TISIDB

Summary
Symbol	CCR7
Name	chemokine (C-C motif) receptor 7
Aliases	BLR2; CDw197; CD197; CMKBR7; EBI1; CC-CKR-7; CCR-7; Bukitt's lymphoma receptor 2; CC chemokine receptor 7; E ......
Chromosomal Location	17q12-q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cell membrane; Multi-pass membrane protein.
Domain	PF00001 7 transmembrane receptor (rhodopsin family)
Function	Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.

> Gene Ontology [ TOP ]
Biological Process	GO:0000302 response to reactive oxygen species GO:0001767 establishment of lymphocyte polarity GO:0001768 establishment of T cell polarity GO:0001771 immunological synapse formation GO:0001819 positive regulation of cytokine production GO:0001952 regulation of cell-matrix adhesion GO:0001954 positive regulation of cell-matrix adhesion GO:0002237 response to molecule of bacterial origin GO:0002407 dendritic cell chemotaxis GO:0002408 myeloid dendritic cell chemotaxis GO:0002429 immune response-activating cell surface receptor signaling pathway GO:0002437 inflammatory response to antigenic stimulus GO:0002438 acute inflammatory response to antigenic stimulus GO:0002468 dendritic cell antigen processing and presentation GO:0002521 leukocyte differentiation GO:0002524 hypersensitivity GO:0002526 acute inflammatory response GO:0002573 myeloid leukocyte differentiation GO:0002577 regulation of antigen processing and presentation GO:0002579 positive regulation of antigen processing and presentation GO:0002604 regulation of dendritic cell antigen processing and presentation GO:0002606 positive regulation of dendritic cell antigen processing and presentation GO:0002673 regulation of acute inflammatory response GO:0002675 positive regulation of acute inflammatory response GO:0002685 regulation of leukocyte migration GO:0002687 positive regulation of leukocyte migration GO:0002688 regulation of leukocyte chemotaxis GO:0002690 positive regulation of leukocyte chemotaxis GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002757 immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0002861 regulation of inflammatory response to antigenic stimulus GO:0002863 positive regulation of inflammatory response to antigenic stimulus GO:0002864 regulation of acute inflammatory response to antigenic stimulus GO:0002866 positive regulation of acute inflammatory response to antigenic stimulus GO:0002883 regulation of hypersensitivity GO:0002885 positive regulation of hypersensitivity GO:0002920 regulation of humoral immune response GO:0002922 positive regulation of humoral immune response GO:0006644 phospholipid metabolic process GO:0006816 calcium ion transport GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0006959 humoral immune response GO:0006979 response to oxidative stress GO:0007015 actin filament organization GO:0007159 leukocyte cell-cell adhesion GO:0007160 cell-matrix adhesion GO:0007163 establishment or maintenance of cell polarity GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0007254 JNK cascade GO:0008037 cell recognition GO:0008064 regulation of actin polymerization or depolymerization GO:0008154 actin polymerization or depolymerization GO:0009100 glycoprotein metabolic process GO:0009101 glycoprotein biosynthetic process GO:0009306 protein secretion GO:0009988 cell-cell recognition GO:0010035 response to inorganic substance GO:0010559 regulation of glycoprotein biosynthetic process GO:0010560 positive regulation of glycoprotein biosynthetic process GO:0010810 regulation of cell-substrate adhesion GO:0010811 positive regulation of cell-substrate adhesion GO:0019216 regulation of lipid metabolic process GO:0019882 antigen processing and presentation GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030010 establishment of cell polarity GO:0030031 cell projection assembly GO:0030041 actin filament polymerization GO:0030098 lymphocyte differentiation GO:0030099 myeloid cell differentiation GO:0030217 T cell differentiation GO:0030335 positive regulation of cell migration GO:0030593 neutrophil chemotaxis GO:0030595 leukocyte chemotaxis GO:0030832 regulation of actin filament length GO:0030833 regulation of actin filament polymerization GO:0030838 positive regulation of actin filament polymerization GO:0031098 stress-activated protein kinase signaling cascade GO:0031268 pseudopodium organization GO:0031269 pseudopodium assembly GO:0031272 regulation of pseudopodium assembly GO:0031274 positive regulation of pseudopodium assembly GO:0031294 lymphocyte costimulation GO:0031295 T cell costimulation GO:0031334 positive regulation of protein complex assembly GO:0031346 positive regulation of cell projection organization GO:0031349 positive regulation of defense response GO:0031529 ruffle organization GO:0031589 cell-substrate adhesion GO:0032103 positive regulation of response to external stimulus GO:0032271 regulation of protein polymerization GO:0032273 positive regulation of protein polymerization GO:0032496 response to lipopolysaccharide GO:0032535 regulation of cellular component size GO:0032609 interferon-gamma production GO:0032611 interleukin-1 beta production GO:0032612 interleukin-1 production GO:0032615 interleukin-12 production GO:0032649 regulation of interferon-gamma production GO:0032651 regulation of interleukin-1 beta production GO:0032652 regulation of interleukin-1 production GO:0032655 regulation of interleukin-12 production GO:0032735 positive regulation of interleukin-12 production GO:0032844 regulation of homeostatic process GO:0032845 negative regulation of homeostatic process GO:0032872 regulation of stress-activated MAPK cascade GO:0032874 positive regulation of stress-activated MAPK cascade GO:0032956 regulation of actin cytoskeleton organization GO:0032970 regulation of actin filament-based process GO:0033077 T cell differentiation in thymus GO:0033674 positive regulation of kinase activity GO:0034694 response to prostaglandin GO:0034695 response to prostaglandin E GO:0036336 dendritic cell migration GO:0038115 chemokine (C-C motif) ligand 19 signaling pathway GO:0038116 chemokine (C-C motif) ligand 21 signaling pathway GO:0040017 positive regulation of locomotion GO:0042110 T cell activation GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043254 regulation of protein complex assembly GO:0043383 negative T cell selection GO:0043410 positive regulation of MAPK cascade GO:0043491 protein kinase B signaling GO:0043550 regulation of lipid kinase activity GO:0043551 regulation of phosphatidylinositol 3-kinase activity GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity GO:0044089 positive regulation of cellular component biogenesis GO:0045058 T cell selection GO:0045060 negative thymic T cell selection GO:0045061 thymic T cell selection GO:0045785 positive regulation of cell adhesion GO:0045834 positive regulation of lipid metabolic process GO:0045860 positive regulation of protein kinase activity GO:0046328 regulation of JNK cascade GO:0046330 positive regulation of JNK cascade GO:0046847 filopodium assembly GO:0048872 homeostasis of number of cells GO:0050663 cytokine secretion GO:0050701 interleukin-1 secretion GO:0050702 interleukin-1 beta secretion GO:0050704 regulation of interleukin-1 secretion GO:0050706 regulation of interleukin-1 beta secretion GO:0050707 regulation of cytokine secretion GO:0050708 regulation of protein secretion GO:0050727 regulation of inflammatory response GO:0050729 positive regulation of inflammatory response GO:0050851 antigen receptor-mediated signaling pathway GO:0050852 T cell receptor signaling pathway GO:0050854 regulation of antigen receptor-mediated signaling pathway GO:0050856 regulation of T cell receptor signaling pathway GO:0050857 positive regulation of antigen receptor-mediated signaling pathway GO:0050862 positive regulation of T cell receptor signaling pathway GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0050900 leukocyte migration GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0051208 sequestering of calcium ion GO:0051209 release of sequestered calcium ion into cytosol GO:0051235 maintenance of location GO:0051238 sequestering of metal ion GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051258 protein polymerization GO:0051272 positive regulation of cellular component movement GO:0051282 regulation of sequestering of calcium ion GO:0051283 negative regulation of sequestering of calcium ion GO:0051403 stress-activated MAPK cascade GO:0051480 regulation of cytosolic calcium ion concentration GO:0051489 regulation of filopodium assembly GO:0051491 positive regulation of filopodium assembly GO:0051493 regulation of cytoskeleton organization GO:0051495 positive regulation of cytoskeleton organization GO:0051896 regulation of protein kinase B signaling GO:0051897 positive regulation of protein kinase B signaling GO:0055074 calcium ion homeostasis GO:0060326 cell chemotaxis GO:0060401 cytosolic calcium ion transport GO:0060402 calcium ion transport into cytosol GO:0060491 regulation of cell projection assembly GO:0070098 chemokine-mediated signaling pathway GO:0070302 regulation of stress-activated protein kinase signaling cascade GO:0070304 positive regulation of stress-activated protein kinase signaling cascade GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070509 calcium ion import GO:0070588 calcium ion transmembrane transport GO:0070838 divalent metal ion transport GO:0071593 lymphocyte aggregation GO:0071594 thymocyte aggregation GO:0071621 granulocyte chemotaxis GO:0071622 regulation of granulocyte chemotaxis GO:0071624 positive regulation of granulocyte chemotaxis GO:0071731 response to nitric oxide GO:0071887 leukocyte apoptotic process GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072511 divalent inorganic cation transport GO:0072610 interleukin-12 secretion GO:0072676 lymphocyte migration GO:0090022 regulation of neutrophil chemotaxis GO:0090023 positive regulation of neutrophil chemotaxis GO:0090066 regulation of anatomical structure size GO:0090218 positive regulation of lipid kinase activity GO:0090630 activation of GTPase activity GO:0097021 lymphocyte migration into lymphoid organs GO:0097022 lymphocyte migration into lymph node GO:0097026 dendritic cell dendrite assembly GO:0097028 dendritic cell differentiation GO:0097029 mature conventional dendritic cell differentiation GO:0097529 myeloid leukocyte migration GO:0097530 granulocyte migration GO:0097553 calcium ion transmembrane import into cytosol GO:1901654 response to ketone GO:1902622 regulation of neutrophil migration GO:1902624 positive regulation of neutrophil migration GO:1902656 calcium ion import into cytosol GO:1903018 regulation of glycoprotein metabolic process GO:1903020 positive regulation of glycoprotein metabolic process GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903725 regulation of phospholipid metabolic process GO:1903727 positive regulation of phospholipid metabolic process GO:1990266 neutrophil migration GO:2000021 regulation of ion homeostasis GO:2000106 regulation of leukocyte apoptotic process GO:2000107 negative regulation of leukocyte apoptotic process GO:2000147 positive regulation of cell motility GO:2000508 regulation of dendritic cell chemotaxis GO:2000510 positive regulation of dendritic cell chemotaxis GO:2000520 regulation of immunological synapse formation GO:2000522 positive regulation of immunological synapse formation GO:2000523 regulation of T cell costimulation GO:2000525 positive regulation of T cell costimulation GO:2000526 positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation GO:2000547 regulation of dendritic cell dendrite assembly
Molecular Function	GO:0001637 G-protein coupled chemoattractant receptor activity GO:0001653 peptide receptor activity GO:0004896 cytokine receptor activity GO:0004950 chemokine receptor activity GO:0008528 G-protein coupled peptide receptor activity GO:0016493 C-C chemokine receptor activity GO:0019955 cytokine binding GO:0019956 chemokine binding GO:0019957 C-C chemokine binding GO:0035757 chemokine (C-C motif) ligand 19 binding GO:0035758 chemokine (C-C motif) ligand 21 binding GO:0038117 C-C motif chemokine 19 receptor activity GO:0038121 C-C motif chemokine 21 receptor activity
Cellular Component	GO:0009897 external side of plasma membrane GO:0098552 side of membrane

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04060 Cytokine-cytokine receptor interaction hsa04062 Chemokine signaling pathway
Reactome	R-HSA-380108: Chemokine receptors bind chemokines R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-418594: G alpha (i) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-375276: Peptide ligand-binding receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR

Summary
Symbol	CCR7
Name	chemokine (C-C motif) receptor 7
Aliases	BLR2; CDw197; CD197; CMKBR7; EBI1; CC-CKR-7; CCR-7; Bukitt's lymphoma receptor 2; CC chemokine receptor 7; E ......
Chromosomal Location	17q12-q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between CCR7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

[ TOP ]

Literatures describing the relation between CCR7 and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
29630987	ovarian carcinoma	Promote immunity (T cell function); increase the efficacy of immunotherapy	This was associated with skin production of CCR7 and CXCR4 at vaccination sites driving DC migration.
16990769	leukemia	Promote immunity(infiltration)	Anti-BCP-ALL T cells expressed CD49d and CXCR4 (implicated in the recruitment to bone marrow), and CD62L and CCR7 (involved in the migration to lymphoid organs). In accordance with this profile, T cells significantly migrated in response to the chemokines CXCL12 and CCL19.

Summary
Symbol	CCR7
Name	chemokine (C-C motif) receptor 7
Aliases	BLR2; CDw197; CD197; CMKBR7; EBI1; CC-CKR-7; CCR-7; Bukitt's lymphoma receptor 2; CC chemokine receptor 7; E ......
Chromosomal Location	17q12-q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of CCR7 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA	Resistant to T cell-mediated killing
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	CCR7
Name	chemokine (C-C motif) receptor 7
Aliases	BLR2; CDw197; CD197; CMKBR7; EBI1; CC-CKR-7; CCR-7; Bukitt's lymphoma receptor 2; CC chemokine receptor 7; E ......
Chromosomal Location	17q12-q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of CCR7 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.941	0.213
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	2.054	0.116
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.116	0.923
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.131	0.868
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.253	0.865
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.633	0.767
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	1.866	0.0255
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	2.43	0.0469
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	1.311	0.314
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	2.548	0.00505
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	2.131	0.132
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.226	0.424

> Mutation difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the mutation difference of CCR7 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	1.4	-1.4	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	1.7	-1.7	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	5.9	-1.1	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	9.1	-1.4	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	6.2	-6.2	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	2.6	3.7	-1.1	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	4.5	7.7	-3.2	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	CCR7
Name	chemokine (C-C motif) receptor 7
Aliases	BLR2; CDw197; CD197; CMKBR7; EBI1; CC-CKR-7; CCR-7; Bukitt's lymphoma receptor 2; CC chemokine receptor 7; E ......
Chromosomal Location	17q12-q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CCR7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	CCR7
Name	chemokine (C-C motif) receptor 7
Aliases	BLR2; CDw197; CD197; CMKBR7; EBI1; CC-CKR-7; CCR-7; Bukitt's lymphoma receptor 2; CC chemokine receptor 7; E ......
Chromosomal Location	17q12-q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CCR7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CCR7. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	CCR7
Name	chemokine (C-C motif) receptor 7
Aliases	BLR2; CDw197; CD197; CMKBR7; EBI1; CC-CKR-7; CCR-7; Bukitt's lymphoma receptor 2; CC chemokine receptor 7; E ......
Chromosomal Location	17q12-q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CCR7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	CCR7
Name	chemokine (C-C motif) receptor 7
Aliases	BLR2; CDw197; CD197; CMKBR7; EBI1; CC-CKR-7; CCR-7; Bukitt's lymphoma receptor 2; CC chemokine receptor 7; E ......
Chromosomal Location	17q12-q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of CCR7 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	CCR7
Name	chemokine (C-C motif) receptor 7
Aliases	BLR2; CDw197; CD197; CMKBR7; EBI1; CC-CKR-7; CCR-7; Bukitt's lymphoma receptor 2; CC chemokine receptor 7; E ......
Chromosomal Location	17q12-q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between CCR7 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	CCR7
Name	chemokine (C-C motif) receptor 7
Aliases	BLR2; CDw197; CD197; CMKBR7; EBI1; CC-CKR-7; CCR-7; Bukitt's lymphoma receptor 2; CC chemokine receptor 7; E ......
Chromosomal Location	17q12-q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting CCR7 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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