TISIDB

Summary
Symbol	BIRC2
Name	baculoviral IAP repeat containing 2
Aliases	cIAP1; hiap-2; MIHB; RNF48; c-IAP1; NFR2-TRAF signalling complex protein; apoptosis inhibitor 1; API1; bacul ......
Chromosomal Location	11q22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cytoplasm. Nucleus. Note=Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells.
Domain	PF00653 Inhibitor of Apoptosis domain PF00619 Caspase recruitment domain
Function	Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.

> Gene Ontology [ TOP ]
Biological Process	GO:0000209 protein polyubiquitination GO:0001666 response to hypoxia GO:0001819 positive regulation of cytokine production GO:0001890 placenta development GO:0001959 regulation of cytokine-mediated signaling pathway GO:0002218 activation of innate immune response GO:0002221 pattern recognition receptor signaling pathway GO:0002224 toll-like receptor signaling pathway GO:0002697 regulation of immune effector process GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0002756 MyD88-independent toll-like receptor signaling pathway GO:0002757 immune response-activating signal transduction GO:0002758 innate immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002831 regulation of response to biotic stimulus GO:0006513 protein monoubiquitination GO:0006921 cellular component disassembly involved in execution phase of apoptosis GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0009615 response to virus GO:0010466 negative regulation of peptidase activity GO:0010498 proteasomal protein catabolic process GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway GO:0010939 regulation of necrotic cell death GO:0010951 negative regulation of endopeptidase activity GO:0010955 negative regulation of protein processing GO:0014074 response to purine-containing compound GO:0016485 protein processing GO:0030522 intracellular receptor signaling pathway GO:0031333 negative regulation of protein complex assembly GO:0031349 positive regulation of defense response GO:0031396 regulation of protein ubiquitination GO:0031398 positive regulation of protein ubiquitination GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0034121 regulation of toll-like receptor signaling pathway GO:0034612 response to tumor necrosis factor GO:0035666 TRIF-dependent toll-like receptor signaling pathway GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway GO:0036293 response to decreased oxygen levels GO:0038061 NIK/NF-kappaB signaling GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus GO:0039529 RIG-I signaling pathway GO:0039531 regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway GO:0039535 regulation of RIG-I signaling pathway GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043254 regulation of protein complex assembly GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043900 regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0045471 response to ethanol GO:0045861 negative regulation of proteolysis GO:0046683 response to organophosphorus GO:0048608 reproductive structure development GO:0050688 regulation of defense response to virus GO:0050727 regulation of inflammatory response GO:0050792 regulation of viral process GO:0051259 protein oligomerization GO:0051291 protein heterooligomerization GO:0051346 negative regulation of hydrolase activity GO:0051591 response to cAMP GO:0051604 protein maturation GO:0051607 defense response to virus GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0060544 regulation of necroptotic process GO:0060546 negative regulation of necroptotic process GO:0060547 negative regulation of necrotic cell death GO:0060759 regulation of response to cytokine stimulus GO:0061458 reproductive system development GO:0070265 necrotic cell death GO:0070266 necroptotic process GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway GO:0070482 response to oxygen levels GO:0070534 protein K63-linked ubiquitination GO:0070613 regulation of protein processing GO:0070936 protein K48-linked ubiquitination GO:0071356 cellular response to tumor necrosis factor GO:0072593 reactive oxygen species metabolic process GO:0097194 execution phase of apoptosis GO:0097300 programmed necrotic cell death GO:0097305 response to alcohol GO:0097340 inhibition of cysteine-type endopeptidase activity GO:0097341 zymogen inhibition GO:0097343 ripoptosome assembly GO:0098542 defense response to other organism GO:0098586 cellular response to virus GO:1900044 regulation of protein K63-linked ubiquitination GO:1901026 ripoptosome assembly involved in necroptotic process GO:1902442 regulation of ripoptosome assembly involved in necroptotic process GO:1902443 negative regulation of ripoptosome assembly involved in necroptotic process GO:1902523 positive regulation of protein K63-linked ubiquitination GO:1902524 positive regulation of protein K48-linked ubiquitination GO:1902525 regulation of protein monoubiquitination GO:1902527 positive regulation of protein monoubiquitination GO:1902914 regulation of protein polyubiquitination GO:1902916 positive regulation of protein polyubiquitination GO:1903317 regulation of protein maturation GO:1903318 negative regulation of protein maturation GO:1903320 regulation of protein modification by small protein conjugation or removal GO:1903322 positive regulation of protein modification by small protein conjugation or removal GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process GO:2000116 regulation of cysteine-type endopeptidase activity GO:2000117 negative regulation of cysteine-type endopeptidase activity GO:2000377 regulation of reactive oxygen species metabolic process
Molecular Function	GO:0003713 transcription coactivator activity GO:0004842 ubiquitin-protein transferase activity GO:0004857 enzyme inhibitor activity GO:0004866 endopeptidase inhibitor activity GO:0004869 cysteine-type endopeptidase inhibitor activity GO:0016874 ligase activity GO:0019787 ubiquitin-like protein transferase activity GO:0030414 peptidase inhibitor activity GO:0032182 ubiquitin-like protein binding GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process GO:0043130 ubiquitin binding GO:0047485 protein N-terminus binding GO:0061134 peptidase regulator activity GO:0061135 endopeptidase regulator activity GO:0098770 FBXO family protein binding
Cellular Component	GO:0000803 sex chromosome GO:0001741 XY body GO:0009898 cytoplasmic side of plasma membrane GO:0035631 CD40 receptor complex GO:0043235 receptor complex GO:0045121 membrane raft GO:0098552 side of membrane GO:0098562 cytoplasmic side of membrane GO:0098589 membrane region GO:0098802 plasma membrane receptor complex GO:0098857 membrane microdomain

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04064 NF-kappa B signaling pathway hsa04120 Ubiquitin mediated proteolysis hsa04210 Apoptosis hsa04390 Hippo signaling pathway hsa04510 Focal adhesion hsa04621 NOD-like receptor signaling pathway hsa04668 TNF signaling pathway
Reactome	R-HSA-166054: Activated TLR4 signalling R-HSA-109581: Apoptosis R-HSA-111465: Apoptotic cleavage of cellular proteins R-HSA-75153: Apoptotic execution phase R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-73887: Death Receptor Signalling R-HSA-5688426: Deubiquitination R-HSA-937041: IKK complex recruitment mediated by RIP1 R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-392499: Metabolism of proteins R-HSA-166166: MyD88-independent TLR3/TLR4 cascade R-HSA-168638: NOD1/2 Signaling Pathway R-HSA-168643: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-597592: Post-translational protein modification R-HSA-5357801: Programmed Cell Death R-HSA-5213460: RIPK1-mediated regulated necrosis R-HSA-5218859: Regulated Necrosis R-HSA-5357905: Regulation of TNFR1 signaling R-HSA-5675482: Regulation of necroptotic cell death R-HSA-162582: Signal Transduction R-HSA-5676594: TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-75893: TNF signaling R-HSA-5357956: TNFR1-induced NFkappaB signaling pathway R-HSA-5668541: TNFR2 non-canonical NF-kB pathway R-HSA-937061: TRIF-mediated TLR3/TLR4 signaling R-HSA-168164: Toll Like Receptor 3 (TLR3) Cascade R-HSA-166016: Toll Like Receptor 4 (TLR4) Cascade R-HSA-168898: Toll-Like Receptors Cascades R-HSA-5689880: Ub-specific processing proteases

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa04064 NF-kappa B signaling pathway
hsa04120 Ubiquitin mediated proteolysis
hsa04210 Apoptosis
hsa04390 Hippo signaling pathway
hsa04510 Focal adhesion
hsa04621 NOD-like receptor signaling pathway
hsa04668 TNF signaling pathway

Reactome

R-HSA-166054: Activated TLR4 signalling
R-HSA-109581: Apoptosis
R-HSA-111465: Apoptotic cleavage of cellular proteins
R-HSA-75153: Apoptotic execution phase
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-73887: Death Receptor Signalling
R-HSA-5688426: Deubiquitination
R-HSA-937041: IKK complex recruitment mediated by RIP1
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-392499: Metabolism of proteins
R-HSA-166166: MyD88-independent TLR3/TLR4 cascade
R-HSA-168638: NOD1/2 Signaling Pathway
R-HSA-168643: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
R-HSA-597592: Post-translational protein modification
R-HSA-5357801: Programmed Cell Death
R-HSA-5213460: RIPK1-mediated regulated necrosis
R-HSA-5218859: Regulated Necrosis
R-HSA-5357905: Regulation of TNFR1 signaling
R-HSA-5675482: Regulation of necroptotic cell death
R-HSA-162582: Signal Transduction
R-HSA-5676594: TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
R-HSA-75893: TNF signaling
R-HSA-5357956: TNFR1-induced NFkappaB signaling pathway
R-HSA-5668541: TNFR2 non-canonical NF-kB pathway
R-HSA-937061: TRIF-mediated TLR3/TLR4 signaling
R-HSA-168164: Toll Like Receptor 3 (TLR3) Cascade
R-HSA-166016: Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168898: Toll-Like Receptors Cascades
R-HSA-5689880: Ub-specific processing proteases

Summary
Symbol	BIRC2
Name	baculoviral IAP repeat containing 2
Aliases	cIAP1; hiap-2; MIHB; RNF48; c-IAP1; NFR2-TRAF signalling complex protein; apoptosis inhibitor 1; API1; bacul ......
Chromosomal Location	11q22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between BIRC2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

[ TOP ]

Literatures describing the relation between BIRC2 and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
21282461	Bladder Carcinoma	Inhibit immunity	Degradation of the RIP1 K63 ubiquitin ligases cIAP1/2 amplifies the CD40-mediated cytotoxic effect, whereas inhibition of CYLD, a RIP1 K63 deubiquitinating enzyme, reduces it.

Summary
Symbol	BIRC2
Name	baculoviral IAP repeat containing 2
Aliases	cIAP1; hiap-2; MIHB; RNF48; c-IAP1; NFR2-TRAF signalling complex protein; apoptosis inhibitor 1; API1; bacul ......
Chromosomal Location	11q22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of BIRC2 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	logFC: -2.28; FDR: 0.02860	Resistant to T cell-mediated killing
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	logFC: -2.49; FDR: 0.01650	Resistant to T cell-mediated killing
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	STARS Score: 6.26; FDR: 0.000	Resistant to T cell-mediated killing
28723893	CRISPR-Cas9	melanoma	B16	GVAX	STARS Score: 6.48; FDR: 0.001	Resistant to T cell-mediated killing
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	BIRC2
Name	baculoviral IAP repeat containing 2
Aliases	cIAP1; hiap-2; MIHB; RNF48; c-IAP1; NFR2-TRAF signalling complex protein; apoptosis inhibitor 1; API1; bacul ......
Chromosomal Location	11q22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of BIRC2 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.796	0.116
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-1.095	0.615
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.577	0.72
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.073	0.813
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.225	0.902
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.122	0.959
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.459	0.312
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.143	0.937
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.768	0.694
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.498	0.737
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.725	0.754
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.092	0.115

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of BIRC2 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	2.7	1	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	3.4	0.3	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	BIRC2
Name	baculoviral IAP repeat containing 2
Aliases	cIAP1; hiap-2; MIHB; RNF48; c-IAP1; NFR2-TRAF signalling complex protein; apoptosis inhibitor 1; API1; bacul ......
Chromosomal Location	11q22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BIRC2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	BIRC2
Name	baculoviral IAP repeat containing 2
Aliases	cIAP1; hiap-2; MIHB; RNF48; c-IAP1; NFR2-TRAF signalling complex protein; apoptosis inhibitor 1; API1; bacul ......
Chromosomal Location	11q22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BIRC2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BIRC2. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	BIRC2
Name	baculoviral IAP repeat containing 2
Aliases	cIAP1; hiap-2; MIHB; RNF48; c-IAP1; NFR2-TRAF signalling complex protein; apoptosis inhibitor 1; API1; bacul ......
Chromosomal Location	11q22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BIRC2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	BIRC2
Name	baculoviral IAP repeat containing 2
Aliases	cIAP1; hiap-2; MIHB; RNF48; c-IAP1; NFR2-TRAF signalling complex protein; apoptosis inhibitor 1; API1; bacul ......
Chromosomal Location	11q22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of BIRC2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	BIRC2
Name	baculoviral IAP repeat containing 2
Aliases	cIAP1; hiap-2; MIHB; RNF48; c-IAP1; NFR2-TRAF signalling complex protein; apoptosis inhibitor 1; API1; bacul ......
Chromosomal Location	11q22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between BIRC2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	BIRC2
Name	baculoviral IAP repeat containing 2
Aliases	cIAP1; hiap-2; MIHB; RNF48; c-IAP1; NFR2-TRAF signalling complex protein; apoptosis inhibitor 1; API1; bacul ......
Chromosomal Location	11q22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting BIRC2 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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