Browse BSN

Summary
SymbolBSN
Namebassoon presynaptic cytomatrix protein
Aliases zinc finger protein 231; neuronal double zinc finger protein; ZNF231; bassoon (presynaptic cytomatrix protei ......
Chromosomal Location3p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Cell junction, synapse, synaptosome Cytoplasm, cytoskeleton. Note=Localized to the active zone of presynaptic density.
Domain PF05715 Piccolo Zn-finger
Function

Is thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act through binding to ERC2/CAST1. Essential in regulated neurotransmitter release from a subset of brain glutamatergic synapses. Involved in the formation of the retinal photoreceptor ribbon synapses (By similarity).

> Gene Ontology
 
Biological Process GO:0007416 synapse assembly
GO:0035418 protein localization to synapse
GO:0050808 synapse organization
Molecular Function -
Cellular Component GO:0005938 cell cortex
GO:0014069 postsynaptic density
GO:0030424 axon
GO:0030425 dendrite
GO:0030863 cortical cytoskeleton
GO:0044306 neuron projection terminus
GO:0044448 cell cortex part
GO:0048786 presynaptic active zone
GO:0048788 cytoskeleton of presynaptic active zone
GO:0060076 excitatory synapse
GO:0098793 presynapse
GO:0098794 postsynapse
GO:0098831 presynaptic active zone cytoplasmic component
GO:0099568 cytoplasmic region
GO:0099569 presynaptic cytoskeleton
GO:0099572 postsynaptic specialization
GO:0099738 cell cortex region
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolBSN
Namebassoon presynaptic cytomatrix protein
Aliases zinc finger protein 231; neuronal double zinc finger protein; ZNF231; bassoon (presynaptic cytomatrix protei ......
Chromosomal Location3p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between BSN and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolBSN
Namebassoon presynaptic cytomatrix protein
Aliases zinc finger protein 231; neuronal double zinc finger protein; ZNF231; bassoon (presynaptic cytomatrix protei ......
Chromosomal Location3p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of BSN in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolBSN
Namebassoon presynaptic cytomatrix protein
Aliases zinc finger protein 231; neuronal double zinc finger protein; ZNF231; bassoon (presynaptic cytomatrix protei ......
Chromosomal Location3p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of BSN in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.3010.133
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.3250.492
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.280.424
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1390.655
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1780.926
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0850.971
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.6140.182
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.6720.375
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.7670.284
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1660.709
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.0680.917
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1280.469
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of BSN in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141735.7035.70.0118
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103400400.497
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 414250250.222
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.1110.11
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.113.6-2.51
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211723.811.8120.427
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86250250.473
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131123.118.24.91
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382721.111.1100.338
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221331.815.416.40.431
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.27.1-0.91
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolBSN
Namebassoon presynaptic cytomatrix protein
Aliases zinc finger protein 231; neuronal double zinc finger protein; ZNF231; bassoon (presynaptic cytomatrix protei ......
Chromosomal Location3p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BSN. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolBSN
Namebassoon presynaptic cytomatrix protein
Aliases zinc finger protein 231; neuronal double zinc finger protein; ZNF231; bassoon (presynaptic cytomatrix protei ......
Chromosomal Location3p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BSN. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BSN.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolBSN
Namebassoon presynaptic cytomatrix protein
Aliases zinc finger protein 231; neuronal double zinc finger protein; ZNF231; bassoon (presynaptic cytomatrix protei ......
Chromosomal Location3p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BSN. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolBSN
Namebassoon presynaptic cytomatrix protein
Aliases zinc finger protein 231; neuronal double zinc finger protein; ZNF231; bassoon (presynaptic cytomatrix protei ......
Chromosomal Location3p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of BSN expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolBSN
Namebassoon presynaptic cytomatrix protein
Aliases zinc finger protein 231; neuronal double zinc finger protein; ZNF231; bassoon (presynaptic cytomatrix protei ......
Chromosomal Location3p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between BSN and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolBSN
Namebassoon presynaptic cytomatrix protein
Aliases zinc finger protein 231; neuronal double zinc finger protein; ZNF231; bassoon (presynaptic cytomatrix protei ......
Chromosomal Location3p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting BSN collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.