Browse BRINP2

Summary
SymbolBRINP2
Namebone morphogenetic protein/retinoic acid inducible neural-specific 2
Aliases DBCCR1L2; FAM5B; family with sequence similarity 5, member B; DBCCR1-like protein 2; DBCCR1-like2; bone morp ......
Chromosomal Location1q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted
Domain PF01823 MAC/Perforin domain
Function

Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition.

> Gene Ontology
 
Biological Process GO:0001101 response to acid chemical
GO:0007050 cell cycle arrest
GO:0007346 regulation of mitotic cell cycle
GO:0010720 positive regulation of cell development
GO:0032526 response to retinoic acid
GO:0045666 positive regulation of neuron differentiation
GO:0045786 negative regulation of cell cycle
GO:0045930 negative regulation of mitotic cell cycle
GO:0050769 positive regulation of neurogenesis
GO:0051962 positive regulation of nervous system development
GO:0071229 cellular response to acid chemical
GO:0071300 cellular response to retinoic acid
GO:0071396 cellular response to lipid
Molecular Function -
Cellular Component GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0044297 cell body
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolBRINP2
Namebone morphogenetic protein/retinoic acid inducible neural-specific 2
Aliases DBCCR1L2; FAM5B; family with sequence similarity 5, member B; DBCCR1-like protein 2; DBCCR1-like2; bone morp ......
Chromosomal Location1q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between BRINP2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolBRINP2
Namebone morphogenetic protein/retinoic acid inducible neural-specific 2
Aliases DBCCR1L2; FAM5B; family with sequence similarity 5, member B; DBCCR1-like protein 2; DBCCR1-like2; bone morp ......
Chromosomal Location1q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of BRINP2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell logFC: -2.12; FDR: 0.04220 Resistant to T cell-mediated killing
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolBRINP2
Namebone morphogenetic protein/retinoic acid inducible neural-specific 2
Aliases DBCCR1L2; FAM5B; family with sequence similarity 5, member B; DBCCR1-like protein 2; DBCCR1-like2; bone morp ......
Chromosomal Location1q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of BRINP2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.2090.198
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.190.713
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2230.587
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.90.178
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.6450.118
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0420.973
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.4220.55
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.8770.588
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1920.907
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.4610.312
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.4610.492
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.130.646
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of BRINP2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277318.516.42.10.772
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275918.518.6-0.11
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382710.511.1-0.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221313.615.4-1.81
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.27.1-0.91
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolBRINP2
Namebone morphogenetic protein/retinoic acid inducible neural-specific 2
Aliases DBCCR1L2; FAM5B; family with sequence similarity 5, member B; DBCCR1-like protein 2; DBCCR1-like2; bone morp ......
Chromosomal Location1q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BRINP2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolBRINP2
Namebone morphogenetic protein/retinoic acid inducible neural-specific 2
Aliases DBCCR1L2; FAM5B; family with sequence similarity 5, member B; DBCCR1-like protein 2; DBCCR1-like2; bone morp ......
Chromosomal Location1q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BRINP2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BRINP2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolBRINP2
Namebone morphogenetic protein/retinoic acid inducible neural-specific 2
Aliases DBCCR1L2; FAM5B; family with sequence similarity 5, member B; DBCCR1-like protein 2; DBCCR1-like2; bone morp ......
Chromosomal Location1q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BRINP2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolBRINP2
Namebone morphogenetic protein/retinoic acid inducible neural-specific 2
Aliases DBCCR1L2; FAM5B; family with sequence similarity 5, member B; DBCCR1-like protein 2; DBCCR1-like2; bone morp ......
Chromosomal Location1q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of BRINP2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolBRINP2
Namebone morphogenetic protein/retinoic acid inducible neural-specific 2
Aliases DBCCR1L2; FAM5B; family with sequence similarity 5, member B; DBCCR1-like protein 2; DBCCR1-like2; bone morp ......
Chromosomal Location1q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between BRINP2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolBRINP2
Namebone morphogenetic protein/retinoic acid inducible neural-specific 2
Aliases DBCCR1L2; FAM5B; family with sequence similarity 5, member B; DBCCR1-like protein 2; DBCCR1-like2; bone morp ......
Chromosomal Location1q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting BRINP2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.