Browse CCT8

Summary
SymbolCCT8
Namechaperonin containing TCP1, subunit 8 (theta)
Aliases Cctq; PRED71; C21orf112; chromosome 21 open reading frame 112; D21S246; CCT-theta; TCP-1-theta; renal carcin ......
Chromosomal Location21q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, cilium basal body
Domain PF00118 TCP-1/cpn60 chaperonin family
Function

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.

> Gene Ontology
 
Biological Process GO:0000723 telomere maintenance
GO:0006278 RNA-dependent DNA biosynthetic process
GO:0006403 RNA localization
GO:0006457 protein folding
GO:0007004 telomere maintenance via telomerase
GO:0007338 single fertilization
GO:0007339 binding of sperm to zona pellucida
GO:0008037 cell recognition
GO:0009566 fertilization
GO:0009988 cell-cell recognition
GO:0010833 telomere maintenance via telomere lengthening
GO:0031647 regulation of protein stability
GO:0032200 telomere organization
GO:0032204 regulation of telomere maintenance
GO:0032206 positive regulation of telomere maintenance
GO:0032210 regulation of telomere maintenance via telomerase
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0032844 regulation of homeostatic process
GO:0032846 positive regulation of homeostatic process
GO:0033044 regulation of chromosome organization
GO:0034502 protein localization to chromosome
GO:0034504 protein localization to nucleus
GO:0035036 sperm-egg recognition
GO:0046931 pore complex assembly
GO:0050821 protein stabilization
GO:0051052 regulation of DNA metabolic process
GO:0051054 positive regulation of DNA metabolic process
GO:0060249 anatomical structure homeostasis
GO:0070198 protein localization to chromosome, telomeric region
GO:0070199 establishment of protein localization to chromosome
GO:0070200 establishment of protein localization to telomere
GO:0070202 regulation of establishment of protein localization to chromosome
GO:0070203 regulation of establishment of protein localization to telomere
GO:0071897 DNA biosynthetic process
GO:0090670 RNA localization to Cajal body
GO:0090671 telomerase RNA localization to Cajal body
GO:0090672 telomerase RNA localization
GO:1900180 regulation of protein localization to nucleus
GO:1900182 positive regulation of protein localization to nucleus
GO:1901998 toxin transport
GO:1903405 protein localization to nuclear body
GO:1903829 positive regulation of cellular protein localization
GO:1904356 regulation of telomere maintenance via telomere lengthening
GO:1904358 positive regulation of telomere maintenance via telomere lengthening
GO:1904814 regulation of protein localization to chromosome, telomeric region
GO:1904816 positive regulation of protein localization to chromosome, telomeric region
GO:1904851 positive regulation of establishment of protein localization to telomere
GO:1904867 protein localization to Cajal body
GO:1904869 regulation of protein localization to Cajal body
GO:1904871 positive regulation of protein localization to Cajal body
GO:1904872 regulation of telomerase RNA localization to Cajal body
GO:1904874 positive regulation of telomerase RNA localization to Cajal body
GO:1904951 positive regulation of establishment of protein localization
GO:1990173 protein localization to nucleoplasm
GO:2000278 regulation of DNA biosynthetic process
GO:2000573 positive regulation of DNA biosynthetic process
GO:2001252 positive regulation of chromosome organization
Molecular Function GO:0016887 ATPase activity
GO:0042623 ATPase activity, coupled
GO:0045296 cadherin binding
GO:0050839 cell adhesion molecule binding
GO:0051082 unfolded protein binding
GO:0098631 protein binding involved in cell adhesion
GO:0098632 protein binding involved in cell-cell adhesion
GO:0098641 cadherin binding involved in cell-cell adhesion
Cellular Component GO:0002199 zona pellucida receptor complex
GO:0005813 centrosome
GO:0005832 chaperonin-containing T-complex
GO:0005874 microtubule
GO:0005913 cell-cell adherens junction
GO:0005929 cilium
GO:0044297 cell body
GO:0044445 cytosolic part
GO:0045111 intermediate filament cytoskeleton
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-390471: Association of TriC/CCT with target proteins during biosynthesis
R-HSA-5620922: BBSome-mediated cargo-targeting to cilium
R-HSA-5620920: Cargo trafficking to the periciliary membrane
R-HSA-390466: Chaperonin-mediated protein folding
R-HSA-5617833: Cilium Assembly
R-HSA-6814122: Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-389958: Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
R-HSA-390450: Folding of actin by CCT/TriC
R-HSA-389960: Formation of tubulin folding intermediates by CCT/TriC
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-392499: Metabolism of proteins
R-HSA-6798695: Neutrophil degranulation
R-HSA-1852241: Organelle biogenesis and maintenance
R-HSA-389957: Prefoldin mediated transfer of substrate to CCT/TriC
R-HSA-391251: Protein folding
Summary
SymbolCCT8
Namechaperonin containing TCP1, subunit 8 (theta)
Aliases Cctq; PRED71; C21orf112; chromosome 21 open reading frame 112; D21S246; CCT-theta; TCP-1-theta; renal carcin ......
Chromosomal Location21q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CCT8 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolCCT8
Namechaperonin containing TCP1, subunit 8 (theta)
Aliases Cctq; PRED71; C21orf112; chromosome 21 open reading frame 112; D21S246; CCT-theta; TCP-1-theta; renal carcin ......
Chromosomal Location21q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CCT8 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCCT8
Namechaperonin containing TCP1, subunit 8 (theta)
Aliases Cctq; PRED71; C21orf112; chromosome 21 open reading frame 112; D21S246; CCT-theta; TCP-1-theta; renal carcin ......
Chromosomal Location21q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CCT8 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.140.561
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.0710.982
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.1840.937
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1630.594
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.5470.764
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3230.89
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1180.809
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2840.899
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1250.958
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2490.905
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.690.831
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.2260.00114
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CCT8 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.1011.10.0181
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.1011.10.0286
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCCT8
Namechaperonin containing TCP1, subunit 8 (theta)
Aliases Cctq; PRED71; C21orf112; chromosome 21 open reading frame 112; D21S246; CCT-theta; TCP-1-theta; renal carcin ......
Chromosomal Location21q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CCT8. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCCT8
Namechaperonin containing TCP1, subunit 8 (theta)
Aliases Cctq; PRED71; C21orf112; chromosome 21 open reading frame 112; D21S246; CCT-theta; TCP-1-theta; renal carcin ......
Chromosomal Location21q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CCT8. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CCT8.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCCT8
Namechaperonin containing TCP1, subunit 8 (theta)
Aliases Cctq; PRED71; C21orf112; chromosome 21 open reading frame 112; D21S246; CCT-theta; TCP-1-theta; renal carcin ......
Chromosomal Location21q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CCT8. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCCT8
Namechaperonin containing TCP1, subunit 8 (theta)
Aliases Cctq; PRED71; C21orf112; chromosome 21 open reading frame 112; D21S246; CCT-theta; TCP-1-theta; renal carcin ......
Chromosomal Location21q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CCT8 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCCT8
Namechaperonin containing TCP1, subunit 8 (theta)
Aliases Cctq; PRED71; C21orf112; chromosome 21 open reading frame 112; D21S246; CCT-theta; TCP-1-theta; renal carcin ......
Chromosomal Location21q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CCT8 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCCT8
Namechaperonin containing TCP1, subunit 8 (theta)
Aliases Cctq; PRED71; C21orf112; chromosome 21 open reading frame 112; D21S246; CCT-theta; TCP-1-theta; renal carcin ......
Chromosomal Location21q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CCT8 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.