Browse CD24

Summary
SymbolCD24
NameCD24 molecule
Aliases CD24A; CD24 antigen (small cell lung carcinoma cluster 4 antigen); CD antigen CD24; Small cell lung carcinom ......
Chromosomal Location6q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane; Lipid-anchor, GPI-anchor.
Domain PF14984 CD24 protein
Function

May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity).

> Gene Ontology
 
Biological Process GO:0001655 urogenital system development
GO:0001666 response to hypoxia
GO:0001818 negative regulation of cytokine production
GO:0001822 kidney development
GO:0001959 regulation of cytokine-mediated signaling pathway
GO:0002237 response to molecule of bacterial origin
GO:0002694 regulation of leukocyte activation
GO:0002696 positive regulation of leukocyte activation
GO:0002764 immune response-regulating signaling pathway
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0007159 leukocyte cell-cell adhesion
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0016055 Wnt signaling pathway
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0018212 peptidyl-tyrosine modification
GO:0022407 regulation of cell-cell adhesion
GO:0022409 positive regulation of cell-cell adhesion
GO:0030856 regulation of epithelial cell differentiation
GO:0030858 positive regulation of epithelial cell differentiation
GO:0031294 lymphocyte costimulation
GO:0031295 T cell costimulation
GO:0032594 protein transport within lipid bilayer
GO:0032595 B cell receptor transport within lipid bilayer
GO:0032596 protein transport into membrane raft
GO:0032597 B cell receptor transport into membrane raft
GO:0032599 protein transport out of membrane raft
GO:0032600 chemokine receptor transport out of membrane raft
GO:0032835 glomerulus development
GO:0032907 transforming growth factor beta3 production
GO:0032910 regulation of transforming growth factor beta3 production
GO:0032913 negative regulation of transforming growth factor beta3 production
GO:0032943 mononuclear cell proliferation
GO:0032944 regulation of mononuclear cell proliferation
GO:0032946 positive regulation of mononuclear cell proliferation
GO:0033606 chemokine receptor transport within lipid bilayer
GO:0033674 positive regulation of kinase activity
GO:0035850 epithelial cell differentiation involved in kidney development
GO:0036293 response to decreased oxygen levels
GO:0042098 T cell proliferation
GO:0042102 positive regulation of T cell proliferation
GO:0042104 positive regulation of activated T cell proliferation
GO:0042110 T cell activation
GO:0042129 regulation of T cell proliferation
GO:0042632 cholesterol homeostasis
GO:0043405 regulation of MAP kinase activity
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043627 response to estrogen
GO:0045730 respiratory burst
GO:0045785 positive regulation of cell adhesion
GO:0045860 positive regulation of protein kinase activity
GO:0046006 regulation of activated T cell proliferation
GO:0046651 lymphocyte proliferation
GO:0050670 regulation of lymphocyte proliferation
GO:0050671 positive regulation of lymphocyte proliferation
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050798 activated T cell proliferation
GO:0050863 regulation of T cell activation
GO:0050865 regulation of cell activation
GO:0050867 positive regulation of cell activation
GO:0050870 positive regulation of T cell activation
GO:0051249 regulation of lymphocyte activation
GO:0051251 positive regulation of lymphocyte activation
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051668 localization within membrane
GO:0055074 calcium ion homeostasis
GO:0055088 lipid homeostasis
GO:0055092 sterol homeostasis
GO:0060759 regulation of response to cytokine stimulus
GO:0061005 cell differentiation involved in kidney development
GO:0061097 regulation of protein tyrosine kinase activity
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0061318 renal filtration cell differentiation
GO:0061326 renal tubule development
GO:0070482 response to oxygen levels
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0070661 leukocyte proliferation
GO:0070663 regulation of leukocyte proliferation
GO:0070665 positive regulation of leukocyte proliferation
GO:0071593 lymphocyte aggregation
GO:0071604 transforming growth factor beta production
GO:0071634 regulation of transforming growth factor beta production
GO:0071635 negative regulation of transforming growth factor beta production
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0072001 renal system development
GO:0072006 nephron development
GO:0072009 nephron epithelium development
GO:0072010 glomerular epithelium development
GO:0072073 kidney epithelium development
GO:0072080 nephron tubule development
GO:0072112 glomerular visceral epithelial cell differentiation
GO:0072139 glomerular parietal epithelial cell differentiation
GO:0072160 nephron tubule epithelial cell differentiation
GO:0072182 regulation of nephron tubule epithelial cell differentiation
GO:0072311 glomerular epithelial cell differentiation
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072657 protein localization to membrane
GO:0090150 establishment of protein localization to membrane
GO:0090183 regulation of kidney development
GO:0090184 positive regulation of kidney development
GO:0097193 intrinsic apoptotic signaling pathway
GO:0198738 cell-cell signaling by wnt
GO:1903037 regulation of leukocyte cell-cell adhesion
GO:1903039 positive regulation of leukocyte cell-cell adhesion
GO:1903044 protein localization to membrane raft
GO:2000696 regulation of epithelial cell differentiation involved in kidney development
GO:2000698 positive regulation of epithelial cell differentiation involved in kidney development
GO:2000768 positive regulation of nephron tubule epithelial cell differentiation
Molecular Function GO:0008047 enzyme activator activity
GO:0019207 kinase regulator activity
GO:0019209 kinase activator activity
GO:0019887 protein kinase regulator activity
GO:0030295 protein kinase activator activity
GO:0030296 protein tyrosine kinase activator activity
Cellular Component GO:0009897 external side of plasma membrane
GO:0031225 anchored component of membrane
GO:0031233 intrinsic component of external side of plasma membrane
GO:0031362 anchored component of external side of plasma membrane
GO:0045121 membrane raft
GO:0046658 anchored component of plasma membrane
GO:0098552 side of membrane
GO:0098589 membrane region
GO:0098857 membrane microdomain
> KEGG and Reactome Pathway
 
KEGG hsa04640 Hematopoietic cell lineage
Reactome R-HSA-422475: Axon guidance
R-HSA-1266738: Developmental Biology
R-HSA-373760: L1CAM interactions
Summary
SymbolCD24
NameCD24 molecule
Aliases CD24A; CD24 antigen (small cell lung carcinoma cluster 4 antigen); CD antigen CD24; Small cell lung carcinom ......
Chromosomal Location6q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CD24 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between CD24 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
22819865Pancreatic AdenocarcinomaPromote immunityIntratumor injection of human CD24 and Her2/neu-specific T-bodies completely eliminated the tumors from most animals. In contrast, the CD24-specific T-bodies prolonged survival of mice in which only a subpopulation of the tumor cells expressed the antigen. T-bodies specific to CD24, a putative cancer stem cell antigen, were effective against PAC xenografts that had only a subset of antigen-expressing cells.
Summary
SymbolCD24
NameCD24 molecule
Aliases CD24A; CD24 antigen (small cell lung carcinoma cluster 4 antigen); CD antigen CD24; Small cell lung carcinom ......
Chromosomal Location6q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CD24 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCD24
NameCD24 molecule
Aliases CD24A; CD24 antigen (small cell lung carcinoma cluster 4 antigen); CD antigen CD24; Small cell lung carcinom ......
Chromosomal Location6q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CD24 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14121.2920.157
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.4630.764
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)871.8840.163
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9161.0830.174
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.5670.786
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.7340.505
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0110.991
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.5230.305
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-1.6210.29
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 4801
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 2801
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0890.66
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolCD24
NameCD24 molecule
Aliases CD24A; CD24 antigen (small cell lung carcinoma cluster 4 antigen); CD antigen CD24; Small cell lung carcinom ......
Chromosomal Location6q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CD24. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCD24
NameCD24 molecule
Aliases CD24A; CD24 antigen (small cell lung carcinoma cluster 4 antigen); CD antigen CD24; Small cell lung carcinom ......
Chromosomal Location6q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CD24. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CD24.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCD24
NameCD24 molecule
Aliases CD24A; CD24 antigen (small cell lung carcinoma cluster 4 antigen); CD antigen CD24; Small cell lung carcinom ......
Chromosomal Location6q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CD24. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCD24
NameCD24 molecule
Aliases CD24A; CD24 antigen (small cell lung carcinoma cluster 4 antigen); CD antigen CD24; Small cell lung carcinom ......
Chromosomal Location6q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CD24 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCD24
NameCD24 molecule
Aliases CD24A; CD24 antigen (small cell lung carcinoma cluster 4 antigen); CD antigen CD24; Small cell lung carcinom ......
Chromosomal Location6q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CD24 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCD24
NameCD24 molecule
Aliases CD24A; CD24 antigen (small cell lung carcinoma cluster 4 antigen); CD antigen CD24; Small cell lung carcinom ......
Chromosomal Location6q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CD24 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.