Browse CASP7

Summary
SymbolCASP7
Namecaspase 7, apoptosis-related cysteine peptidase
Aliases MCH3; CMH-1; ICE-LAP3; caspase 7, apoptosis-related cysteine protease; CASP-7; LICE2; ICE-like apoptotic pro ......
Chromosomal Location10q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm.
Domain -
Function

Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.

> Gene Ontology
 
Biological Process GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0010950 positive regulation of endopeptidase activity
GO:0010952 positive regulation of peptidase activity
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045862 positive regulation of proteolysis
GO:0052547 regulation of peptidase activity
GO:0052548 regulation of endopeptidase activity
GO:0097194 execution phase of apoptosis
GO:2000116 regulation of cysteine-type endopeptidase activity
GO:2001056 positive regulation of cysteine-type endopeptidase activity
Molecular Function GO:0004175 endopeptidase activity
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04210 Apoptosis
hsa04668 TNF signaling pathway
Reactome R-HSA-111459: Activation of caspases through apoptosome-mediated cleavage
R-HSA-109581: Apoptosis
R-HSA-111465: Apoptotic cleavage of cellular proteins
R-HSA-75153: Apoptotic execution phase
R-HSA-111471: Apoptotic factor-mediated response
R-HSA-264870: Caspase-mediated cleavage of cytoskeletal proteins
R-HSA-111461: Cytochrome c-mediated apoptotic response
R-HSA-109606: Intrinsic Pathway for Apoptosis
R-HSA-5357801: Programmed Cell Death
R-HSA-111463: SMAC binds to IAPs
R-HSA-111469: SMAC-mediated apoptotic response
R-HSA-111464: SMAC-mediated dissociation of IAP
Summary
SymbolCASP7
Namecaspase 7, apoptosis-related cysteine peptidase
Aliases MCH3; CMH-1; ICE-LAP3; caspase 7, apoptosis-related cysteine protease; CASP-7; LICE2; ICE-like apoptotic pro ......
Chromosomal Location10q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CASP7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolCASP7
Namecaspase 7, apoptosis-related cysteine peptidase
Aliases MCH3; CMH-1; ICE-LAP3; caspase 7, apoptosis-related cysteine protease; CASP-7; LICE2; ICE-like apoptotic pro ......
Chromosomal Location10q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CASP7 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.55 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolCASP7
Namecaspase 7, apoptosis-related cysteine peptidase
Aliases MCH3; CMH-1; ICE-LAP3; caspase 7, apoptosis-related cysteine protease; CASP-7; LICE2; ICE-like apoptotic pro ......
Chromosomal Location10q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CASP7 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.2440.399
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.3260.858
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1710.88
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0690.815
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0140.992
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1710.913
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0490.891
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.2410.861
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1590.917
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.7010.619
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.4170.494
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1260.0777
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolCASP7
Namecaspase 7, apoptosis-related cysteine peptidase
Aliases MCH3; CMH-1; ICE-LAP3; caspase 7, apoptosis-related cysteine protease; CASP-7; LICE2; ICE-like apoptotic pro ......
Chromosomal Location10q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CASP7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCASP7
Namecaspase 7, apoptosis-related cysteine peptidase
Aliases MCH3; CMH-1; ICE-LAP3; caspase 7, apoptosis-related cysteine protease; CASP-7; LICE2; ICE-like apoptotic pro ......
Chromosomal Location10q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CASP7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CASP7.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCASP7
Namecaspase 7, apoptosis-related cysteine peptidase
Aliases MCH3; CMH-1; ICE-LAP3; caspase 7, apoptosis-related cysteine protease; CASP-7; LICE2; ICE-like apoptotic pro ......
Chromosomal Location10q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CASP7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCASP7
Namecaspase 7, apoptosis-related cysteine peptidase
Aliases MCH3; CMH-1; ICE-LAP3; caspase 7, apoptosis-related cysteine protease; CASP-7; LICE2; ICE-like apoptotic pro ......
Chromosomal Location10q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CASP7 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCASP7
Namecaspase 7, apoptosis-related cysteine peptidase
Aliases MCH3; CMH-1; ICE-LAP3; caspase 7, apoptosis-related cysteine protease; CASP-7; LICE2; ICE-like apoptotic pro ......
Chromosomal Location10q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CASP7 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCASP7
Namecaspase 7, apoptosis-related cysteine peptidase
Aliases MCH3; CMH-1; ICE-LAP3; caspase 7, apoptosis-related cysteine protease; CASP-7; LICE2; ICE-like apoptotic pro ......
Chromosomal Location10q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CASP7 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting CASP7.
ID Name Drug Type Targets #Targets
DB03384FicaSmall MoleculeCASP71
DB05408EmricasanSmall MoleculeCASP1, CASP3, CASP73