal muscle tissue development
GO:0007548 sex differentiation
GO:0007565 female pregnancy
GO:0007568 aging
GO:0007569 cell aging
GO:0008406 gonad development
GO:0008544 epidermis development
GO:0008584 male gonad development
GO:0008585 female gonad development
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0008637 apoptotic mitochondrial changes
GO:0009100 glycoprotein metabolic process
GO:0009101 glycoprotein biosynthetic process
GO:0009267 cellular response to starvation
GO:0009314 response to radiation
GO:0009411 response to UV
GO:0009416 response to light stimulus
GO:0009615 response to virus
GO:0009636 response to toxic substance
GO:0009791 post-embryonic development
GO:0009991 response to extracellular stimulus
GO:0009994 oocyte differentiation
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0010039 response to iron ion
GO:0010212 response to ionizing radiation
GO:0010224 response to UV-B
GO:0010332 response to gamma radiation
GO:0010506 regulation of autophagy
GO:0010507 negative regulation of autophagy
GO:0010522 regulation of calcium ion transport into cytosol
GO:0010523 negative regulation of calcium ion transport into cytosol
GO:0010559 regulation of glycoprotein biosynthetic process
GO:0010623 programmed cell death involved in cell development
GO:0010720 positive regulation of cell development
GO:0010721 negative regulation of cell development
GO:0010810 regulation of cell-substrate adhesion
GO:0010821 regulation of mitochondrion organization
GO:0010822 positive regulation of mitochondrion organization
GO:0010830 regulation of myotube differentiation
GO:0010831 positive regulation of myotube differentiation
GO:0010948 negative regulation of cell cycle process
GO:0010959 regulation of metal ion transport
GO:0014031 mesenchymal cell development
GO:0014041 regulation of neuron maturation
GO:0014042 positive regulation of neuron maturation
GO:0014706 striated muscle tissue development
GO:0014812 muscle cell migration
GO:0014902 myotube differentiation
GO:0014904 myotube cell development
GO:0014909 smooth muscle cell migration
GO:0014910 regulation of smooth muscle cell migration
GO:0014911 positive regulation of smooth muscle cell migration
GO:0016049 cell growth
GO:0016050 vesicle organization
GO:0016202 regulation of striated muscle tissue development
GO:0016311 dephosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0018209 peptidyl-serine modification
GO:0018210 peptidyl-threonine modification
GO:0018958 phenol-containing compound metabolic process
GO:0019058 viral life cycle
GO:0019079 viral genome replication
GO:0019740 nitrogen utilization
GO:0019748 secondary metabolic process
GO:0021548 pons development
GO:0021700 developmental maturation
GO:0021747 cochlear nucleus development
GO:0022037 metencephalon development
GO:0022404 molting cycle process
GO:0022405 hair cycle process
GO:0022412 cellular process involved in reproduction in multicellular organism
GO:0022602 ovulation cycle process
GO:0022612 gland morphogenesis
GO:0022898 regulation of transmembrane transporter activity
GO:0030004 cellular monovalent inorganic cation homeostasis
GO:0030098 lymphocyte differentiation
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
GO:0030278 regulation of ossification
GO:0030279 negative regulation of ossification
GO:0030307 positive regulation of cell growth
GO:0030308 negative regulation of cell growth
GO:0030318 melanocyte differentiation
GO:0030335 positive regulation of cell migration
GO:0030336 negative regulation of cell migration
GO:0030641 regulation of cellular pH
GO:0030888 regulation of B cell proliferation
GO:0030890 positive regulation of B cell proliferation
GO:0030902 hindbrain development
GO:0031069 hair follicle morphogenesis
GO:0031099 regeneration
GO:0031102 neuron projection regeneration
GO:0031103 axon regeneration
GO:0031589 cell-substrate adhesion
GO:0031647 regulation of protein stability
GO:0031667 response to nutrient levels
GO:0031668 cellular response to extracellular stimulus
GO:0031669 cellular response to nutrient levels
GO:0031960 response to corticosteroid
GO:0032409 regulation of transporter activity
GO:0032469 endoplasmic reticulum calcium ion homeostasis
GO:0032835 glomerulus development
GO:0032844 regulation of homeostatic process
GO:0032845 negative regulation of homeostatic process
GO:0032847 regulation of cellular pH reduction
GO:0032848 negative regulation of cellular pH reduction
GO:0032943 mononuclear cell proliferation
GO:0032944 regulation of mononuclear cell proliferation
GO:0032946 positive regulation of mononuclear cell proliferation
GO:0033028 myeloid cell apoptotic process
GO:0033032 regulation of myeloid cell apoptotic process
GO:0033033 negative regulation of myeloid cell apoptotic process
GO:0033059 cellular pigmentation
GO:0033077 T cell differentiation in thymus
GO:0033135 regulation of peptidyl-serine phosphorylation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033555 multicellular organismal response to stress
GO:0033687 osteoblast proliferation
GO:0033688 regulation of osteoblast proliferation
GO:0033689 negative regulation of osteoblast proliferation
GO:0034329 cell junction assembly
GO:0034330 cell junction organization
GO:0034332 adherens junction organization
GO:0034333 adherens junction assembly
GO:0034599 cellular response to oxidative stress
GO:0034762 regulation of transmembrane transport
GO:0034976 response to endoplasmic reticulum stress
GO:0035094 response to nicotine
GO:0035239 tube morphogenesis
GO:0035264 multicellular organism growth
GO:0035265 organ growth
GO:0035794 positive regulation of mitochondrial membrane permeability
GO:0036037 CD8-positive, alpha-beta T cell activation
GO:0036293 response to decreased oxygen levels
GO:0036294 cellular response to decreased oxygen levels
GO:0036473 cell death in response to oxidative stress
GO:0038034 signal transduction in absence of ligand
GO:0040013 negative regulation of locomotion
GO:0040014 regulation of multicellular organism growth
GO:0040017 positive regulation of locomotion
GO:0040018 positive regulation of multicellular organism growth
GO:0042100 B cell proliferation
GO:0042110 T cell activation
GO:0042113 B cell activation
GO:0042149 cellular response to glucose starvation
GO:0042303 molting cycle
GO:0042391 regulation of membrane potential
GO:0042440 pigment metabolic process
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042551 neuron maturation
GO:0042594 response to starvation
GO:0042596 fear response
GO:0042633 hair cycle
GO:0042692 muscle cell differentiation
GO:0042698 ovulation cycle
GO:0043029 T cell homeostasis
GO:0043271 negative regulation of ion transport
GO:0043276 anoikis
GO:0043279 response to alkaloid
GO:0043368 positive T cell selection
GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
GO:0043374 CD8-positive, alpha-beta T cell differentiation
GO:0043375 CD8-positive, alpha-beta T cell lineage commitment
GO:0043393 regulation of protein binding
GO:0043473 pigmentation
GO:0043496 regulation of protein homodimerization activity
GO:0043497 regulation of protein heterodimerization activity
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0043583 ear development
GO:0043588 skin development
GO:0043900 regulation of multi-organism process
GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism
GO:0044706 multi-multicellular organism process
GO:0044708 single-organism behavior
GO:0044770 cell cycle phase transition
GO:0044772 mitotic cell cycle phase transition
GO:0044843 cell cycle G1/S phase transition
GO:0045058 T cell selection
GO:0045069 regulation of viral genome replication
GO:0045137 development of primary sexual characteristics
GO:0045165 cell fate commitment
GO:0045216 cell-cell junction organization
GO:0045634 regulation of melanocyte differentiation
GO:0045636 positive regulation of melanocyte differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045786 negative regulation of cell cycle
GO:0045844 positive regulation of striated muscle tissue development
GO:0045851 pH reduction
GO:0045852 pH elevation
GO:0045926 negative regulation of growth
GO:0045927 positive regulation of growth
GO:0045930 negative regulation of mitotic cell cycle
GO:0046545 development of primary female sexual characteristics
GO:0046546 development of primary male sexual characteristics
GO:0046631 alpha-beta T cell activation
GO:0046632 alpha-beta T cell differentiation
GO:0046651 lymphocyte proliferation
GO:0046660 female sex differentiation
GO:0046661 male sex differentiation
GO:0046666 retinal cell programmed cell death
GO:0046668 regulation of retinal cell programmed cell death
GO:0046671 negative regulation of retinal cell programmed cell death
GO:0046902 regulation of mitochondrial membrane permeability
GO:0048041 focal adhesion assembly
GO:0048066 developmental pigmentation
GO:0048070 regulation of developmental pigmentation
GO:0048087 positive regulation of developmental pigmentation
GO:0048469 cell maturation
GO:0048477 oogenesis
GO:0048511 rhythmic process
GO:0048536 spleen development
GO:0048538 thymus development
GO:0048545 response to steroid hormone
GO:0048546 digestive tract morphogenesis
GO:0048565 digestive tract development
GO:0048592 eye morphogenesis
GO:0048599 oocyte development
GO:0048608 reproductive structure development
GO:0048634 regulation of muscle organ development
GO:0048636 positive regulation of muscle organ development
GO:0048638 regulation of developmental growth
GO:0048639 positive regulation of developmental growth
GO:0048641 regulation of skeletal muscle tissue development
GO:0048643 positive regulation of skeletal muscle tissue development
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048678 response to axon injury
GO:0048730 epidermis morphogenesis
GO:0048732 gland development
GO:0048741 skeletal muscle fiber development
GO:0048742 regulation of skeletal muscle fiber development
GO:0048743 positive regulation of skeletal muscle fiber development
GO:0048747 muscle fiber development
GO:0048753 pigment granule organization
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048762 mesenchymal cell differentiation
GO:0048857 neural nucleus development
GO:0048871 multicellular organismal homeostasis
GO:0048872 homeostasis of number of cells
GO:0048873 homeostasis of number of cells within a tissue
GO:0050670 regulation of lymphocyte proliferation
GO:0050671 positive regulation of lymphocyte proliferation
GO:0050769 positive regulation of neurogenesis
GO:0050792 regulation of viral process
GO:0050851 antigen receptor-mediated signaling pathway
GO:0050853 B cell receptor signaling pathway
GO:0050864 regulation of B cell activation
GO:0050865 regulation of cell activation
GO:0050867 positive regulation of cell activation
GO:0050871 positive regulation of B cell activation
GO:0050931 pigment cell differentiation
GO:0050932 regulation of pigment cell differentiation
GO:0050942 positive regulation of pigment cell differentiation
GO:0051051 negative regulation of transport
GO:0051098 regulation of binding
GO:0051146 striated muscle cell differentiation
GO:0051147 regulation of muscle cell differentiation
GO:0051149 positive regulation of muscle cell differentiation
GO:0051153 regulation of striated muscle cell differentiation
GO:0051155 positive regulation of striated muscle cell differentiation
GO:0051204 protein insertion into mitochondrial membrane
GO:0051205 protein insertion into membrane
GO:0051249 regulation of lymphocyte activation
GO:0051251 positive regulation of lymphocyte activation
GO:0051271 negative regulation of cellular component movement
GO:0051272 positive regulation of cellular component movement
GO:0051384 response to glucocorticoid
GO:0051402 neuron apoptotic process
GO:0051452 intracellular pH reduction
GO:0051453 regulation of intracellular pH
GO:0051454 intracellular pH elevation
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051607 defense response to virus
GO:0051881 regulation of mitochondrial membrane potential
GO:0051882 mitochondrial depolarization
GO:0051899 membrane depolarization
GO:0051900 regulation of mitochondrial depolarization
GO:0051902 negative regulation of mitochondrial depolarization
GO:0051924 regulation of calcium ion transport
GO:0051926 negative regulation of calcium ion transport
GO:0051962 positive regulation of nervous system development
GO:0055001 muscle cell development
GO:0055002 striated muscle cell development
GO:0055067 monovalent inorganic cation homeostasis
GO:0055074 calcium ion homeostasis
GO:0055123 digestive system development
GO:0060249 anatomical structure homeostasis
GO:0060401 cytosolic calcium ion transport
GO:0060402 calcium ion transport into cytosol
GO:0060485 mesenchyme development
GO:0060537 muscle tissue development
GO:0060538 skeletal muscle organ development
GO:0060562 epithelial tube morphogenesis
GO:0060675 ureteric bud morphogenesis
GO:0060993 kidney morphogenesis
GO:0061138 morphogenesis of a branching epithelium
GO:0061326 renal tubule development
GO:0061333 renal tubule morphogenesis
GO:0061458 reproductive system development
GO:0061564 axon development
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070482 response to oxygen levels
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0070585 protein localization to mitochondrion
GO:0070661 leukocyte proliferation
GO:0070663 regulation of leukocyte proliferation
GO:0070665 positive regulation of leukocyte proliferation
GO:0070838 divalent metal ion transport
GO:0070997 neuron death
GO:0071453 cellular response to oxygen levels
GO:0071456 cellular response to hypoxia
GO:0071496 cellular response to external stimulus
GO:0071593 lymphocyte aggregation
GO:0071594 thymocyte aggregation
GO:0072001 renal system development
GO:0072006 nephron development
GO:0072009 nephron epithelium development
GO:0072028 nephron morphogenesis
GO:0072073 kidney epithelium development
GO:0072078 nephron tubule morphogenesis
GO:0072080 nephron tubule development
GO:0072088 nephron epithelium morphogenesis
GO:0072163 mesonephric epithelium development
GO:0072164 mesonephric tubule development
GO:0072171 mesonephric tubule morphogenesis
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072511 divalent inorganic cation transport
GO:0072593 reactive oxygen species metabolic process
GO:0072655 establishment of protein localization to mitochondrion
GO:0072657 protein localization to membrane
GO:0090150 establishment of protein localization to membrane
GO:0090559 regulation of membrane permeability
GO:0090596 sensory organ morphogenesis
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097345 mitochondrial outer membrane permeabilization
GO:0098542 defense response to other organism
GO:0098773 skin epidermis development
GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1901099 negative regulation of signal transduction in absence of ligand
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:1901615 organic hydroxy compound metabolic process
GO:1901861 regulation of muscle tissue development
GO:1901863 positive regulation of muscle tissue development
GO:1901987 regulation of cell cycle phase transition
GO:1901988 negative regulation of cell cycle phase transition
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1901991 negative regulation of mitotic cell cycle phase transition
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902532 negative regulation of intracellular signal transduction
GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death
GO:1902806 regulation of cell cycle G1/S phase transition
GO:1902807 negative regulation of cell cycle G1/S phase transition
GO:1903018 regulation of glycoprotein metabolic process
GO:1903429 regulation of cell maturation
GO:1903431 positive regulation of cell maturation
GO:1903747 regulation of establishment of protein localization to mitochondrion
GO:1903749 positive regulation of establishment of protein localization to mitochondrion
GO:1903829 positive regulation of cellular protein localization
GO:1903900 regulation of viral life cycle
GO:1904180 negative regulation of membrane depolarization
GO:1904951 positive regulation of establishment of protein localization
GO:1990267 response to transition metal nanoparticle
GO:2000021 regulation of ion homeostasis
GO:2000027 regulation of organ morphogenesis
GO:2000045 regulation of G1/S transition of mitotic cell cycle
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
GO:2000146 negative regulation of cell motility
GO:2000147 positive regulation of cell motility
GO:2000209 regulation of anoikis
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2000378 negative regulation of reactive oxygen species metabolic process
GO:2000811 negative regulation of anoikis
GO:2001233 regulation of apoptotic signaling pathway
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001235 positive regulation of apoptotic signaling pathway
GO:2001236 regulation of extrinsic apoptotic signaling pathway
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001242 regulation of intrinsic apoptotic signaling pathway
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Molecular Function GO:0002020 protease binding
GO:0008134 transcription factor binding
GO:0015267 channel activity
GO:0016247 channel regulator activity
GO:0016248 channel inhibitor activity
GO:0019902 phosphatase binding
GO:0019903 protein phosphatase binding
GO:0022803 passive transmembrane transporter activity
GO:0031625 ubiquitin protein ligase binding
GO:0044389 ubiquitin-like protein ligase binding
GO:0046982 protein heterodimerization activity
GO:0051400 BH domain binding
GO:0051434 BH3 domain binding
GO:0051721 protein phosphatase 2A binding
GO:0070513 death domain binding
Cellular Component GO:0005635 nuclear envelope
GO:0005741 mitochondrial outer membrane
GO:0019867 outer membrane
GO:0031965 nuclear membrane
GO:0031968 organelle outer membrane
GO:0043209 myelin sheath
GO:0046930 pore complex
> KEGG and Reactome Pathway
 
KEGG hsa04064 NF-kappa B signaling pathway
hsa04066 HIF-1 signaling pathway
hsa04071 Sphingolipid signaling pathway
hsa04140 Regulation of autophagy
hsa04141 Protein processing in endoplasmic reticulum
hsa04151 PI3K-Akt signaling pathway
hsa04210 Apoptosis
hsa04261 Adrenergic signaling in cardiomyocytes
hsa04340 Hedgehog signaling pathway
hsa04510 Focal adhesion
hsa04621 NOD-like receptor signaling pathway
hsa04630 Jak-STAT signaling pathway
hsa04722 Neurotrophin signaling pathway
hsa04725 Cholinergic synapse
Reactome R-HSA-111447: Activation of BAD and translocation to mitochondria
R-HSA-114452: Activation of BH3-only proteins
R-HSA-109581: Apoptosis
R-HSA-111453: BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-168256: Immune System
R-HSA-622312: Inflammasomes
R-HSA-168249: Innate Immune System
R-HSA-6785807: Interleukin-4 and 13 signaling
R-HSA-109606: Intrinsic Pathway for Apoptosis
R-HSA-168643: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
R-HSA-5357801: Programmed Cell Death
R-HSA-449147: Signaling by Interleukins
R-HSA-844455: The NLRP1 inflammasome
Summary
SymbolBCL2
NameB-cell CLL/lymphoma 2
Aliases Bcl-2; PPP1R50; protein phosphatase 1, regulatory subunit 50; Apoptosis regulator Bcl-2
Chromosomal Location18q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between BCL2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between BCL2 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
10697273Central nervous system lymphomaInhibit immunityOverexpression of BCL-2, BCL-X, and BAX in primary central nervous system lymphomas that occur in immunosuppressed patients.
10657650Colon carcinomaInhibit immunityEstablishment of an immune response against cancer may depend on the capacity of dendritic cells to transfer tumor Ags into T cell-rich areas. Fluorescence-labeled mononuclear cells with a phenotype of MHC class II+ dendritic cells are also found in the T cell areas of the draining lymph nodes. Interestingly, no fluorescent cell can be found in lymph nodes after a s.c. injection of Bcl2-transfected apoptosis-resistant tumor cells that yielded progressive tumors.
24516200Ovarian carcinomaInhibit immunity (T cell function); immunotherapy targetPan-Bcl-2 inhibitor, GX15-070 (obatoclax), decreases human T regulatory lymphocytes while preserving effector T lymphocytes: a rationale for its use in combination immunotherapy. Furthermore, GX15 increased the apoptosis of regulatory T cells (Tregs), profoundly downregulated FOXP3 and CTLA-4 in a dose-dependent manner, and decreased their suppressive function. Treating PBMCs obtained from ovarian cancer patients with GX15 also resulted in increased CD8(+):Treg and CD4(+):Treg ratios. These results support preclinical studies in which mice vaccinated before treatment with GX15 showed the greatest reduction in metastatic lung tumors as a result of increased apoptotic resistance of mature CD8(+) T cells and decreased Treg function brought about by GX15.
Summary
SymbolBCL2
NameB-cell CLL/lymphoma 2
Aliases Bcl-2; PPP1R50; protein phosphatase 1, regulatory subunit 50; Apoptosis regulator Bcl-2
Chromosomal Location18q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of BCL2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolBCL2
NameB-cell CLL/lymphoma 2
Aliases Bcl-2; PPP1R50; protein phosphatase 1, regulatory subunit 50; Apoptosis regulator Bcl-2
Chromosomal Location18q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of BCL2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.6640.144
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.9650.465
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.430.721
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0770.859
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.4150.795
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.6950.737
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.3610.284
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.5570.713
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0880.961
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.7740.519
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.9410.585
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2720.0547
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of BCL2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610100-1000.143
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolBCL2
NameB-cell CLL/lymphoma 2
Aliases Bcl-2; PPP1R50; protein phosphatase 1, regulatory subunit 50; Apoptosis regulator Bcl-2
Chromosomal Location18q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BCL2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolBCL2
NameB-cell CLL/lymphoma 2
Aliases Bcl-2; PPP1R50; protein phosphatase 1, regulatory subunit 50; Apoptosis regulator Bcl-2
Chromosomal Location18q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BCL2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BCL2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolBCL2
NameB-cell CLL/lymphoma 2
Aliases Bcl-2; PPP1R50; protein phosphatase 1, regulatory subunit 50; Apoptosis regulator Bcl-2
Chromosomal Location18q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BCL2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolBCL2
NameB-cell CLL/lymphoma 2
Aliases Bcl-2; PPP1R50; protein phosphatase 1, regulatory subunit 50; Apoptosis regulator Bcl-2
Chromosomal Location18q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of BCL2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolBCL2
NameB-cell CLL/lymphoma 2
Aliases Bcl-2; PPP1R50; protein phosphatase 1, regulatory subunit 50; Apoptosis regulator Bcl-2
Chromosomal Location18q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between BCL2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolBCL2
NameB-cell CLL/lymphoma 2
Aliases Bcl-2; PPP1R50; protein phosphatase 1, regulatory subunit 50; Apoptosis regulator Bcl-2
Chromosomal Location18q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting BCL2 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting BCL2.
ID Name Drug Type Targets #Targets
DB01050IbuprofenSmall MoleculeBCL2, CFTR, FABP2, PLAT, PPARA, PPARG, PTGS1, PTGS2, SLC15A1, THBD10
DB01229PaclitaxelSmall MoleculeBCL2, MAP2, MAP4, MAPT, NR1I2, TUBB16
DB01248DocetaxelSmall MoleculeBCL2, MAP2, MAP4, MAPT, NR1I2, TUBB16
DB01367RasagilineSmall MoleculeBCL2, MAOB2
DB05281S-8184Small MoleculeBCL2, TUBA4A2
DB05297Paclitaxel docosahexaenoic acidSmall MoleculeBCL21
DB06307ApoptoneSmall MoleculeBCL21
DB06756Glycine betaineSmall MoleculeBCL21
DB08871EribulinSmall MoleculeBCL2, TUBB12
DB09213DexibuprofenSmall MoleculeBCL2, CFTR, FABP2, PLAT, PPARG, PTGS1, PTGS2, THBD8
DB09401IsosorbideSmall MoleculeBCL2, BCL2L1, MCL13
DB11581VenetoclaxSmall MoleculeBCL21
DB12191ObatoclaxSmall MoleculeBCL21
DB12340NavitoclaxSmall MoleculeBAD, BCL2, BCL2L23