Browse CATSPER3

Summary
SymbolCATSPER3
Namecation channel, sperm associated 3
Aliases CACRC; ca(v)-like protein; calcium channel repeat containing 1; one-repeat calcium channel-like protein; put ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of sperm tail.
Domain PF00520 Ion transport protein
Function

Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.

> Gene Ontology
 
Biological Process GO:0001508 action potential
GO:0006814 sodium ion transport
GO:0006816 calcium ion transport
GO:0007281 germ cell development
GO:0007283 spermatogenesis
GO:0007286 spermatid development
GO:0007338 single fertilization
GO:0008037 cell recognition
GO:0009566 fertilization
GO:0009988 cell-cell recognition
GO:0015672 monovalent inorganic cation transport
GO:0021700 developmental maturation
GO:0022412 cellular process involved in reproduction in multicellular organism
GO:0030317 flagellated sperm motility
GO:0032570 response to progesterone
GO:0034762 regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0035036 sperm-egg recognition
GO:0042391 regulation of membrane potential
GO:0048232 male gamete generation
GO:0048240 sperm capacitation
GO:0048469 cell maturation
GO:0048515 spermatid differentiation
GO:0048545 response to steroid hormone
GO:0051899 membrane depolarization
GO:0070588 calcium ion transmembrane transport
GO:0070838 divalent metal ion transport
GO:0072511 divalent inorganic cation transport
GO:0086010 membrane depolarization during action potential
GO:0097722 sperm motility
GO:1901654 response to ketone
Molecular Function GO:0005216 ion channel activity
GO:0005244 voltage-gated ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005261 cation channel activity
GO:0005262 calcium channel activity
GO:0015085 calcium ion transmembrane transporter activity
GO:0015267 channel activity
GO:0022803 passive transmembrane transporter activity
GO:0022832 voltage-gated channel activity
GO:0022836 gated channel activity
GO:0022838 substrate-specific channel activity
GO:0022843 voltage-gated cation channel activity
GO:0046873 metal ion transmembrane transporter activity
GO:0072509 divalent inorganic cation transmembrane transporter activity
Cellular Component GO:0001669 acrosomal vesicle
GO:0005891 voltage-gated calcium channel complex
GO:0005929 cilium
GO:0030141 secretory granule
GO:0031514 motile cilium
GO:0034702 ion channel complex
GO:0034703 cation channel complex
GO:0034704 calcium channel complex
GO:0036128 CatSper complex
GO:0097223 sperm part
GO:0099503 secretory vesicle
GO:1902495 transmembrane transporter complex
GO:1990351 transporter complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1187000: Fertilization
R-HSA-1474165: Reproduction
R-HSA-1300642: Sperm Motility And Taxes
Summary
SymbolCATSPER3
Namecation channel, sperm associated 3
Aliases CACRC; ca(v)-like protein; calcium channel repeat containing 1; one-repeat calcium channel-like protein; put ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CATSPER3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolCATSPER3
Namecation channel, sperm associated 3
Aliases CACRC; ca(v)-like protein; calcium channel repeat containing 1; one-repeat calcium channel-like protein; put ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CATSPER3 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCATSPER3
Namecation channel, sperm associated 3
Aliases CACRC; ca(v)-like protein; calcium channel repeat containing 1; one-repeat calcium channel-like protein; put ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CATSPER3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-1.1740.0371
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2140.841
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-2.3830.0605
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1480.684
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.9150.184
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.7870.245
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.3850.571
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-1.2250.161
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0350.736
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CATSPER3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916012.5-12.50.52
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59022.2-22.20.505
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCATSPER3
Namecation channel, sperm associated 3
Aliases CACRC; ca(v)-like protein; calcium channel repeat containing 1; one-repeat calcium channel-like protein; put ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CATSPER3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCATSPER3
Namecation channel, sperm associated 3
Aliases CACRC; ca(v)-like protein; calcium channel repeat containing 1; one-repeat calcium channel-like protein; put ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CATSPER3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CATSPER3.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCATSPER3
Namecation channel, sperm associated 3
Aliases CACRC; ca(v)-like protein; calcium channel repeat containing 1; one-repeat calcium channel-like protein; put ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CATSPER3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCATSPER3
Namecation channel, sperm associated 3
Aliases CACRC; ca(v)-like protein; calcium channel repeat containing 1; one-repeat calcium channel-like protein; put ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CATSPER3 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCATSPER3
Namecation channel, sperm associated 3
Aliases CACRC; ca(v)-like protein; calcium channel repeat containing 1; one-repeat calcium channel-like protein; put ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CATSPER3 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCATSPER3
Namecation channel, sperm associated 3
Aliases CACRC; ca(v)-like protein; calcium channel repeat containing 1; one-repeat calcium channel-like protein; put ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CATSPER3 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.