| Summary | |
|---|---|
| Symbol | CD209 |
| Name | CD209 molecule |
| Aliases | DC-SIGN; CDSIGN; DC-SIGN1; CLEC4L; CD209 antigen; C-type lectin domain family 4 member L; C-type lectin doma ...... |
| Chromosomal Location | 19p13 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
| Subcellular Location | Isoform 1: Cell membrane Single-pass type II membrane protein ; SUBCELLULAR LOCATION: Isoform 2: Cell membrane Single-pass type II membrane protein ; SUBCELLULAR LOCATION: Isoform 3: Cell membrane Single-pass type II membrane protein ; SUBCELLULAR LOCATION: Isoform 4: Cell membrane Single-pass type II membrane protein ; SUBCELLULAR LOCATION: Isoform 5: Cell membrane Single-pass type II membrane protein ; SUBCELLULAR LOCATION: Isoform 6: Secreted ; SUBCELLULAR LOCATION: Isoform 7: Secreted ; SUBCELLULAR LOCATION: Isoform 8: Secreted ; SUBCELLULAR LOCATION: Isoform 9: Secreted ; SUBCELLULAR LOCATION: Isoform 10: Secreted ; SUBCELLULAR LOCATION: Isoform 11: Secreted ; SUBCELLULAR LOCATION: Isoform 12: Secreted |
| Domain |
PF00059 Lectin C-type domain |
| Function |
Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. ; FUNCTION: On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells. ; FUNCTION: (Microbial infection) Acts as an attachment receptor for HIV-1 and HIV-2. ; FUNCTION: (Microbial infection) Acts as an attachment receptor for Ebolavirus. ; FUNCTION: (Microbial infection) Acts as an attachment receptor for Cytomegalovirus. ; FUNCTION: (Microbial infection) Acts as an attachment receptor for HCV. ; FUNCTION: (Microbial infection) Acts as an attachment receptor for Dengue virus. ; FUNCTION: (Microbial infection) Acts as an attachment receptor for Measles virus. ; FUNCTION: (Microbial infection) Acts as an attachment receptor for Herpes simplex virus 1. ; FUNCTION: (Microbial infection) Acts as an attachment receptor for Influenzavirus A. ; FUNCTION: (Microbial infection) Acts as an attachment receptor for SARS coronavirus. ; FUNCTION: (Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus. ; FUNCTION: (Microbial infection) Acts as an attachment receptor for Lassa virus (PubMed:23966408). Acts as an attachment receptor for Marburg virusn. ; FUNCTION: (Microbial infection) Acts as an attachment receptor for Respiratory syncytial virus. ; FUNCTION: (Microbial infection) Acts as an attachment receptor for Rift valley fever virus and uukuniemi virus. ; FUNCTION: (Microbial infection) Acts as an attachment receptor for West-nile virus. ; FUNCTION: (Microbial infection) Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of bacterial pathogen antigens, including Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA (PubMed:16379498). Recognition of M.tuberculosis by dendritic cells occurs partially via this molecule (PubMed:16092920, PubMed:21203928). |
| Biological Process |
GO:0002218 activation of innate immune response GO:0002220 innate immune response activating cell surface receptor signaling pathway GO:0002223 stimulatory C-type lectin receptor signaling pathway GO:0002250 adaptive immune response GO:0002429 immune response-activating cell surface receptor signaling pathway GO:0002694 regulation of leukocyte activation GO:0002757 immune response-activating signal transduction GO:0002758 innate immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007159 leukocyte cell-cell adhesion GO:0008037 cell recognition GO:0009988 cell-cell recognition GO:0015833 peptide transport GO:0019048 modulation by virus of host morphology or physiology GO:0019058 viral life cycle GO:0019062 virion attachment to host cell GO:0019079 viral genome replication GO:0019882 antigen processing and presentation GO:0022407 regulation of cell-cell adhesion GO:0030260 entry into host cell GO:0031349 positive regulation of defense response GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0035821 modification of morphology or physiology of other organism GO:0042098 T cell proliferation GO:0042110 T cell activation GO:0042129 regulation of T cell proliferation GO:0042886 amide transport GO:0044003 modification by symbiont of host morphology or physiology GO:0044406 adhesion of symbiont to host GO:0044409 entry into host GO:0044650 adhesion of symbiont to host cell GO:0044766 multi-organism transport GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0046651 lymphocyte proliferation GO:0046718 viral entry into host cell GO:0046794 transport of virus GO:0046968 peptide antigen transport GO:0048002 antigen processing and presentation of peptide antigen GO:0050670 regulation of lymphocyte proliferation GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0051249 regulation of lymphocyte activation GO:0051701 interaction with host GO:0051806 entry into cell of other organism involved in symbiotic interaction GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051828 entry into other organism involved in symbiotic interaction GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0071593 lymphocyte aggregation GO:0075733 intracellular transport of virus GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules GO:1902579 multi-organism localization GO:1902581 multi-organism cellular localization GO:1902583 multi-organism intracellular transport GO:1903037 regulation of leukocyte cell-cell adhesion |
| Molecular Function |
GO:0001618 virus receptor activity GO:0003823 antigen binding GO:0005537 mannose binding GO:0030246 carbohydrate binding GO:0033218 amide binding GO:0042277 peptide binding GO:0042605 peptide antigen binding GO:0046790 virion binding GO:0048029 monosaccharide binding |
| Cellular Component | - |
| KEGG |
hsa04145 Phagosome |
| Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-8851680: Butyrophilin (BTN) family interactions R-HSA-5621481: C-type lectin receptors (CLRs) R-HSA-5621575: CD209 (DC-SIGN) signaling R-HSA-168256: Immune System R-HSA-168249: Innate Immune System |
| Summary | |
|---|---|
| Symbol | CD209 |
| Name | CD209 molecule |
| Aliases | DC-SIGN; CDSIGN; DC-SIGN1; CLEC4L; CD209 antigen; C-type lectin domain family 4 member L; C-type lectin doma ...... |
| Chromosomal Location | 19p13 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content | Literatures that report relations between CD209 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
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Literatures describing the relation between CD209 and anti-tumor immunity in human cancer.
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| Summary | |
|---|---|
| Symbol | CD209 |
| Name | CD209 molecule |
| Aliases | DC-SIGN; CDSIGN; DC-SIGN1; CLEC4L; CD209 antigen; C-type lectin domain family 4 member L; C-type lectin doma ...... |
| Chromosomal Location | 19p13 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
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> High-throughput Screening
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Statistical results of CD209 in screening data sets for detecting immune reponses.
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| Summary | |
|---|---|
| Symbol | CD209 |
| Name | CD209 molecule |
| Aliases | DC-SIGN; CDSIGN; DC-SIGN1; CLEC4L; CD209 antigen; C-type lectin domain family 4 member L; C-type lectin doma ...... |
| Chromosomal Location | 19p13 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
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Points in the above scatter plot represent the expression difference of CD209 in various data sets.
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Points in the above scatter plot represent the mutation difference of CD209 in various data sets.
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| Summary | |
|---|---|
| Symbol | CD209 |
| Name | CD209 molecule |
| Aliases | DC-SIGN; CDSIGN; DC-SIGN1; CLEC4L; CD209 antigen; C-type lectin domain family 4 member L; C-type lectin doma ...... |
| Chromosomal Location | 19p13 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CD209. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
| Summary | |
|---|---|
| Symbol | CD209 |
| Name | CD209 molecule |
| Aliases | DC-SIGN; CDSIGN; DC-SIGN1; CLEC4L; CD209 antigen; C-type lectin domain family 4 member L; C-type lectin doma ...... |
| Chromosomal Location | 19p13 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CD209. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CD209. > Immunoinhibitor > Immunostimulator > MHC molecule |
| Summary | |
|---|---|
| Symbol | CD209 |
| Name | CD209 molecule |
| Aliases | DC-SIGN; CDSIGN; DC-SIGN1; CLEC4L; CD209 antigen; C-type lectin domain family 4 member L; C-type lectin doma ...... |
| Chromosomal Location | 19p13 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CD209. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
| Summary | |
|---|---|
| Symbol | CD209 |
| Name | CD209 molecule |
| Aliases | DC-SIGN; CDSIGN; DC-SIGN1; CLEC4L; CD209 antigen; C-type lectin domain family 4 member L; C-type lectin doma ...... |
| Chromosomal Location | 19p13 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Distribution of CD209 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
| Summary | |
|---|---|
| Symbol | CD209 |
| Name | CD209 molecule |
| Aliases | DC-SIGN; CDSIGN; DC-SIGN1; CLEC4L; CD209 antigen; C-type lectin domain family 4 member L; C-type lectin doma ...... |
| Chromosomal Location | 19p13 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Associations between CD209 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
| Summary | |
|---|---|
| Symbol | CD209 |
| Name | CD209 molecule |
| Aliases | DC-SIGN; CDSIGN; DC-SIGN1; CLEC4L; CD209 antigen; C-type lectin domain family 4 member L; C-type lectin doma ...... |
| Chromosomal Location | 19p13 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content | Drugs targeting CD209 collected from DrugBank database. |
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There is no record. |