Summary | |
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Symbol | CD74 |
Name | CD74 molecule, major histocompatibility complex, class II invariant chain |
Aliases | HLA-DR-gamma; Ia-associated invariant chain; gamma chain of class II antigens; MHC HLA-DR gamma chain; DHLAG ...... |
Chromosomal Location | 5q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type II membrane protein Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane. |
Domain |
PF09307 CLIP PF08831 Class II MHC-associated invariant chain trimerisation domain PF00086 Thyroglobulin type-1 repeat |
Function |
Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. |
Biological Process |
GO:0000187 activation of MAPK activity GO:0001516 prostaglandin biosynthetic process GO:0001776 leukocyte homeostasis GO:0001782 B cell homeostasis GO:0001783 B cell apoptotic process GO:0001819 positive regulation of cytokine production GO:0001959 regulation of cytokine-mediated signaling pathway GO:0001961 positive regulation of cytokine-mediated signaling pathway GO:0002250 adaptive immune response GO:0002260 lymphocyte homeostasis GO:0002274 myeloid leukocyte activation GO:0002367 cytokine production involved in immune response GO:0002440 production of molecular mediator of immune response GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002468 dendritic cell antigen processing and presentation GO:0002478 antigen processing and presentation of exogenous peptide antigen GO:0002495 antigen processing and presentation of peptide antigen via MHC class II GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002521 leukocyte differentiation GO:0002577 regulation of antigen processing and presentation GO:0002579 positive regulation of antigen processing and presentation GO:0002604 regulation of dendritic cell antigen processing and presentation GO:0002606 positive regulation of dendritic cell antigen processing and presentation GO:0002683 negative regulation of immune system process GO:0002685 regulation of leukocyte migration GO:0002687 positive regulation of leukocyte migration GO:0002688 regulation of leukocyte chemotaxis GO:0002690 positive regulation of leukocyte chemotaxis GO:0002694 regulation of leukocyte activation GO:0002695 negative regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002700 regulation of production of molecular mediator of immune response GO:0002702 positive regulation of production of molecular mediator of immune response GO:0002718 regulation of cytokine production involved in immune response GO:0002720 positive regulation of cytokine production involved in immune response GO:0002790 peptide secretion GO:0002791 regulation of peptide secretion GO:0002792 negative regulation of peptide secretion GO:0002828 regulation of type 2 immune response GO:0002830 positive regulation of type 2 immune response GO:0002901 mature B cell apoptotic process GO:0002902 regulation of B cell apoptotic process GO:0002903 negative regulation of B cell apoptotic process GO:0002905 regulation of mature B cell apoptotic process GO:0002906 negative regulation of mature B cell apoptotic process GO:0006457 protein folding GO:0006458 'de novo' protein folding GO:0006631 fatty acid metabolic process GO:0006633 fatty acid biosynthetic process GO:0006636 unsaturated fatty acid biosynthetic process GO:0006690 icosanoid metabolic process GO:0006692 prostanoid metabolic process GO:0006693 prostaglandin metabolic process GO:0007159 leukocyte cell-cell adhesion GO:0007162 negative regulation of cell adhesion GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage GO:0010934 macrophage cytokine production GO:0010935 regulation of macrophage cytokine production GO:0015833 peptide transport GO:0016053 organic acid biosynthetic process GO:0016064 immunoglobulin mediated immune response GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0019724 B cell mediated immunity GO:0019882 antigen processing and presentation GO:0019883 antigen processing and presentation of endogenous antigen GO:0019884 antigen processing and presentation of exogenous antigen GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0022407 regulation of cell-cell adhesion GO:0022408 negative regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030098 lymphocyte differentiation GO:0030217 T cell differentiation GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0030335 positive regulation of cell migration GO:0030593 neutrophil chemotaxis GO:0030595 leukocyte chemotaxis GO:0030888 regulation of B cell proliferation GO:0030890 positive regulation of B cell proliferation GO:0032103 positive regulation of response to external stimulus GO:0032147 activation of protein kinase activity GO:0032602 chemokine production GO:0032642 regulation of chemokine production GO:0032722 positive regulation of chemokine production GO:0032844 regulation of homeostatic process GO:0032845 negative regulation of homeostatic process GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032946 positive regulation of mononuclear cell proliferation GO:0033077 T cell differentiation in thymus GO:0033559 unsaturated fatty acid metabolic process GO:0033674 positive regulation of kinase activity GO:0035691 macrophage migration inhibitory factor signaling pathway GO:0040017 positive regulation of locomotion GO:0042092 type 2 immune response GO:0042100 B cell proliferation GO:0042110 T cell activation GO:0042113 B cell activation GO:0042116 macrophage activation GO:0042770 signal transduction in response to DNA damage GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042886 amide transport GO:0043030 regulation of macrophage activation GO:0043368 positive T cell selection GO:0043383 negative T cell selection GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0044283 small molecule biosynthetic process GO:0045058 T cell selection GO:0045059 positive thymic T cell selection GO:0045060 negative thymic T cell selection GO:0045061 thymic T cell selection GO:0045580 regulation of T cell differentiation GO:0045581 negative regulation of T cell differentiation GO:0045582 positive regulation of T cell differentiation GO:0045619 regulation of lymphocyte differentiation GO:0045620 negative regulation of lymphocyte differentiation GO:0045621 positive regulation of lymphocyte differentiation GO:0045785 positive regulation of cell adhesion GO:0045860 positive regulation of protein kinase activity GO:0046394 carboxylic acid biosynthetic process GO:0046456 icosanoid biosynthetic process GO:0046457 prostanoid biosynthetic process GO:0046651 lymphocyte proliferation GO:0048002 antigen processing and presentation of peptide antigen GO:0048144 fibroblast proliferation GO:0048145 regulation of fibroblast proliferation GO:0048146 positive regulation of fibroblast proliferation GO:0048872 homeostasis of number of cells GO:0050670 regulation of lymphocyte proliferation GO:0050671 positive regulation of lymphocyte proliferation GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050863 regulation of T cell activation GO:0050864 regulation of B cell activation GO:0050865 regulation of cell activation GO:0050866 negative regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050868 negative regulation of T cell activation GO:0050870 positive regulation of T cell activation GO:0050871 positive regulation of B cell activation GO:0050900 leukocyte migration GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0051048 negative regulation of secretion GO:0051051 negative regulation of transport GO:0051084 'de novo' posttranslational protein folding GO:0051085 chaperone mediated protein folding requiring cofactor GO:0051249 regulation of lymphocyte activation GO:0051250 negative regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051272 positive regulation of cellular component movement GO:0060326 cell chemotaxis GO:0060759 regulation of response to cytokine stimulus GO:0060760 positive regulation of response to cytokine stimulus GO:0060907 positive regulation of macrophage cytokine production GO:0061077 chaperone-mediated protein folding GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response GO:0061082 myeloid leukocyte cytokine production GO:0070227 lymphocyte apoptotic process GO:0070228 regulation of lymphocyte apoptotic process GO:0070229 negative regulation of lymphocyte apoptotic process GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070665 positive regulation of leukocyte proliferation GO:0071593 lymphocyte aggregation GO:0071594 thymocyte aggregation GO:0071621 granulocyte chemotaxis GO:0071622 regulation of granulocyte chemotaxis GO:0071624 positive regulation of granulocyte chemotaxis GO:0071887 leukocyte apoptotic process GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0072330 monocarboxylic acid biosynthetic process GO:0072331 signal transduction by p53 class mediator GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator GO:0072567 chemokine (C-X-C motif) ligand 2 production GO:0090022 regulation of neutrophil chemotaxis GO:0090023 positive regulation of neutrophil chemotaxis GO:0090087 regulation of peptide transport GO:0097193 intrinsic apoptotic signaling pathway GO:0097529 myeloid leukocyte migration GO:0097530 granulocyte migration GO:1901796 regulation of signal transduction by p53 class mediator GO:1901797 negative regulation of signal transduction by p53 class mediator GO:1902105 regulation of leukocyte differentiation GO:1902106 negative regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1902165 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902532 negative regulation of intracellular signal transduction GO:1902622 regulation of neutrophil migration GO:1902624 positive regulation of neutrophil migration GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903038 negative regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903706 regulation of hemopoiesis GO:1903707 negative regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis GO:1990266 neutrophil migration GO:2000106 regulation of leukocyte apoptotic process GO:2000107 negative regulation of leukocyte apoptotic process GO:2000147 positive regulation of cell motility GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2001020 regulation of response to DNA damage stimulus GO:2001021 negative regulation of response to DNA damage stimulus GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001242 regulation of intrinsic apoptotic signaling pathway GO:2001243 negative regulation of intrinsic apoptotic signaling pathway |
Molecular Function |
GO:0001540 beta-amyloid binding GO:0003823 antigen binding GO:0004896 cytokine receptor activity GO:0019955 cytokine binding GO:0023023 MHC protein complex binding GO:0023026 MHC class II protein complex binding GO:0033218 amide binding GO:0035718 macrophage migration inhibitory factor binding GO:0042277 peptide binding GO:0042287 MHC protein binding GO:0042289 MHC class II protein binding GO:0042658 MHC class II protein binding, via antigen binding groove GO:0044183 protein binding involved in protein folding GO:0050998 nitric-oxide synthase binding |
Cellular Component |
GO:0005765 lysosomal membrane GO:0005770 late endosome GO:0005771 multivesicular body GO:0005775 vacuolar lumen GO:0005802 trans-Golgi network GO:0009897 external side of plasma membrane GO:0012507 ER to Golgi transport vesicle membrane GO:0030133 transport vesicle GO:0030134 ER to Golgi transport vesicle GO:0030135 coated vesicle GO:0030136 clathrin-coated vesicle GO:0030139 endocytic vesicle GO:0030176 integral component of endoplasmic reticulum membrane GO:0030658 transport vesicle membrane GO:0030659 cytoplasmic vesicle membrane GO:0030662 coated vesicle membrane GO:0030665 clathrin-coated vesicle membrane GO:0030666 endocytic vesicle membrane GO:0030669 clathrin-coated endocytic vesicle membrane GO:0031227 intrinsic component of endoplasmic reticulum membrane GO:0031984 organelle subcompartment GO:0032588 trans-Golgi network membrane GO:0035692 macrophage migration inhibitory factor receptor complex GO:0035693 NOS2-CD74 complex GO:0042611 MHC protein complex GO:0042613 MHC class II protein complex GO:0043202 lysosomal lumen GO:0043235 receptor complex GO:0045334 clathrin-coated endocytic vesicle GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane GO:0098552 side of membrane GO:0098553 lumenal side of endoplasmic reticulum membrane GO:0098791 Golgi subcompartment GO:0098852 lytic vacuole membrane |
KEGG |
hsa04612 Antigen processing and presentation |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-202733: Cell surface interactions at the vascular wall R-HSA-109582: Hemostasis R-HSA-168256: Immune System R-HSA-2132295: MHC class II antigen presentation |
Summary | |
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Symbol | CD74 |
Name | CD74 molecule, major histocompatibility complex, class II invariant chain |
Aliases | HLA-DR-gamma; Ia-associated invariant chain; gamma chain of class II antigens; MHC HLA-DR gamma chain; DHLAG ...... |
Chromosomal Location | 5q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CD74 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CD74 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CD74 |
Name | CD74 molecule, major histocompatibility complex, class II invariant chain |
Aliases | HLA-DR-gamma; Ia-associated invariant chain; gamma chain of class II antigens; MHC HLA-DR gamma chain; DHLAG ...... |
Chromosomal Location | 5q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CD74 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CD74 |
Name | CD74 molecule, major histocompatibility complex, class II invariant chain |
Aliases | HLA-DR-gamma; Ia-associated invariant chain; gamma chain of class II antigens; MHC HLA-DR gamma chain; DHLAG ...... |
Chromosomal Location | 5q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CD74 in various data sets.
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Points in the above scatter plot represent the mutation difference of CD74 in various data sets.
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Summary | |
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Symbol | CD74 |
Name | CD74 molecule, major histocompatibility complex, class II invariant chain |
Aliases | HLA-DR-gamma; Ia-associated invariant chain; gamma chain of class II antigens; MHC HLA-DR gamma chain; DHLAG ...... |
Chromosomal Location | 5q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CD74. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CD74 |
Name | CD74 molecule, major histocompatibility complex, class II invariant chain |
Aliases | HLA-DR-gamma; Ia-associated invariant chain; gamma chain of class II antigens; MHC HLA-DR gamma chain; DHLAG ...... |
Chromosomal Location | 5q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CD74. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CD74. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CD74 |
Name | CD74 molecule, major histocompatibility complex, class II invariant chain |
Aliases | HLA-DR-gamma; Ia-associated invariant chain; gamma chain of class II antigens; MHC HLA-DR gamma chain; DHLAG ...... |
Chromosomal Location | 5q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CD74. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CD74 |
Name | CD74 molecule, major histocompatibility complex, class II invariant chain |
Aliases | HLA-DR-gamma; Ia-associated invariant chain; gamma chain of class II antigens; MHC HLA-DR gamma chain; DHLAG ...... |
Chromosomal Location | 5q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CD74 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CD74 |
Name | CD74 molecule, major histocompatibility complex, class II invariant chain |
Aliases | HLA-DR-gamma; Ia-associated invariant chain; gamma chain of class II antigens; MHC HLA-DR gamma chain; DHLAG ...... |
Chromosomal Location | 5q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CD74 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CD74 |
Name | CD74 molecule, major histocompatibility complex, class II invariant chain |
Aliases | HLA-DR-gamma; Ia-associated invariant chain; gamma chain of class II antigens; MHC HLA-DR gamma chain; DHLAG ...... |
Chromosomal Location | 5q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CD74 collected from DrugBank database. |
There is no record. |