Browse CA2

Summary
SymbolCA2
Namecarbonic anhydrase II
Aliases CA-II; CAII; HEL-76; carbonate dehydratase II; carbonic anhydrase C; epididymis luminal protein 76; Carbonic ......
Chromosomal Location8q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Cell membrane Note=Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells.
Domain PF00194 Eukaryotic-type carbonic anhydrase
Function

Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6.

> Gene Ontology
 
Biological Process GO:0001655 urogenital system development
GO:0001822 kidney development
GO:0001894 tissue homeostasis
GO:0002521 leukocyte differentiation
GO:0002573 myeloid leukocyte differentiation
GO:0002761 regulation of myeloid leukocyte differentiation
GO:0002763 positive regulation of myeloid leukocyte differentiation
GO:0006730 one-carbon metabolic process
GO:0006820 anion transport
GO:0006821 chloride transport
GO:0006857 oligopeptide transport
GO:0006885 regulation of pH
GO:0007270 neuron-neuron synaptic transmission
GO:0009268 response to pH
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0010043 response to zinc ion
GO:0015669 gas transport
GO:0015670 carbon dioxide transport
GO:0015698 inorganic anion transport
GO:0015701 bicarbonate transport
GO:0015711 organic anion transport
GO:0015833 peptide transport
GO:0019755 one-carbon compound transport
GO:0030004 cellular monovalent inorganic cation homeostasis
GO:0030099 myeloid cell differentiation
GO:0030316 osteoclast differentiation
GO:0030641 regulation of cellular pH
GO:0032228 regulation of synaptic transmission, GABAergic
GO:0032230 positive regulation of synaptic transmission, GABAergic
GO:0032844 regulation of homeostatic process
GO:0032846 positive regulation of homeostatic process
GO:0032847 regulation of cellular pH reduction
GO:0032849 positive regulation of cellular pH reduction
GO:0034103 regulation of tissue remodeling
GO:0034105 positive regulation of tissue remodeling
GO:0034405 response to fluid shear stress
GO:0034762 regulation of transmembrane transport
GO:0034764 positive regulation of transmembrane transport
GO:0035442 dipeptide transmembrane transport
GO:0035672 oligopeptide transmembrane transport
GO:0038166 angiotensin-activated signaling pathway
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042476 odontogenesis
GO:0042886 amide transport
GO:0042938 dipeptide transport
GO:0043434 response to peptide hormone
GO:0043627 response to estrogen
GO:0044070 regulation of anion transport
GO:0045124 regulation of bone resorption
GO:0045453 bone resorption
GO:0045637 regulation of myeloid cell differentiation
GO:0045639 positive regulation of myeloid cell differentiation
GO:0045670 regulation of osteoclast differentiation
GO:0045672 positive regulation of osteoclast differentiation
GO:0045780 positive regulation of bone resorption
GO:0045851 pH reduction
GO:0046849 bone remodeling
GO:0046850 regulation of bone remodeling
GO:0046852 positive regulation of bone remodeling
GO:0048545 response to steroid hormone
GO:0048771 tissue remodeling
GO:0048871 multicellular organismal homeostasis
GO:0050804 modulation of synaptic transmission
GO:0050806 positive regulation of synaptic transmission
GO:0051452 intracellular pH reduction
GO:0051453 regulation of intracellular pH
GO:0051932 synaptic transmission, GABAergic
GO:0055067 monovalent inorganic cation homeostasis
GO:0060249 anatomical structure homeostasis
GO:0071375 cellular response to peptide hormone stimulus
GO:0071417 cellular response to organonitrogen compound
GO:0071498 cellular response to fluid shear stress
GO:0072001 renal system development
GO:0090087 regulation of peptide transport
GO:0090088 regulation of oligopeptide transport
GO:0090089 regulation of dipeptide transport
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:1902105 regulation of leukocyte differentiation
GO:1902107 positive regulation of leukocyte differentiation
GO:1903706 regulation of hemopoiesis
GO:1903708 positive regulation of hemopoiesis
GO:1904385 cellular response to angiotensin
GO:1990267 response to transition metal nanoparticle
GO:1990776 response to angiotensin
GO:2000021 regulation of ion homeostasis
GO:2000878 positive regulation of oligopeptide transport
GO:2000880 positive regulation of dipeptide transport
GO:2001148 regulation of dipeptide transmembrane transport
GO:2001150 positive regulation of dipeptide transmembrane transport
GO:2001225 regulation of chloride transport
Molecular Function GO:0004064 arylesterase activity
GO:0004089 carbonate dehydratase activity
GO:0016829 lyase activity
GO:0016835 carbon-oxygen lyase activity
GO:0016836 hydro-lyase activity
GO:0052689 carboxylic ester hydrolase activity
Cellular Component GO:0005902 microvillus
GO:0016323 basolateral plasma membrane
GO:0030424 axon
GO:0043209 myelin sheath
GO:0045177 apical part of cell
GO:0098858 actin-based cell projection
> KEGG and Reactome Pathway
 
KEGG hsa04964 Proximal tubule bicarbonate reclamation
hsa04966 Collecting duct acid secretion
hsa04971 Gastric acid secretion
hsa04972 Pancreatic secretion
hsa04976 Bile secretion
hsa00910 Nitrogen metabolism
Reactome R-HSA-1237044: Erythrocytes take up carbon dioxide and release oxygen
R-HSA-1247673: Erythrocytes take up oxygen and release carbon dioxide
R-HSA-1430728: Metabolism
R-HSA-1480926: O2/CO2 exchange in erythrocytes
R-HSA-1475029: Reversible hydration of carbon dioxide
Summary
SymbolCA2
Namecarbonic anhydrase II
Aliases CA-II; CAII; HEL-76; carbonate dehydratase II; carbonic anhydrase C; epididymis luminal protein 76; Carbonic ......
Chromosomal Location8q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CA2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between CA2 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
16299253MelanomaInhibit immunityCarbonic anhydrase II is a tumor vessel endothelium-associated antigen targeted by dendritic cell therapy. These findings suggest that CA-II is a tumor vessel endothelium-associated antigen in melanoma and other cancers, and elicitation of serum anti-CA-II antibody by dendritic cell therapy may be associated with good clinical outcome including tumor reduction.
Summary
SymbolCA2
Namecarbonic anhydrase II
Aliases CA-II; CAII; HEL-76; carbonate dehydratase II; carbonic anhydrase C; epididymis luminal protein 76; Carbonic ......
Chromosomal Location8q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CA2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCA2
Namecarbonic anhydrase II
Aliases CA-II; CAII; HEL-76; carbonate dehydratase II; carbonic anhydrase C; epididymis luminal protein 76; Carbonic ......
Chromosomal Location8q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CA2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0750.882
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.5930.636
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.5680.54
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2260.582
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0820.951
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.4140.781
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.6520.27
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.2230.87
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-1.4750.262
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.5540.801
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-1.0680.754
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.5220.0102
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CA2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 414250250.222
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.44.13.30.61
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.43.440.587
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.85.9-1.11
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86016.7-16.70.429
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCA2
Namecarbonic anhydrase II
Aliases CA-II; CAII; HEL-76; carbonate dehydratase II; carbonic anhydrase C; epididymis luminal protein 76; Carbonic ......
Chromosomal Location8q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CA2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCA2
Namecarbonic anhydrase II
Aliases CA-II; CAII; HEL-76; carbonate dehydratase II; carbonic anhydrase C; epididymis luminal protein 76; Carbonic ......
Chromosomal Location8q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CA2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CA2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCA2
Namecarbonic anhydrase II
Aliases CA-II; CAII; HEL-76; carbonate dehydratase II; carbonic anhydrase C; epididymis luminal protein 76; Carbonic ......
Chromosomal Location8q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CA2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCA2
Namecarbonic anhydrase II
Aliases CA-II; CAII; HEL-76; carbonate dehydratase II; carbonic anhydrase C; epididymis luminal protein 76; Carbonic ......
Chromosomal Location8q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CA2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCA2
Namecarbonic anhydrase II
Aliases CA-II; CAII; HEL-76; carbonate dehydratase II; carbonic anhydrase C; epididymis luminal protein 76; Carbonic ......
Chromosomal Location8q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CA2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCA2
Namecarbonic anhydrase II
Aliases CA-II; CAII; HEL-76; carbonate dehydratase II; carbonic anhydrase C; epididymis luminal protein 76; Carbonic ......
Chromosomal Location8q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CA2 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting CA2.
ID Name Drug Type Targets #Targets
DB00232MethyclothiazideSmall MoleculeCA1, CA2, CA4, SLC12A14
DB00273TopiramateSmall MoleculeCA1, CA2, CA3, CA4, GABRA1, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5 ......23
DB00311EthoxzolamideSmall MoleculeCA1, CA2, CA3, CA4, CA75
DB00391SulpirideSmall MoleculeCA2, CA3, DRD2, DRD34
DB00436BendroflumethiazideSmall MoleculeCA1, CA2, CA4, KCNMA1, SLC12A35
DB00482CelecoxibSmall MoleculeCA2, CA3, PDPK1, PTGS24
DB00562BenzthiazideSmall MoleculeCA1, CA12, CA2, CA4, CA9, SLC12A36
DB00580ValdecoxibSmall MoleculeCA2, CA3, PTGS23
DB00606CyclothiazideSmall MoleculeCA1, CA2, CA4, FXYD2, SFRP45
DB00695FurosemideSmall MoleculeCA2, SLC12A12
DB00703MethazolamideSmall MoleculeCA1, CA2, CA3, CA4, CA75
DB00774HydroflumethiazideSmall MoleculeATP1A1, CA1, CA12, CA2, CA4, CA9, KCNMA1, SLC12A18
DB00819AcetazolamideSmall MoleculeAQP1, CA1, CA12, CA14, CA2, CA3, CA4, CA78
DB00869DorzolamideSmall MoleculeCA1, CA2, CA3, CA44
DB00880ChlorothiazideSmall MoleculeCA1, CA2, CA4, SLC12A34
DB00909ZonisamideSmall MoleculeCA1, CA10, CA11, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, ......31
DB00999HydrochlorothiazideSmall MoleculeCA1, CA12, CA2, CA4, CA9, KCNMA1, SLC12A37
DB01021TrichlormethiazideSmall MoleculeATP1A1, CA1, CA2, CA4, SLC12A15
DB01031EthinamateSmall MoleculeCA1, CA22
DB01119DiazoxideSmall MoleculeATP1A1, CA1, CA2, KCNJ11, KCNMA1, SLC12A36
DB01144DiclofenamideSmall MoleculeCA1, CA2, CA3, CA4, CA75
DB01194BrinzolamideSmall MoleculeCA1, CA2, CA3, CA4, CA5A5
DB01325QuinethazoneSmall MoleculeCA1, CA2, SLC12A1, SLC12A2, SLC12A35
DB016714-(Hydroxymercury)Benzoic AcidSmall MoleculeCA21
DB01748N-Benzyl-4-Sulfamoyl-BenzamideSmall MoleculeCA21
DB017844-FlourobenzenesulfonamideSmall MoleculeCA21
DB01942Formic AcidSmall MoleculeACYP2, CA2, CASK, CTBP1, CYTH2, FGF1, GGACT, GPHN, HMOX1, NOS1, PV ......12
DB01964AL5424Small MoleculeCA21
DB02069N-(2-Flouro-Benzyl)-4-Sulfamoyl-BenzamideSmall MoleculeCA21
DB020873,5-DifluorobenzenesulfonamideSmall MoleculeCA21
DB02220AL7089ASmall MoleculeCA21
DB022214-(Aminosulfonyl)-N-[(2,4,6-Trifluorophenyl)Methyl]-BenzamideSmall MoleculeCA21
DB02292IrosustatSmall MoleculeCA2, STS2
DB024294-(Aminosulfonyl)-N-[(4-Fluorophenyl)Methyl]-BenzamideSmall MoleculeCA21
DB02479(R)-N-(3-Indol-1-Yl-2-Methyl-Propyl)-4-Sulfamoyl-BenzamideSmall MoleculeCA21
DB02535Aminodi(Ethyloxy)EthylaminocarbonylbenzenesulfonamideSmall MoleculeCA21
DB02602AL7182Small MoleculeCA21
DB02610N-(2,3,4,5,6-Pentaflouro-Benzyl)-4-Sulfamoyl-BenzamideSmall MoleculeCA21
DB02679CyanamideSmall MoleculeCA2, CTSK2
DB028614-(Aminosulfonyl)-N-[(3,4,5-Trifluorophenyl)Methyl]-BenzamideSmall MoleculeCA21
DB02866DansylamideSmall MoleculeCA21
DB02894Sulfamic Acid 2,3-O-(1-Methylethylidene)-4,5-O-Sulfonyl-Beta-Fructopyranose EsterSmall MoleculeCA21
DB02986N-(2-Thienylmethyl)-2,5-ThiophenedisulfonamideSmall MoleculeCA21
DB030394-(Aminosulfonyl)-N-[(2,5-Difluorophenyl)Methyl]-BenzamideSmall MoleculeCA21
DB03221AL7099ASmall MoleculeCA21
DB03262Al-6619, [2h-Thieno[3,2-E]-1,2-Thiazine-6-Sulfonamide,2-(3-Hydroxyphenyl)-3-(4-Morpholinyl)-, 1,1-Dioxide]Small MoleculeCA21
DB032702,6-DifluorobenzenesulfonamideSmall MoleculeCA21
DB032941-Methyl-3-Oxo-1,3-Dihydro-Benzo[C]Isothiazole-5-Sulfonic Acid AmideSmall MoleculeCA21
DB03333(4-sulfamoyl-phenyl)-thiocarbamic acid O-(2-thiophen-3-yl-ethyl) esterSmall MoleculeCA21
DB033854-MethylimidazoleSmall MoleculeCA2, CA5A, MB3
DB03526AL5927Small MoleculeCA21
DB035941,2,4-TriazoleSmall MoleculeCA21
DB03596N-[2-(1h-Indol-5-Yl)-Butyl]-4-Sulfamoyl-BenzamideSmall MoleculeCA21
DB03598Al-6629, [2h-Thieno[3,2-E]-1,2-Thiazine-6-Sulfonamide,2-(3-Methoxyphenyl)-3-(4-Morpholinyl)-, 1,1-Dioxide]Small MoleculeCA21
DB036974-Sulfonamide-[1-(4-Aminobutane)]BenzamideSmall MoleculeCA21
DB03844N-(2,6-Diflouro-Benzyl)-4-Sulfamoyl-BenzamideSmall MoleculeCA21
DB03877AL4623Small MoleculeCA21
DB03904UreaSmall MoleculeARG1, CA2, CTNNB13
DB03950(S)-N-(3-Indol-1-Yl-2-Methyl-Propyl)-4-Sulfamoyl-BenzamideSmall MoleculeCA21
DB03975Mercuribenzoic AcidSmall MoleculeCA21
DB040024-Sulfonamide-[4-(Thiomethylaminobutane)]BenzamideSmall MoleculeCA21
DB04081(4s-Trans)-4-(Methylamino)-5,6-Dihydro-6-Methyl-4h-Thieno(2,3-B)Thiopyran-2-Sulfonamide-7,7-DioxideSmall MoleculeCA21
DB04089AL5300Small MoleculeCA21
DB041804-(Aminosulfonyl)-N-[(2,4-Difluorophenyl)Methyl]-BenzamideSmall MoleculeCA21
DB042033-Mercuri-4-AminobenzenesulfonamideSmall MoleculeCA21
DB04371AL6528Small MoleculeCA21
DB043943-Nitro-4-(2-Oxo-Pyrrolidin-1-Yl)-BenzenesulfonamideSmall MoleculeCA21
DB045494-(Aminosulfonyl)-N-[(2,3,4-Trifluorophenyl)Methyl]-BenzamideSmall MoleculeCA21
DB046004-[(3-BROMO-4-O-SULFAMOYLBENZYL)(4-CYANOPHENYL)AMINO]-4H-[1,2,4]-TRIAZOLESmall MoleculeCA21
DB046014-[(4-O-SULFAMOYLBENZYL)(4-CYANOPHENYL)AMINO]-4H-[1,2,4]-TRIAZOLESmall MoleculeCA21
DB047631-N-(4-SULFAMOYLPHENYL-ETHYL)-2,4,6-TRIMETHYLPYRIDINIUMSmall MoleculeCA21
DB068915-{[(4-AMINO-3-CHLORO-5-FLUOROPHENYL)SULFONYL]AMINO}-1,3,4-THIADIAZOLE-2-SULFONAMIDESmall MoleculeCA21
DB069542-(cycloheptylmethyl)-1,1-dioxido-1-benzothiophen-6-yl sulfamateSmall MoleculeCA21
DB07048N-[(2R)-5-(aminosulfonyl)-2,3-dihydro-1H-inden-2-yl]-2-propylpentanamideSmall MoleculeCA21
DB070505-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamideSmall MoleculeCA21
DB07363THIOPHENE-2,5-DISULFONIC ACID 2-AMIDE-5-(4-METHYL-BENZYLAMIDE)Small MoleculeCA21
DB074674-chloro-N-[(2S)-2-methyl-2,3-dihydro-1H-indol-1-yl]-3-sulfamoylbenzamideSmall MoleculeCA21
DB07476N-[4-(AMINOSULFONYL)PHENYL]-2-MERCAPTOBENZAMIDESmall MoleculeCA21
DB07596(17beta)-17-(cyanomethyl)-2-methoxyestra-1(10),2,4-trien-3-yl sulfamateSmall MoleculeCA21
DB076325-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamideSmall MoleculeCA21
DB07710PHENYLALANYLAMINODI(ETHYLOXY)ETHYL BENZENESULFONAMIDEAMINOCARBONYLBENZENESULFONAMIDESmall MoleculeCA21
DB07742N-(2,3-DIFLUORO-BENZYL)-4-SULFAMOYL-BENZAMIDESmall MoleculeCA21
DB080462-chloro-5-[(1S)-1-hydroxy-3-oxo-2H-isoindol-1-yl]benzenesulfonamideSmall MoleculeCA21
DB080832-(1,3-thiazol-4-yl)-1H-benzimidazole-5-sulfonamideSmall MoleculeCA21
DB08155N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDESmall MoleculeCA1, CA22
DB081563-[4-(AMINOSULFONYL)PHENYL]PROPANOIC ACIDSmall MoleculeCA1, CA22
DB08157ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATESmall MoleculeCA1, CA22
DB08165indane-5-sulfonamideSmall MoleculeCA21
DB082024-({[(4-METHYLPIPERAZIN-1-YL)AMINO]CARBONOTHIOYL}AMINO)BENZENESULFONAMIDESmall MoleculeCA21
DB08301N-({[4-(AMINOSULFONYL)PHENYL]AMINO}CARBONYL)-4-METHYLBENZENESULFONAMIDESmall MoleculeCA21
DB08329SulthiameSmall MoleculeCA21
DB08416(9BETA,13ALPHA,14BETA,17ALPHA)-2-METHOXYESTRA-1,3,5(10)-TRIENE-3,17-DIYL DISULFAMATESmall MoleculeCA21
DB08418(4aS,4bR,10bS,12aS)-12a-methyl-1,3-dioxo-2-(pyridin-3-ylmethyl)-1,2,3,4,4a,4b,5,6,10b,11,12,12a-dodecahydronaphtho[2,1-f]isoquinolin-8-yl sulfamateSmall MoleculeCA21
DB086456-CHLORO-3-(DICHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDESmall MoleculeCA21
DB086592-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamideSmall MoleculeCA21
DB087656-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDESmall MoleculeCA2, MIF2
DB087824-(2-AMINOETHYL)BENZENESULFONAMIDESmall MoleculeCA21
DB08846Ellagic AcidSmall MoleculeCA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1 ......17
DB09460Sodium carbonateSmall MoleculeCA1, CA2, CA4, CA94
DB09472Sodium sulfateSmall MoleculeCA1, CA22