Summary | |
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Symbol | BRINP2 |
Name | bone morphogenetic protein/retinoic acid inducible neural-specific 2 |
Aliases | DBCCR1L2; FAM5B; family with sequence similarity 5, member B; DBCCR1-like protein 2; DBCCR1-like2; bone morp ...... |
Chromosomal Location | 1q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted |
Domain |
PF01823 MAC/Perforin domain |
Function |
Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. |
Biological Process |
GO:0001101 response to acid chemical GO:0007050 cell cycle arrest GO:0007346 regulation of mitotic cell cycle GO:0010720 positive regulation of cell development GO:0032526 response to retinoic acid GO:0045666 positive regulation of neuron differentiation GO:0045786 negative regulation of cell cycle GO:0045930 negative regulation of mitotic cell cycle GO:0050769 positive regulation of neurogenesis GO:0051962 positive regulation of nervous system development GO:0071229 cellular response to acid chemical GO:0071300 cellular response to retinoic acid GO:0071396 cellular response to lipid |
Molecular Function | - |
Cellular Component |
GO:0030425 dendrite GO:0043025 neuronal cell body GO:0044297 cell body |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | BRINP2 |
Name | bone morphogenetic protein/retinoic acid inducible neural-specific 2 |
Aliases | DBCCR1L2; FAM5B; family with sequence similarity 5, member B; DBCCR1-like protein 2; DBCCR1-like2; bone morp ...... |
Chromosomal Location | 1q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between BRINP2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | BRINP2 |
Name | bone morphogenetic protein/retinoic acid inducible neural-specific 2 |
Aliases | DBCCR1L2; FAM5B; family with sequence similarity 5, member B; DBCCR1-like protein 2; DBCCR1-like2; bone morp ...... |
Chromosomal Location | 1q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of BRINP2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | BRINP2 |
Name | bone morphogenetic protein/retinoic acid inducible neural-specific 2 |
Aliases | DBCCR1L2; FAM5B; family with sequence similarity 5, member B; DBCCR1-like protein 2; DBCCR1-like2; bone morp ...... |
Chromosomal Location | 1q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of BRINP2 in various data sets.
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Points in the above scatter plot represent the mutation difference of BRINP2 in various data sets.
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Summary | |
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Symbol | BRINP2 |
Name | bone morphogenetic protein/retinoic acid inducible neural-specific 2 |
Aliases | DBCCR1L2; FAM5B; family with sequence similarity 5, member B; DBCCR1-like protein 2; DBCCR1-like2; bone morp ...... |
Chromosomal Location | 1q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BRINP2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | BRINP2 |
Name | bone morphogenetic protein/retinoic acid inducible neural-specific 2 |
Aliases | DBCCR1L2; FAM5B; family with sequence similarity 5, member B; DBCCR1-like protein 2; DBCCR1-like2; bone morp ...... |
Chromosomal Location | 1q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BRINP2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BRINP2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | BRINP2 |
Name | bone morphogenetic protein/retinoic acid inducible neural-specific 2 |
Aliases | DBCCR1L2; FAM5B; family with sequence similarity 5, member B; DBCCR1-like protein 2; DBCCR1-like2; bone morp ...... |
Chromosomal Location | 1q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BRINP2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | BRINP2 |
Name | bone morphogenetic protein/retinoic acid inducible neural-specific 2 |
Aliases | DBCCR1L2; FAM5B; family with sequence similarity 5, member B; DBCCR1-like protein 2; DBCCR1-like2; bone morp ...... |
Chromosomal Location | 1q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of BRINP2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | BRINP2 |
Name | bone morphogenetic protein/retinoic acid inducible neural-specific 2 |
Aliases | DBCCR1L2; FAM5B; family with sequence similarity 5, member B; DBCCR1-like protein 2; DBCCR1-like2; bone morp ...... |
Chromosomal Location | 1q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between BRINP2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | BRINP2 |
Name | bone morphogenetic protein/retinoic acid inducible neural-specific 2 |
Aliases | DBCCR1L2; FAM5B; family with sequence similarity 5, member B; DBCCR1-like protein 2; DBCCR1-like2; bone morp ...... |
Chromosomal Location | 1q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting BRINP2 collected from DrugBank database. |
There is no record. |