TISIDB

Summary
Symbol	BSG
Name	basigin (Ok blood group)
Aliases	EMMPRIN; CD147; Ok blood group; OK; basigin; 5F7; M6; TCSF; CD147 antigen; OK blood group antigen; collagena ......
Chromosomal Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cell membrane Single-pass type I membrane protein Melanosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In spermatozoa, localized on the principal piece of caput and in the middle piece during transit in the corpus and cauda epididymides (By similarity).
Domain	-
Function	Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3, SLC16A8 and SLC16A11 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.

> Gene Ontology [ TOP ]
Biological Process	GO:0001890 placenta development GO:0001893 maternal placenta development GO:0006090 pyruvate metabolic process GO:0006612 protein targeting to membrane GO:0006820 anion transport GO:0007009 plasma membrane organization GO:0007565 female pregnancy GO:0007566 embryo implantation GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0014074 response to purine-containing compound GO:0015711 organic anion transport GO:0015718 monocarboxylic acid transport GO:0022617 extracellular matrix disassembly GO:0030198 extracellular matrix organization GO:0042475 odontogenesis of dentin-containing tooth GO:0042476 odontogenesis GO:0043062 extracellular structure organization GO:0043434 response to peptide hormone GO:0044706 multi-multicellular organism process GO:0046683 response to organophosphorus GO:0046689 response to mercury ion GO:0046697 decidualization GO:0046942 carboxylic acid transport GO:0048608 reproductive structure development GO:0050900 leukocyte migration GO:0051591 response to cAMP GO:0060135 maternal process involved in female pregnancy GO:0061458 reproductive system development GO:0072657 protein localization to membrane GO:0072659 protein localization to plasma membrane GO:0072661 protein targeting to plasma membrane GO:0090002 establishment of protein localization to plasma membrane GO:0090150 establishment of protein localization to membrane GO:1901652 response to peptide GO:1990267 response to transition metal nanoparticle GO:1990778 protein localization to cell periphery
Molecular Function	GO:0005342 organic acid transmembrane transporter activity GO:0005537 mannose binding GO:0008028 monocarboxylic acid transmembrane transporter activity GO:0030246 carbohydrate binding GO:0045296 cadherin binding GO:0046943 carboxylic acid transmembrane transporter activity GO:0048029 monosaccharide binding GO:0050839 cell adhesion molecule binding GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion
Cellular Component	GO:0001669 acrosomal vesicle GO:0002080 acrosomal membrane GO:0005913 cell-cell adherens junction GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0030055 cell-substrate junction GO:0030141 secretory granule GO:0030659 cytoplasmic vesicle membrane GO:0030667 secretory granule membrane GO:0042383 sarcolemma GO:0042470 melanosome GO:0045121 membrane raft GO:0048770 pigment granule GO:0097223 sperm part GO:0098589 membrane region GO:0098857 membrane microdomain GO:0099503 secretory vesicle

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-210991: Basigin interactions R-HSA-425471: Bile salt and organic anion SLC transporters R-HSA-202733: Cell surface interactions at the vascular wall R-HSA-1474228: Degradation of the extracellular matrix R-HSA-1474244: Extracellular matrix organization R-HSA-109582: Hemostasis R-HSA-216083: Integrin cell surface interactions R-HSA-1430728: Metabolism R-HSA-433692: Proton-coupled monocarboxylate transport R-HSA-70268: Pyruvate metabolism R-HSA-71406: Pyruvate metabolism and Citric Acid (TCA) cycle R-HSA-425407: SLC-mediated transmembrane transport R-HSA-1428517: The citric acid (TCA) cycle and respiratory electron transport R-HSA-382551: Transmembrane transport of small molecules R-HSA-425366: Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds

> KEGG and Reactome Pathway

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KEGG

Reactome

R-HSA-210991: Basigin interactions
R-HSA-425471: Bile salt and organic anion SLC transporters
R-HSA-202733: Cell surface interactions at the vascular wall
R-HSA-1474228: Degradation of the extracellular matrix
R-HSA-1474244: Extracellular matrix organization
R-HSA-109582: Hemostasis
R-HSA-216083: Integrin cell surface interactions
R-HSA-1430728: Metabolism
R-HSA-433692: Proton-coupled monocarboxylate transport
R-HSA-70268: Pyruvate metabolism
R-HSA-71406: Pyruvate metabolism and Citric Acid (TCA) cycle
R-HSA-425407: SLC-mediated transmembrane transport
R-HSA-1428517: The citric acid (TCA) cycle and respiratory electron transport
R-HSA-382551: Transmembrane transport of small molecules
R-HSA-425366: Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds

Summary
Symbol	BSG
Name	basigin (Ok blood group)
Aliases	EMMPRIN; CD147; Ok blood group; OK; basigin; 5F7; M6; TCSF; CD147 antigen; OK blood group antigen; collagena ......
Chromosomal Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between BSG and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

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Literatures describing the relation between BSG and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
29210217	Hepatocellular Carcinoma	Inhibit immunity	The efficacy of I131 -metuximab (I131 -mab), a newly developed agent that targets CD147, as a radio-immunotherapy for local HCC, has been validated in clinical practice.
20406987	Primary Effusion Lymphoma	Inhibit immunity	We also found that emmprin promotes invasiveness, as well as colony formation, by primary effusion lymphoma cells derived from human tumors. Collectively, these data implicate KSHV activation of emmprin as an important mechanism for cancer progression and support the potential utility of targeting emmprin as a novel therapeutic approach for KSHV-associated tumors.

Summary
Symbol	BSG
Name	basigin (Ok blood group)
Aliases	EMMPRIN; CD147; Ok blood group; OK; basigin; 5F7; M6; TCSF; CD147 antigen; OK blood group antigen; collagena ......
Chromosomal Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of BSG in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	BSG
Name	basigin (Ok blood group)
Aliases	EMMPRIN; CD147; Ok blood group; OK; basigin; 5F7; M6; TCSF; CD147 antigen; OK blood group antigen; collagena ......
Chromosomal Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of BSG in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.134	0.708
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.266	0.952
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.435	0.889
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.187	0.644
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.181	0.943
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.188	0.951
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.261	0.632
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.503	0.833
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.003	0.999
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.05	0.985
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-0.119	0.977
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.08	0.337

> Mutation difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the mutation difference of BSG in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	0	0	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	0	0	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	12.5	-12.5	0.52
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	28.6	-28.6	0.491
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	2.6	0	2.6	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	6.2	0	6.2	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	BSG
Name	basigin (Ok blood group)
Aliases	EMMPRIN; CD147; Ok blood group; OK; basigin; 5F7; M6; TCSF; CD147 antigen; OK blood group antigen; collagena ......
Chromosomal Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BSG. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	BSG
Name	basigin (Ok blood group)
Aliases	EMMPRIN; CD147; Ok blood group; OK; basigin; 5F7; M6; TCSF; CD147 antigen; OK blood group antigen; collagena ......
Chromosomal Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BSG. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BSG. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	BSG
Name	basigin (Ok blood group)
Aliases	EMMPRIN; CD147; Ok blood group; OK; basigin; 5F7; M6; TCSF; CD147 antigen; OK blood group antigen; collagena ......
Chromosomal Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BSG. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	BSG
Name	basigin (Ok blood group)
Aliases	EMMPRIN; CD147; Ok blood group; OK; basigin; 5F7; M6; TCSF; CD147 antigen; OK blood group antigen; collagena ......
Chromosomal Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of BSG expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	BSG
Name	basigin (Ok blood group)
Aliases	EMMPRIN; CD147; Ok blood group; OK; basigin; 5F7; M6; TCSF; CD147 antigen; OK blood group antigen; collagena ......
Chromosomal Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between BSG and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	BSG
Name	basigin (Ok blood group)
Aliases	EMMPRIN; CD147; Ok blood group; OK; basigin; 5F7; M6; TCSF; CD147 antigen; OK blood group antigen; collagena ......
Chromosomal Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting BSG collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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